CN218652594U

CN218652594U - Children skull repairing material

Info

Publication number: CN218652594U
Application number: CN202222993858.5U
Authority: CN
Inventors: 崔云; 宋天喜; 朱金亮; 何志敏; 胡艳丽; 吴晶晶; 胡刚; 仇志烨; 崔孟龙
Original assignee: Weifang Aojing Health Technology Co ltd; Aojing Medical Technology Co ltd
Current assignee: Weifang Aojing Health Technology Co ltd; Aojing Medical Technology Co ltd
Priority date: 2022-11-10
Filing date: 2022-11-10
Publication date: 2023-03-21
Anticipated expiration: 2032-11-10

Abstract

The utility model relates to a skull repair materials technical field, in particular to children's skull repair materials. The embodiment of the utility model provides a children skull repairing material, which comprises an inclusion and a telescopic net, wherein the telescopic net is wrapped in the inclusion; the telescopic net comprises a plurality of strip-shaped bodies, two ends of each strip-shaped body are movably connected with end points of the two strip-shaped bodies respectively to form the telescopic net, and each strip-shaped body rotates on the same plane by taking the movable connection part as an axis to extend or contract the telescopic net. The embodiment of the utility model provides a children skull repairing material can provide a skull repairing material that mechanical properties and deformability are strong.

Description

Children skull repairing material

Technical Field

The utility model relates to a skull repair materials technical field, in particular to children's skull repair materials.

Background

When the skull defect range of the child patient is large, the skull needs to be repaired by the aid of skull repair materials.

In the related art, the skull repairing material is mineralized collagen. However, the skull of a child patient can grow and deform continuously, the gradual degradation of mineralized collagen and the regeneration of bone tissues are performed synchronously, but the mechanical property and the deformation capability of the mineralized collagen cannot meet the requirements of the growth and the deformation of the skull of the child due to the deformation, the poor mechanical strength of new bone tissues and the like.

Therefore, in order to overcome the defects, a skull repair material for children is urgently needed.

SUMMERY OF THE UTILITY MODEL

The embodiment of the utility model provides a children skull repairing material can provide a skull repairing material that mechanical properties and deformability are strong.

The embodiment of the utility model provides a children skull repairing material, which comprises an inclusion and a telescopic net, wherein the telescopic net is wrapped in the inclusion;

the telescopic net comprises a plurality of strip-shaped bodies, two ends of each strip-shaped body are movably connected with end points of the two strip-shaped bodies respectively to form the telescopic net, and each strip-shaped body rotates on the same plane by taking the movable connection part as an axis to extend or contract the telescopic net.

In one possible design, the end points of the bars are provided with through holes perpendicular to the bars, and a rotating shaft penetrates through the through holes of the two bars to movably connect the two bars.

In one possible design, the inclusion is made of mineralized collagen.

In one possible design, the inclusion is made of type I collagen.

In a possible design, the movable joint is provided with two connecting pieces, and the two connecting pieces are respectively perpendicular to two sides of the plane where the telescopic net is located.

In one possible embodiment, the cross section of the connecting element in the direction away from the expansion net is gradually larger.

In one possible design, the strip is made of titanium metal.

In one possible design, the outer portion of the inclusion is wrapped with a reinforcing layer made of poly-epsilon-caprolactone.

In one possible design, the inclusion is prepared by 3D printing techniques.

In one possible design, the inclusion has a porosity of 38 to 58%.

Compared with the prior art, the utility model following beneficial effect has at least:

in this embodiment, the expansion net is formed by movably connecting a plurality of strip bodies end to end, the strip bodies can rotate on the same plane by taking the movable connection parts as shafts so as to extend or contract the expansion net, the expansion and contraction performance of the expansion net enables the skull repairing material to deform adaptively along with the growth of the skull of the child, and the requirement of the growth and deformation of the skull of the child can be met. The width, the connection number and the opening and closing degree of the strip-shaped body can be designed to further match with proper mechanical properties. In addition, the expansion net can only be contracted and expanded in a plane, cannot be deformed in the vertical direction of the expansion net, and can provide excellent mechanical properties in the vertical direction, so that the mechanical properties of the skull repairing material in the vertical direction are improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a children skull repairing material provided by an embodiment of the present invention;

fig. 2 is a schematic structural diagram of an expansion net provided in an embodiment of the present invention.

