CN219342177U - Weightlessness simulation effect slewing device system capable of monitoring cell growth state on line in real time - Google Patents
Weightlessness simulation effect slewing device system capable of monitoring cell growth state on line in real time Download PDFInfo
- Publication number
- CN219342177U CN219342177U CN202121128889.3U CN202121128889U CN219342177U CN 219342177 U CN219342177 U CN 219342177U CN 202121128889 U CN202121128889 U CN 202121128889U CN 219342177 U CN219342177 U CN 219342177U
- Authority
- CN
- China
- Prior art keywords
- impedance
- cell culture
- cells
- real time
- monitoring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The weightlessness simulation effect slewing device system capable of monitoring the growth state of cells in real time on line comprises: a swivel device body; a cell culture vessel with an impedance sensitive electrode for providing a carrier for cell wall-attached growth and sensing impedance changes during cell culture; and the peripheral detection and analysis module is used for realizing detection, processing and analysis of cell impedance signals and is respectively connected with the impedance sensitive electrodes of the rotating device body and the cell culture container. The utility model can monitor the cell growth state in real time, without standard and with high sensitivity, and provides a monitoring technical guarantee for objective and accurate research of ground simulated weightless cell culture experiments; meanwhile, the utility model can also be used for monitoring the cell growth in real time in the cell culture industry and experimental research based on gyrators in the fields of biotechnology, medical diagnosis and the like.
Description
Technical Field
The utility model relates to a biological monitoring device, in particular to a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time.
Background
The cell weightlessness simulation effect rotating device is an important basic platform for cell culture research in a weightless environment on the ground, however, the existing weightless simulation effect rotating device does not have a function of monitoring the growth state of cells on line in real time, and cannot capture the cell change in the rotating process, so that important hidden information may be lost. Conventional cell proliferation detection means, such as microscopic imaging, fluorescent marker detection, flow cytometry and the like, are difficult to realize quantitative detection, or require special treatment of cells, or take out cells to stop culture, and cannot realize real-time monitoring of cell growth in the rotation process.
Disclosure of Invention
The utility model aims to provide a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time.
The utility model relates to a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, which comprises: the rotary device body is used for realizing continuous rotation of the cells with controllable conditions; a cell culture container with an impedance sensitive electrode for providing a carrier for cell wall-attached growth and sensing impedance changes during cell culture, the cell culture container with the impedance sensitive electrode being disposed within the body of the slewing device; and the peripheral detection and analysis module is used for realizing detection, processing and analysis of cell impedance signals and is respectively connected with the impedance sensitive electrodes of the rotating device body and the cell culture container.
The utility model discloses a weightlessness simulation effect turning device system capable of monitoring the growth state of cells on line in real time, wherein a cell culture container comprises a fully-closed cell culture pond for accommodating the cells, a plurality of impedance sensitive electrodes are arranged at the bottom of the cell culture pond and connected with pin bonding pads, and the pin bonding pads are connected with an impedance reading circuit of a peripheral detection and analysis module.
The utility model relates to a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, wherein the shape of an impedance sensitive electrode is interdigital, annular or circular.
The utility model relates to a weightlessness simulation effect rotating device system capable of monitoring the growth state of cells on line in real time, wherein an impedance sensitive electrode is directly processed on the inner wall of the bottom surface of a cell culture pond or is embedded into the bottom surface of a culture container after being prepared on a glass substrate.
According to the weightlessness simulation effect slewing device system capable of monitoring the cell growth state on line in real time, the impedance sensitive electrode is connected with the pin pad, the pin pad is led out of a wire in a welding or clamping mode, and the wire is connected to an impedance reading circuit of a peripheral detection analysis module through the slewing culture device body.
