CN219346889U - Biological sample access device and biological sample storage equipment - Google Patents

Abstract

The utility model relates to a biological sample access device and biological sample storage equipment, wherein the biological sample access device comprises a lifting mechanism, a sample access mechanism and a freezing frame, wherein at least two sample supporting pieces with different heights in the vertical direction are arranged on the freezing frame, and a sample placing space for placing a sample box is arranged on the sample supporting pieces. When the lifting mechanism is connected with the freezing frame, the lifting mechanism drives the freezing frame to move relative to the sample storage and retrieval mechanism in the vertical direction under the action of driving force, so that one sample placing space is at least partially positioned in the reciprocating movement space of the sample storage and retrieval mechanism; and the sample storing and taking mechanism reciprocates in the reciprocating space relative to the freezing frame under the action of the driving force so as to take out the sample boxes from the sample placing space or place the sample boxes in the sample placing space, thereby being capable of efficiently storing or taking out the stacked sample boxes.

Description

Biological sample access device and biological sample storage equipment

Technical Field

The application relates to the field of low-temperature storage, in particular to a biological sample access device and biological sample storage equipment.

Background

The lower the temperature is, the lower the biochemical reaction speed of the biological sample is, the better the stability of various components in the biological sample is, and the longer the preservation time is, so that the biological sample is usually put in a freezing tube of a sample box at present and then the sample box is stored in a refrigerator with a low-temperature environment inside, so that the low-temperature preservation of the biological sample is realized.

In order to store more cartridges, the cartridges are placed in a stacked manner, i.e., a plurality of cartridges are placed in a refrigerator in a stacked manner in a vertical direction. In the prior art, in order to take out a certain sample cartridge, it is necessary to take out the target sample cartridge after all the sample cartridges placed thereon are removed. For example, in the scheme disclosed in the utility model patent with publication number CN209027170U, the sample box is placed in the manner as described above, and the biological sample low-temperature storage device disclosed in the patent comprises a refrigerator mechanism, a transfer box transmission mechanism and a first grabbing device, wherein the transfer box transmission mechanism is arranged at one end of the refrigerator mechanism, a plurality of storage square tubes are arranged in the refrigerator mechanism, and the first grabbing device is arranged at the upper side of the refrigerator mechanism. The process of storing and taking out the sample box by the low-temperature storage device is as follows: the method comprises the steps that firstly, a sample box of a transfer mechanism of a transfer box is taken out and moved to the upper side of a storage square tube through a first grabbing device, then the sample box is placed inside the storage square tube through the first grabbing device, and the sample box is stored in the storage square tube in a mode of being stacked from bottom to top in sequence. If the target sample box is placed at the bottommost layer, the first grabbing device is required to take out all sample boxes placed above the bottommost layer sample box, so that the target sample box can be taken out, and the sample boxes can be accessed in such a way that the sample box accessing efficiency is low.

Disclosure of Invention

In view of the above, the present utility model provides a biological sample access device for overcoming the technical problem of low access efficiency of stacked sample cartridges in the prior art.

In a first aspect, embodiments of the present application disclose a biological sample access device comprising: lifting mechanism, sample access mechanism and cryopreservation frame, wherein: the sample storage rack is provided with at least two sample supporting pieces with different heights in the vertical direction, and a sample placing space for placing the sample box is formed in the sample supporting pieces. When the lifting mechanism is connected with the freezing frame, the lifting mechanism drives the freezing frame to move along the vertical direction relative to the sample storage mechanism under the action of a driving force, so that one sample placing space is at least partially positioned in the reciprocating movement space of the sample storage mechanism; and the sample access mechanism reciprocates in the reciprocation space relative to the freezing frame under the action of driving force to take out the sample cartridge from the sample placement space or place the sample cartridge in the sample placement space.

In an optional embodiment of the present utility model, the number of the freezing frames is plural, one of the freezing frames is a target lifting frame, and the lifting mechanism is detachably connected with the freezing frames; when the lifting mechanism is connected with the target lifting frame, the lifting mechanism drives the target lifting frame to move along the vertical direction relative to the sample storage mechanism.

In an alternative embodiment of the present utility model, the biological sample access device further includes a horizontal position adjustment mechanism, and the horizontal position adjustment mechanism is connected to all of the freezing frames. When the horizontal position adjusting mechanism adjusts the target lifting frame to the horizontal position connected with the lifting mechanism, the lifting mechanism is connected with or disconnected from the target lifting frame.

In an alternative embodiment of the present utility model, the horizontal position adjusting mechanism includes a rotation shaft and a rotation frame, and all the freezing frames are located on the rotation frame; the rotating shaft is arranged in the vertical direction and is connected with the rotating frame; the rotating shaft drives the rotating frame and all the freezing frames to rotate relative to the lifting mechanism under the action of driving force so as to adjust the target lifting frame to a horizontal position connected with the lifting mechanism.

In an alternative embodiment of the utility model, the lifting mechanism comprises a lifting connecting piece and a telescopic assembly arranged along the vertical direction, wherein the lifting connecting piece is connected with the telescopic assembly; under the action of a driving force, the length of the telescopic component in the vertical direction is changed, so that the lifting connecting piece is driven to move in the vertical direction relative to the sample storing and taking mechanism.

