CN214181903U - Silica gel column chromatography device - Google Patents

Abstract

The utility model provides a device is used in silica gel column chromatography, which comprises a supporting rack, the silica gel column, consider the dish, first pipeline and consideration dish actuating mechanism that opens and shuts, the vertical fixed setting of silica gel column is on the support frame, it includes curved funnel to consider the dish, filter screen and second pipeline, the filter screen sets up in curved funnel, one side of curved funnel articulates and sets up in silica gel column one side, still set up one and the coaxial pivoted rotary joint of curved funnel in silica gel column one side, rotary joint is used for realizing the swivelling joint of first conveyer pipe and second conveyer pipe, consider that the dish opens and shuts actuating mechanism and is used for realizing closely cooperating and the separation of curved funnel and silica gel column bobbin base portion. The filter disc in the device can be tightly attached to the bottom of the silica gel column in the chromatography process under the jacking pressure of the filter disc opening and closing driving mechanism, so that the silica gel leakage phenomenon is avoided; meanwhile, the opening of the filter disc can be smoothly realized by utilizing the filter disc opening and closing driving mechanism, so that the cleaning and the maintenance of a filter screen in the filter disc are convenient to realize.

Description

Silica gel column chromatography device

Technical Field

The utility model relates to a silica gel column chromatography device.

Background

The separation principle of silica gel chromatography is to separate substances according to different adsorption forces of the substances on silica gel, in general, substances with larger polarity are easy to be adsorbed by the silica gel, substances with weaker polarity are not easy to be adsorbed by the silica gel, and the whole chromatography process is the adsorption, desorption, re-adsorption and re-desorption processes. In the field of drug production, a silica gel chromatography is commonly used for separating substances, and the problems of silica gel leakage and inconvenient filter screen cleaning and maintenance exist in the chromatography process of silica gel column chromatography equipment adopted by the existing drug manufacturers.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a silica gel column chromatography device, a filter disc in the device can be tightly attached to the bottom of a silica gel column cylinder in the chromatography process under the jacking pressure of a filter disc opening and closing driving mechanism, thereby avoiding the occurrence of silica gel leakage; meanwhile, the opening of the filter disc can be smoothly realized by utilizing the filter disc opening and closing driving mechanism, so that the cleaning and the maintenance of a filter screen in the filter disc are convenient to realize.

The utility model provides a technical scheme that its technical problem adopted is: a silica gel column chromatography device comprises a support frame, a silica gel column, a filter disc, a first conveying pipeline and a filter disc opening and closing driving mechanism, wherein the silica gel column is vertically and fixedly arranged on the support frame, the filter disc comprises an arc-shaped funnel, a filter screen and a second conveying pipeline, an inner edge of the arc-shaped funnel is provided with an inner concave step, the filter screen is arranged in the inner concave step through a bolt fixing clamp, a first annular sealing gasket is further arranged in the inner concave step, the first annular sealing gasket is positioned on the outer side of the filter screen, one side of the arc-shaped funnel is hinged and arranged on a first L-shaped lug arranged on the side wall of the silica gel column, a second L-shaped lug is arranged on the front side of the first L-shaped lug, a rotary joint capable of coaxially rotating with the arc-shaped funnel is arranged on the second L-shaped lug, the first conveying pipeline is connected with a fixed interface of the rotary joint, the second conveying pipeline is used for realizing the through connection of the arc-shaped funnel and the movable connector of the rotary joint, and the filter disc opening and closing driving mechanism is used for realizing the close fit and separation of the arc-shaped funnel and the bottom of the silica gel column barrel.

Preferably, the filter screen is a stainless steel filter screen, and the aperture of the stainless steel filter screen is 0.45-10 μm.

Preferably, the filter screen is a stainless steel sintering net, and the aperture of the stainless steel sintering net is 0.45-10 μm.

Furthermore, an inner groove matched with the first annular sealing gasket is arranged on the inner edge of the lower part of the silica gel column barrel.

Preferably, a second annular sealing gasket is arranged between the filter screen and the concave step.

Furthermore, a rubber outlet pipe communicated with the inside of the silica gel column casing is arranged on the outer side of the lower part of the silica gel column casing, and a switch valve adjacent to the silica gel column casing is arranged on the rubber outlet pipe.

Further, consider dish actuating mechanism that opens and shuts to include the cylinder, the telescopic link tip of cylinder with the swing end of arc funnel is articulated to be connected, the stiff end of cylinder with the support frame is articulated to be connected, can realize closely cooperating of arc funnel and silica gel column bottom portion through stretching out of the telescopic link of cylinder, can realize opening of arc funnel from silica gel column bottom portion through the flexible back of the telescopic link of cylinder.

Further, set up on the arc funnel one with the adjacent third L shape journal stirrup of the telescopic link tip of cylinder the last cover of third L shape journal stirrup sets up an adjusting threaded rod the fixed clamp plate that sets up in lower part of adjusting threaded rod makes the lower part of clamp plate roof pressure silica gel column section of thick bamboo through rotatory adjusting threaded rod after the bottom lock of arc funnel and silica gel column section of thick bamboo is in the same place, can realize the inseparable lock of arc funnel and silica gel column section of thick bamboo.

