CN219423377U - Skull repairing material for children - Google Patents

Abstract

The utility model relates to the technical field of skull repairing materials, in particular to a child skull repairing material. The embodiment of the utility model provides a child skull repairing material which sequentially comprises a first repairing layer and a second repairing layer along the thickness direction, wherein the first repairing layer is a side facing away from the intracranial, and the second repairing layer is a side facing towards the intracranial; the preparation materials of the first repairing layer and the second repairing layer are collagen with sponge structures, the porosity of the first repairing layer is smaller than that of the second repairing layer, a telescopic net is arranged in the first repairing layer and comprises a plurality of strip bodies, two ends of each strip body are respectively and movably connected with the endpoints of the two strip bodies to form a telescopic net, and each strip body rotates on the same plane by taking the movable connection part as an axis to extend or retract the telescopic net. The embodiment of the utility model provides a skull repairing material for children, which can provide a skull repairing material with strong mechanical property and deformation capability.

Description

Skull repairing material for children

Technical Field

The utility model relates to the technical field of skull repairing materials, in particular to a child skull repairing material.

Background

When the skull defect range of the child patient is large, the skull needs to be repaired by the skull repairing material.

In the related art, the skull repairing material is mineralized collagen. However, the skull of the child patient is continuously grown and deformed, mineralized collagen is gradually degraded and synchronously regenerated with bone tissue, but the mechanical properties and deformability of mineralized collagen cannot meet the demands of growth and deformation of the child skull due to deformation, poor mechanical strength of the new bone tissue and the like.

Thus, in response to the above shortcomings, there is an urgent need for a child skull repair material.

Disclosure of Invention

The embodiment of the utility model provides a skull repairing material for children, which can provide a skull repairing material with strong mechanical property and deformation capability.

The embodiment of the utility model provides a child skull repairing material which sequentially comprises a first repairing layer and a second repairing layer along the thickness direction, wherein the first repairing layer is a side facing away from the intracranial, and the second repairing layer is a side facing towards the intracranial;

the preparation materials of the first repair layer and the second repair layer are collagen with a sponge structure, and the porosity of the first repair layer is smaller than that of the second repair layer;

the first repairing layer is internally provided with a telescopic net, the telescopic net comprises a plurality of strip-shaped bodies, two ends of each strip-shaped body are respectively and movably connected with the end points of the two strip-shaped bodies to form the telescopic net, and each strip-shaped body rotates on the same plane by taking the movable connection part as an axis to extend or retract the telescopic net.

In one possible design, the end points of the bars are respectively provided with a through hole perpendicular to the bars, and the rotating shaft penetrates through the through holes of the two bars to movably connect the two bars.

In one possible design, the movable connection part is provided with two connecting pieces, and the two connecting pieces are respectively perpendicular to two sides of the plane where the telescopic net is located.

In one possible design, the cross section of the connecting element in the direction away from the telescopic net becomes gradually larger.

In one possible design, the strip is made of titanium metal.

In one possible design, mineralized collagen is attached to the inner walls of the pores of the first repair layer.

In one possible design, the mass ratio of collagen to mineralized collagen in the first repair layer is 100: (55-60).

In one possible design, the thickness of the second repair layer is 1-3 mm.

In one possible design, the collagen is type I collagen.

Compared with the prior art, the utility model has at least the following beneficial effects:

in the embodiment, the telescopic net is added into the skull repairing material, and is wrapped in the skull repairing material as a framework, so that the telescopic net can provide excellent mechanical properties. The expansion of the expansion net enables the skull repairing material to be deformed adaptively along with the growth of the skull of the child, can meet the requirement of the growth and deformation of the skull of the child, and can be further matched with proper mechanical properties through the design of the width, the number of connection and the opening and closing degree of the strip-shaped body. In addition, the telescopic net can only shrink and stretch on the plane, cannot deform in the vertical direction of the telescopic net, can provide excellent mechanical properties in the vertical direction, and further improves the mechanical properties of the skull repairing material in the vertical direction.

