CN219148654U - Compound eggshell membrane skin subsides of tissue repair - Google Patents
Compound eggshell membrane skin subsides of tissue repair Download PDFInfo
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- CN219148654U CN219148654U CN202320101834.6U CN202320101834U CN219148654U CN 219148654 U CN219148654 U CN 219148654U CN 202320101834 U CN202320101834 U CN 202320101834U CN 219148654 U CN219148654 U CN 219148654U
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- eggshell membrane
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- tissue repair
- woven fabric
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- 229940012466 egg shell membrane Drugs 0.000 title claims abstract description 95
- 230000017423 tissue regeneration Effects 0.000 title claims abstract description 43
- 150000001875 compounds Chemical class 0.000 title description 2
- 239000010410 layer Substances 0.000 claims abstract description 149
- 239000002131 composite material Substances 0.000 claims abstract description 63
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 32
- 102000008186 Collagen Human genes 0.000 claims abstract description 29
- 108010035532 Collagen Proteins 0.000 claims abstract description 29
- 229920001436 collagen Polymers 0.000 claims abstract description 29
- 239000012790 adhesive layer Substances 0.000 claims abstract description 17
- 239000003292 glue Substances 0.000 claims abstract description 8
- 239000007933 dermal patch Substances 0.000 abstract description 7
- 239000012528 membrane Substances 0.000 abstract description 7
- 230000037303 wrinkles Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 4
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- 102000000541 Defensins Human genes 0.000 description 2
- 108010002069 Defensins Proteins 0.000 description 2
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- 108010000912 Egg Proteins Proteins 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 102000004338 Transferrin Human genes 0.000 description 2
- 108090000901 Transferrin Proteins 0.000 description 2
- 238000006065 biodegradation reaction Methods 0.000 description 2
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- 238000003860 storage Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Materials For Medical Uses (AREA)
Abstract
The utility model discloses a tissue repair composite eggshell membrane skin patch which comprises a non-woven fabric, a glue layer and a composite eggshell membrane layer which are sequentially laminated and fixed from bottom to top; the composite eggshell membrane layer consists of a collagen layer and an eggshell membrane layer, wherein the collagen layer and the eggshell membrane layer are positioned on the same horizontal layer, one layer is used as an inner layer, the other layer is used as an outer layer, and the outer layer surrounds the inner layer to form the composite eggshell membrane layer; one surface of the adhesive layer is coated on the non-woven fabric, and the other surface of the adhesive layer is adhered with the composite eggshell membrane layer; the surface area of the non-woven fabric is equal to or larger than that of each layer positioned on the non-woven fabric, and the non-woven fabric is used for fixing the integral tissue repair composite eggshell membrane patch on the sore affected part. According to the utility model, the eggshell membrane and the collagen are compounded for the membrane skin patch, so that the eggshell membrane and the collagen are not easy to wrinkle and slide, the pasting operation is convenient, and the use process is simple.
Description
Technical Field
The utility model relates to the field of membrane patches, in particular to a tissue repair composite eggshell membrane patch.
Background
Human tissue and organ repair is a worldwide medical problem, however, with the development of artificial tissue repair materials and related medical techniques, local repair of human tissue and organs is possible. Artificial tissue repair materials have become an indispensable medical device in modern surgery. Human tissue repair materials are widely used, for example: pleura, peritoneal repair, repair of pericardium, repair of dura/dura mater defect, repair of bladder, repair of hernia, repair of female pelvic floor dysfunction, repair of nerve conduit defect, repair of blood vessel, repair of ligament, and repair of breast augmentation.
However, the materials currently used as tissue repair membranes are mainly: autologous tissue and synthetic high molecular polymers (such as nylon, terylene, silicone rubber, etc.). The former has limited sources of raw materials, high price and difficult mass production; the latter has poor strength, hard and soft texture, poor biocompatibility, easy generation of foreign body sensation and pain, common corrosion and infection and other complications, and can only be used for parts with low requirements on mechanical strength and comfort.
Because the tissue repair biological film is mostly thin, transparent, soft and easy to wrinkle, and inconvenient to paste.
Eggshell membrane is the white film between eggshell and egg white.
Collagen is a biopolymer, the main component in animal connective tissue, and is also the most abundant and most widely distributed functional protein in mammals. Collagen has good biocompatibility, biodegradability and bioactivity. Collagen is generally a white or transparent powder, and the molecules are in the form of elongated rods, with relative molecular masses ranging from about 2kD to 300 kD.
