CN219480581U

CN219480581U - Double-layer micro-needle eye patch for delivering eye medicine

Info

Publication number: CN219480581U
Application number: CN202320914762.7U
Authority: CN
Inventors: 刘彪; 崔紫铭; 洪贵凤; 王艺婕; 张欣茹; 徐智苑
Original assignee: Individual
Current assignee: Individual
Priority date: 2023-04-21
Filing date: 2023-04-21
Publication date: 2023-08-08
Anticipated expiration: 2033-04-21

Abstract

The utility model relates to the technical field of microneedle eye patches, in particular to a double-layer microneedle eye patch capable of being used for eye drug delivery. The double-layer microneedle eye patch comprises methacrylic acid hyaluronic acid, hyaluronic acid and a reverse microneedle, wherein the hyaluronic acid is fixedly connected to the interior of the methacrylic acid hyaluronic acid, the reverse microneedle is fixedly connected to the upper end of the methacrylic acid hyaluronic acid, a compound is arranged in the reverse microneedle, the outer side of the methacrylic acid hyaluronic acid is clamped with a hard protective shell through a placing groove, a limiting block is fixedly connected to one end of the methacrylic acid hyaluronic acid, and the limiting block is arranged on the inner side of a limiting groove. According to the double-layer microneedle eye patch, the methacrylic acid hyaluronic acid, the hyaluronic acid and the reverse microneedle are arranged, so that different compounds or various compounds can be attached to the surface of the reverse microneedle, then the effect of releasing different medicines or various medicines can be achieved, and meanwhile the effect of eye drug delivery can be achieved.

Description

Double-layer micro-needle eye patch for delivering eye medicine

Technical Field

The utility model relates to the technical field of micro-needle eye patches, in particular to a double-layer micro-needle eye patch for delivering eye medicines.

Background

The micro-needle is generally composed of micro-scale protrusions, can penetrate through a biological membrane to generate a transport path to increase the absorption of medicines, does not cause pain at the same time, does not need professional nursing staff to administer medicines, is a novel convenient, effective and safe drug delivery system, is a minimally invasive painless and penetrable drug delivery mode, and can deliver medicines to the anterior segment and the posterior segment of the eye;

the patent document with the publication number of CN217988151U discloses a microneedle membrane and a microneedle patch, comprising a base and a needle body. The needle body comprises a tip, a rod body and a base, and the rod body is connected with the tip and the base. The needle body further comprises a first wall and a third wall, and the third wall is positioned at the bottom of the needle body. The third wall includes a first edge and a movable edge, the first edge being connected to the base. The movable edge comprises an arc edge, the needle body turns around the first edge, the first wall and the base are located on the same plane, the arc edge of the third wall turns to abut against one side of the base, which is close to the needle body, and a base hole is formed at the joint of the needle body and the base. Alternatively, the active edge includes a second edge and a third edge. The needle body turns around the first edge, the first wall and the base are located on the same plane, the third edge of the third wall turns over to abut against one side of the base, which is close to the needle body, and a base hole is formed at the joint of the needle body and the base.

Since the microneedle has a single-layer structure and cannot release various drugs, a double-layer microneedle eye patch for delivering ocular drugs is proposed for the above-mentioned problems.

Disclosure of Invention

The utility model aims to provide a double-layer micro-needle eye patch for delivering eye medicines, which solves the problem that the micro-needle eye patch can not realize release of various medicines.

In order to achieve the above purpose, the present utility model provides the following technical solutions:

the utility model provides a double-deck microneedle eye subsides that can be used to eye drug delivery, includes methacrylic acid hyaluronic acid, hyaluronic acid and reverse microneedle, the inside fixedly connected with hyaluronic acid of methacrylic acid hyaluronic acid, methacrylic acid hyaluronic acid upper end fixedly connected with reverse microneedle, the inside compound that is equipped with of reverse microneedle, methacrylic acid hyaluronic acid outside is through standing groove and stereoplasm protective housing block, methacrylic acid hyaluronic acid one end fixedly connected with stopper, the stopper sets up in the spacing inslot side, reverse microneedle sets up in the protective housing inboard, stereoplasm protective housing upper end fixedly connected with oil absorbing paper.

Preferably, the diameter of the tip of the reverse microneedle is 10 μm, the height of the reverse microneedle is 500 μm, the width of the substrate of the reverse microneedle is 250 μm, a plurality of reverse microneedles are arranged, the reverse microneedles are arranged in a rectangular array, and the distance between the reverse microneedles is 400 μm.

Preferably, the protection grooves are formed in a plurality, the protection grooves are arranged in a rectangular array, and the protection grooves correspond to the reverse microneedles one by one.

Preferably, the cross section size of stopper and spacing groove is equal, the cross section size of oil absorbing paper and stereoplasm protective housing is equal.

Preferably, the reverse microneedle is arranged in a hollow mode, and the compound is attached to the inner wall of the reverse microneedle.

Compared with the prior art, the utility model has the beneficial effects that:

according to the utility model, through the arrangement of the methacrylic acid hyaluronic acid, the hyaluronic acid and the reverse microneedle, different compounds or a plurality of compounds can be attached to the surface of the reverse microneedle, so that the effect of releasing different drugs or a plurality of drugs can be realized, the effect of delivering eye drugs can be achieved, meanwhile, the protection of the whole microneedle eye patch in the packaging and transferring process is facilitated through the arrangement of the hard protective shell and the oil absorbing paper, and the oil absorption of the pasting position can be facilitated through the oil absorbing paper during use, so that the stability during use can be improved.

Drawings

FIG. 1 is a schematic diagram of the overall structure of the present utility model;

fig. 2 is a schematic bottom view of the hard protective case of the present utility model.

