CN219526518U - Antibody purification device for accelerating antibody purification speed - Google Patents
Antibody purification device for accelerating antibody purification speed Download PDFInfo
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- CN219526518U CN219526518U CN202223118103.7U CN202223118103U CN219526518U CN 219526518 U CN219526518 U CN 219526518U CN 202223118103 U CN202223118103 U CN 202223118103U CN 219526518 U CN219526518 U CN 219526518U
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Abstract
The utility model provides an antibody purification device for accelerating the antibody purification speed, which relates to the technical field of antibody purification. When the device is used, the filter cylinder is fixedly connected with the device body, the problem that potential safety hazards appear due to loosening of the device caused by impact force generated in the process of centrifugation is solved, the rotation of the device body and the deslagging device are utilized to form relative motion, after purification is completed, raw material residues in the device are lifted by utilizing the electric telescopic rod, the residues are clear by utilizing the arc-shaped scraping plate, the cleaning in a bin is ensured, the new round of purification can be performed through the material injection port, the working efficiency is improved, the problem of manual deslagging is solved, and the device is low in price and has universality.
Description
Technical Field
The utility model relates to the technical field of antibody purification, in particular to an antibody purification device for accelerating the antibody purification speed.
Background
The existing antibody purification device is found to be split when in use, and most of the antibody purification device is firstly required to be put on a filtering device for preliminary filtration so as to remove some unnecessary cell structures and impurities, and then is put in a centrifugal machine for centrifugal filtration and purification again, so that the device requires a plurality of times of operations of staff, the purification speed is reduced, pollution is possibly caused in the transfer process, and the normal use of the antibody is influenced.
An antibody purification apparatus for accelerating the purification rate of an antibody is disclosed in chinese patent publication No. CN 202122036417.1.
However, the above-mentioned technical solution has the following drawbacks that when the purification is performed, the device uses the connection relationship between the buckle and the device main body to fix the filter cartridge and the device main body, but when the device main body rotates at a high speed, the liquid in the filter cartridge impacts the cylinder wall due to the effect of centrifugal force, so that the filter cartridge generates vibration, the tower buckle is impacted and loosened, and the connection between the cover plate and the device main body is loosened, thereby causing potential safety hazards.
Disclosure of Invention
The utility model aims to provide an antibody purification device for accelerating the antibody purification speed, and aims to solve the problem that centrifugal force in the prior art causes impact on tower buckle connection, so that the device is disconnected and dangerous.
In order to achieve the above purpose, the utility model adopts the following technical scheme: the device comprises a device body, wherein a raw material barrel is fixedly connected to the device body, a hollow top plate is arranged on the raw material barrel, an irregular boss is fixedly connected to the hollow top plate, a groove is formed in the irregular boss, and a deslagging mechanism is arranged on the groove.
According to a further technical scheme, the slag removing mechanism comprises a top fixing plate, a cover plate is rotatably connected to the top fixing plate, an electric telescopic rod is fixedly connected to the cover plate, a lifting plate is fixedly connected to the electric telescopic rod, a slag removing ring is fixedly connected to the cover plate, a plurality of arc slag removing blades are fixedly connected to the slag removing ring, the slag removing ring is rotatably installed on an irregular boss through a groove, a plurality of feed inlets are formed in the irregular boss and the cover plate, and sealing plugs are arranged on each feed inlet.
According to a further technical scheme, slag outlet holes are formed in the slag removing ring, and an annular collecting box is arranged on the slag removing ring.
According to a further technical scheme, a guide block is fixedly connected to the raw material barrel, a buffer column is fixedly connected to the guide block, and the buffer column is fixedly connected with the device body.
According to a further technical scheme, the device comprises a discharge port arranged on the device body, and a filter screen is fixedly connected to the discharge port.
According to a further technical scheme, the device comprises a driving motor which is rotationally connected with a support column, and a fixed rotating mechanism which is fixedly connected with the support column.
According to a further technical scheme, the fixed rotating mechanism comprises a fixed seat, a plurality of connecting rods are fixedly connected to the fixed seat, a fixed column is fixedly connected to each connecting rod upper gauge, and a limiting ring is fixedly connected to each fixed column.
According to a further technical scheme, the device body is fixedly connected with a fixing ring, a limiting chute is arranged on the fixing ring, and the limiting chute is connected with a limiting ring in a sliding mode.