At present, the application of the eggshell membrane and the collagen to the membrane skin patch is not found, so that the utility model is provided.
Disclosure of Invention
In view of the above, the present utility model provides a tissue repair composite eggshell membrane patch, which is made by compounding eggshell membrane and collagen on a membrane patch, and the eggshell membrane and collagen are not easy to wrinkle and slip, so that the application process is simple.
The adopted technical scheme is as follows:
a tissue repair composite eggshell membrane patch comprises a non-woven fabric, a glue layer and a composite eggshell membrane layer which are sequentially laminated and fixed from bottom to top; wherein,,
the composite eggshell membrane layer consists of a collagen layer and an eggshell membrane layer, wherein the collagen layer and the eggshell membrane layer are positioned on the same horizontal layer, one layer is used as an inner layer, the other layer is used as an outer layer, and the outer layer surrounds the inner layer to form the composite eggshell membrane layer;
one surface of the adhesive layer is coated on the non-woven fabric, and the other surface of the adhesive layer is adhered with the composite eggshell membrane layer;
the surface area of the non-woven fabric is equal to or larger than that of each layer positioned on the non-woven fabric, and the non-woven fabric is used for fixing the integral tissue repair composite eggshell membrane patch on the sore affected part.
Further, the tissue repair composite eggshell membrane patch further comprises a sealing bag, wherein the overall tissue repair composite eggshell membrane patch comprises a non-woven fabric, a glue layer and a composite eggshell membrane layer which are sequentially laminated and fixed, and the overall tissue repair composite eggshell membrane patch is packaged in the sealing bag in an aseptic mode.
Further, in 3 layers of non-woven fabrics, adhesive layers and composite eggshell membrane layers which are sequentially laminated and fixed, the surface area of the lower layer is equal to or larger than that of the upper layer in the upper layer and the lower layer which are adjacent to each other.
Further, the thickness of the composite eggshell membrane layer is 10-100 mu m.
Further, the eggshell membrane layer is an outer layer, and the collagen layer is an inner layer.
Further, the inner layer is round or square, and the outer layer is round or square.
Further, the outer layer and the inner layer are combined into an integral round or square shape.
The utility model has the beneficial effects that:
in a first aspect, the present utility model uses collagen and eggshell membrane in combination in a membrane patch, the biological effects of eggshell membrane including: (1) antibacterial: the eggshell membrane contains defensin, egg transferrin and keratin polypeptide, and has antibacterial effect. (2) Promote wound healing: the eggshell membrane contains abundant collagen, and is an essential material for wound healing. The eggshell membrane can be used for contacting affected part of sore to stop bleeding, promote cell regeneration and repair wound. Collagen is natural protein of human body, has larger affinity, weaker antigenicity, good biocompatibility and biodegradation safety to protein molecules on the surface of skin, can be degraded and absorbed, and has good adhesive force. The collagen has absorbability, has excellent platelet aggregation performance, good hemostatic effect, good smoothness and elasticity, and good adhesiveness to wound surface, and can achieve satisfactory hemostatic effect under compression in a short time.
In the second aspect, because the existing biological film has an ultrathin structure and is transparent, the biological film is difficult to clamp and easy to lose and wrinkle when taken out by forceps, and even the biological film is easy to move and run after the application is completed. However, the adhesive layer and the non-woven fabric are arranged, so that forceps are not needed when the tissue repair biological film patch is used, the biological film on the tissue repair biological film patch is simply aligned to a sore, the whole tissue repair biological film patch is covered above the sore, and the periphery of the non-woven fabric is pressed. Therefore, the utility model is very convenient and simple to use.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a tissue repair composite eggshell membrane patch of example 1.
Fig. 2 is a cross-sectional view of a tissue repair composite eggshell membrane patch of example 1. Wherein the sealing bag is not shown.
Fig. 3 is a schematic structural diagram of a tissue repair composite eggshell membrane patch of example 2.
Fig. 4 is a schematic structural diagram of a tissue repair composite eggshell membrane patch of example 3.
Fig. 5 is a schematic structural diagram of a tissue repair composite eggshell membrane patch of example 4.
Fig. 6 is a cross-sectional view of a tissue repair composite eggshell membrane patch of example 5. Wherein the sealing bag is not shown.
