CN219369670U - Manual low-pressure chromatographic column - Google Patents
Manual low-pressure chromatographic column Download PDFInfo
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- CN219369670U CN219369670U CN202223541373.9U CN202223541373U CN219369670U CN 219369670 U CN219369670 U CN 219369670U CN 202223541373 U CN202223541373 U CN 202223541373U CN 219369670 U CN219369670 U CN 219369670U
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Abstract
The utility model provides a manual low-pressure chromatographic column, which comprises a columnar frame and a glass tube arranged in the columnar frame, wherein an adjusting nut and a screw rod which is connected with the adjusting nut in a threaded manner are arranged on the columnar frame, and a piston is arranged on a part of the screw rod extending into the glass tube; the piston is sleeved with a sealing ring for sealing the side gap, and the screw rod is provided with a sealing adjusting mechanism for adjusting the compression state of the sealing ring; the piston, the glass tube and the bottom of the columnar frame are enclosed to form a column bed area; the screw rod is provided with a first liquid passing pipe which extends to the piston and is communicated with the column bed area, and the bottom of the columnar frame is provided with a second liquid passing pipe which is communicated with the column bed area; the compression adjustment of the column bed forming process is realized, the sealing effect is improved, and the stability of the column bed is ensured.
Description
Technical Field
The utility model relates to the field of chromatographic columns, in particular to a manual low-pressure chromatographic column.
Background
Chromatographic separation techniques are widely used in different forms for separating chemical and biological substances and have found many applications in the preparation, purification and analysis of compounds, liquid chromatographic separation being used in many pharmaceutical and biological industries. As disclosed in chinese patent CN104364645a, a chromatographic column, publication No. 2015.02.18, specifically comprises a tubular housing and a first end unit detachably connected to a first end of the tubular housing, a second end unit detachably connected to a second end of the tubular housing, an adapter assembly movably mounted in the tubular housing, an adapter rod connected to the adapter assembly and extending to an opening of the first end unit, and a filter mounted on the adapter assembly; although the adapter assembly can be replaced and molded by the inner bed, the possibility of leakage of the bed can be caused during the up-and-down movement and adjustment of the adapter assembly, and the stability of the bed can be affected.
Disclosure of Invention
Aiming at the defects existing in the prior art, the utility model provides a manual low-pressure chromatographic column, which realizes the compression adjustment of the column bed forming process, improves the sealing effect and ensures the stability of the column bed.
In order to achieve the above purpose, the present utility model adopts the following technical scheme:
the manual low-pressure chromatographic column comprises a columnar frame and a glass tube arranged in the columnar frame, wherein an adjusting nut and a screw rod which is in threaded connection with the adjusting nut are arranged on the columnar frame, and a piston is arranged on a part of the screw rod extending into the glass tube; the piston is sleeved with a sealing ring for sealing the side gap, and the screw rod is provided with a sealing adjusting mechanism for adjusting the compression state of the sealing ring; the piston, the glass tube and the bottom of the columnar frame are enclosed to form a column bed area; the screw rod is provided with a first liquid passing pipe extending to the piston and communicated with the bed area, and the bottom of the columnar frame is provided with a second liquid passing pipe communicated with the bed area.
Preferably, the seal adjusting mechanism comprises a compression ring sleeved on the piston and an adjusting ring sleeved on the screw rod, and the adjusting ring is connected with the compression ring through a plurality of inclined rods; an adjusting rod extending to the adjusting ring is arranged in the screw rod, and the adjusting rod is connected with the adjusting ring through a connecting pin; the top of the screw rod is in threaded connection with a small knob for pushing the adjusting rod to move downwards; and a reset spring for pushing the adjusting rod to move upwards is arranged in the screw rod.
Preferably, the piston and the bottom of the columnar frame are both provided with a microporous filter screen, and the microporous filter screen is used for covering the liquid passing port of the first liquid passing pipe and the liquid passing port of the second liquid passing pipe, which are positioned in the column bed area.
Preferably, the columnar frame comprises a bottom flange and a top flange, and a plurality of pull rods uniformly distributed along the circumferential direction are arranged between the bottom flange and the top flange.