The beneficial effects of the utility model are as follows:
when the device is used, the filter cylinder is fixedly connected with the device body, the problem that potential safety hazards appear due to loosening of the device caused by impact force generated in the process of centrifugation is solved, the rotation of the device body and the deslagging device are utilized to form relative motion, after purification is completed, raw material residues in the device are lifted by utilizing the electric telescopic rod, the residues are removed by utilizing the arc-shaped scraping plate, cleaning in a bin is ensured, a new round of purification can be performed through the material injection port, the working efficiency is improved, the problem of manual deslagging is solved, and the device is low in price and has universality.
The slag removing device is fixed with the device body through the fixing base, so that the friction problem between meshing caused by centrifugal force of the device is solved, potential safety hazards are reduced, and the service life of the device is prolonged.
Drawings
Fig. 1 is a schematic overall structure of an embodiment of the present utility model.
Fig. 2 is a schematic cross-sectional structure of an embodiment of the present utility model.
Fig. 3 is a schematic partial structure of an embodiment of the present utility model.
In the figure: 1. a device body; 11. a discharge port; 12. a filter screen; 13. a driving motor; 14. a support column; 15. a limiting ring; 16. a fixing ring; 17. limiting sliding grooves; 2. a raw material cylinder; 21. a hollow top plate; 22. irregular bosses; 23. a groove; 24. a flow guiding block; 25. a buffer column; 26. a feed inlet; 27. a sealing plug; 3. a deslagging mechanism; 31. a fixing plate; 32. a cover plate; 33. an electric telescopic rod; 34. a deslagging ring; 35. slag removal blades; 36. slag outlet holes; 37. an annular collection box; 38. a lifting plate; 4. a fixed rotating mechanism; 41. a fixing seat; 42. a connecting rod; 43. and fixing the column.
Detailed Description
The following describes the embodiments of the present utility model further with reference to the drawings.
As shown in fig. 1, an antibody purification device for accelerating the antibody purification speed comprises a device body 1, wherein a raw material barrel 2 is fixedly connected to the device body 1, a hollow top plate 21 is arranged on the raw material barrel 2, an irregular boss 22 is fixedly connected to the hollow top plate 21, a groove 23 is arranged on the irregular boss 22, and a deslagging mechanism 3 is arranged on the groove 23; by fixing the raw material barrel 2 to the apparatus body 1, the moment generated when the raw material barrel 2 is operated can be effectively dispersed by utilizing the structural stability of the apparatus body 1.
As shown in fig. 1, fig. 2 and fig. 3, specifically, the deslagging mechanism 3 includes a cover plate 32 rotatably connected to a top fixing plate 31 of the top fixing plate 31, an electric telescopic rod 33 fixedly connected to the cover plate 32, a lifting plate 38 fixedly connected to the electric telescopic rod 33, a deslagging ring 34 fixedly connected to the cover plate 32, a plurality of arc deslagging blades 35 preferably 6 arc deslagging blades 35 fixedly connected to the deslagging ring 34, the deslagging ring 34 rotatably mounted on the irregular boss 22 through a groove 23, a plurality of feed inlets 26 provided on the irregular boss 22 and the cover plate 32, and preferably 6 feed inlets 26, a sealing plug 27 provided on each feed inlet 26, and a raw material conveying operation by opening the sealing plug 27 is started, the electric telescopic rod 33 drives the lifting plate 38 to lift the processed raw material residues, and when lifted to the top, the raw material residues are conveyed out through the arc deslagging blades 35 of the body 1.
Further, slag outlet holes 36 are formed in the slag removing ring 34, the number of the preferred slag outlet holes 36 is 6, an annular collecting box 37 is arranged on the slag removing ring 34, and when raw material residues are conveyed to the annular collecting box 37 through the slag removing holes 36 through the arc-shaped slag removing blades 35, slag discharging is completed, and the function of cleaning the residues in the device is achieved.
As shown in fig. 2, specifically, a guide block 24 is fixedly connected to the raw material barrel 2, a buffer column 25 is fixedly connected to the guide block 24, the buffer column 25 is fixedly connected to the device body 1, a discharge port 11 is provided on the device body 1, and a filter screen 12 is fixedly connected to the discharge port 11. The device working chamber, former storage bucket 2 carries out centrifugal purification through the centrifugal action to the raw materials for the raw materials after the preliminary purification falls into on the guide block 24 through centrifugal force, guide block 24 and the engagement of device body 1 inner wall, simultaneously, send into discharge gate 11 with the raw materials after the preliminary purification, discharge gate 11 department is provided with filter screen 12, carries out secondary purification through filter screen 12, guide block 24 mounted position is higher than discharge gate 11, makes through centrifugal force and gravity can not have the heap on the guide block 24, makes things convenient for the later stage clearance, improves the utilization ratio of raw materials.