The utility model has the advantages that: the utility model has simple structure and convenient processing and manufacturing; when the arc funnel is tightly arranged at the lower part of the silica gel column by the cylinder, the first annular sealing pad arranged in the arc funnel is tightly compressed, and then the arc funnel is hermetically connected with the silica gel column, so that the silica gel leakage phenomenon can not occur when the silica gel column is used for chromatography; the expansion and contraction of the cylinder can realize the convenient opening and closing of the filter disc, so that the normal cleaning and maintenance of the filter screen are convenient for workers; when the filter screen adopts the stainless steel sintering net, because of the high bulk strength of stainless steel sintering net, compressive resistance is strong, when silica gel column chromatography, can not take place great deformation, ensured filter fineness then to be convenient for the filter effect of silica gel column.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some of the preferred embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a cross-sectional view of a filter disc;

FIG. 3 is an enlarged view of FIG. 1 at A;

FIG. 4 is an enlarged view of FIG. 2 at B;

in the figure: the device comprises a support frame 1, a silica gel column barrel 2, a first L-shaped support lug 21, a second L-shaped support lug 211, an inner groove 22, a rubber outlet pipe 23, a switching valve 24, an arc-shaped funnel 31, a filter screen 32, a second conveying pipeline 33, a first annular sealing gasket 34, a bolt 35, a second annular sealing gasket 36, a first conveying pipeline 4, a rotary joint 41, an air cylinder 5, a third L-shaped support lug 61, an adjusting threaded rod 62 and a pressing plate 63.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the following specific embodiments and accompanying drawings 1-4, and it is obvious that the described embodiments are only a part of the preferred embodiments of the present invention, and not all embodiments. Those skilled in the art can make similar variations without departing from the spirit of the invention, and therefore the invention is not limited by the specific embodiments disclosed below.

The utility model provides a silica gel column chromatography device (as shown in figure 1), which comprises a support frame 1, a silica gel column 2, a filter disc, a first conveying pipeline 4 and a filter disc opening and closing driving mechanism, wherein the silica gel column 2 is vertically and fixedly arranged on the support frame 1, the silica gel column 2 is used for containing silica gel liquid and solution which needs to separate substances, the filter disc comprises an arc-shaped funnel 31, a filter screen 32 and a second conveying pipeline 33, an inner edge of the arc-shaped funnel 31 is provided with an inner concave step, the filter screen 32 is fixedly clamped in the inner concave step through a bolt 35, a first annular sealing gasket 34 is also arranged in the inner concave step, the first annular sealing gasket 34 is positioned outside the filter screen 32, the first annular sealing gasket 34 is used for realizing butt joint sealing between the bottom of the silica gel column 2 and the arc-shaped funnel 31, and is convenient for realizing stable clamping of the first annular sealing gasket 34, here, be provided with on the lower part of silica gel column casing 2 along the edge with first annular sealing gasket 34 matched with inner groovy 22, after arc funnel 31 and silica gel column casing 2 block together, first annular sealing gasket 34 block is put in indent step and inner groovy 22, has then realized the spacing of first annular sealing gasket 34, one side of arc funnel 31 is articulated to be set up on a first L shape journal stirrup 21 that sets up on the lateral wall of silica gel column casing 2, set up a second L shape journal stirrup 211 in the front side of first L shape journal stirrup 21, set up on second L shape journal stirrup 211 can with arc funnel 31 coaxial rotation's rotary joint 41, utilize rotary joint 41 to connect first pipeline 4 and second pipeline 32 to when arc funnel 31 drives second pipeline 32 and swings, do not influence the connectivity of second pipeline 32 and first pipeline 32, first pipeline 4 with rotary joint 41's fixed interface is connected, second pipeline 33 realizes the through connection of arc funnel 31 and rotary joint 41's activity interface, from the solution that arc funnel 31 flowed out, directly flows into first pipeline 4 through second pipeline 32 and rotary joint 41, consider that the dish actuating mechanism that opens and shuts is used for realizing closely cooperating and the separation of arc funnel 31 and silica gel column casing 2 bottom, in this embodiment, open and shut actuating mechanism with the filter dish and set up to cylinder 5, the concrete implementation mode that cylinder 5 and arc funnel 31 are connected does: the telescopic link tip of cylinder 5 with the swing end that the arc leaked 31 to fight is articulated to be connected, the stiff end of cylinder 5 with support frame 1 is articulated to be connected, can realize closely cooperating of arc funnel 31 and 2 bottoms of silica gel column casing through stretching out of the telescopic link of cylinder 5, can realize opening of arc funnel 31 from 2 bottoms of silica gel column casing through retracting of the telescopic link of cylinder 5.