Preferably, a plurality of support frames uniformly distributed along the circumferential direction are arranged on the bottom flange, and rollers are arranged on the support frames.
Preferably, the adjusting nut is rotatably mounted on the top flange, and a large knob is mounted on the adjusting nut.
Preferably, a supporting hanging block for supporting the second liquid passing pipe is arranged on the bottom flange; the second liquid passing pipe is of a bending structure.
Preferably, a first joint is connected to the part of the upper end of the first liquid passing pipe extending out of the screw rod, and a second joint is connected to the tail end of the second liquid passing pipe; the first liquid passing pipe is a sample liquid inlet pipe, and the second liquid passing pipe is a sample liquid outlet pipe.
Preferably, the top flange, the bottom flange and the pull rod are all made of stainless steel.
Compared with the prior art, the utility model has the following beneficial effects:
the piston is adjusted to move downwards through the cooperation of the screw rod and the adjusting nut when the bed is formed, so that the bed area is adjusted and compressed, and the piston can be sealed after moving in place through the sealing adjusting mechanism, so that the piston can be in contact with and sealed in the adjusting process, and the piston is sealed after moving in place; let seal state adjust according to the bed shaping process and adjust to can be convenient for realize removing and guarantee sealed effect.
Drawings
FIG. 1 is a schematic diagram of an embodiment of the present utility model;
FIG. 2 is a schematic cross-sectional view of an embodiment of the present utility model;
FIG. 3 is a schematic view of a partial enlarged structure at A in FIG. 2;
in the drawing the view of the figure,
the column frame 1, the bottom flange 101, the top flange 102, the pull rod 103, the glass tube 2, the adjusting nut 3, the screw rod 4, the piston 5, the sealing adjusting mechanism 6, the compression ring 61, the adjusting ring 62, the diagonal rod 63, the adjusting rod 64, the connecting pin 65, the small knob 66, the return spring 67, the column bed area 7, the first liquid passing tube 8, the second liquid passing tube 9, the microporous filter screen 10, the supporting frame 11, the roller 12, the large knob 13, the supporting hanging block 14 and the sealing ring 15.
Detailed Description
The present utility model will be further described with reference to the accompanying drawings and specific examples, which are not intended to be limiting, so that those skilled in the art will better understand the utility model and practice it.
As shown in fig. 1 to 3, the embodiment of the utility model provides a manual low-pressure chromatographic column, which comprises a columnar frame 1 and a glass tube 2 arranged in the columnar frame 1, wherein an adjusting nut 3 and a screw rod 4 which is in threaded connection with the adjusting nut 3 are arranged on the columnar frame 1, a piston 5 is arranged at a part of the screw rod 4 extending into the glass tube 2, and the piston 5 can be moved by rotating the adjusting nut 3 and under the limit action of sliding fit of the piston 5 in the glass tube 2, so that the screw rod 4 can move to carry the piston 5; in order to seal the side gap after the piston 5 moves in place, a sealing ring 15 for sealing the side gap is sleeved on the piston 5, a sealing adjusting mechanism 6 for adjusting the pressing state of the sealing ring 15 is arranged on the screw rod 4, the sealing adjusting mechanism can contact the sealing state when the piston 5 needs to move, and the sealing adjustment is performed after the piston 5 moves in place, so that the bottom of the piston 5, the glass tube 2 and the bottom of the columnar frame 1 are enclosed to form a column bed area 7, and the column bed area 7 with a good sealing effect is formed; in particular, when the chromatographic column is used, the liquid is mainly led to flow through the bed area 7 and then is respectively collected according to the outflow time difference of different components; specifically, when the bed region 7 is formed, the fine particle suspension is poured, the suspension is extruded by moving the piston 5 until the excessive liquid is discharged, and then a compacted bed is formed, so that the bed can be adjusted or replaced according to actual conditions after use.
In order to facilitate the inflow and outflow of the sample into and out of the bed region 7, a first liquid passing pipe 8 extending to the piston 5 and communicated with the bed region 7 is arranged on the screw rod 4, and a second liquid passing pipe 9 communicated with the bed region 7 is arranged at the bottom of the columnar frame 1.