In an optional embodiment of the present utility model, the lifting mechanism further includes a first driving motor connected to the telescopic assembly, the lifting connection member includes a hook, a first end of the hook is connected to an output shaft of the first driving motor, and all the freezing frames are provided with connection members. When the first driving motor drives the hook to rotate by a first preset angle along a first rotation direction, the second end of the hook is connected with the connecting piece of the target lifting frame. When the first driving motor drives the hook to rotate by a second preset angle along a second rotation direction, the second end of the hook is disconnected with the connecting piece of the target lifting frame; wherein the first rotational direction and the second rotational direction are opposite rotational directions.

In an alternative embodiment of the present utility model, the lifting mechanism further includes a contact plate, a first limit switch, and a second limit switch; an output shaft of the first driving motor is connected with the contact piece; the first limit switch and the second limit switch are arranged on the telescopic component along the movement direction of the contact piece. When the first driving motor drives the contact piece to rotate for a first preset angle along a first rotation direction, the contact piece is contacted with the first limit switch, so that the first driving motor stops rotating; when the first driving motor drives the contact piece to rotate for a second preset angle along a second rotation direction, the contact piece is contacted with the second limit switch, so that the first driving motor stops rotating.

In an optional embodiment of the present utility model, the hook includes a first portion and a second portion that are both elongated, the first portion is disposed along a vertical direction, a first end of the first portion is connected to an output shaft of the first driving motor, a second end of the first portion is connected to the second portion, the second portion is perpendicular to the first portion, all of the freezing frames are provided with elongated connection holes, and the first preset angle and the second preset angle are both 90 degrees.

In an optional embodiment of the present utility model, the lifting connection piece further includes a first positioning piece, and all the freezing frames are provided with a second positioning piece detachably connected with the first positioning piece; after the first positioning piece is connected with the second positioning piece of the target lifting frame, the first driving motor drives the hook to rotate along the first rotation direction or the second rotation direction.

A second aspect of an embodiment of the present application discloses a biological sample storage device comprising a biological sample access apparatus and a refrigerator as described in the first aspect above; wherein, the refrigerator is internally provided with a low-temperature storage space; the freezing frame is positioned in the low-temperature storage space, and the lifting mechanism and the sample access mechanism are positioned in the low-temperature storage space or outside the low-temperature storage space.

The biological sample storage device comprises a lifting mechanism, a sample storage mechanism and a freezing frame, wherein at least two sample supporting pieces with different heights in the vertical direction are arranged on the freezing frame, and sample placing spaces for placing sample boxes are formed in the sample supporting pieces. The sample storage device can be connected with the freezing storage rack through the lifting mechanism and drives the freezing storage rack to move along the vertical direction so as to move sample storage spaces with different vertical heights into a reciprocating motion space with the sample storage mechanism, and the sample storage mechanism can take out the sample box positioned on the non-top layer only by executing one storage operation. Compared with the prior art, the biological sample access device provided by the utility model is convenient for storing or taking out the sample box and improves the access efficiency of the sample box.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 is a schematic structural view of a lifting mechanism in a biological sample access device according to an embodiment of the present disclosure;

FIG. 2 is a schematic view of a lifting mechanism of a biological sample access device according to an embodiment of the present disclosure;

FIG. 3 is a schematic diagram of a biological sample storage device according to an embodiment of the disclosure;

FIG. 4 is a schematic perspective view of a biological sample storage device according to an embodiment of the present application;

FIG. 5 is a schematic structural view of an alternative biological sample storage device provided by the examples of this application;

FIG. 6 is a schematic perspective view of the structure of an alternative embodiment biological sample storage device provided by the examples of this application;

FIG. 7 is a schematic view of a sample transfer mechanism in a biological sample storage device according to an embodiment of the present application;

FIG. 8 is a schematic diagram of an external docking mechanism in a biological sample storage device according to an embodiment of the present application;

fig. 9 is a schematic structural view of an uncapping mechanism in a biological sample storage device according to an embodiment of the present application;

fig. 10 is a schematic structural view of a cover opening mechanism in a biological sample storage device according to an embodiment of the present application.

Reference numerals: 1-a refrigerator; 2-a lifting mechanism; 21-lifting connection; 22-telescoping assembly; 3-a sample access mechanism; 4-a freezing storage rack; 5-a horizontal position adjusting mechanism; 51-a rotation axis; 52-rotating rack; 6-a first drive motor; 7-contact pieces; 71-a first connecting piece; 72-a second connecting piece; 8-a first limit switch; 9-a second limit switch; 10-a sample transfer mechanism; 10 a-a grasping assembly; 10 b-horizontal transfer assembly; 11-an external docking mechanism; 11 a-a support plate; 11 b-positioning blocks; 12-a cover opening mechanism; 12 a-a first drive mechanism; 12 b-a second drive mechanism; 12 c-a heat-preserving upper cover; 12 d-a third drive mechanism.

Detailed Description

The following description of the technical solutions in the embodiments of the present application will be made clearly and completely with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

In the present utility model, the azimuth or positional relationship indicated by the terms "upper", "lower", "outer", and the like are based on the azimuth or positional relationship shown in the drawings. These terms are only used to better describe the utility model and its embodiments and are not intended to limit the scope of the indicated devices, elements or components to the particular orientations or to configure and operate in the particular orientations.