The utility model discloses a weight loss simulation effect rotating device system capable of monitoring the growth state of cells in real time on line, wherein the rotating device body comprises a supporting end, a rotating transmission structure, a rotating shaft connecting plate and a rotating condition control module, the supporting end is separated from two sides of the rotating shaft connecting plate and is provided with supporting holes, the rotating shaft connecting plate is rotatably arranged on the supporting end through the supporting holes of the supporting end, the rotating condition control module comprises a motor and a control component which are arranged on the supporting end, an output shaft of the motor is connected with the rotating shaft connecting plate, a cell culture container is arranged on the rotating shaft connecting plate so as to enable the cell culture container and the rotating shaft connecting plate to rotate at the same speed, the control component of the rotating condition control module is used for setting and adjusting the rotating parameters of the rotating shaft connecting plate, the rotating transmission structure comprises an electric connector which is rotatably arranged on the supporting end through the supporting holes, a front end lead of the electric connector is connected with a pin pad of the cell culture container, and a rear end lead of the electric connector is connected with a peripheral detection analysis module.
The utility model discloses a weightlessness simulation effect slewing device system capable of monitoring a cell growth state on line in real time, wherein a peripheral detection analysis module comprises impedance detection equipment and an upper computer, the impedance detection equipment is connected with the upper computer, the impedance detection equipment is connected with an electric connector and used for collecting cell impedance changes, and the upper computer is used for processing data of the impedance detection equipment and outputting analysis results on a screen of the upper computer.
The utility model discloses a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, wherein a peripheral detection analysis module further comprises a time-sharing sequential gating module, and the time-sharing sequential gating module is connected between an electric connector and impedance detection equipment and is used for time-sharing sequential gating detection of current or voltage of one or more impedance sensitive electrodes.
The utility model discloses a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, wherein impedance detection equipment is a commercial electrical impedance instrument, an electrochemical workstation or an independently built impedance acquisition analysis module, and is used for carrying out operation processing on current and voltage values detected by each electrode in the same round and outputting an impedance-time curve corresponding to the average state or the local area state of the cells according to requirements.
The utility model discloses a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, wherein impedance detection equipment is an independently built impedance acquisition and analysis module, the independently built impedance acquisition and analysis module comprises a data acquisition chip, a digital lock-in amplifier and a display screen, and the data acquisition chip is connected with a time-sharing sequential gating module.
The weightlessness simulation effect rotating device system capable of monitoring the cell growth state on line in real time is oriented to the field of aerospace medical experiments, can monitor the cell growth state in real time, without standard and with high sensitivity, and provides a monitoring technical guarantee for objective and accurate research of ground simulation weightlessness cell culture experiments. Meanwhile, the weightlessness simulation effect slewing device system capable of monitoring the cell growth state on line in real time can be also used for monitoring the cell growth in real time in the cell culture industry and experimental research based on gyrators in the fields of biotechnology, medical diagnosis and the like.
Drawings
FIG. 1 is a schematic diagram of a cell culture vessel of a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time;
FIG. 2 is a schematic diagram of the structure of a turning device body of the turning device system for simulating effect of loss of weight, which can monitor the growth state of cells on line in real time;
FIG. 3 is a schematic diagram of a system of a weight loss simulation effect slewing device capable of monitoring the growth state of cells on line in real time.
Detailed Description
As shown in fig. 1, 2 and 3, the weightlessness simulation effect turning device system capable of monitoring the growth state of cells on line in real time of the utility model comprises: a cell culture vessel 1 with an impedance sensitive electrode for providing a carrier for cell wall-attached growth and sensing impedance changes during cell culture; the cell culture container with the impedance sensitive electrode is arranged in the rotating device body; and the peripheral detection and analysis module is used for realizing detection, processing and analysis of cell impedance signals and is respectively connected with the impedance sensitive electrodes of the rotating device body and the cell culture container.
The utility model discloses a weightlessness simulation effect turning device system capable of monitoring the growth state of cells on line in real time, wherein a cell culture container comprises a fully-closed cell culture pond for accommodating cells, a plurality of same or different impedance sensitive electrodes 11 are arranged on the inner wall of the bottom of the cell culture container 1, the impedance sensitive electrodes are connected with pin pads 12, and the pin pads are connected with an impedance reading circuit of a peripheral detection analysis module.
The cell culture container comprises a closed cell culture pond for accommodating cells, a plurality of impedance sensitive electrodes are arranged at the bottom of the cell culture pond and connected with a pin bonding pad, and the pin bonding pad is connected with an impedance reading circuit of the peripheral detection analysis module.
The cell culture vessel is fully closed, and thus can be used for cell culture in any posture (such as resting flat, resting inclined, continuous rotation).