Specifically, the seal adjusting mechanism 6 can adjust whether the seal ring 15 is in a compressed state, and the seal adjusting mechanism 6 comprises a compression ring 61 sleeved on the piston 5 and an adjusting ring 62 sleeved on the screw rod 4, wherein the adjusting ring 62 is connected with the compression ring 61 through a plurality of inclined rods 63; an adjusting rod 64 extending to the adjusting ring 62 is arranged in the screw rod 4, and the adjusting rod 64 is connected with the adjusting ring 62 through a connecting pin 65; the top of the screw rod 4 is in threaded connection with a small knob 66 for pushing the adjusting rod 64 to move downwards; a reset spring 67 for pushing the adjusting rod 64 to move upwards is arranged in the screw rod 4; when the small knob 66 is rotated, the adjusting rod 64 can be pushed to move downwards, so that the adjusting ring 62 is carried to move, the inclined rod 63 is pushed to enable the compression ring 61 to compress the sealing ring 15, and therefore the gap is sealed; when the sealing state is required to be released, the small knob 66 is released, the adjusting rod 64 is lifted under the action of the return spring 67, and the compression ring 61 is released from the sealing ring 15, so that the sealing state is released.
Specifically, in order to avoid the leakage of suspended particles in the bed, the piston 5 and the bottom of the columnar frame 1 are both provided with a microporous filter screen 10, the microporous filter screen 10 is used for covering the liquid passing port of the first liquid passing pipe 8 and the second liquid passing pipe 9 located in the bed region 7, and only liquid can flow through under the action of the microporous filter screen 10, so that the suspended particles cannot leak.
Specifically, the columnar frame 1 includes a bottom flange 101 and a top flange 102, a plurality of tie rods 103 are circumferentially and uniformly distributed between the bottom flange 101 and the top flange 102, and the top flange 102 and the bottom flange 101 compress both ends of the glass tube 2 through the action of the tie rods 103, so that the glass tube 2 can be compressed and reliably supported.
Meanwhile, in order to facilitate the movement of the whole device, a plurality of supporting frames 11 are installed on the bottom flange 101 uniformly distributed along the circumferential direction, and rollers 12 are installed on the supporting frames 11.
The adjusting nut 3 is rotatably installed on the top flange 102, a large knob 13 is installed on the adjusting nut 3, and the adjusting nut 3 can be driven to rotate through the large knob 13.
In order to support the second liquid passing pipe 9 and buffer the liquid flowing out of the second liquid passing pipe 9, a supporting hanging block 14 for supporting the second liquid passing pipe 9 is arranged on the bottom flange 101; and the second liquid passing pipe 9 is of a bending structure.
Further, a first joint is connected to the part of the upper end of the first liquid passing pipe 8 extending out of the screw rod 4, and a second joint is connected to the end of the second liquid passing pipe 9; the first liquid passing pipe 8 is a sample liquid inlet pipe, and the second liquid passing pipe 9 is a sample liquid outlet pipe, and is convenient to connect a liquid circulation pipeline through a first connector and a second connector.
In order to improve the reliability and durability of the overall structure, the top flange 102, the bottom flange 101 and the pull rod 103 are made of stainless steel.
In the description of the present utility model, it should be understood that the terms "orientation" or "positional relationship" are based on the orientation or positional relationship shown in the drawings, and are merely for convenience of description and to simplify the description, rather than to indicate or imply that the apparatus or elements referred to must have a particular orientation, be constructed and operate in a particular orientation, and therefore should not be construed as limiting the utility model.
In the present utility model, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.
In the description of the present utility model, it should be noted that, directions or positional relationships indicated by terms such as "center", "upper", "lower", "left", "right", "inner", "outer", etc., are directions or positional relationships based on those shown in the drawings, or are directions or positional relationships conventionally put in use of the inventive product, are merely for convenience of describing the present utility model and simplifying the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific direction, be constructed and operated in a specific direction, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.
