CN219462039U

CN219462039U - Eggshell membrane skin patch for tissue repair

Info

Publication number: CN219462039U
Application number: CN202320101829.5U
Authority: CN
Inventors: 邹潮; 朱征
Original assignee: Chengong Xiamen Bio Tech Co ltd
Current assignee: Chengong Xiamen Bio Tech Co ltd
Priority date: 2023-02-02
Filing date: 2023-02-02
Publication date: 2023-08-04
Anticipated expiration: 2033-02-02

Abstract

The utility model discloses a tissue repair eggshell membrane skin patch which comprises a non-woven fabric, a glue layer, an activated carbon adsorption layer, an eggshell membrane and a fiber layer which are sequentially laminated and fixed from bottom to top, wherein the fiber layer is used for being attached to an affected part of a sore and can absorb seepage; eggshell membrane for contacting wound, stopping bleeding, promoting cell regeneration and repairing wound; the activated carbon adsorption layer is used for adsorbing microorganisms and sore liquid and preventing external microorganisms from entering cells; the adhesive layer is used for bonding the activated carbon adsorption layer on the non-woven fabric; the surface area of the non-woven fabric is larger than that of the adhesive layer, and the non-woven fabric is used for fixing the whole tissue repair eggshell membrane patch on the sore wound. The egg shell membrane is used, is not easy to wrinkle and slide, is convenient to paste, has a simple use process and can avoid polluting microorganisms.

Description

Eggshell membrane skin patch for tissue repair

Technical Field

The utility model relates to the field of membrane patches, in particular to a tissue repair eggshell membrane patch.

Background

Human tissue and organ repair is a worldwide medical problem, however, with the development of artificial tissue repair materials and related medical techniques, local repair of human tissue and organs is possible. Artificial tissue repair materials have become an indispensable medical device in modern surgery. Human tissue repair materials are widely used, for example: pleura, peritoneal repair, repair of pericardium, repair of dura/dura mater defect, repair of bladder, repair of hernia, repair of female pelvic floor dysfunction, repair of nerve conduit defect, repair of blood vessel, repair of ligament, and repair of breast augmentation.

However, the materials currently used as tissue repair membranes are mainly: autologous tissue and synthetic high molecular polymers (such as nylon, terylene, silicone rubber, etc.). The former has limited sources of raw materials, high price and difficult mass production; the latter has poor strength, hard and soft texture, poor biocompatibility, easy generation of foreign body sensation and pain, common corrosion and infection and other complications, and can only be used for parts with low requirements on mechanical strength and comfort.

Because the tissue repair biological film is mostly thin, transparent, soft and easy to wrinkle, inconvenient to paste and easy to pollute microorganisms in the using process.

Eggshell membrane is the white film between eggshell and egg white. The eggshell membrane is not used for membrane skin patches at present, and the utility model is completed.

Disclosure of Invention

In view of the above, the present utility model provides a tissue repair eggshell membrane patch, which uses eggshell membranes, which are not easy to wrinkle and slide, are convenient for pasting operation, have simple use process and can avoid polluting microorganisms.

The adopted technical scheme is as follows:

the utility model provides an eggshell membrane skin subsides are restoreed to tissue, includes from down upwards stacks gradually fixed non-woven fabrics, glue film, active carbon adsorption layer, eggshell membrane and fibrous layer, wherein:

the fiber layer is used for being attached to the sore wound and can absorb seepage;

eggshell membrane for contacting wound, stopping bleeding, promoting cell regeneration and repairing wound;

the activated carbon adsorption layer is used for adsorbing microorganisms and sore liquid and preventing external microorganisms from entering cells;

one surface of the adhesive layer is coated on the non-woven fabric, and the other surface of the adhesive layer is bonded with the activated carbon adsorption layer;

a nonwoven fabric having a surface area equal to or greater than each layer disposed thereon, the nonwoven fabric being used to secure the integral tissue repair eggshell membrane patch to the sore.

Further, the device also comprises a sealing bag, wherein the whole tissue is repaired by the eggshell membrane skin patch, and the eggshell membrane skin patch comprises a non-woven fabric, a glue layer, an activated carbon adsorption layer, an eggshell membrane and a fiber layer which are sequentially laminated and fixed, and the whole tissue is packaged in the sealing bag in an aseptic manner.

Further, in 5 layers of non-woven fabrics, adhesive layers, activated carbon adsorption layers, eggshell membranes and fiber layers which are sequentially laminated and fixed, the surface area of the lower layer is equal to or larger than that of the upper layer in two adjacent upper and lower layers.

Further, the total thickness of the fiber layer and the eggshell membrane is 10-100 μm.

Further, the whole tissue repair eggshell membrane skin patch comprises a non-woven fabric, a glue layer, an activated carbon adsorption layer, an eggshell membrane and a fiber layer which are sequentially laminated and fixed, wherein the whole thickness is 1-5mm.

Further, the overall thickness of the integral tissue repair eggshell membrane patch is 2-3mm.

Further, the eggshell membrane has a rectangular, square, right circular or elliptical shape.