In the figure:

1-inclusion;

2-a reinforcing layer;

3-a telescopic net;

31-connecting piece.

Detailed Description

In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the following will combine the drawings in the embodiments of the present invention to clearly and completely describe the technical solution in the embodiments of the present invention, and obviously, the described embodiments are some embodiments of the present invention, rather than all embodiments, based on the embodiments in the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative work belong to the scope of the present invention.

In the description of the embodiments of the present invention, unless explicitly specified or limited otherwise, the terms "first", "second", and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance; the term "plurality" means two or more unless specified or indicated otherwise; the terms "connected", "fixed", and the like are to be construed broadly and may, for example, be fixed or removable or integral or electrical; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present invention can be understood according to specific situations by those of ordinary skill in the art.

In the description of the present invention, it should be understood that the terms "upper" and "lower" used in the description of the embodiments of the present invention are used in the angle shown in the drawings, and should not be construed as limiting the embodiments of the present invention. In addition, in this context, it will also be understood that when an element is referred to as being "on" or "under" another element, it can be directly on "or" under "the other element or be indirectly on" or "under" the other element via an intermediate element.

As shown in fig. 1 and fig. 2, the embodiment of the present invention provides a children skull repairing material, which comprises an inclusion 1 and an expansion net 3, wherein the expansion net 3 is wrapped in the inclusion 1;

the telescopic net 3 comprises a plurality of strip-shaped bodies, two ends of each strip-shaped body are respectively movably connected with end points of the two strip-shaped bodies to form the telescopic net 3, and each strip-shaped body rotates on the same plane by taking the movable connection part as a shaft to extend or contract the telescopic net 3.

In this embodiment, the retractable net 3 is formed by movably connecting a plurality of strip bodies end to end, the strip bodies can rotate on the same plane by taking the movable connection part as an axis so as to extend or contract the retractable net 3, the flexibility of the retractable net 3 enables the skull repairing material to deform adaptively along with the growth of the skull of the child, and the requirement of the growth and deformation of the skull of the child can be met. In addition, the telescopic net 3 can only be contracted and extended in a plane, cannot be deformed in the vertical direction of the telescopic net 3, and can provide excellent mechanical properties in the vertical direction, so that the mechanical properties of the skull repairing material in the vertical direction are improved. The width, the connection number and the opening and closing degree of the strip-shaped body can be designed to further match with proper mechanical properties.

In some embodiments of the present invention, the end points of the bars are provided with through holes perpendicular to the bars, and the rotating shaft passes through the through holes of the two bars to movably connect the two bars.

In this embodiment, the strip-shaped body is rotatable along the rotation shaft, and the through-hole and the rotation shaft are simple and practical in structure, and can realize the function of rotating along the shaft with a simple structure.

In some embodiments of the present invention, the preparation material of the inclusion 1 is mineralized collagen.

In this example, mineralized collagen is rich in nutrients that promote bone growth, and using mineralized collagen to make inclusion 1 can increase the rate of skull repair.