In this embodiment, the first repair layer is made of collagen, which has biocompatibility and degradability, and excellent porosity, and is beneficial to the crawling growth of new bone cells. The second collagen layer is made of collagen, the collagen also has the characteristic of swelling by absorbing water, the porosity of the second collagen layer is larger than that of the first collagen layer, after the skull is repaired by using the composite material and facing to one side in the skull, if cerebrospinal fluid leaks, the second collagen layer swells after absorbing a small amount of cerebrospinal fluid rapidly, and provides hydrostatic pressure to press the dura mater, so that the cerebrospinal fluid is prevented from further leaking.

Drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are some embodiments of the present utility model, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic structural view of a child skull repair material provided by an embodiment of the present utility model;

fig. 2 is a schematic structural diagram of a telescopic net according to an embodiment of the present utility model.

In the figure:

1-a first repair layer;

2-a second repair layer;

3-a telescoping net;

31-connection piece.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present utility model more apparent, the technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model, and it is apparent that the described embodiments are some embodiments of the present utility model, but not all embodiments, and all other embodiments obtained by those skilled in the art without making any inventive effort based on the embodiments of the present utility model are within the scope of protection of the present utility model.

In the description of embodiments of the present utility model, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying any relative importance unless explicitly specified or limited otherwise; the term "plurality" means two or more, unless specified or indicated otherwise; the terms "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, integrally connected, or electrically connected; can be directly connected or indirectly connected through an intermediate medium. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

In the description of the present specification, it should be understood that the terms "upper", "lower", and the like used in the embodiments of the present utility model are described in terms of the angles shown in the drawings, and should not be construed as limiting the embodiments of the present utility model. In the context of this document, it will also be understood that when an element is referred to as being "on" or "under" another element, it can be directly on the other element or be indirectly on the other element through intervening elements.

As shown in fig. 1 and fig. 2, the embodiment of the utility model provides a skull repairing material for children, which sequentially comprises a first repairing layer and a second repairing layer along the thickness direction, wherein the first repairing layer is a side facing away from the intracranial, and the second repairing layer is a side facing towards the intracranial;

the preparation materials of the first repair layer and the second repair layer are collagen with a sponge structure, and the porosity of the first repair layer is smaller than that of the second repair layer;

the first repairing layer is provided with a telescopic net, the telescopic net comprises a plurality of strip bodies, two ends of each strip body are respectively and movably connected with the end points of the two strip bodies to form the telescopic net, and each strip body rotates on the same plane by taking the movable connection part as an axis to extend or retract the telescopic net.

In the embodiment, the telescopic net is added into the skull repairing material, and is wrapped in the skull repairing material as a framework, so that the telescopic net can provide excellent mechanical properties. The expansion of the expansion net enables the skull repairing material to be deformed adaptively along with the growth of the skull of the child, can meet the requirement of the growth and deformation of the skull of the child, and can be further matched with proper mechanical properties through the design of the width, the number of connection and the opening and closing degree of the strip-shaped body. In addition, the telescopic net can only shrink and stretch on the plane, cannot deform in the vertical direction of the telescopic net, can provide excellent mechanical properties in the vertical direction, and further improves the mechanical properties of the skull repairing material in the vertical direction.

In this embodiment, the first repair layer is made of collagen, which has biocompatibility and degradability, and excellent porosity, and is beneficial to the crawling growth of new bone cells. The second collagen layer is made of collagen, the collagen also has the characteristic of swelling by absorbing water, the porosity of the second collagen layer is larger than that of the first collagen layer, after the skull is repaired by using the composite material and facing to one side in the skull, if cerebrospinal fluid leaks, the second collagen layer swells after absorbing a small amount of cerebrospinal fluid rapidly, and provides hydrostatic pressure to press the dura mater, so that the cerebrospinal fluid is prevented from further leaking.

In some embodiments of the present utility model, the end points of the two bars are respectively provided with a through hole perpendicular to the bars, and the rotating shaft passes through the through holes of the two bars to movably connect the two bars.

In this embodiment, the strip body can rotate along the rotating shaft, and the through hole and the rotating shaft have simple and practical structures, so that the function of rotating along the shaft can be realized under a simple structure.