As shown in fig. 1, specifically, a driving motor 13 is rotatably connected to the device body 1, a support column 14 is fixedly connected to the driving motor 13, and a fixed rotation mechanism 4 is fixedly connected to the support column 14. The driving motor 13 drives the device body to rotate, driving power is provided for the device body 1, and the supporting column 14 provides a fixing effect for the driving motor 13.
As shown in fig. 1, specifically, the fixed rotating mechanism 4 includes a fixed seat 41, a plurality of connecting rods 42 are fixedly connected to the fixed seat 41, the number of preferred connecting rods 42 is 6, each connecting rod 42 is fixedly connected with a fixed column 43, a limiting ring 15 is fixedly connected to the fixed column 43, the fixed column 43 is in bolted connection with the hollow top plate 21, and the fixed column 43 is connected with the hollow top plate 21 through the fixed column 43 to realize the fixing effect on the slag removing mechanism 3.
Further, the device body 1 is fixedly connected with a fixed ring 16, the fixed ring 16 is provided with a limiting chute 17, the limiting chute 17 is slidably connected with a limiting ring 15, and the device body 1 keeps stability when rotating at a high speed through the cooperation between the fixed ring 16 and the limiting ring 15.
Claims (8)
1. The utility model provides an accelerate antibody purification speed antibody purification device, its characterized in that, including device body (1), fixedly connected with feed cylinder (2) on device body (1), be provided with cavity roof (21) on feed cylinder (2), fixedly connected with boss (22) on cavity roof (21), be provided with recess (23) on boss (22), be provided with slag removal mechanism (3) on recess (23).
2. The antibody purification speed accelerating antibody purification device according to claim 1, wherein the deslagging mechanism (3) comprises a top fixing plate (31) and a cover plate (32) rotatably connected to the top fixing plate (31), the cover plate (32) is fixedly connected with an electric telescopic rod (33), the electric telescopic rod (33) is fixedly connected with a lifting plate (38), the cover plate (32) is fixedly connected with a deslagging ring (34), the deslagging ring (34) is fixedly connected with a plurality of arc deslagging blades (35), the deslagging ring (34) is rotatably mounted on a boss (22) through a groove (23), a plurality of feed inlets (26) are formed in the boss (22) and the cover plate (32), and a sealing plug (27) is arranged on each feed inlet (26).
3. The antibody purification device for accelerating the antibody purification according to claim 2, wherein the slag removing ring (34) is provided with a slag outlet (36), and the slag removing ring (34) is provided with an annular collecting box (37).
4. The antibody purification device for accelerating the antibody purification speed according to claim 1, wherein a diversion block (24) is fixedly connected to the raw material barrel (2), a buffer column (25) is fixedly connected to the diversion block (24), and the buffer column (25) is fixedly connected with the device body (1).
5. The antibody purification device for accelerating the antibody purification according to claim 4, wherein a discharge port (11) is arranged on the device body (1), and a filter screen (12) is fixedly connected to the discharge port (11).
6. The antibody purification device with the increased antibody purification speed according to claim 5, wherein a driving motor (13) is arranged on the device body (1), a supporting column (14) is fixedly connected to the driving motor (13), and a fixed rotating mechanism (4) is fixedly connected to the supporting column (14).
7. The antibody purification device with the increased antibody purification speed according to claim 6, wherein the fixed rotating mechanism (4) comprises a fixed seat (41), a plurality of connecting rods (42) are fixedly connected to the fixed seat (41), a fixed column (43) is fixedly connected to each connecting rod (42) through an upper gauge, a limiting ring (15) is fixedly connected to the fixed column (43), and the fixed column (43) is in bolt connection with the hollow top plate (21).
8. The antibody purification device for accelerating the antibody purification speed according to claim 6, wherein a fixed ring (16) is fixedly connected on the device body (1), a limiting chute (17) is arranged on the fixed ring (16), and a limiting ring (15) is connected on the limiting chute (17) in a sliding way.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223118103.7U CN219526518U (en) | 2022-11-23 | 2022-11-23 | Antibody purification device for accelerating antibody purification speed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223118103.7U CN219526518U (en) | 2022-11-23 | 2022-11-23 | Antibody purification device for accelerating antibody purification speed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219526518U true CN219526518U (en) | 2023-08-15 |
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ID=87580896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223118103.7U Active CN219526518U (en) | 2022-11-23 | 2022-11-23 | Antibody purification device for accelerating antibody purification speed |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219526518U (en) |
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2022
- 2022-11-23 CN CN202223118103.7U patent/CN219526518U/en active Active
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