The preparation method of the mineralized collagen comprises the following steps:

step 1, dissolving collagen in any one of hydrochloric acid, nitric acid or acetic acid to prepare an acid solution of the collagen, wherein the concentration of the collagen is 0.01-0.2 g/ml;

step 2, dropwise adding a calcium salt solution into the acid solution of the collagen, wherein the addition amount of calcium ions is 0.1-2 mol per gram of the collagen;

step 3, dropwise adding a phosphoric acid solution into the solution obtained in the step 2, wherein the molar ratio of the addition amount of phosphate ions to the addition amount of calcium ions in the step S1-2 is Ca/P = 1/1-2/1;

step 4, dripping NaOH solution into the solution obtained in the step 3 to form a mixed solution, and adjusting the pH value to 6-8;

step 5, standing the mixed solution obtained in the step 4 for 4-12 hours, centrifuging at the speed of 3000-6000 r/min to obtain precipitates, and performing air blast drying at the temperature of 50-70 ℃ for 24-72 hours to obtain mineralized collagen particles;

and 6, putting the mineralized collagen particles obtained in the step 5 into a crucible for grinding until no obvious particles exist, so as to obtain mineralized collagen powder.

In some embodiments of the present invention, the inclusion body 1 is made of type I collagen.

In this embodiment, type I collagen, as a fibrin, has high tensile strength, biodegradability, low antigenic activity, low irritation, and low cytotoxicity, and can be used as an artificial organ scaffold, and can also be used as a wound dressing to induce cell adhesion, promote cell proliferation, and further repair wound in cooperation with novacells and tissues.

The preparation method of the type I collagen comprises the following steps:

(1) Removing redundant fascia, fat, muscle and the like on the bovine achilles tendon, washing with tap water, neatly arranging in a freezing box, freezing at-20 ℃ for at least 12h;

(2) Cutting frozen bovine achilles tendon into slices of about 1mm, placing in a filter screen, and washing until the liquid is clear;

(3) Enzymolysis: carrying out enzymolysis on the cleaned bovine achilles tendon slices, and fully stirring for not less than 72h; wherein the mass ratio of the enzymolysis liquid to the bovine achilles tendon is 130:1, the volume ratio of purified water to acetic acid in the enzymolysis liquid is 25:1, the mass ratio of the purified water to the pepsin is 15:1.

(4) Salting out: and centrifuging the solution after enzymolysis, taking supernatant, adding the supernatant into a sodium chloride solution to separate out white flocculent collagen, filtering and washing, and draining water.

(5) And (3) dialysis: pouring the salted-out material into a dialysis bag, wherein the volume of the material is about 1/3 of that of the dialysis bag; placing the dialysis bag in a dialysate of 0.057mol/L acetic acid solution for 6 days, surreptitiously heating to 10-20 deg.C, and replacing the dialysate every 3 days; then placing the dialysis bag in 0.00057mol/L acetic acid solution for dialysis for 5 days, wherein the dialysis temperature is 10-20 ℃, and the dialysate is replaced every 1 day; dialyzing in 0.0000057mol/L acetic acid solution at pH of 5.5-5.5 from day 12, wherein the dialysis temperature is 10-20 deg.C, and changing the dialysate once a day as required.

(6) Freeze-drying

The sample is subjected to the following freeze drying process, wherein the freeze drying process comprises a pre-freezing stage, a first sublimation stage, a second sublimation stage and a temperature reduction stage, and the process conditions of each stage are as follows:

a pre-freezing stage: the target temperature is-12 to-8 ℃, the speed is 3 to 4.0 ℃/min, and the constant temperature duration is 280 to 320min;

a first sublimation stage: vacuumizing, wherein the air entrainment is 90-110 Pa, the target temperature is-4-2 ℃, the speed is 0.6-0.8 ℃/min, and the constant temperature duration is 1300-1340 min;

the second sublimation stage, vacuumization, 90-110 Pa aeration, including five temperature-rising steps, respectively:

the temperature is between-1 and 1 ℃, the speed is between 0.2 and 0.3 ℃/min, and the constant temperature duration is between 110 and 130min;

the temperature is 8-12 ℃, the speed is 1.0-1.2 ℃/min, and the constant temperature duration is 110-130 min;

the temperature is 18-22 ℃, the speed is 1.0-1.2 ℃/min, and the constant temperature duration is 110-130 min;

the temperature is between 28 and 32 ℃, the speed is between 1.0 and 1.2 ℃/min, and the constant temperature duration is between 110 and 130min;

38-42 ℃, the speed is 1.0-1.2 ℃/min, the constant temperature duration is as follows: judging the end point every 10 minutes until the end point is qualified; the end point is judged to be less than or equal to 0.9Pa/10min;

and (3) cooling: cooling to room temperature at a rate of 1.4-1.6 deg.C/min;

obtaining the type I collagen.