In some embodiments of the present utility model, two connectors are provided at the articulation, the two connectors being perpendicular to the two sides of the plane in which the telescopic net lies, respectively.

In this embodiment, the connecting member may strengthen the bonding strength between the expansion net and the first repair layer.

In some embodiments of the utility model, the cross-section of the connector in the direction away from the telescopic net becomes progressively larger.

In this embodiment, the cross section of the connecting piece in the direction away from the telescopic net gradually becomes larger to form a horn shape or an inverted cone shape, so that the bonding strength between the telescopic net and the first repairing layer can be further enhanced.

In some embodiments of the utility model, the strip is made of titanium metal.

In this example, titanium has a low density and excellent mechanical properties, and does not burden the patient.

In some embodiments of the utility model, mineralized collagen is attached to the inner walls of the pores of the first repair layer.

In some embodiments of the utility model, mineralized collagen is attached to the inner walls of the pores of the first repair layer.

In this embodiment, the mineralized collagen contains Ca, P, and other elements, which are released during degradation of the mineralized collagen, and these elements are beneficial to forming new bone cells and accelerating the repair rate of the skull.

The preparation method of mineralized collagen comprises the following steps:

step 1, dissolving collagen in any one of hydrochloric acid, nitric acid or acetic acid to prepare an acid solution of the collagen, wherein the concentration of the collagen is 0.01-0.2 g/ml;

step 2, dropwise adding a calcium salt solution into the acid solution of the collagen, wherein the addition amount of calcium ions is 0.1-2 mol of calcium ions added to each gram of collagen;

step 3, dropwise adding a phosphoric acid solution into the solution obtained in the step 2, wherein the molar ratio of the addition amount of phosphate ions to the addition amount of calcium ions in the step S1-2 is Ca/P=1/1-2/1;

step 4, dropwise adding a NaOH solution into the solution obtained in the step 3 to form a mixed solution, and adjusting the pH value to 6-8;

step 5, standing the mixed solution obtained in the step 4 for 4-12 hours, centrifuging at a speed of 3000-6000 r/min to obtain precipitate, and drying at 50-70 ℃ for 24-72 hours by air blast to obtain mineralized collagen particles;

and step 6, placing the mineralized collagen particles obtained in the step 5 into a crucible for grinding until no obvious particles exist, and obtaining mineralized collagen powder.

In some embodiments of the utility model, the mass ratio of collagen to mineralized collagen in the first repair layer in the mixed solution is 100: (55-60).

In this example, the mass ratio of collagen to mineralized collagen was 100: (55-60) if the mass ratio of collagen to mineralized collagen is higher than the above range, the mineralized collagen is too small, the effect of promoting the growth of new bone cells is not obvious, and if the mass ratio of collagen to mineralized collagen is lower than the above range, the collagen porosity is lowered.

In some embodiments of the present utility model, the thickness of the second repair layer is 1 to 3mm.

In this embodiment, if the thickness of the second repair layer is less than 1mm, it is difficult to provide enough hydrostatic pressure to prevent the cerebrospinal fluid from further leaking, and if the thickness of the second repair layer is more than 1-3 mm, the overall strength of the repair material is too low.

In some embodiments of the utility model, the collagen is type I collagen.

In this embodiment, the collagen is preferably type I collagen, and the preparation method of type I collagen includes:

(1) Removing superfluous fascia, fat, muscle and the like on the beef achilles tendon, washing with tap water, and orderly arranging in a freezing box for freezing at-20 ℃ for at least 12 hours;

(2) Cutting frozen Achilles tendon into slices of about 1mm, and placing into a filter screen for turning and washing until the liquid is clear;

(3) Enzymolysis: carrying out enzymolysis on the cleaned beef achilles tendon slices, and fully stirring, wherein the enzymolysis time is not less than 72 hours; wherein the mass ratio of the enzymolysis liquid to the bovine Achilles tendon is 130:1, the volume ratio of purified water to acetic acid in the enzymolysis liquid is 25:1, the mass ratio of the purified water to the pepsin is 15:1.