Finally, it is noted that the above embodiments are only for illustrating the technical solution of the present utility model and not for limiting the same, and although the present utility model has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications and equivalents may be made thereto without departing from the spirit and scope of the technical solution of the present utility model, which is intended to be covered by the scope of the claims of the present utility model.
Claims (9)
1. A manual low pressure chromatographic column, characterized in that: the glass tube comprises a columnar frame (1) and a glass tube (2) arranged in the columnar frame (1), wherein an adjusting nut (3) and a screw rod (4) connected with the adjusting nut (3) in a threaded manner are arranged on the columnar frame (1), and a piston (5) is arranged at a part of the screw rod (4) extending into the glass tube (2);
a sealing ring (15) for sealing the side gap is sleeved on the piston (5), and a sealing adjusting mechanism (6) for adjusting the compression state of the sealing ring (15) is arranged on the screw rod (4);
the piston (5), the glass tube (2) and the bottom of the columnar frame (1) are enclosed to form a column bed area (7);
the screw rod (4) is provided with a first liquid passing pipe (8) which extends to the piston (5) and is communicated with the column bed area (7), and the bottom of the columnar frame (1) is provided with a second liquid passing pipe (9) which is communicated with the column bed area (7).
2. A manual low pressure chromatography column according to claim 1, wherein: the sealing adjusting mechanism (6) comprises a compression ring (61) sleeved on the piston (5) and an adjusting ring (62) sleeved on the screw rod (4), and the adjusting ring (62) is connected with the compression ring (61) through a plurality of inclined rods (63);
an adjusting rod (64) extending to the adjusting ring (62) is arranged in the screw rod (4), and the adjusting rod (64) is connected with the adjusting ring (62) through a connecting pin (65);
a small knob (66) for pushing the adjusting rod (64) to move downwards is connected with the top of the screw rod (4) in a threaded manner;
a reset spring (67) for pushing the adjusting rod (64) to move upwards is arranged in the screw rod (4).
3. A manual low pressure chromatography column according to claim 1, wherein: the piston (5) with micropore filter screen (10) that column frame (1) bottom all installed, micropore filter screen (10) are used for covering first liquid pipe (8) liquid pipe (9) are located cross the liquid mouth of bed district (7).
4. A manual low pressure chromatography column according to claim 1, wherein: the columnar frame (1) comprises a bottom flange (101) and a top flange (102), and a plurality of pull rods (103) uniformly distributed along the circumferential direction are arranged between the bottom flange (101) and the top flange (102).
5. A manual low pressure chromatography column according to claim 4, wherein: a plurality of support frames (11) which are uniformly distributed along the circumferential direction are arranged on the bottom flange (101), and rollers (12) are arranged on the support frames (11).
6. A manual low pressure chromatography column according to claim 4, wherein: the adjusting nut (3) is rotatably arranged on the top flange (102), and the adjusting nut (3) is provided with a large knob (13).
7. A manual low pressure chromatography column according to claim 4, wherein: a supporting hanging block (14) for supporting the second liquid passing pipe (9) is arranged on the bottom flange (101);
the second liquid passing pipe (9) is of a bending structure.
8. A manual low pressure chromatography column according to claim 1, wherein: the part of the upper end of the first liquid passing pipe (8) extending out of the screw rod (4) is connected with a first joint, and the tail end of the second liquid passing pipe (9) is connected with a second joint;
the first liquid passing pipe (8) is a sample liquid inlet pipe, and the second liquid passing pipe (9) is a sample liquid outlet pipe.
9. A manual low pressure chromatography column according to claim 4, wherein: the top flange (102), the bottom flange (101) and the pull rod (103) are all made of stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223541373.9U CN219369670U (en) | 2022-12-29 | 2022-12-29 | Manual low-pressure chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223541373.9U CN219369670U (en) | 2022-12-29 | 2022-12-29 | Manual low-pressure chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219369670U true CN219369670U (en) | 2023-07-18 |
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ID=87153187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223541373.9U Active CN219369670U (en) | 2022-12-29 | 2022-12-29 | Manual low-pressure chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219369670U (en) |
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- 2022-12-29 CN CN202223541373.9U patent/CN219369670U/en active Active
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