Also, some of the terms described above may be used to indicate other meanings in addition to orientation or positional relationships, for example, the term "upper" may also be used to indicate some sort of attachment or connection in some cases. The specific meaning of these terms in the present utility model will be understood by those of ordinary skill in the art according to the specific circumstances.

Furthermore, the terms "mounted," "disposed," "configured to," and "connected" are to be construed broadly. For example, it may be a fixed connection, a removable connection, or a unitary construction; may be a mechanical connection, or an electrical connection; either directly, indirectly, through intermediaries, or through internal communication between two devices, elements, or components. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.

Furthermore, the terms "first," "second," and the like, are used primarily to distinguish between different devices, elements, or components (the particular species and configurations may be the same or different), and are not used to indicate or imply the relative importance and number of devices, elements, or components so indicated. Unless otherwise indicated, the meaning of "a plurality" is two or more.

Example 1

As shown in fig. 1 to 8, an embodiment of the present utility model discloses a biological sample access device, including: lifting mechanism 2, sample access mechanism 3 and cryopreservation frame 4, wherein:

the freezing frame 4 is provided with at least two sample supporting pieces with different heights in the vertical direction, and the sample supporting pieces are provided with sample placing spaces for placing sample boxes; when the lifting mechanism 2 is connected with the freezing and storing frame 4, the lifting mechanism 2 drives the freezing and storing frame 4 to move along the vertical direction relative to the sample storing and taking mechanism 3 under the action of driving force, so that one sample placing space is at least partially positioned in the reciprocating movement space of the sample storing and taking mechanism 3; and the sample access mechanism 3 reciprocates in the reciprocation space with respect to the freezing frame 4 by the driving force to take out or place the sample cartridge from or in the sample placement space.

In the present embodiment, the biological sample storage apparatus includes the biological sample access device and the refrigerator 1, the inside of the refrigerator 1 has a low-temperature storage space that accommodates a plurality of freezing shelves 4, and a low-temperature environment can be generated in the low-temperature storage space. Wherein, the low temperature environment refers to an environment with the temperature of-80 ℃ or below-80 ℃, and the preservation of the biological sample in the environment can reduce the biochemical reaction of the biological sample and maintain the stability of various components in the biological sample. The biological sample access means is for storing the sample cartridge in the low-temperature storage space of the refrigerator 1 or taking out the sample cartridge from the low-temperature storage space of the refrigerator 1.

In this embodiment, the freezing frame 4 is used for placing the sample box to be stored, the freezing frame 4 is provided with a sample support, and the sample support is provided with a sample placing space for placing the sample box. The specific structure, shape and size of the freezing frame 4 and the sample support member are not limited, and can be set correspondingly according to practical application requirements.

In this embodiment, the lifting mechanism 2 is configured to drive the freezing frame 4 to move along a vertical direction relative to the sample storage mechanism 3, so as to at least partially lift a sample placement space on the freezing frame 4 into a reciprocating space of the sample storage mechanism 3, and lower the freezing frame 4 into a low-temperature storage space of the refrigerator 1. The specific structure, shape and size of the lifting mechanism 2 and the connection mode of the lifting mechanism 2 and the freezing frame 4 are not limited, and can be correspondingly set according to practical application requirements. For example, the lifting mechanism 2 and the freezing and storing frame 4 may be fixedly connected, and the lifting mechanism 2 and the freezing and storing frame 4 may be detachably connected.

In addition, the reciprocating space is a space in which the sample accessing mechanism 3 can take out the sample cartridge from the cryopreservation frame 4 or store the sample cartridge in the cryopreservation frame 4, and the sample accessing mechanism 3 can move toward the cryopreservation frame 4 and extend into the sample placing space in the reciprocating space, and move away from the cryopreservation frame 4 and withdraw from the sample placing space to take out the sample cartridge from the sample placing space or store the sample cartridge in the sample placing space.

In this embodiment, the sample storage mechanism 3 can reciprocate relative to the freezing frame 4 under the action of the driving force, so as to store the sample box placed on the sample storage mechanism 3 or at other positions in a sample placing space of the freezing frame 4 or take out the sample box from a sample placing space of the freezing frame 4. The specific structure, shape, size and installation position of the sample access mechanism 3 are not limited, and can be set correspondingly according to practical application requirements. For example, the sample storage mechanism 3 may include a blade for supporting the sample cartridge, and the sample cartridge may be taken out from the sample placement space or stored in the sample placement space by the reciprocating movement of the blade; for another example, the sample storage mechanism 3 may include a manipulator, and the sample cartridge may be held and transported by the manipulator, so that the sample cartridge may be taken out from the sample placement space or stored in the sample placement space.

Alternatively, in order to increase the number of storable sample cartridges, a plurality of the freezing shelves 4 may be placed in the biological sample storage device, and one or more sample placement spaces may be provided on each freezing shelf 4. When the number of the freezing frames 4 is plural, in order to simplify the structural complexity of the lifting mechanism 2, that is, without using plural lifting mechanisms 2 connected to the freezing frames 4 respectively, it is preferable that the lifting mechanism 2 is detachably connected to all the freezing frames 4, and one of the freezing frames 4 is a target lifting frame. When the lifting mechanism 2 is connected with one target lifting frame in all the freezing frames 4, the lifting mechanism 2 drives the target lifting frame to move in the vertical direction relative to the sample storing and taking mechanism 3.