The utility model relates to a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, wherein the shape of an impedance sensitive electrode is interdigital, annular or circular. The impedance sensitive electrode shape is an interdigital, ring, circular or other special shape with detection sensitivity/resolution meeting the test requirements.
The utility model relates to a weightlessness simulation effect rotating device system capable of monitoring the growth state of cells on line in real time, wherein an impedance sensitive electrode is directly processed on the inner wall of the bottom surface of a cell culture pond or is embedded into the bottom surface of a culture container after being prepared on a glass substrate.
According to the weightlessness simulation effect slewing device system capable of monitoring the cell growth state on line in real time, the impedance sensitive electrode is connected with the pin pad, the pin pad is led out of a wire in a welding or clamping mode, and the wire is connected to an impedance reading circuit of a peripheral detection analysis module through the slewing culture device body.
The utility model discloses a weight loss simulation effect rotating device system capable of monitoring the growth state of cells in real time on line, wherein the rotating device body comprises a supporting end 21, a rotating transmission structure, a rotating shaft connecting plate 23 and a rotating condition control module 24, the supporting end is separated from two sides of the rotating shaft connecting plate and is provided with supporting holes, the rotating shaft connecting plate is rotatably arranged on the supporting end through the supporting holes of the supporting end, the rotating condition control module comprises a motor and a control component which are arranged on the supporting end, an output shaft of the motor is connected with the rotating shaft connecting plate, a cell culture container is arranged on the rotating shaft connecting plate so as to enable the cell culture container and the rotating shaft connecting plate to rotate at the same speed, the control component of the rotating condition control module is used for setting and adjusting the rotating parameters of the rotating shaft connecting plate, the rotating transmission structure comprises an electric connector 25 rotatably arranged on the supporting end through the supporting holes, a front lead of the electric connector is connected with a pin pad of the cell culture container, and a rear lead of the electric connector is connected with a peripheral detection analysis module.
The utility model discloses a weightlessness simulation effect slewing device system capable of monitoring a cell growth state on line in real time, wherein a peripheral detection analysis module comprises an impedance detection device 32 and an upper computer 33, the impedance detection device is connected with the upper computer, the impedance detection device is connected with an electric connector and is used for collecting cell impedance changes, and the upper computer is used for processing data of the impedance detection device and outputting analysis results on a screen of the upper computer.
The utility model discloses a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, wherein a peripheral detection analysis module further comprises a time-sharing sequential gating module, and the time-sharing sequential gating module is connected between an electric connector and impedance detection equipment and is used for time-sharing sequential gating detection of current or voltage of one or more impedance sensitive electrodes.
The utility model discloses a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, wherein impedance detection equipment is a commercial electrical impedance instrument, an electrochemical workstation or an independently built impedance acquisition analysis module, and is used for carrying out operation processing on current and voltage values detected by each electrode in the same round and outputting an impedance-time curve corresponding to the average state or the local area state of the cells according to requirements.
The utility model discloses a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, wherein impedance detection equipment is an independently built impedance acquisition and analysis module, the independently built impedance acquisition and analysis module comprises a data acquisition chip, a digital lock-in amplifier and a display screen, and the data acquisition chip is connected with a time-sharing sequential gating module.
The weightlessness simulation effect turning device system capable of monitoring the cell growth state on line in real time can be applied to the research fields of medicine, life science, cell biology and the like, integrates a detection system based on an electrical impedance spectroscopy, and has the function of monitoring the cell state on line in real time.
The weightlessness simulation effect rotating device system capable of monitoring the growth state of the cells on line in real time can realize on-line detection and continuous monitoring without marking, invasiveness and influence on the normal growth of the cells.
The utility model relates to a weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time, which mainly comprises a cell culture container with an impedance sensitive electrode, a slewing device body and a peripheral detection and analysis module.
The cell culture container with the impedance sensitive electrode provides a carrier for cell adherence growth and senses impedance change in the cell culture process, the rotary device body realizes continuous rotation of cells with controllable conditions, and the peripheral detection and analysis module realizes detection, processing and analysis of cell impedance signals.