In the figure: 1-methacrylic acid hyaluronic acid, 2-hyaluronic acid, 3-reverse microneedles, 4-compound, 5-limiting block, 6-hard protective shell, 7-oil absorbing paper, 8-limiting groove, 9-placing groove and 10-protecting groove.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments in accordance with the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

Referring to fig. 1-2, the present utility model provides a technical solution:

the utility model provides a double-deck microneedle eye subsides that can be used to eye drug delivery, including methacrylic acid hyaluronic acid 1, hyaluronic acid 2 and reverse microneedle 3, methacrylic acid hyaluronic acid 1 inside fixedly connected with hyaluronic acid 2, methacrylic acid hyaluronic acid 1 upper end fixedly connected with reverse microneedle 3, reverse microneedle 3 inside is equipped with compound 4, methacrylic acid hyaluronic acid 1 outside is through standing groove 9 and the block of stereoplasm protective housing 6, methacrylic acid hyaluronic acid 1 one end fixedly connected with stopper 5, stopper 5 sets up in spacing inslot 8, reverse microneedle 3 sets up in protection groove 10 inboard, stereoplasm protective housing 6 upper end fixedly connected with oil absorption paper 7.

The diameter of the tip of the reverse micro needle 3 is 10 mu m, the height of the reverse micro needle is 500 mu m, the width of the substrate of the reverse micro needle 3 is 250 mu m, a plurality of reverse micro needles 3 are arranged, the reverse micro needles 3 are arranged in a rectangular array, the distance between the reverse micro needles 3 is 400 mu m, and the tissue penetrating device is suitable for tissue penetrating; the protection grooves 10 are formed in a plurality, the protection grooves 10 are arranged in a rectangular array, and the protection grooves 10 correspond to the reverse micro-needles 3 one by one, so that the reverse micro-needles 3 can be well protected in the packaging and transferring process; the cross sections of the limiting block 5 and the limiting groove 8 are equal in size, and the cross sections of the oil absorbing paper 7 and the hard protective shell 6 are equal in size, so that the microneedle eye patch is taken out of the hard protective shell 6 as a whole when in use; the reverse micro needle 3 is internally provided with a hollow structure, and the compound 4 is attached to the inner wall of the reverse micro needle 3, so that different medicines can be attached as required, and the transfer of the medicines is facilitated.

The working flow is as follows: in the process of preparing the micro-needle eye patch, a main body is manufactured by a hyaluronic acid 2 (HA) inner core and a methacrylic acid hyaluronic acid 1 (ME-HA) outer layer, wherein high-solubility HA is covered by ME-HA, the double-layer eye patch can penetrate through the wet cornea surface, a small amount of ME-HA aqueous solution (containing or not containing therapeutic compound) is centrifuged into a reverse micro-needle 3 (MN) structure in a Polydimethylsiloxane (PDMS) master mold, in a PDMS mold of plasma treatment, as hydrophilic and viscous ME-HA polymers tend to be adhered to the hydrophilic surface of an MN cavity, a hollow MN structure is formed after the micro-needle eye patch is dried at room temperature, then unmodified HA solution (containing or not containing therapeutic compound) is filled in the residual cavity, and is air-dried to form a solid MN, finally, the pure HA solution is introduced into the PDMS mold at the top of the MN array, after drying, the MN patch is peeled off from the mold, and is exposed under ultraviolet rays, the ME-HA outer layer is crosslinked, then the outer layer is adhered to the outer side of the methacrylic acid 1, and the hydrophilic and the viscous ME-HA polymer is adhered to the outer layer, and the hydrophilic and the viscous ME-HA polymer is adhered to the hydrophilic and the hydrophilic ME-HA polymer is adhered to the hydrophilic surface of the MN core eye patch.

Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A double-layer microneedle eye patch for ocular drug delivery, comprising methacrylic acid hyaluronic acid (1), hyaluronic acid (2) and inverted microneedles (3), characterized in that: the novel anti-theft protection device is characterized in that hyaluronic acid (1) is fixedly connected with hyaluronic acid (2) inside, the upper end of the hyaluronic acid (1) is fixedly connected with a reverse microneedle (3), a compound (4) is arranged inside the reverse microneedle (3), the outer side of the hyaluronic acid (1) is clamped with a hard protection shell (6) through a placing groove (9), one end of the hyaluronic acid (1) is fixedly connected with a limiting block (5), the limiting block (5) is arranged on the inner side of a limiting groove (8), the reverse microneedle (3) is arranged on the inner side of a protection groove (10), and the upper end of the hard protection shell (6) is fixedly connected with oil absorbing paper (7).

2. A bilayer microneedle patch for ocular drug delivery according to claim 1, wherein: the diameter of the tip of each reverse micro needle (3) is 10 mu m, the height of each reverse micro needle is 500 mu m, the base width of each reverse micro needle (3) is 250 mu m, a plurality of reverse micro needles (3) are arranged, the reverse micro needles (3) are arranged in a rectangular array, and the distance between the reverse micro needles (3) is 400 mu m.

3. A bilayer microneedle patch for ocular drug delivery according to claim 1, wherein: the protection grooves (10) are formed in a plurality, the protection grooves (10) are arranged in a rectangular array, and the protection grooves (10) correspond to the reverse microneedles (3) one by one.

4. A bilayer microneedle patch for ocular drug delivery according to claim 1, wherein: the cross sections of the limiting blocks (5) and the limiting grooves (8) are equal in size, and the cross sections of the oil absorbing paper (7) and the hard protective shell (6) are equal in size.

5. A bilayer microneedle patch for ocular drug delivery according to claim 1, wherein: the inside of the reverse micro needle (3) is hollow, and the compound (4) is attached to the inner wall of the reverse micro needle (3).