The structures of all the freezing frames 4 can be the same or different, and the target lifting frame is the freezing frame 4 for placing the sample box to be taken out or the freezing frame 4 for storing the sample box to be stored. The arrangement of all the freezing frames 4 in the low-temperature storage space of the refrigerator 1 is not limited, and the freezing frames can be correspondingly arranged according to the actual application requirements. For example, the plurality of freezing shelves 4 may be arranged in the circumferential direction in the low-temperature storage space, and may be arranged in a plurality of turns; the plurality of freezing shelves 4 may be arranged in sequence in the longitudinal direction and/or the width direction.

Further, considering that different freezing frames 4 may be placed at different horizontal positions in the low-temperature storage space of the refrigerator 1, that is, different horizontal positions of the freezing frames 4 on a plane parallel to the horizontal plane, the horizontal position of the target lifting frame with respect to the lifting mechanism 2 may be adjusted by providing the horizontal position adjusting mechanism 5 so that the horizontal position of the target lifting frame is located at a position where connection with the lifting mechanism 2 is possible, that is, the target lifting frame is located at a horizontal position where connection with the lifting mechanism 2 is possible, so that the lifting mechanism 2 may be connected with the target lifting frame through further movement.

Specifically, the biological sample access apparatus may further include a horizontal position adjustment mechanism 5, the horizontal position adjustment mechanism 5 being connected to all of the freezing shelves 4; when the horizontal position adjusting mechanism 5 adjusts the target lifting frame to the horizontal position connected to the lifting mechanism 2, the lifting mechanism 2 is connected to or disconnected from the target lifting frame.

The specific structure and the installation position of the horizontal position adjusting mechanism 5, the connection mode of all the freezing frames 4 and the horizontal position adjusting mechanism 5, and the adjustment mode of the horizontal position of the target lifting frame are not limited, and can be correspondingly set according to the actual application requirements. For example, all the freezing frames 4 may be directly placed on the horizontal position adjusting mechanism 5, or all the freezing frames 4 may be connected to the horizontal position adjusting mechanism 5 by a limiting structure or a connecting structure. For another example, the horizontal position adjusting mechanism 5 may adjust the horizontal position of the target lifting frame by rotating the rotating structure, or adjust the horizontal position of the target lifting frame by matching the slide rail and the slide block.

Further, referring to fig. 4, the horizontal position adjusting mechanism 5 may include a rotation shaft 51 and a rotation frame 52, and all of the freezing shelves 4 are placed on the rotation frame 52; the rotating shaft 51 is arranged in the vertical direction, and the rotating shaft 51 is connected with the rotating frame 52; the rotating shaft 51 drives the rotating frame 52 and all the freezing frames 4 to rotate relative to the lifting mechanism 2 under the action of driving force so as to adjust the target lifting frame to a horizontal position connected with the lifting mechanism 2.

The horizontal position adjusting mechanism 5 adopts a structure formed by the rotating shaft 51 and the rotating frame 52, so that the space occupation can be reduced, and the miniaturization design of the whole structure is facilitated. In addition, the installation positions and connection modes of the rotation shaft 51 and the rotation frame 52 are not limited, and may be set accordingly according to practical application requirements. For example, the rotation shaft 51 may be installed above or below the rotation frame 52, and the rotation shaft 51 may be embedded in the rotation frame 52.

Further, the rotating frame 52 may include a first fixing mechanism, and the freezing frame 4 may include a second fixing mechanism; when the freezing frame 4 is not connected with the lifting mechanism 2, the first fixing mechanism is cooperatively connected with the second fixing mechanism to limit the movement of the freezing frame 4 relative to the rotating frame 52.

In consideration of the fact that the rotating frame 52 rotates, the freezing frame 4 placed on the rotating frame 52 may move relative to the rotating frame 52 due to inertia if the freezing frame 4 is not limited. By providing the first fixing mechanism and the second fixing mechanism in cooperation with each other, therefore, the movement of the cryopreservation frame 4 relative to the rotating frame 52 can be restricted, and the shake of the cryopreservation frame 4 and the sample box placed thereon can be reduced.

In addition, the specific structures of the first fixing mechanism and the second fixing mechanism are not limited, and corresponding setting can be performed according to actual application requirements. For example, the first fixing structure and the second fixing structure may be hanging grooves and hanging lugs, which are adapted in shape, size, arrangement position and number, respectively, and the rotating frame 52 and the freezing frame 4 are connected by the cooperation of the hanging grooves and the hanging lugs, so as to limit the movement of the freezing frame 4 relative to the rotating frame 52 as much as possible.

Further, in order to achieve a detachable connection with the target lifting frame while improving space utilization, the lifting mechanism 2 may further comprise a lifting connection 21 and a telescopic assembly 22 arranged in a vertical direction, wherein the lifting connection 21 is connected with the telescopic assembly 22. Under the action of the driving force, the length of the telescopic assembly 22 in the vertical direction is changed, so that the lifting connecting piece 21 moves to a connecting position connected with the target lifting frame in the vertical direction; after the lifting connecting piece 21 is connected with the target lifting frame, the telescopic assembly 22 can drive the lifting connecting piece 21 and the target lifting frame to move along the vertical direction relative to the sample storing and taking mechanism 3.