The utility model has the beneficial effects that:

in a first aspect, the present utility model uses eggshell membrane in a membrane patch, the biological effects of eggshell membrane comprising: (1) antibacterial: the eggshell membrane contains defensin, egg transferrin and keratin polypeptide, and has antibacterial effect. (2) Promote wound healing: the eggshell membrane contains abundant collagen, and is an essential material for wound healing. The eggshell membrane can be used for contacting affected part of sore to stop bleeding, promote cell regeneration and repair wound.

In the second aspect, because the existing biological film has an ultrathin structure and is transparent, the biological film is difficult to clamp and easy to lose and wrinkle when taken out by forceps, and even the biological film is easy to move and run after the application is completed. However, the adhesive layer and the non-woven fabric are arranged, so that forceps are not needed when the tissue repair biological film patch is used, the biological film on the tissue repair biological film patch is simply aligned to a sore, the whole tissue repair biological film patch is covered above the sore, and the periphery of the non-woven fabric is pressed. Therefore, the utility model is very convenient and simple to use.

In a third aspect, the utility model employs an activated carbon adsorption layer for adsorbing microorganisms and sore liquid to prevent external microorganisms from entering cells; microorganisms including bacteria, viruses, etc., avoid microbial contamination.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 is a schematic structural diagram of a tissue repair eggshell membrane patch of example 1.

Fig. 2 is a schematic cross-sectional view of a tissue repair eggshell membrane patch according to example 1. Wherein the sealing bag is not shown.

Fig. 3 is a schematic cross-sectional view of a tissue repair eggshell membrane patch according to example 2. Wherein the sealing bag is not shown.

Detailed Description

The technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are only preferred embodiments of the present utility model, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Example 1

Referring to fig. 1 and 2, the eggshell membrane skin patch for tissue repair comprises a non-woven fabric 5, a glue layer 4, an activated carbon adsorption layer 3, eggshell membranes 2 and a fiber layer 1 which are laminated and fixed in sequence from bottom to top. Wherein:

the fiber layer 1 is used for being attached to the sore and affected part and can absorb the seepage. The fibrous layer has a plurality of through holes. The fibrous layer may be a gel-forming fibrous dressing (gellingfibrous), also known as hydrophilic fibrous dressing (Hydrofibers), an absorbent wound dressing. Which contains synthetic fibers made of sodium carboxymethyl cellulose (CMC) and reinforcing cellulose fibers. When the fibrous layer absorbs the exudation, a gel is formed, thereby maintaining a moist wound environment, promoting self-soluble debridement and granulation tissue growth, and thus helping wound healing.

Eggshell membrane 2 is used for contacting affected part of sore, and has hemostatic, cell regeneration promoting, and wound repairing effects. Eggshell membrane (ESM) is a rich resource with inherently complex structures and components provided in nature. At least 6000 ten thousand tons of hen eggs are produced worldwide each year, and it is very attractive to utilize this waste resource to positively impact on sustainable development worldwide.

And the activated carbon adsorption layer 3 is used for adsorbing microorganisms and sore liquid and preventing external microorganisms from entering cells. The active carbon is prepared by using carbon-containing substances such as sawdust, shell, lignite and the like as raw materials through carbonization and activation, and the active carbon is fixed through a glue layer to form an active carbon adsorption layer.

The adhesive layer 4, one side of the adhesive layer 4 is coated on the non-woven fabric, and the other side of the adhesive layer 4 is adhered with an active carbon adsorption layer; the activated carbon adsorption layer 3 is bonded on the non-woven fabric 5 through the adhesive layer 4. The adhesive layer can adopt the existing non-woven adhesive, can be a copolymer emulsion formed by acrylic acid, vinyl acetate and other multi-element copolymerization grafting modification, belongs to self-crosslinking adhesives, has strong mechanical stability and thermal stability, and can be infinitely diluted in soft water.

The nonwoven fabric 5 has a surface area equal to or greater than that of each layer located thereon, i.e., the nonwoven fabric has a surface area equal to or greater than that of the adhesive layer 4, the activated carbon adsorption layer 3, the eggshell membrane 2, or the fibrous layer 1. The non-woven fabric 5 is used for fixing the whole tissue repair eggshell membrane patch on the sore affected part. The non-woven fabric is also called a needled non-woven fabric, and can be produced by adopting polyester fiber (PET) materials and adopting a needling process.

As a preferred embodiment, the tissue repair eggshell membrane patch may further comprise a sealed pouch. The sealing bag can repair the whole tissue, namely the eggshell membrane skin patch comprises a non-woven fabric 5, a glue layer 4, an activated carbon adsorption layer 3, eggshell membranes 2 and a fiber layer 1 which are sequentially laminated and fixed, and the whole tissue is packaged in the sealing bag 6 in an aseptic manner. Thus being convenient for storage and being taken out from the sealing bag when in use.

And in 5 layers of non-woven fabrics 5, adhesive layers 4, activated carbon adsorption layers 3, eggshell membranes 2 and fiber layers 1 which are sequentially laminated and fixed, the surface area of the lower layer is equal to or larger than that of the upper layer in two adjacent upper and lower layers. As an alternative embodiment, among the 5 layers, two adjacent upper and lower layers have a surface area larger than that of the upper layer. As a further preferred embodiment, the length and width values of the lower layer are larger than those of the upper layer in two adjacent upper and lower layers.