In some embodiments of the present invention, the movable connection portion is provided with two connecting members 31, and the two connecting members 31 are perpendicular to two sides of the plane where the retractable net 3 is located.

In this embodiment, the connecting member 31 is provided to enhance the bonding strength between the expansion net 3 and the enclosure 1.

In some embodiments of the present invention, the cross section of the connecting member 31 away from the direction of the expansion net 3 becomes larger gradually.

In this embodiment, the cross section of the connecting member 31 in the direction away from the telescopic net 3 gradually becomes larger to form a trumpet shape or an inverted cone shape, and thus the bonding strength between the telescopic net 3 and the inclusion 1 can be further enhanced.

In some embodiments of the invention, the strip is made of titanium.

In this example, titanium has a low density and excellent mechanical properties, and does not burden the patient.

In some embodiments of the present invention, the outer portion of the inclusion 1 is wrapped with a reinforcing layer 2, and the reinforcing layer 2 is made of poly-epsilon-caprolactone.

In the embodiment, the poly-epsilon-caprolactone has good biodegradability, biocompatibility and nontoxicity, and is widely used as a medical biodegradable material and a drug controlled release system.

In some embodiments of the present invention, the inclusion 1 is prepared by 3D printing technology.

In the embodiment, the 3D printing technology can obtain the children skull repairing material matched with the damaged shape of the skull, and the porosity of the children skull repairing material can be controlled by setting the parameters of the filling density.

In some embodiments of the present invention, the inclusion 1 has a porosity of 38 to 58%.

In this embodiment, the inclusion 1 has a porosity of 38 to 58%, which can provide a growth space for the new bone tissue and provide excellent mechanical support for the inclusion.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention in its corresponding aspects.

Claims

1. The children skull repairing material is characterized by comprising an inclusion (1) and a telescopic net (3), wherein the telescopic net (3) is wrapped in the inclusion (1);

the telescopic net (3) comprises a plurality of strip-shaped bodies, two ends of each strip-shaped body are movably connected with end points of the two strip-shaped bodies respectively to form the telescopic net (3), and each strip-shaped body rotates on the same plane by taking the movable connection position as an axis to extend or contract the telescopic net (3).

2. The children's skull repairing material according to claim 1, wherein the end points of the strips are provided with through holes perpendicular to the strips, and a rotating shaft passes through the through holes of the two strips to movably connect the two strips.

3. Children skull repair material according to claim 1, wherein the preparation material of the inclusion (1) is mineralized collagen.

4. The children's skull repairing material according to claim 1, wherein the preparation material of the inclusion body (1) is type I collagen.

5. Children skull repair material according to claim 1, wherein two connectors (31) are arranged at the articulation, wherein the two connectors (31) are perpendicular to the two sides of the plane of the expansion net (3).

6. Children skull repair material according to claim 5, wherein the cross section of the connector (31) away from the expansion net (3) is gradually larger.

7. The children's skull repairing material according to claim 1, wherein the strip is made of titanium.

8. The children's skull repair material according to claim 1, characterized in that the inclusion (1) is externally wrapped with a reinforcement layer (2), and the reinforcement layer (2) is made of poly-epsilon-caprolactone.

9. The children's skull repairing material according to claim 1, wherein the inclusions (1) are prepared by 3D printing techniques.

10. The children's skull repairing material according to claim 1, wherein the inclusion (1) has a porosity of 38-58%.