(4) Salting out: centrifuging the solution after enzymolysis, taking supernatant, adding the supernatant into sodium chloride solution, separating out white flocculent collagen, filtering and cleaning, and draining water.

(5) And (3) dialysis: filling the salted-out material into a dialysis bag, wherein the filling volume is about 1/3 of that of the dialysis bag; placing the dialysis bag in 0.057mol/L acetic acid solution for 6 days, and changing the dialysis solution every 3 days at 10-20deg.C; then placing the dialysis bag in 0.00057mol/L acetic acid solution for dialysis for 5 days, wherein the dialysis temperature is 10-20 ℃, and the dialysate is changed every 1 day; dialyzing in 0.0000057mol/L acetic acid solution from day 12 to pH 5.5-5.5, and dialyzing at 10-20deg.C, and changing dialysate once daily as required.

(6) Freeze-drying

The sample is subjected to a freeze-drying process comprising a pre-freezing stage, a first sublimation stage, a second sublimation stage and a cooling stage, wherein the process conditions of each stage are as follows:

pre-freezing: the target temperature is-12 to-8 ℃, the speed is 3-4.0 ℃/min, and the constant temperature duration is 280-320 min;

a first sublimation stage: vacuumizing, aerating at 90-110 Pa, wherein the target temperature is-4 to-2 ℃, the speed is 0.6-0.8 ℃/min, and the constant temperature duration is 1300-1340 min;

in the second sublimation stage, vacuumizing and aerating at 90-110 Pa, wherein the second sublimation stage comprises five temperature-rising steps of respectively:

-1 ℃, the speed is 0.2-0.3 ℃/min, and the constant temperature duration is 110-130 min;

8-12 ℃, the speed is 1.0-1.2 ℃/min, and the constant temperature duration is 110-130 min;

the temperature is 18-22 ℃, the speed is 1.0-1.2 ℃/min, and the constant temperature duration is 110-130 min;

the temperature is 28-32 ℃, the speed is 1.0-1.2 ℃/min, and the constant temperature duration is 110-130 min;

38-42 ℃, the speed is 1.0-1.2 ℃/min, and the constant temperature duration is as follows: performing end point judgment every 10 minutes until the end point judgment is qualified; judging the end point to be less than or equal to 0.9Pa/10min;

and (3) a cooling stage: cooling to room temperature at a speed of 1.4-1.6 ℃/min;

and obtaining the collagen sponge raw material.

It should be noted that all lyophilization processes of the present utility model can use the lyophilization process described above.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present utility model, and are not limiting; although the utility model has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present utility model.

Claims (7)

1. The skull repairing material for children is characterized by sequentially comprising a first repairing layer and a second repairing layer along the thickness direction, wherein the first repairing layer is a side facing away from the intracranial, and the second repairing layer is a side facing towards the intracranial;

the preparation materials of the first repair layer and the second repair layer are collagen with a sponge structure, and the porosity of the first repair layer is smaller than that of the second repair layer;

the first repairing layer is internally provided with a telescopic net, the telescopic net comprises a plurality of strip-shaped bodies, two ends of each strip-shaped body are respectively and movably connected with the end points of the two strip-shaped bodies to form the telescopic net, and each strip-shaped body rotates on the same plane by taking the movable connection part as an axis to extend or retract the telescopic net.

2. A child skull repair material according to claim 1, wherein the end points of the strips are each provided with a through hole perpendicular to the strips, and a rotation shaft passes through the through holes of two strips to movably connect the two strips.

3. A child skull repair material according to claim 1, wherein the articulation is provided with two connectors, each perpendicular to both sides of the plane of the telescopic mesh.

4. A child skull repair material according to claim 3, wherein the cross section of the connector in the direction away from the telescopic mesh becomes progressively larger.

5. A child skull repair material according to claim 1, wherein the strip is made of titanium metal.

6. A pediatric skull repair material according to claim 1, wherein the thickness of the second repair layer is 1-3 mm.

7. A pediatric skull repair material according to claim 1, wherein the collagen is type I collagen.