The thickness of the 5 layers is not limited, and the 5 layers can be set according to actual needs. As an alternative embodiment, the total thickness of the fibre layer 1 and the eggshell membrane 2 is 10-100 μm.

And as an alternative specific embodiment, the whole tissue repair eggshell membrane skin patch comprises a non-woven fabric 5, a glue layer 4, an activated carbon adsorption layer 3, an eggshell membrane 2 and a fiber layer 1 which are sequentially laminated and fixed, wherein the whole thickness is 1-5mm, preferably 2-3mm.

The shape of eggshell membrane 2 includes, but is not limited to, rectangular, square, right circular, or oval. The eggshell membrane may also be shaped. The special shape is any irregular shape, the size of the eggshell membrane can be designed according to the shape of the sore or customized according to the size of the sore, and the eggshell membrane area can cover the whole sore and is equal to or larger than the area of the sore.

To sum up, in a first aspect, the present tissue repair eggshell membrane patch uses eggshell membrane in a membrane patch, the biological effects of eggshell membrane comprising: (1) antibacterial: the eggshell membrane contains defensin, egg transferrin and keratin polypeptide, and has antibacterial effect. (2) Promote wound healing: the eggshell membrane contains abundant collagen, and is an essential material for wound healing. The eggshell membrane can be used for contacting affected part of sore to stop bleeding, promote cell regeneration and repair wound.

In the second aspect, because the existing biological film has an ultrathin structure and is transparent, the biological film is difficult to clamp and easy to lose and wrinkle when taken out by forceps, and even the biological film is easy to move and run after the application is completed. However, the eggshell membrane skin patch for tissue repair is provided with the fiber layer, the adhesive layer and the non-woven fabric, so that tweezers are not needed during use, the biomembrane on the biomembrane skin patch for tissue repair is simply aligned to a sore, the whole biomembrane skin patch for tissue repair is covered above the sore, and the periphery of the non-woven fabric is pressed. Therefore, the tissue repair eggshell membrane patch is very convenient and simple to use.

In the third aspect, the tissue repair eggshell membrane skin patch adopts an active carbon adsorption layer, wherein the active carbon adsorption layer is used for adsorbing microorganisms and sore liquid and preventing external microorganisms from entering cells; microorganisms including bacteria, viruses, etc., avoid microbial contamination.

Example 2

Referring to example 1, unlike example 1, as shown in fig. 3, in this example, the nonwoven fabric 5, the adhesive layer 4, the activated carbon adsorption layer 3, the eggshell membrane 2 and the fibrous layer 1 are laminated and fixed in this order, and the surface areas of the nonwoven fabric 5 and the adhesive layer 4 are equally overlapped; the surface areas of the activated carbon adsorption layer 3, the eggshell membrane 2 and the fiber layer 1 are overlapped two by two. The surface area of the non-woven fabric 5 or the adhesive layer 4 is larger than the surface area of the activated carbon adsorption layer 3, the eggshell membrane 2 or the fiber layer 1.

Wherein the surface areas are equal, and the length and the width of the two are equal.

The above list of detailed descriptions is only specific to practical embodiments of the present utility model, and they are not intended to limit the scope of the present utility model, and all equivalent embodiments or modifications that do not depart from the spirit of the present utility model should be included in the scope of the present utility model.

Claims

1. The utility model provides a tissue repair eggshell membrane skin subsides, its characterized in that, includes from down upwards stacks gradually fixed non-woven fabrics, glue film, active carbon adsorbed layer, eggshell membrane and fibrous layer, wherein:

2. The tissue repair eggshell membrane patch according to claim 1, further comprising a sealing bag, wherein the overall tissue repair eggshell membrane patch comprises a nonwoven fabric, a glue layer, an activated carbon adsorption layer, eggshell membrane and a fiber layer which are laminated and fixed in sequence, and the overall tissue repair eggshell membrane patch is packaged in the sealing bag in an aseptic manner.

3. The tissue repair eggshell membrane patch according to claim 1, wherein the surface area of the lower layer is equal to or greater than the surface area of the upper layer in every two adjacent upper and lower layers of 5 layers of sequentially laminated and fixed non-woven fabric, adhesive layer, activated carbon adsorption layer, eggshell membrane and fiber layer.

4. The tissue repair eggshell membrane patch of claim 1, wherein the total thickness of the fibrous layer and eggshell membrane is 10-100 μιη.

5. The tissue repair eggshell membrane patch according to claim 1, wherein the overall tissue repair eggshell membrane patch comprises a nonwoven fabric, a glue layer, an activated carbon adsorption layer, eggshell membranes and a fiber layer which are laminated and fixed in sequence, and the overall thickness is 1-5mm.

6. The tissue repair eggshell membrane patch according to claim 5, wherein the overall thickness of the overall tissue repair eggshell membrane patch is 2-3mm.

7. The tissue repair eggshell membrane patch of claim 1, wherein the eggshell membrane has a rectangular, square, right circular or oval shape.