The specific structure, size, material and number of the lifting connector 21 and the telescopic component 22 are not limited, and can be set correspondingly according to practical application requirements. For example, referring to fig. 2, the lifting mechanism 2 may comprise two lifting links 21 for detachable connection with two target lifting frames, respectively. For another example, the lifting connection piece 21 may be a clamping jaw, and a clamping structure matched with the clamping jaw may be arranged on the freezing storage rack 4; the lifting connecting piece 21 can be a hook, and connecting holes with different shapes matched with the hook can be formed in the freezing storage rack 4. As another example, the telescoping assembly 22 may include at least one of a telescoping rod, a double-layered slide rail, and a connecting chain, which may vary in length.

Further, in order to automatically connect or disconnect the lifting mechanism 2 and the target lifting frame, the lifting mechanism 2 further comprises a first driving motor 6 connected to the telescopic assembly 22, and an output shaft of the first driving motor 6 is connected to the lifting connection 21. When the output shaft of the first driving motor 6 rotates, the lifting connection member 21 can be driven to rotate.

Further, it may be preferable that the lifting connection 21 comprises a hook, a first end of which is connected to the output shaft of the first driving motor 6, and correspondingly, the whole freezing frame 4 is provided with a connection member adapted in shape and size to the second end of the hook. When the first driving motor 6 drives the hook to rotate by a first preset angle along the first rotation direction, the second end of the hook can be connected with the connecting piece of the target lifting frame, namely, the connection with the target lifting frame is realized. When the first driving motor 6 drives the hook to rotate by a second preset angle along the second rotation direction, the second end of the hook can be disconnected with the target lifting frame, namely, the connection with the target lifting frame is released. Wherein the first rotational direction and the second rotational direction are opposite rotational directions.

Wherein, the first driving motor 6 is used for providing driving force for the rotation of the hook, so that the second end of the hook is connected with or disconnected from the connecting piece of the target lifting frame. The first preset angle and the second preset angle may be equal or unequal. The output shaft of the first driving motor 6 can be directly connected with the hook or indirectly connected with the hook. Through adopting couple and connecting piece complex structure, not only simple structure is convenient for carry out the automation moreover and form and release the connection.

In addition, the power of the first driving motor 6 and the shape, size and material of the hook are not limited, and may be set accordingly according to practical application requirements. For example, the hooks may be inverted T-shaped, I-shaped, or double J-shaped, and the connectors may be different shaped connecting holes, or different shaped hooks, respectively.

Further, the lifting mechanism 2 further comprises a contact piece 7, a first limit switch 8 and a second limit switch 9; an output shaft of the first driving motor 6 is connected with the contact piece 7; the first limit switch 8 and the second limit switch 9 are mounted on the telescopic assembly 22 along the movement direction of the contact piece 7. When the first driving motor 6 drives the contact piece 7 to rotate a first preset angle along a first rotation direction, the contact piece 7 contacts with the first limit switch 8 to stop the rotation of the first driving motor 6; when the first driving motor 6 drives the contact piece 7 to rotate by a second preset angle along the second rotation direction, the contact piece 7 contacts with the second limit switch 9, so that the first driving motor 6 stops rotating.

When the contact piece 7 contacts the first limit switch 8 or the second limit switch 9, the first driving motor 6 stops rotating, so that poor connection effect between the hook and the freezing storage rack 4 or connection failure caused by overlarge rotation angle of the lifting connecting piece 21 can be avoided. In addition, the specific structure, size and material of the contact 7 are not limited, and can be set correspondingly according to practical application requirements.

Further, the contact piece 7 may include a first connection piece 71 and a second connection piece 72 connected. When the first driving motor 6 drives the first connection piece 71 and the second connection piece 72 to rotate along the first rotation direction and the first connection piece 71 contacts with the first limit switch 8, the first driving motor 6 stops rotating, and the rotation angle of the first driving motor 6 is a first preset angle. When the first driving motor 6 drives the first connection piece 71 and the second connection piece 72 to rotate along the second rotation direction and the second connection piece 72 contacts with the second limit switch 9, the first driving motor 6 stops rotating, and the rotation angle of the first driving motor 6 is a second preset angle.

Wherein, contact 7 comprises first connection piece 71 and second connection piece 72 connection, confirms first angle of predetermineeing through the contained angle between first connection piece 71 and the second connection piece 72, can avoid couple turned angle too big to cause couple and sample to store between the condition that the connection effect is not good or can't remove the connection to because contact 7's structure is comparatively simple, not only be convenient for carry out production and processing, be convenient for determine first angle of predetermineeing and second angle of predetermineeing moreover when the assembly.

Further, the shape of the hook can be preferably an inverted T shape with a simple structure, the hook comprises a first part and a second part which are both in a long strip shape, the first part is placed along the vertical direction, the first end of the first part is connected with the output shaft of the first driving motor, the second end of the first part is connected with the second part, the second part is perpendicular to the first part, and correspondingly, long strip-shaped connecting holes are formed in all the freezing frames 4.

The second end of the inverted T-shaped hook is in a strip shape, the shape of the cross section is not limited, and the shape can be selected correspondingly according to actual requirements. For example, the second end of the inverted T-shaped hook may be a cuboid, a long cylinder, or a curved cylinder; accordingly, the connecting hole may be a rectangular parallelepiped hole or a curved hole.

Further, in order to make the connection effect of the inverted T-shaped hook and the freezing storage rack 4 better, it is preferable that the first preset angle and the second preset angle are both 90 degrees.

Further, the lifting connecting piece 21 further comprises a first positioning piece, and the second positioning piece detachably connected with the first positioning piece is arranged on all the freezing frames 4; after the first positioning piece is connected with the second positioning piece of the target lifting frame, the first driving motor 6 drives the hook to rotate along the first rotation direction or along the second rotation direction.

The first positioning piece is connected with the second positioning piece of the target lifting frame, so that the target lifting frame can be limited to move relative to the lifting mechanism 2 in the process of forming or releasing connection between the lifting mechanism 2 and the target lifting frame, and the success rate of connection between the lifting mechanism 2 and the target lifting frame is improved.

In addition, the specific structure, the setting positions, the number, the size and the material of the first positioning piece and the second positioning piece are not limited, and the corresponding setting can be carried out according to the actual application requirements. For example, the first positioning member and the second positioning member may be a pair or a plurality of pairs of positioning pins and positioning holes, respectively, the shape, the size, the setting position and the number of which are all adapted, and the lifting connection member 21 and the target lifting frame are connected by the cooperation of the positioning pins and the positioning holes for avoiding the movement of the target lifting frame.

As can be seen from the above description of the present embodiment, the biological sample access apparatus provided in the present embodiment includes a lifting mechanism 2, a sample access mechanism 3 and a freezing frame 4, wherein the freezing frame 4 is provided with at least two sample support members with different heights in the vertical direction, and the sample support members are provided with sample placement spaces for placing sample boxes. According to the utility model, the lifting mechanism 2 can be connected with the freezing and storing frame 4 and drives the freezing and storing frame 4 to move along the vertical direction, so that sample placing spaces with different vertical heights can be moved into the reciprocating movement space with the sample storing and taking mechanism 3, and thus, stacked sample boxes can be stored or taken out efficiently.

Example two

As shown in fig. 1 to 10, the present embodiment discloses a biological sample storage device including a biological sample access apparatus and a refrigerator 1 as described in embodiment one, wherein the inside of the refrigerator 1 is a low-temperature storage space; the freezing frame 4 is positioned inside the low-temperature storage space, and the lifting mechanism 2 and the sample access mechanism 3 are positioned inside or outside the low-temperature storage space.

In this embodiment, a biological sample to be stored at a low temperature is usually placed in a sample box, the sample box is stored on a freezing shelf 4 including a sample placing space, and the freezing shelf 4 is placed in the low temperature storing space of the refrigerator 1. The size and shape of the refrigerator 1 and the low-temperature storage space may be determined according to practical application requirements.

In the present embodiment, the lifting mechanism 2 and the sample accessing mechanism 3 may be located inside the low-temperature storage space, or may be located outside the low-temperature storage space, which is not limited in this embodiment. The lifting mechanism 2 is used for driving the freezing frame 4 to move along the vertical direction relative to the sample storing and taking mechanism 3; the sample access mechanism 3 is used to take out the sample cartridge from the sample placement space or place the sample cartridge in the sample placement space. When the lifting mechanism 2 drives the freezing frame 4 to move so that a sample placing space is at least partially positioned in the reciprocating space of the sample storing and taking mechanism 3, the sample storing and taking mechanism 3 performs reciprocating motion to store and take the sample box.

Optionally, in order to enable interaction of the biological sample storage device with a user, i.e. to enable transfer of the sample cartridge between the inside and the outside of the biological sample storage device, the biological sample storage device may further comprise an external docking mechanism 11; the sample cartridge may be placed on the external docking mechanism 11, and the external docking mechanism 11 may transfer the sample cartridge from the outside of the biological sample storage device to the inside of the biological sample storage device, or transfer the sample cartridge from the inside of the biological sample storage device to the outside of the biological sample storage device.

Further, the external docking mechanism 11 may include a support plate 11a, and transfer of the sample cartridge is achieved by reciprocation of the support plate 11 a. In particular, the biological sample storage device may include a housing provided with an interface, and the support plate 11a may reciprocate with respect to the interface under the action of a driving force to transfer the sample cartridge from the outside of the biological sample storage device to the inside of the biological sample storage device or to transfer the sample cartridge from the inside of the biological sample storage device to the outside of the biological sample storage device.

Further, referring to fig. 8, in order to prevent the sample cartridge from moving relative to the support plate 11a during the reciprocating movement of the support plate 11a, a positioning block 11b may be provided on the support plate 11a, and a region for placing the sample cartridge is formed between the positioning blocks 11b to restrict the movement of the sample cartridge relative to the support plate 11a during the reciprocating movement of the support plate 11 a.

The number, shape and material of the positioning blocks 11b are not limited, and can be set correspondingly according to practical application requirements. Further, four L-shaped positioning blocks 11b can be preferable, so that not only can the positioning of the sample box be realized, but also the structure is simple, and the processing and the assembly are convenient.

Further, since the external docking mechanism 11 is far from the sample access mechanism 3, in order to facilitate transfer of the sample cartridge between the external docking mechanism 11 and the sample access mechanism 3, the biological sample storage device may further comprise a sample transfer mechanism 10; the sample transfer mechanism 10 can transfer the sample cartridge located on the external docking mechanism 11 to the sample access mechanism 3 or transfer the sample cartridge located on the sample access mechanism 3 to the external docking mechanism 11 by a driving force.

Wherein the sample transfer mechanism 10 can transfer the sample cartridge between the external docking mechanism 11 and the sample access mechanism 3. The specific structure of the sample transfer mechanism 10 is not limited, and the sample transfer mechanism 10 can be set according to practical application requirements, for example, the sample transfer mechanism 10 can grasp a sample box by a manipulator to transfer the sample box, can transfer the sample box by a conveyor belt, or can transfer the sample box by the cooperation of the manipulator and the conveyor belt.

Further, referring to fig. 7, the sample transfer mechanism 10 may include a gripping module 10a and a horizontal transfer module 10b, and the horizontal transfer module 10b transfers the sample cartridge placed on the sample access mechanism 3 to a gripping position under the action of a driving force so that the gripping module 10a grips the sample cartridge and places the sample cartridge on the external docking mechanism 11; alternatively, the gripping module 10a grips the sample cartridge placed on the external docking mechanism 11 by the driving force, and transfers the sample cartridge to the gripping position, so that the horizontal transfer module 10b transfers the sample cartridge to the sample access mechanism 3.

Wherein, by arranging the grabbing component 10a, the sample box can be flexibly grabbed and placed; the range of motion of the grasping assembly 10a can be increased by providing a horizontal transfer assembly 10 b.

Further, in order to facilitate management of the sample box stored in the biological sample storage device, the sample box may be provided with bar code information for identifying or tracing the sample box, and correspondingly, the biological sample storage device may further include a code scanning mechanism (not shown) facing the external docking mechanism 11, where the code scanning mechanism may identify the bar code information on the sample box when the sample box is located on the external docking mechanism 11.

The code scanning mechanism can identify bar code information of the sample box placed on the external docking mechanism 11, and can identify and record information of the sample box to be stored in the biological sample storage device or the sample box taken out from the biological sample storage device so as to intelligently manage the sample box. In addition, the installation position of the code scanning mechanism is not limited, but it is necessary to ensure that the code scanning mechanism can read and obtain the bar code information on the sample cartridge when the sample cartridge is located on the external docking mechanism 11.

Optionally, the refrigerator 1 is provided with an opening, and the biological sample storage device may further include a cover opening mechanism 12 mounted on the refrigerator 1, the cover opening mechanism 12 being used for opening or closing the opening; when the cover opening mechanism 12 is in the open state, the internal environment of the refrigerator 1 may be communicated with the external environment to store the sample cartridge in the interior of the refrigerator 1 or to take out the sample cartridge from the interior of the refrigerator 1; when the opening on the refrigerator 1 is in a closed state, the door opening mechanism 12 can isolate the internal environment and the external environment of the refrigerator 1.

Wherein, through setting up uncapping mechanism 12, can make when need not carrying out the access to the sample box, seal the opening on the refrigerator 1 to make the inside better cold insulation effect that has of refrigerator 1.

Further, referring to fig. 9, in order to automatically open or close the opening on the refrigerator 1, the door opening mechanism 12 may include a first driving mechanism 12a, a second driving mechanism 12b, and a heat-insulating upper cover 12c, the heat-insulating upper cover 12c being disposed above the opening of the refrigerator 1, the first driving mechanism 12a being connected to the second driving mechanism 12b and the heat-insulating upper cover 12c, the heat-insulating upper cover 12c being movable in a vertical direction with respect to the refrigerator 1 by the first driving mechanism 12a, the first driving mechanism 12a being reciprocally movable in a direction perpendicular to the vertical direction with respect to the refrigerator 1 by the second driving mechanism 12b to close or open the opening of the refrigerator 1. Wherein the first drive mechanism 12a and the second drive mechanism 12b each generate a driving force by electric power.

In order to obtain a better cold insulation effect, the size of the upper heat insulation cover 12c needs to be matched with the opening of the refrigerator 1, and the material of the upper heat insulation cover 12c is selected as much as possible from materials with better heat insulation performance.

Further, the biological sample storage device may include a first displacement sensor and a second displacement sensor, and a sensing block adapted to the first displacement sensor and the second displacement sensor may be further provided on the first driving mechanism 12 a.

The horizontal movement travel of the first driving mechanism 12a may be determined by the distance between the first displacement sensor and the second displacement sensor, and the specific setting positions of the first displacement sensor and the second displacement sensor are not limited, and may be reasonably set according to the actual application requirements. The first drive mechanism 12a can be controlled in horizontal movement distance by providing the first displacement sensor and the second displacement sensor to further control the opening and closing degree of the insulating upper cover 12c to the opening of the insulating container.

Further, referring to fig. 10, in order to automatically open or close the opening of the refrigerator 1, the cover opening mechanism 12 may further include a third driving mechanism 12d and a heat insulation upper cover 12c, the heat insulation upper cover 12c is disposed above the opening of the refrigerator 1, the third driving mechanism 12d is connected to one side of the heat insulation upper cover 12c, and the heat insulation upper cover 12c may be rotated with respect to the refrigerator 1 to close or open the opening of the refrigerator 1 under the driving of the third driving mechanism 12 d. Wherein the third driving mechanism 12d generates a driving force by electric power.

In this specification, each embodiment is described in a progressive manner, and the same or similar parts of each embodiment are referred to each other, and each embodiment mainly describes differences from other embodiments.

The foregoing is merely an example of the present application and is not intended to limit the present application. Many modifications and variations of this application will be apparent to those skilled in the art. Any modifications, equivalent substitutions, improvements, etc. which are within the spirit and principles of the present application are intended to be included within the scope of the claims of the present application.

Claims (10)

1. A biological sample access device, comprising: lifting mechanism, sample access mechanism and cryopreservation frame, wherein:

the freezing frame is provided with at least two sample supporting pieces with different heights in the vertical direction, and the sample supporting pieces are provided with sample placing spaces for placing sample boxes;

when the lifting mechanism is connected with the freezing frame, the lifting mechanism drives the freezing frame to move along the vertical direction relative to the sample storage mechanism under the action of a driving force, so that one sample placing space is at least partially positioned in the reciprocating movement space of the sample storage mechanism; and the sample access mechanism reciprocates in the reciprocation space relative to the freezing frame under the action of driving force to take out the sample cartridge from the sample placement space or place the sample cartridge in the sample placement space.

2. The biological sample access apparatus of claim 1, wherein the number of the freezing shelves is a plurality, one of the plurality of freezing frames is a target lifting frame, and the lifting mechanism is detachably connected with the plurality of freezing frames; when the lifting mechanism is connected with the target lifting frame, the lifting mechanism drives the target lifting frame to move along the vertical direction relative to the sample storage mechanism.

3. The biological sample access device of claim 2, further comprising a horizontal position adjustment mechanism coupled to all of the cryopreservation shelves;

when the horizontal position adjusting mechanism adjusts the target lifting frame to the horizontal position connected with the lifting mechanism, the lifting mechanism is connected with or disconnected from the target lifting frame.

4. The biological sample access apparatus of claim 3, wherein the horizontal position adjustment mechanism comprises a rotation shaft and a swivel mount, all of the cryopreservation shelves being located on the swivel mount; the rotating shaft is arranged in the vertical direction and is connected with the rotating frame; the rotating shaft drives the rotating frame and all the freezing frames to rotate relative to the lifting mechanism under the action of driving force so as to adjust the target lifting frame to a horizontal position connected with the lifting mechanism.

5. The biological sample access apparatus of claim 2, wherein the lifting mechanism comprises a lifting connection and a telescoping assembly disposed in a vertical direction, wherein:

the lifting connecting piece is connected with the telescopic component; under the action of a driving force, the length of the telescopic component in the vertical direction is changed, so that the lifting connecting piece is driven to move in the vertical direction relative to the sample storing and taking mechanism.

6. The biological sample access apparatus of claim 5, wherein the lifting mechanism further comprises a first drive motor connected to the telescoping assembly, the lifting connector comprises a hook, a first end of the hook is connected to an output shaft of the first drive motor, and connectors are provided on all of the cryopreservation shelves;

when the first driving motor drives the hook to rotate a first preset angle along a first rotation direction, the second end of the hook is connected with the connecting piece of the target lifting frame;

when the first driving motor drives the hook to rotate by a second preset angle along a second rotation direction, the second end of the hook is disconnected with the connecting piece of the target lifting frame; wherein the first rotational direction and the second rotational direction are opposite rotational directions.

7. The biological sample access device of claim 6, wherein the lifting mechanism further comprises a contact tab, a first limit switch, and a second limit switch;

an output shaft of the first driving motor is connected with the contact piece; the first limit switch and the second limit switch are arranged on the telescopic component along the movement direction of the contact piece;

when the first driving motor drives the contact piece to rotate for a first preset angle along a first rotation direction, the contact piece is contacted with the first limit switch, so that the first driving motor stops rotating; when the first driving motor drives the contact piece to rotate for a second preset angle along a second rotation direction, the contact piece is contacted with the second limit switch, so that the first driving motor stops rotating.

8. The biological sample access apparatus of claim 7, wherein the hook comprises a first portion and a second portion which are both elongated, the first portion is disposed along a vertical direction, a first end of the first portion is connected with an output shaft of the first driving motor, a second end of the first portion is connected with the second portion, the second portion is perpendicular to the first portion, all of the freezing frames are provided with elongated connecting holes, and the first preset angle and the second preset angle are both 90 degrees.

9. The biological sample access apparatus of claim 6, wherein the lifting connection further comprises a first positioning member, and wherein all of the freezing shelves are provided with a second positioning member detachably connected to the first positioning member; after the first positioning piece is connected with the second positioning piece of the target lifting frame, the first driving motor drives the hook to rotate along the first rotation direction or the second rotation direction.

10. A biological sample storage device comprising the biological sample access apparatus of any one of claims 1 to 9 and a refrigerator; wherein, the refrigerator is internally provided with a low-temperature storage space; the freezing frame is positioned in the low-temperature storage space, and the lifting mechanism and the sample access mechanism are positioned in the low-temperature storage space or outside the low-temperature storage space.

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