The cell culture container is characterized in that a plurality of same or different impedance sensitive electrodes are arranged on the inner wall of the bottom of the cell culture container according to requirements, the electrode can be in an interdigital shape, an annular shape, a round shape or other optimized shapes, the electrode can be directly processed on the inner wall of the bottom of the cell culture container or embedded into the bottom of the cell culture container after being prepared on a glass and other easily-processed substrates, the electrode is provided with a pin pad, a wire can be led out from the pin pad in a welding, clamping and other modes, and the electrode is connected to an impedance reading circuit of a peripheral detection analysis module through a rotary culture device body.
The rotary device body comprises a supporting end, a rotary transmission structure, a rotary shaft connecting plate, a rotary condition control module and the like. The support hole of the support end is internally provided with a rotary transmission structure which comprises an electric connector, so that reliable transmission of electric signals in a rotary state can be realized. The rotating shaft connecting plate can be cantilever type or two-end supporting type, and the cell culture container is arranged on the connecting plate. The front end leads of the electrical connector may be connected to lead wires on the cell culture container pin pads or soldered directly to the pin pads. The control circuit of the rotation condition control module can set and adjust parameters such as rotation speed.
The peripheral detection analysis module can be realized in two modes, and the main components of one mode comprise a commercial impedance analyzer, an electrochemical workstation or other impedance detection equipment and an upper computer, the impedance analyzer is used for collecting cell impedance change, data are transmitted to the upper computer and then processed by software such as MATLAB, labVIEW, and an analysis result is output on a screen of the upper computer. In another mode, an integrated data detection, analysis and display module is formed by constructing a data analysis module such as a data acquisition chip and a digital lock-in amplifier, a display screen and the like.
After the technical scheme is adopted, the cell weightlessness simulation effect turning device system capable of monitoring the growth state on line in real time has the following remarkable characteristics:
the impedance detection electrode is integrated in the closed cell culture container, so that the cell growth state under the ground simulated weightlessness revolving state can be monitored in a label-free, quantitative and real-time manner, and the limitation that the growth condition cannot be monitored in real time in the early cell revolving culture process is broken through;
by arranging a plurality of electrodes on the ground of the cell culture plate, selecting to average or locally pay attention to according to the attention point, objectivity and accuracy can be considered when the growth condition of cells in the culture container is obtained;
by analyzing the cell impedance change on each electrode individually and monitoring the growth condition of the cells in different areas, the abnormal growth of the cells during the simulated weightless culture can be found in time, and important basis and reference can be provided for whether manual intervention needs to be applied.
The specific application embodiment of the weightlessness simulation effect slewing device system capable of monitoring the growth state of cells in real time on line is as follows:
the cell culture container with the impedance sensitive electrode is formed by bonding a glass substrate sputtered with Jin Cha finger electrodes and a cell culture tank main body, wherein 1 or more gold finger electrodes (3 electrodes are arranged in the embodiment) are arranged on the glass substrate, and main parameters of each gold electrode are as follows: 16 pairs of interdigital electrodes, each pair of interdigital electrodes has the width and the interval of 100 mu m, the interdigital length of 5mm and Jin Cenghou nm, and the bonding pad size of 2mm multiplied by 2.5mm; the cell culture pond body (namely a cell culture container) is formed by pouring Polydimethylsiloxane (PDMS), the wall thickness is 1mm, the inner edge of the contact surface with the glass substrate is not covered with the interdigital electrode pair, and the outer edge is not covered with the electrode pin pad. The signals measured by the gold electrodes are conducted to impedance detection equipment through an electric connector (conductive slip ring), the number of the conductive slip ring paths corresponds to that of the interdigital electrodes, and 2 paths of the conductive slip ring are welded on 2 bonding pads of each interdigital electrode respectively. The impedance detection equipment can be a commercial electrical impedance instrument, an electrochemical workstation or an independent impedance acquisition and analysis module, and calculates an impedance value corresponding to cells adhered on the electrode according to a current or voltage signal conducted by the Jin Cha finger electrode. After the related data are processed by the data processing algorithm of the upper computer, the cell proliferation conditions at different positions on the cell culture container substrate can be obtained, or the average cell proliferation conditions on the cell culture container substrate can be obtained by averaging. The conductive slip ring can still transmit signals under the rotation state of the weightlessness simulation effect, so that the method can be used for carrying out real-time online detection on the growth state of the cells under the weightlessness simulation effect.