In this embodiment, the filtering net 32 can be a stainless steel filtering net or a stainless steel sintering net, and the aperture of the stainless steel filtering net and the aperture of the stainless steel sintering net are 0.45-10 μm, so the stainless steel sintering net has the advantages of high strength, strong pressure resistance, and difficult deformation, and the like, and therefore the stainless steel sintering net is preferably used as the filtering net 32.

In the chromatography process, in order to prevent the silica gel solution from flowing into the arc-shaped funnel 31 from the gap between the filter screen 32 and the concave step, a second annular sealing gasket 36 is arranged between the filter screen 32 and the concave step, and the filter screen 32 is compressed by a bolt 35 to realize the compression of the second annular sealing gasket 36.

After the chromatography, in order to facilitate the discharge of the silica gel mixed liquid in the silica gel column 2, a glue outlet pipe 23 communicated with the inside of the silica gel column 2 is arranged outside the lower part of the silica gel column 2, and a switch valve 24 adjacent to the silica gel column 2 is arranged on the glue outlet pipe 23.

In practical application, for the reliability that improves the inseparable block of arc funnel 31 and silica gel column casing 2 to prevent that cylinder 5 from breaking down, arc funnel 31 and silica gel column casing 2 take place the separation phenomenon, here, set up one on arc funnel 31 with the adjacent third L shape journal stirrup 61 of the telescopic link tip of cylinder 5 set up an adjusting screw 62 on the third L shape journal stirrup 61 the fixed clamp plate 63 that sets up in lower part of adjusting screw 62, after arc funnel 31 and silica gel column casing 2's bottom lock are in the same place, make clamp plate 63 roof pressure silica gel column casing 2's lower part through rotatory adjusting screw 62, can realize the inseparable lock of arc funnel 31 and silica gel column casing 2.

In addition to the technical features described in the specification, the technology is known to those skilled in the art.

The above description is provided for the preferred embodiments and examples of the present invention with reference to the accompanying drawings, but the present invention is not limited to the above embodiments and examples, and it will be apparent to those skilled in the art that various modifications and variations can be made without departing from the spirit of the present invention, and these modifications and variations should be construed as the protection scope of the present invention.

Claims (8)

1. A silica gel column chromatography device is characterized by comprising a support frame, a silica gel column, a filter disc, a first conveying pipeline and a filter disc opening and closing driving mechanism, wherein the silica gel column is vertically and fixedly arranged on the support frame, the filter disc comprises an arc-shaped funnel, a filter screen and a second conveying pipeline, an inner edge of the arc-shaped funnel is provided with an inner concave step, the filter screen is arranged in the inner concave step through a bolt fixing clamp, a first annular sealing gasket is further arranged in the inner concave step, the first annular sealing gasket is positioned on the outer side of the filter screen, one side of the arc-shaped funnel is hinged and arranged on a first L-shaped lug arranged on the side wall of the silica gel column, a second L-shaped lug is arranged on the front side of the first L-shaped lug, a rotary joint capable of coaxially rotating with the arc-shaped funnel is arranged on the second L-shaped lug, first pipeline with rotary joint's fixed interface is connected, second pipeline realizes the through connection of arc funnel and rotary joint's activity interface, consider that the dish actuating mechanism that opens and shuts to be used for realizing closely cooperating and the separation of arc funnel and silica gel column bobbin base portion.

2. The apparatus as claimed in claim 1, wherein the filter is a stainless steel filter having a pore size of 0.45 to 10 μm.

3. The apparatus as claimed in claim 1, wherein the filter is a stainless steel sintered mesh having a pore size of 0.45 to 10 μm.

4. The apparatus as claimed in claim 2 or 3, wherein an inner groove is provided on the inner edge of the lower part of the silica gel column to be fitted with the first annular packing.

5. The apparatus as claimed in claim 1, wherein a second annular packing is provided between the filter and the inwardly recessed step.

6. The apparatus as claimed in claim 5, wherein a rubber discharge tube communicating with the inside of the lower part of the silica gel column is provided on the outer side of the lower part of the silica gel column, and a switching valve adjacent to the silica gel column is provided on the rubber discharge tube.

7. The device as claimed in claim 6, wherein the driving mechanism comprises a cylinder, the end of the telescopic rod of the cylinder is hinged to the swing end of the arc-shaped funnel, the fixed end of the cylinder is hinged to the supporting frame, the arc-shaped funnel can be tightly fitted to the bottom of the silica gel column by extending the telescopic rod of the cylinder, and the arc-shaped funnel can be opened from the bottom of the silica gel column by retracting the telescopic rod of the cylinder.

8. The device as claimed in claim 7, wherein the arced funnel is provided with a third L-shaped lug adjacent to the end of the telescopic rod of the cylinder, the third L-shaped lug is sleeved with an adjusting threaded rod, a pressing plate is fixedly arranged at the lower part of the adjusting threaded rod, and after the arced funnel and the bottom of the silica gel column are fastened together, the pressing plate presses against the lower part of the silica gel column by rotating the adjusting threaded rod, so that the arced funnel and the silica gel column can be fastened tightly.

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