Detailed Description
The technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are only preferred embodiments of the present utility model, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Example 1
Referring to fig. 1 and 2, a tissue repair composite eggshell membrane patch comprises a non-woven fabric 3, a glue layer 2 and a composite eggshell membrane layer 1 which are laminated and fixed in sequence from bottom to top; wherein,,
the composite eggshell membrane layer 1 consists of a collagen layer 11 and an eggshell membrane layer 12, wherein the collagen layer 11 and the eggshell membrane layer 12 are positioned on the same horizontal layer, one layer is used as an inner layer, the other layer is used as an outer layer, and the outer layer surrounds the inner layer to form the composite eggshell membrane layer. The collagen layer may be used as an outer layer and the eggshell membrane layer may be used as an inner layer. The collagen layer may be used as an inner layer and the eggshell membrane layer may be used as an outer layer. The latter is selected in this embodiment, i.e. eggshell membrane layer 12 is the outer layer and collagen layer 11 is the inner layer. The inner layer may be circular or square, and the outer layer may be annular or square. The outer layer and the inner layer can be combined into an integral round or square composite eggshell membrane layer. In this embodiment, the inner layer is square, and the outer layer is in a shape of a circle.
One surface of the adhesive layer 2 is coated on the non-woven fabric 3, and the other surface of the adhesive layer is adhered with the composite eggshell membrane layer 1. The composite eggshell membrane layer 1 is bonded on the non-woven fabric 3 through the adhesive layer 2. The adhesive layer can adopt the existing non-woven adhesive, can be a copolymer emulsion formed by acrylic acid, vinyl acetate and other multi-element copolymerization grafting modification, belongs to self-crosslinking adhesives, has strong mechanical stability and thermal stability, and can be infinitely diluted in soft water.
The nonwoven 3 has a surface area equal to or greater than that of each layer lying thereon, i.e. the nonwoven has a surface area equal to or greater than that of the glue layer or the composite eggshell membrane layer. The non-woven fabric 3 is used for fixing the integral tissue repair composite eggshell membrane patch on the sore affected part. The non-woven fabric is also called a needled non-woven fabric, and can be produced by adopting polyester fiber (PET) materials and adopting a needling process.
As a preferred embodiment, the tissue repair composite eggshell membrane patch may further comprise a sealing pouch 4. The sealing bag 4 can repair the whole tissue into an eggshell membrane skin patch and comprises a non-woven fabric, a glue layer and a composite eggshell membrane layer which are sequentially laminated and fixed, and the whole tissue is packaged in the sealing bag in an aseptic manner. Thus being convenient for storage and being taken out from the sealing bag when in use.
And 3 layers of non-woven fabrics 3, adhesive layers 2 and composite eggshell membrane layers 1 which are sequentially laminated and fixed are arranged in pairs, wherein the surface area of the lower layer is equal to or larger than that of the upper layer in the upper and lower two adjacent layers. As an alternative embodiment, among the 3 layers, two adjacent upper and lower layers have a surface area larger than that of the upper layer. As a further preferred embodiment, the length and width values of the lower layer are larger than those of the upper layer in two adjacent upper and lower layers.
The thickness of the 3 layers is not limited, and the 3 layers can be set according to actual needs. As an alternative embodiment, the thickness of the composite eggshell membrane layer is 10-100 μm.
To sum up, in a first aspect, the tissue repair composite eggshell membrane patch combines collagen and eggshell membrane into a membrane patch, and biological effects of the eggshell membrane include: (1) antibacterial: the eggshell membrane contains defensin, egg transferrin and keratin polypeptide, and has antibacterial effect. (2) Promote wound healing: the eggshell membrane contains abundant collagen, and is an essential material for wound healing. The eggshell membrane can be used for contacting affected part of sore to stop bleeding, promote cell regeneration and repair wound. Collagen is natural protein of human body, has larger affinity, weaker antigenicity, good biocompatibility and biodegradation safety to protein molecules on the surface of skin, can be degraded and absorbed, and has good adhesive force. The collagen has absorbability, has excellent platelet aggregation performance, good hemostatic effect, good smoothness and elasticity, and good adhesiveness to wound surface, and can achieve satisfactory hemostatic effect under compression in a short time.
In the second aspect, because the existing biological film has an ultrathin structure and is transparent, the biological film is difficult to clamp and easy to lose and wrinkle when taken out by forceps, and even the biological film is easy to move and run after the application is completed. However, the tissue repair composite eggshell membrane skin patch is provided with the adhesive layer and the non-woven fabric, so that tweezers are not needed during use, the biomembrane on the tissue repair biomembrane skin patch is simply aligned to a sore, the whole tissue repair biomembrane skin patch is covered above the sore, and the periphery of the non-woven fabric is pressed. Therefore, the tissue repair composite eggshell membrane patch is very convenient and simple to use.
Example 2
Referring to example 1, unlike example 1, in the composite eggshell membrane layer 1 of this example, the inner layer is circular and the outer layer is concentric ring-shaped, as shown in fig. 3.
Example 3
Referring to example 1, unlike example 1, the composite eggshell membrane layer 1 of this example is a circular shape formed by combining an outer layer and an inner layer as a whole, as shown in fig. 4.
Example 4
Referring to example 1, unlike example 1, the composite eggshell membrane layer 1 of this example is a square shape formed by combining an outer layer and an inner layer as a whole, as shown in fig. 5.
Example 5
Referring to example 1, unlike example 1, the surface area of the adhesive layer of this example is equal to the surface area of the nonwoven fabric, as shown in fig. 6. Wherein the surface areas are equal, and the length and the width of the two are equal. The surface area of the adhesive layer is larger than that of the composite eggshell membrane layer.
The above list of detailed descriptions is only specific to practical embodiments of the present utility model, and they are not intended to limit the scope of the present utility model, and all equivalent embodiments or modifications that do not depart from the spirit of the present utility model should be included in the scope of the present utility model.
Claims (7)
1. The tissue repair composite eggshell membrane patch is characterized by comprising a non-woven fabric, a glue layer and a composite eggshell membrane layer which are sequentially laminated and fixed from bottom to top; wherein,,
the composite eggshell membrane layer consists of a collagen layer and an eggshell membrane layer, wherein the collagen layer and the eggshell membrane layer are positioned on the same horizontal layer, one layer is used as an inner layer, the other layer is used as an outer layer, and the outer layer surrounds the inner layer to form the composite eggshell membrane layer;
one surface of the adhesive layer is coated on the non-woven fabric, and the other surface of the adhesive layer is adhered with the composite eggshell membrane layer;
the surface area of the non-woven fabric is equal to or larger than that of each layer positioned on the non-woven fabric, and the non-woven fabric is used for fixing the integral tissue repair composite eggshell membrane patch on the sore affected part.
2. The tissue repair composite eggshell membrane patch of claim 1, further comprising a sealed pouch, wherein the integral tissue repair composite eggshell membrane patch comprises a nonwoven fabric, a glue layer and a composite eggshell membrane layer laminated and fixed in sequence, and wherein the integral tissue repair composite eggshell membrane patch is packaged in the sealed pouch in an aseptic manner.
3. The tissue repair composite eggshell membrane patch according to claim 1, wherein the surface area of the lower layer is equal to or greater than the surface area of the upper layer in every two adjacent upper and lower layers of 3 layers of non-woven fabric, adhesive layer and composite eggshell membrane layer which are sequentially laminated and fixed.
4. The tissue repair composite eggshell membrane patch of claim 1, wherein the thickness of the composite eggshell membrane layer is 10-100 μιη.
5. The tissue repair composite eggshell membrane patch of claim 1, wherein the eggshell membrane layer is an outer layer and the collagen layer is an inner layer.
6. The tissue repair composite eggshell membrane patch of claim 5, wherein the inner layer is circular or square and the outer layer is circular or square.
7. The tissue repair composite eggshell membrane patch of claim 5, wherein the outer layer and the inner layer are combined into an integral round or square shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320101834.6U CN219148654U (en) | 2023-02-02 | 2023-02-02 | Compound eggshell membrane skin subsides of tissue repair |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320101834.6U CN219148654U (en) | 2023-02-02 | 2023-02-02 | Compound eggshell membrane skin subsides of tissue repair |
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| Publication Number | Publication Date |
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| CN219148654U true CN219148654U (en) | 2023-06-09 |
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| CN202320101834.6U Active CN219148654U (en) | 2023-02-02 | 2023-02-02 | Compound eggshell membrane skin subsides of tissue repair |
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| CN (1) | CN219148654U (en) |
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2023
- 2023-02-02 CN CN202320101834.6U patent/CN219148654U/en active Active
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