The working process is as follows: placing the cell to be inoculated and the sterilized closed cell culture container in an ultra-clean workbench, pricking the side wall of the bonding part of the culture pond main body and the substrate of the closed cell culture container by using a 1ml sterile injector, removing the injector main body, sucking the cell culture suspension to be inoculated by using another 1ml sterile injector, injecting the cell culture suspension to be inoculated into the closed cell culture container through the side wall of the culture pond until no bubbles exist in the pond, and pulling out the two 1ml injectors; after welding one end lead of the electric connector, which is close to the rotating shaft connecting plate, to the interdigital electrode bonding pad, fixing the cell culture container on the rotating shaft connecting plate of the rotating device main body; and connecting the lead at the other end of the electric connector to an alligator clip of the impedance detector, connecting a data transmission line of the impedance detector to an upper computer, starting working software of the impedance detector according to the cell growth stage and focus of attention, collecting cell impedance values at fixed time intervals (such as 30-60 min), and carrying out real-time processing analysis on the values by using the upper computer.
The foregoing is merely a preferred embodiment of the present utility model and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present utility model, which are intended to be comprehended within the scope of the present utility model.
Claims (10)
1. The weightlessness simulation effect slewing device system capable of monitoring the growth state of cells in real time on line is characterized by comprising: the rotary device body is used for realizing continuous rotation of the cells with controllable conditions; a cell culture container with an impedance sensitive electrode for providing a carrier for cell wall-attached growth and sensing impedance changes during cell culture, the cell culture container with the impedance sensitive electrode being disposed within the body of the slewing device; and the peripheral detection and analysis module is used for realizing detection, processing and analysis of cell impedance signals and is respectively connected with the impedance sensitive electrodes of the rotating device body and the cell culture container.
2. The weightless simulation effect slewing device system capable of monitoring the growth state of cells on line in real time according to claim 1, wherein the cell culture container comprises a fully-closed cell culture pond for accommodating cells, a plurality of impedance sensitive electrodes are arranged at the bottom of the cell culture pond and connected with pin pads, and the pin pads are connected with an impedance reading circuit of a peripheral detection and analysis module.
3. The system of claim 2, wherein the impedance sensitive electrode is in the shape of an interdigital, ring or circle.
4. The system of claim 2, wherein the impedance sensitive electrode is directly processed on the inner wall of the bottom surface of the cell culture pond or is embedded into the bottom surface of the culture container after being prepared on a glass substrate.
5. The system of the weightless simulation effect rotating device capable of monitoring the growth state of cells on line in real time according to claim 2, wherein the impedance sensitive electrode is connected with a pin pad, the pin pad is led out of a wire in a welding or clamping mode, and the wire is connected to an impedance reading circuit of a peripheral detection and analysis module through the rotating culture device body.
6. The system of claim 2, wherein the body of the rotary device comprises a supporting end, a rotary transmission structure, a rotary shaft connecting plate and a rotary condition control module, the supporting end is separated from two sides of the rotary shaft connecting plate and is provided with supporting holes, the rotary shaft connecting plate is rotatably arranged on the supporting end through the supporting holes of the supporting end, the rotary condition control module comprises a motor and a control component which are arranged on the supporting end, an output shaft of the motor is connected with the rotary shaft connecting plate, a cell culture container is arranged on the rotary shaft connecting plate so as to enable the cell culture container and the rotary shaft connecting plate to rotate at the same speed, the control component of the rotary condition control module is used for setting and adjusting the rotation parameters of the rotary shaft connecting plate, the rotary transmission structure comprises an electric connector rotatably arranged on the supporting end through the supporting holes, a front lead of the electric connector is connected with a pin pad of the cell culture container, and a rear end of the electric connector is connected with the peripheral detection analysis module.
7. The weightless simulation effect slewing device system capable of monitoring the growth state of cells on line in real time according to claim 6, wherein the peripheral detection analysis module comprises an impedance detection device and an upper computer, the impedance detection device is connected with the electric connector and used for collecting the impedance change of the cells, and the upper computer is used for processing the data of the impedance detection device and outputting an analysis result on a screen of the upper computer.
8. The system of claim 7, wherein the peripheral detection and analysis module further comprises a time-sharing sequential gating module connected between the electrical connector and the impedance detection device for time-sharing sequential gating detection of the current or voltage of the one or more impedance sensitive electrodes.
9. The weightlessness simulation effect slewing device system capable of monitoring the growth state of cells on line in real time according to claim 8, wherein the impedance detection equipment is a commercial electrical impedance instrument, an electrochemical workstation or an independently built impedance acquisition analysis module, and is used for performing operation processing on the current and voltage values detected by each electrode in the same round and outputting an impedance-time curve corresponding to the average state or the local area state of the cells according to requirements.
10. The weightless simulation effect slewing device system capable of monitoring the growth state of cells on line in real time according to claim 9, wherein the impedance detection equipment is an independently built impedance acquisition and analysis module, and the independently built impedance acquisition and analysis module comprises a data acquisition chip, a digital lock-in amplifier and a display screen, and the data acquisition chip is connected with the time-sharing sequential gating module.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121128889.3U CN219342177U (en) | 2021-05-25 | 2021-05-25 | Weightlessness simulation effect slewing device system capable of monitoring cell growth state on line in real time |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121128889.3U CN219342177U (en) | 2021-05-25 | 2021-05-25 | Weightlessness simulation effect slewing device system capable of monitoring cell growth state on line in real time |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219342177U true CN219342177U (en) | 2023-07-14 |
Family
ID=87107087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121128889.3U Active CN219342177U (en) | 2021-05-25 | 2021-05-25 | Weightlessness simulation effect slewing device system capable of monitoring cell growth state on line in real time |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219342177U (en) |
-
2021
- 2021-05-25 CN CN202121128889.3U patent/CN219342177U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| USRE38323E1 (en) | Cell potential measurement apparatus having a plurality of microelectrodes | |
| Obien et al. | Revealing neuronal function through microelectrode array recordings | |
| Nisch et al. | A thin film microelectrode array for monitoring extracellular neuronal activity in vitro | |
| CN101576523A (en) | Method for detecting tumour cells by adopting microelectrode array impedance biosensor chip | |
| US20050231186A1 (en) | High throughput electrophysiology system | |
| JPWO2002055653A1 (en) | Extracellular potential measuring device, extracellular potential measuring method using the same, and high-speed drug screening apparatus equipped with the same | |
| JPWO2002099408A1 (en) | Signal detection sensor with multiple electrodes | |
| CN101738418A (en) | Microfluidic chip system integrating cell operation and detection | |
| JP3204875B2 (en) | Cell potential measurement device | |
| CN111304083B (en) | Cell culture chip and method for monitoring cell state thereof | |
| CN110029058B (en) | Multi-sensor integrated on-line nondestructive testing myocardial tissue chip | |
| CN219342177U (en) | Weightlessness simulation effect slewing device system capable of monitoring cell growth state on line in real time | |
| CN202081106U (en) | Online animal cell culture status detecting device | |
| CN106442665B (en) | A kind of preparation method of the Ratio-type aptamer sensor based on screen printing electrode detection antibiotic residue | |
| CN215627964U (en) | Cell continuous rotary slewing device body for realizing controllable conditions | |
| WO1996010742A1 (en) | Electrochemical assessment of cell behaviour and metabolic activity | |
| Eiler et al. | Application of a thin-film transistor array for cellular-resolution electrophysiology and electrochemistry | |
| CN206223724U (en) | A kind of test system of blood sugar instrument | |
| CN113265334A (en) | Weightlessness simulation effect rotating device system capable of monitoring cell growth state on line in real time | |
| CN110243873B (en) | Multifunctional cell sensor system and measuring method thereof | |
| CN101654651A (en) | Device and method for detecting state of anchorage-dependent cell in culture dish | |
| CN202093046U (en) | Device for estimating malignant degree of neuroblastoma | |
| CN115166007B (en) | Cell potential non-contact detection device | |
| Uno | electrochemical impedance sensor for non-invasive living cell monitoring toward CMOS cell culture monitoring platform | |
| Ressler et al. | New concepts for chip-supported multi-well-plates: realization of a 24-well-plate with integrated impedance-sensors for functional cellular screening applications and automated microscope aided cell-based assays |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |