CN219320317U - Sample image scanning device - Google Patents

Abstract

The application discloses a sample image scanning device, includes: the transfer device is used for transferring the sample slide to the transfer device, the transfer device is used for overturning the sample slide, and at least one of the transfer device and the transfer device is also used for transferring the overturned sample slide to the scanning position; the pre-scanning device is used for performing pre-scanning operation on the sample slide positioned in the transfer device; the image scanning device is used for carrying out image scanning operation on the sample slide transferred to the scanning position to obtain a scanning image, the structure of the sample image scanning device is simplified, the speed of carrying out multiple operations on the sample slide is increased, and the technical problems that in the process of scanning the sample slide by the existing scheme and device, the scheme of transferring and adjusting the sample slide when carrying out different operations on the sample slide is complicated, the device mechanism is complicated, the time required for carrying out health analysis on the sample slide is long, and the efficiency is low are solved.

Description

Sample image scanning device

Technical Field

The present application relates to the field of medical instruments, and in particular, to a sample image scanning apparatus.

Background

In the current scenario of health analysis of living beings using biological samples, it is necessary to detect a sample slide coated with the biological sample to obtain corresponding sample information.

Specifically, a user or external slide making equipment samples a sample slide to be detected to sample image scanning equipment, and the sample image scanning equipment can perform a series of operations such as code scanning, pre-scanning and image scanning on the sample slide to be detected, but at present, when different operations are performed on the sample slide, the scheme of transferring and adjusting the sample slide is complicated, a required mechanism is complex, the time required for health analysis on the sample slide is long, and the efficiency is low.

Disclosure of Invention

The application provides a sample image scanning equipment, aim at solving current scheme and equipment and carry out the in-process that scans to the sample slide, carry out the scheme that shifts the sample slide and adjust the gesture when carrying out different operations to the sample slide comparatively loaded down with trivial details, equipment mechanism is comparatively complicated, leads to carrying out healthy analysis required time longer to the sample slide, and the lower technical problem of efficiency.

In a first aspect, the present application provides a sample image scanning apparatus comprising:

The transfer device is used for transferring the sample slide to the transfer device, the transfer device is used for overturning the sample slide, and at least one of the transfer device and the transfer device is also used for transferring the overturned sample slide to the scanning position;

the pre-scanning device is used for performing pre-scanning operation on the sample slide positioned in the transfer device;

and the image scanning device is used for carrying out image scanning operation on the sample slide transferred to the scanning position so as to acquire a scanning image.

In some embodiments, the staging device includes:

a housing seat mechanism for housing a sample slide;

the turnover mechanism is connected with the containing seat mechanism and used for driving the containing seat mechanism to turn over so as to drive the contained sample slide to be converted between a horizontal state and a vertical state.

In some embodiments, the transfer device further comprises a moving mechanism that drives the housing seat mechanism to move between the first station and the second station;

the transfer device is used for transferring the sample slide to the first station; the moving mechanism is used for driving the containing seat mechanism to move to the first station to receive the sample slide and driving the containing seat mechanism containing the sample slide to move to the second station;

The turnover mechanism is used for driving the accommodating seat mechanism positioned at the second station to drive the accommodating sample slide to turn over so as to convert the sample slide from a vertical state to a horizontal state; the moving mechanism is also used for driving the turned accommodating seat mechanism to move to the first station.

In some embodiments, the transfer device includes a first transfer mechanism for transferring a specimen slide in a vertical state to the first station and a second transfer mechanism for feeding a specimen slide in a horizontal state to the scanning position.

In some embodiments, the moving mechanism is further configured to drive the flipped receptacle mechanism at the first station to move toward the scanning position to feed the sample slide received by the receptacle mechanism to the scanning position.

In some embodiments, the scanning position, the first station and the second station are arranged in a straight line, and the turnover mechanism is used for driving the containing seat mechanism positioned at the second station to turn over towards the scanning position, so that the sample slide is converted from a vertical state to a horizontal state.

In some embodiments, the pre-scanning device is arranged corresponding to the first station and is used for performing a pre-scanning operation on a sample slide which is positioned at the first station and is not turned over; and/or the number of the groups of groups,

The sample image scanning device further comprises a first identification device arranged corresponding to the first station, wherein the first identification device is used for identifying the direction of one surface of the sample slide, which is positioned at the first station and coated with the biological sample; and/or the number of the groups of groups,

the transfer device also comprises a rotating mechanism connected with the containing seat mechanism, wherein the rotating mechanism is used for driving the containing seat mechanism to drive the sample slide to rotate by a preset angle and/or when the surface of the sample slide coated with the biological sample faces away from the preset direction,

the sample image scanning device further comprises a code scanning device arranged corresponding to the first station, wherein the code scanning device is used for conducting code scanning operation on the sample slide which is located at the first station and is not turned over so as to obtain bar code information corresponding to the sample slide.

In some embodiments, a pre-scanning device is used to perform a pre-scanning operation on a specimen slide to obtain at least a coating state of a biological specimen on the specimen slide, wherein the pre-scanning device includes one of a low power mirror imaging assembly and a CMOS camera assembly.

The image scanning device is used for performing an image scanning operation associated with at least one of the coating state and the pre-scanning device.

In some embodiments, when the pre-scanning device includes a low power mirror imaging assembly, the image scanning device is used to perform high power mirror scanning of the specimen slide; when the pre-scanning device includes a CMOS camera assembly, the image scanning device is used to perform an image scanning operation on the specimen slide that matches the coating state.

In some embodiments, the pre-scanning device includes an imaging assembly;

the imaging assembly is used for imaging the sample slide under the condition that the distance between the imaging assembly and the first station is in a preset focal length range or the displacement distance of the imaging assembly towards the first station is in a preset focusing range so as to obtain a pre-scanning result.

In summary, an embodiment of the present application provides a sample image scanning apparatus, including: the transfer device is used for transferring the sample slide to the transfer device, the transfer device is used for overturning the sample slide, and at least one of the transfer device and the transfer device is also used for transferring the overturned sample slide to the scanning position; the pre-scanning device is used for performing pre-scanning operation on the sample slide positioned in the transfer device; the image scanning device is used for carrying out image scanning operation on the sample slide transferred to the scanning position to obtain a scanning image, the structure of the sample image scanning device is simplified, the speed of carrying out multiple operations on the sample slide is increased, and the technical problems that in the process of scanning the sample slide by the existing scheme and device, the scheme of transferring and adjusting the sample slide when carrying out different operations on the sample slide is complicated, the device mechanism is complicated, the time required for carrying out health analysis on the sample slide is long, and the efficiency is low are solved.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure of embodiments of the present application.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly introduced below, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 is a block diagram of a sample image scanning apparatus according to an embodiment of the present application;

fig. 2 is a schematic structural diagram of a sample image scanning apparatus according to an embodiment of the present application;

fig. 3 is a schematic structural diagram of a transfer device of a sample image scanning apparatus according to an embodiment of the present application;

fig. 4 is a schematic structural diagram of a housing seat mechanism of a transfer device of a sample image scanning apparatus according to an embodiment of the present application;

fig. 5 is a schematic view of a scenario in which a relay device of a sample image scanning apparatus interacts with a scanning platform according to an embodiment of the present application.

Reference numerals:

100. a sample image scanning device; 10. a transfer device; 20. a transfer device; 21. a housing seat mechanism; 211. a first clamping assembly; 212. a second clamping assembly; 213. clamping the driving assembly; 214. a receiving opening; 22. a turnover mechanism; 221. a drive wheel assembly; 222. a driven wheel assembly; 223. a transmission assembly; 23. a moving mechanism; 30. a pre-scanning device; 31. an imaging mechanism; 32. a baffle; 40. an image scanning device; 41. a scanning platform; 42. an objective lens assembly; 43. a light source assembly; 50. an identification mechanism; 200. a sample slide; 300. slide basket. A. A first station; B. a second station; C. the bits are scanned.

Detailed Description

The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are some, but not all, of the embodiments of the present application. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

In the current scenario of health analysis of living beings using biological samples, it is necessary to detect a sample slide coated with the biological sample to obtain corresponding sample information. Specifically, a user or external slide making equipment samples a sample slide to be detected to sample image scanning equipment, and the sample image scanning equipment can perform a series of operations such as code scanning, pre-scanning and image scanning on the sample slide to be detected, but at present, when different operations are performed on the sample slide, the scheme of transferring and adjusting the sample slide is complicated, a required mechanism is complex, the time required for detecting and analyzing the sample slide is long, and the efficiency is low.

Based on this, the embodiment of the application provides a sample image scanning device. Some embodiments of the present application are described in detail below with reference to the accompanying drawings. The following embodiments and features of the embodiments may be combined with each other without conflict.

Referring to fig. 1 to 2, fig. 1 is a block diagram of a sample image scanning apparatus 100 according to an embodiment of the present application, and fig. 2 is a schematic diagram of a sample image scanning apparatus 100 according to an embodiment of the present application.

As shown in fig. 1 to 2, the specimen image scanning apparatus 100 is at least for performing an image scanning operation on a specimen slide 200, and the specimen image scanning apparatus 100 includes: the transfer device 10, the transfer device 20, the pre-scanning device 30 and the image scanning device 40, wherein the transfer device 10 is used for transferring the sample slide 200 to the transfer device 20, the transfer device 20 is used for overturning the sample slide 200, at least one of the transfer device 10 and the transfer device 20 is also used for transferring the overturned sample slide 200 to the scanning position, the pre-scanning device 30 is used for performing the pre-scanning operation on the sample slide 200 positioned on the transfer device 20, and the image scanning device 40 is used for performing the image scanning operation on the sample slide 200 transferred to the scanning position to acquire a scanned image.

The scanning position may be a predetermined space region in the sample image scanning apparatus 100, and the sample image scanning apparatus 100 may also be provided with a scanning platform 41 for carrying the sample slide 200 to be detected, so that the carrying component forms the aforementioned scanning position.

In the sample image scanning apparatus 100 provided in this embodiment, in the process of scanning the sample slide 200, firstly, the transfer device 10 transfers the sample slide 200 to the transfer device 20, then the transfer device 20 turns over the sample slide 200, meanwhile, the pre-scanning device 30 performs a pre-scanning operation on the sample slide 200 located in the transfer device 20, and at least one of the transfer device 10 and the transfer device 20 transfers the turned sample slide 200 to the scanning position, so that the image scanning device 40 performs an image scanning operation on the sample slide 200 to obtain a scanned image.

It should be appreciated that the sample slide 200 is coated with a biological sample to be scan tested, and that the image scanning operation performed by the image scanning device 40 on the sample slide 200 is specifically scanning the sample slide 200 to obtain an image of the biological sample coated on the sample slide 200.

While exemplary pre-scanning operations performed by the pre-scanning device 30 on the specimen slide 200 may be panoramic scanning the specimen slide 200 to determine the application position of the biological specimen, or preliminary identifying the specimen slide 200 to determine the orientation of the surface of the specimen slide 200 to which the specimen slide 200 is applied, the image scanning device 40 may then adjust the focus of scanning by the image scanning device 40 when performing the image scanning operation on the specimen slide 200 according to the application position determined during the pre-scanning operation, so as to perform more accurate and efficient image operations on the biological specimen.

Further, when the pre-scanning operation performed by the pre-scanning device 30 on the sample slide 200 includes performing a preliminary identification on the sample slide 200 to determine an orientation of the sample slide 200 coated with the sample slide 200, the sample image scanning apparatus 100 provided herein may further perform a further operation according to the orientation of the sample slide 200 coated with the sample slide 200, for example, when the orientation of the sample slide 200 coated with the sample slide 200 matches a preset direction, at least one of the transfer device 10 and the transfer device 20 transfers the flipped sample slide 200 to the scanning position for performing the image scanning operation, and when the orientation of the sample slide 200 coated with the sample slide 200 does not match the preset direction, at least one of the transfer device 10 and the transfer device 20 is required to perform a rotation operation on the sample slide 200 to adjust the orientation of the sample slide 200 coated with the sample slide 200, and then transfer the sample slide 200 to the scanning position for performing the image scanning operation.

Specifically, the image scanning device 40 is, for example, a photomicrograph device, where the photomicrograph device includes an objective lens assembly 42, a scanning platform 41 and a light source assembly 43, the scanning position is disposed on the scanning platform 41, the photomicrograph device performs an image scanning operation on the sample slide 200 transferred to the scanning position of the scanning platform 41 through the objective lens assembly 42, the light source assembly 43 is disposed opposite to the objective lens assembly 42, and the light source assembly 43 is at least used for providing illumination to the sample slide 200 during the image scanning operation.

It should be noted that, the preset direction is specifically set according to the objective lens assembly 42 of the image scanning device 40: in the case that the side of the sample slide 200 coated with the biological sample faces away from the preset direction, when the sample slide 200 is transferred to the scanning position, the side of the sample slide 200 coated with the biological sample faces away from the objective lens assembly 42 of the scanning device. And in the case that the side of the sample slide 200 coated with the biological sample faces the preset direction, when the sample slide 200 is transferred to the scanning position, the side of the sample slide 200 coated with the biological sample faces the objective lens assembly 42 of the scanning device.

Further, the sample slide 200 is formed with two surfaces disposed opposite to each other, and the sample slide 200 transferred to the scanning position is horizontally placed on the scanning platform 41, and when the photomicrograph device performs an image scanning operation on the sample slide 200 through the objective lens assembly 42, since the sample slide 200 is horizontally placed, one of the surfaces of the sample slide 200 faces the objective lens assembly 42, that is, the image scanning device 40 can directly scan and acquire an image of the biological sample coated on the side of the sample slide 200 facing the objective lens assembly 42.

It should also be appreciated that the specimen slide 200 provided to the specimen image scanning apparatus 100 is in an upright position, such as a user or other apparatus that is docked with the specimen image scanning apparatus 100 directly feeds the specimen slide 200 in an upright position to the specimen image scanning apparatus 100, and such as a user or other apparatus feeds a slide basket loaded with the specimen slide 200 to the specimen image scanning apparatus 100 with the specimen slide 200 loaded therein upright. The transfer device 10 of the specimen image scanning apparatus 100 transfers the specimen slide 200 in the vertical state to the transfer device 20 while the specimen slide 200 transferred to the scanning position for image scanning is in the horizontal state.

Based on this, the transfer device 20 needs to invert the specimen slide 200 transferred by the transfer device 10 to convert the specimen slide 200 from the vertical state to the horizontal state, and then at least one of the transfer device 10 and the transfer device 20 transfers the specimen slide 200 in the horizontal state to the scanning position for image scanning. Further, the pre-scanning device 30 performs a pre-scanning operation when the sample slide 200 is located in the transfer device 20, specifically, may perform a pre-scanning operation on the sample slide 200 in a vertical state before turning over, or may perform a pre-scanning operation on the sample slide 200 in a horizontal state after turning over.

According to the scheme, the transfer device 20 for turning the sample slide 200 is arranged, and the pre-scanning operation of the sample slide 200 is implemented at the transfer device 20, so that the structure of the sample image scanning equipment 100 is simplified, the speed for executing multiple operations on the sample slide 200 is increased, the technical problems that in the process of scanning the sample slide 200 by the existing scheme and equipment, the scheme for transferring and adjusting the posture of the sample slide 200 when the sample slide 200 is subjected to different operations is complicated, the equipment mechanism is complex, the time required for detecting and analyzing the sample slide 200 is long, and the efficiency is low are solved.

Referring to fig. 3 and fig. 4, fig. 3 is a schematic structural diagram of a transfer device 20 of a sample image scanning apparatus 100 according to an embodiment of the present application, and fig. 3 is a schematic structural diagram of a receiving seat mechanism 21 of the transfer device 20 of the sample image scanning apparatus 100 according to an embodiment of the present application.

As shown in fig. 1-4, in some embodiments, the transfer device 20 includes a housing seat mechanism 21 and a turning mechanism 22, where the housing seat mechanism 21 is used to house the sample slide 200, and the turning mechanism 22 is connected to the housing seat mechanism 21 and is used to drive the housing seat mechanism 21 to turn over so as to drive the housed sample slide 200 to switch between a horizontal state and a vertical state. Specifically, the housing-seat mechanism 21 is formed with a housing opening 214, and the sample slide 200 enters the housing-seat mechanism 21 through the housing opening 214, so that the housing-seat mechanism 21 houses the sample slide 200.

Further, when the specimen slide 200 does not enter the housing seat mechanism 21 through the housing opening 214, the flip mechanism 22 drives the housing seat mechanism 21 to flip so that the housing opening 214 is vertically upward, and the specimen slide 200 in the vertical state transferred by the transfer mechanism enters the housing seat mechanism 21 through the housing opening 214 from above the housing seat mechanism 21 so that the housing seat mechanism 21 houses the specimen slide 200, as seen from the empty state of the housing seat mechanism 21. After the accommodating seat mechanism 21 accommodates the sample slide 200, the turnover mechanism 22 drives the accommodating seat mechanism 21 to execute the first turnover action, so that the accommodating opening 214 faces the horizontal direction, and the accommodated sample slide 200 is driven to be switched from the vertical state to the horizontal state. Then, at least one of the transfer device 10 and the transfer device 20 transfers the sample slide 200 in the horizontal state to the scanning position and releases, and the housing-seat mechanism 21 resumes idling. Further, after the housing-seat mechanism 21 resumes the empty state, the turning mechanism 22 is further configured to drive the housing-seat mechanism 21 to perform a second turning action, so that the housing opening 214 is switched from being oriented in the horizontal direction to being oriented vertically upwards, so that the next sample slide 200 to be transferred by the transfer device 10 is sent into the housing-seat mechanism 21 through the housing opening 214.

Wherein, the overturning angle of the overturning mechanism 22 for driving the accommodating seat mechanism 21 to execute the first overturning action and the second overturning action is 90 degrees, and the overturning directions of the first overturning action and the second overturning action are opposite.

As shown in fig. 4, specifically, the housing mechanism 21 includes at least a first clamping component 211, a second clamping component 212 and a clamping driving component 213, where the first clamping component 211 and the second clamping component 212 are movably connected and cooperate to form a housing opening 214, and the clamping driving component 213 is connected to at least one of the first clamping component 211 and the second clamping component 212 and is used for driving the first clamping component 211 and the second clamping component 212 to move towards each other to clamp the sample slide 200, or driving the first clamping component 211 and the second clamping component 212 to move away from each other to release the sample slide 200. It should be appreciated that in the process of the flip mechanism 22 driving the housing seat mechanism 21 to flip the housed specimen slide 200 so as to switch the specimen slide 200 from the vertical state to the horizontal state, the clamp driving assembly 213 drives the first clamp assembly 211 and the second clamp assembly 212 to move toward each other to fix the specimen slide 200 to the housing seat mechanism 21.

As shown in fig. 5, in some embodiments, the sample image scanning apparatus 100 provided in this application is provided with a first station a and a second station B corresponding to the transfer device 20 at intervals, and the transfer device 20 further includes a moving mechanism 23 that drives the accommodating seat mechanism 21 to move between the first station a and the second station B.

Specifically, the transfer device 10 is configured to transfer the specimen slide 200 to the first station a, and the moving mechanism 23 is configured to drive the housing seat mechanism 21 to move to the first station a to receive the specimen slide 200, and is configured to drive the housing seat mechanism 21 and the specimen slide 200 housed therein to move to the second station B after receiving the specimen slide 200 transferred by the transfer device 10. The turnover mechanism 22 is used for driving the accommodating seat mechanism 21 positioned at the second station B to drive the accommodating sample slide 200 to turn over so as to convert the sample slide 200 from a vertical state to a horizontal state, and the moving mechanism 23 is also used for driving the turned accommodating seat mechanism 21 to move to the first station A.

It should be understood that the transfer device 20 specifically performs the overturning of the sample slide 200 at the second station B, that is, before and after the overturning mechanism 22 drives the accommodating seat mechanism 21 to overturn, the accommodating seat mechanism 21 and the sample slide 200 accommodated therein change the posture, and the positions of the accommodating seat mechanism 21 and the sample slide 200 accommodated therein are located at the second station B.

Further, when the sample slide 200 does not enter the housing seat mechanism 21 through the housing opening 214, the moving mechanism 23 drives the housing seat mechanism 21 to move to the first station a and the turning mechanism 22 drives the housing seat mechanism 21 to turn over so that the housing opening 214 is vertically upward, and the transferring mechanism transfers the sample slide 200 in the vertical state to the housing seat mechanism 21 located at the first station a so that the housing seat mechanism 21 houses the sample slide 200 through the housing opening 214. After the accommodating seat mechanism 21 accommodates the sample slide 200, the moving mechanism 23 drives the accommodating seat mechanism 21 to move from the first station a to the second station B, and then the turning mechanism 22 drives the accommodating seat mechanism 21 to execute the first turning action so as to drive the accommodated sample slide 200 to be switched from the vertical state to the horizontal state. After at least one of the transfer device 10 and the transfer device 20 transfers the sample slide 200 in the horizontal state to the scanning position C and releases, the housing-seat mechanism 21 resumes idling.

It should be understood that after the transfer device 20 flips the sample slide 200, transferring the flipped sample slide 200 to the scan position C is performed by at least one of the transfer device 10 and the transfer device 20.

In some embodiments, transferring the flipped sample slide 200 to the scan position C is specifically performed by the transfer device 20, wherein the transfer device 20 is movable relative to the scan position C to transfer the flipped sample slide 200 to the scan position C and then release the sample slide 200.

Specifically, the moving mechanism 23 of the transferring device 20 is further configured to drive the flipped housing seat mechanism 21 located at the first station a to move toward the scanning position C, so as to feed the sample slide 200 housed in the housing seat mechanism 21 to the scanning position C.

Further, after the moving mechanism 23 drives the housing seat mechanism 21 to feed the sample slide 200 to the scanning position C, so that the housing seat mechanism 21 is restored to idle, the turning mechanism 22 is further configured to drive the housing seat mechanism 21 to perform a second turning action so that the housing opening 214 is switched from being oriented in a horizontal direction to being oriented in a vertical direction, and the moving mechanism 23 is further configured to drive the housing seat mechanism 21 to move from the second station B to the first station a, so that the housing seat mechanism 21 can receive the next sample slide 200 transferred to the first station a by the transferring device 10.

In some embodiments, the transfer device 20 includes a moving mechanism 23 and a housing mechanism 21, where the moving mechanism 23 is further configured to drive the housing mechanism 21 located at the first station and turned over to move toward the scanning position C, so as to feed the sample slide 200 housed in the housing mechanism 21 to the scanning position C.

Specifically, the housing-seat mechanism 21 can be moved relative to the scanning position C under the drive of the moving mechanism 23, so that the housing-seat mechanism 21 itself and the housed inverted sample slide 200 are moved to the scanning position C together, and after the housing-seat reaches the scanning position C, the housed sample slide 200 is released, and the operation of feeding the inverted sample slide 200 to the scanning position C is completed.

As yet other embodiments, transferring the flipped specimen slide 200 to the scan station C may also be performed by the transporter 10. Specifically, the transfer device 10 at least includes a first transfer mechanism and a second transfer mechanism that are separately disposed, and the first transfer mechanism and the second transfer mechanism operate independently, where the first transfer mechanism is used for transferring the sample slide 200 to the transfer device 20, and the second transfer mechanism is used for transferring the sample to the scanning position C after the transfer device 20 turns over the sample slide 200.

By providing the first transfer mechanism and the second transfer mechanism separately provided, the processes are not interfered with each other, thereby simplifying the structure of the sample image scanning apparatus 100 and speeding up the execution of a plurality of operations on the sample slide 200.

As shown in fig. 5, in some embodiments, the scanning position C, the first station a, and the second station B are arranged in a straight line, and the turning mechanism 22 is used to drive the housing seat mechanism 21 located at the second station B to turn in the direction of the scanning position C, so as to change the sample slide 200 from the vertical state to the horizontal state.

It should be understood that the scanning position C, the first station a and the second station B are disposed in a straight line, and the accommodating seat mechanism 21 can move forward or backward in the extending direction of the straight line Y where the first station a and the second station B are disposed, so as to reach the scanning position C, the first station a or the second station B, that is, only the moving mechanism 23 needs to move back and forth in the extending direction of the straight line Y to realize the movement to the first station a, the second station B or the scanning position C, and does not need to move in the extending direction of the straight line X, thereby simplifying the structure of the sample image scanning device 100 and reducing the occupied space, and optimizing the procedure of the sample image scanning device 100 in a series of operation procedures, so as to save the internal space of the sample image scanning device 100.

Specifically, the transferring device 20 is provided with a moving mechanism 23 for driving the accommodating seat mechanism 21 to advance or retract in the extending direction of the straight line Y where the first station a and the second station B are located.

As shown in fig. 5, further, the sample image scanning apparatus 100 provided in this embodiment specifically sets the first station a, the second station B, and the scanning position C to be sequentially arranged in the extending direction of the straight line Y, that is, the scanning position C is set on a side closer to the second station B, and the turnover mechanism 22 is used for driving the accommodating seat mechanism 21 located at the second station B to turn over in the direction of the scanning position C, so as to avoid the accommodating seat mechanism 21 located at the second station B from turning over in the direction of the first station a, and reduce the space length occupied by the transfer device 20 and the image scanning device 40 in the extending direction of the straight line Y, thereby saving the internal space of the sample image scanning apparatus 100.

In some embodiments, the pre-scanning device 30 is disposed corresponding to the first station a and is configured to perform a pre-scanning operation on the sample slide 200 that is not flipped and is located at the first station a; and/or the number of the groups of groups,

the sample image scanning apparatus 100 further includes a first recognition device disposed corresponding to the first station a, wherein the first recognition device is configured to recognize an orientation of a surface of the sample slide 200 coated with the biological sample at the first station a; and/or the number of the groups of groups,

The transfer device 20 further comprises a rotating mechanism connected to the accommodating seat mechanism 21, and the rotating mechanism is used for driving the accommodating seat mechanism 21 to drive the sample slide 200 to rotate by a preset angle when the surface of the sample slide 200 coated with the biological sample faces away from the preset direction; and/or the number of the groups of groups,

the sample image scanning device 100 further comprises a code scanning device corresponding to the first station a, wherein the code scanning device is used for scanning the sample slide 200 which is not turned over and is positioned at the first station a to obtain bar code information corresponding to the sample slide 200.

It should be appreciated that, in addition to performing a pre-scan operation on the sample slide 200 prior to transferring the sample slide 200 to the scan position C, the sample image scanning apparatus 100 provided in the embodiments of the present application may perform at least one of a plurality of operations of identifying the orientation of the sample slide 200, rotating the sample slide 200, and scanning the sample slide 200 prior to transferring the sample slide 200 to the scan position C.

It should be further understood that, in the embodiment of the present application, the first identifying device and the code scanning device are both disposed corresponding to the first station a, and the above-mentioned operations of identifying the orientation of the sample slide 200, rotating the sample slide 200, and scanning the code are all performed when the sample slide 200 is transferred to the first station a by the transfer device and is not turned over, so that the structure and the working procedure of the sample image scanning apparatus 100 are more compact, and may occupy less space.

The identification of the orientation of the specimen slide 200 is specifically performed by identifying the orientation of the specimen slide 200, specifically, the orientation of the surface of the specimen slide 200 coated with the biological specimen. Specifically, in the case where it is recognized that the surface of the sample slide 200 coated with the biological sample faces away from the predetermined direction, the sample slide 200 is rotated so that the surface of the sample slide 200 coated with the biological sample faces toward the predetermined direction. The code scanning operation specifically scans a preset barcode area on the sample slide 200 to obtain barcode information corresponding to the sample slide 200.

It should be understood that the preset direction is specifically set according to the objective lens assembly 42 of the image scanning device 40: in the case that the side of the sample slide 200 coated with the biological sample faces away from the preset direction, when the sample slide 200 is transferred to the scanning position C, the side of the sample slide 200 coated with the biological sample faces away from the objective lens assembly 42 of the scanning device. While in the case where the side of the sample slide 200 coated with the biological sample is directed in the preset direction, when the sample slide 200 is transferred to the scanning position C, the side of the sample slide 200 coated with the biological sample is directed toward the objective lens assembly 42 of the scanning device.

Specifically, the code scanning device is, for example, a camera or a code scanning gun, and is configured to scan a barcode area preset on the sample slide 200 to obtain barcode information corresponding to the sample slide 200. The bar code information of the sample slide 200 is identified by the code scanning device, so that after the image scanning operation of the sample slide 200 is completed, the bar code information of the sample slide 200 and the scanning result obtained by the image scanning operation of the sample slide 200 are recorded in a correlated manner.

Specifically, the pre-scanning device 30 at least includes an imaging mechanism 31 and a baffle 32, where the imaging mechanism 31 and the baffle 32 are disposed on opposite sides of the first station a. Wherein the imaging mechanism 31 is used for pre-scanning the sample slide 200 in a vertical state after the sample slide 200 is transferred to the first station a by the transfer device and before the sample slide 200 is turned over, and the baffle 32 is used for shielding illumination emitted from a side far away from the imaging mechanism 31 to the sample slide 200 when the pre-scanning mechanism performs the pre-scanning operation on the sample slide 200 so as to reduce interference to the pre-scanning operation and improve imaging effect of the pre-scanning operation, wherein the imaging mechanism 31 comprises a low-power mirror imaging component or a CMOS camera component, for example.

In some embodiments, the pre-scanning operation performed by the pre-scanning device 30 on the sample slide 200 at least includes performing panoramic scanning on the sample slide 200 to determine a coating position of the biological sample to be measured, and correspondingly, the image scanning operation performed by the image scanning device 40 on the sample slide 200 at least includes adjusting an emphasis of scanning by the image scanning device 40 according to the coating position determined during the pre-scanning operation, and performing image scanning according to the determined emphasis, so as to perform an accurate and effective image scanning operation on the biological sample.

As shown in fig. 3, in some embodiments, the turnover mechanism 22 includes a driving wheel assembly 221, a driven wheel assembly 222, and a transmission assembly 223, the accommodating seat mechanism 21 is fixedly mounted on the driven wheel assembly 222, and the transmission assembly 223 is wound around the driving wheel assembly 221 and the driven wheel assembly 222 and is in tensioning fit with the driving wheel assembly 221 and the driven wheel assembly 222, wherein the driving wheel assembly 221 is used for driving the driven wheel assembly 222 to rotate through the transmission assembly 223 so as to drive the accommodating seat mechanism 21 to turn over. Specifically, the transmission assembly 223 is, for example, a transmission belt, and the transmission belt is sleeved on the driving wheel assembly 221 and the driven wheel assembly 222, and when the driving wheel assembly 221 rotates, the transmission belt rotates along with the driving wheel assembly 221 and drives the driven wheel assembly 222 to rotate, so as to drive the accommodating seat mechanism 21 installed on the driven wheel assembly 222 to turn over.

In some embodiments, the pre-scanning device 30 is configured to perform a pre-scanning operation on the specimen slide 200 to obtain at least a coating state of the biological specimen on the specimen slide 200, wherein the pre-scanning device 30 includes one of a low power mirror imaging assembly and a CMOS camera assembly.

Correspondingly, the image scanning device 40 is used for performing an image scanning operation associated with at least one of the coating state and the pre-scanning device 30. Specifically, the image scanning operation performed by the image scanning device 40 may specifically be to adjust the focus of scanning by the image scanning device 40 according to the coating position determined during the pre-scanning operation, so as to perform an accurate and effective image scanning operation on the biological sample on the sample slide 200; whereas in the case where the pre-scanning device 30 includes a low power mirror imaging assembly, the objective lens assembly 42 of the image scanning device 40 includes at least a high power mirror imaging assembly, the image scanning operation may be a high power mirror scanning of the specimen slide 200 by the high power mirror imaging assembly.

In some embodiments, when the pre-scanning device 30 includes a low power mirror imaging assembly, the image scanning device 40 is used to perform high power mirror scanning of the specimen slide 200. Specifically, the high power mirror imaging assembly is configured to high power mirror scan the specimen slide 200 and the low power mirror imaging assembly is configured to low power mirror scan the specimen slide 200. As is readily apparent, the magnification of the specimen slide 200 is lower in the high power mirror scanning than in the low power mirror scanning, and therefore, the specimen image scanning device 40 in the present embodiment performs the low power mirror scanning in the pre-scanning operation, and performs the precise image scanning operation on the biological specimen by the high power mirror assembly having a higher magnification in the image scanning operation.

In yet another embodiment, when the pre-scanning device 30 includes a CMOS camera assembly, the image scanning device 40 is used to perform an image scanning operation on the specimen slide 200 that matches the coating state. Specifically, the image scanning operation of the specimen slide 200 matching the coating state may be panoramic scanning of the specimen slide to determine at least the coating position of the biological specimen on the specimen slide 200.

It should be noted that, the panoramic scanning specifically performs image scanning on the whole sample slide 200 to obtain the appearance outline of the sample slide 200, the coating position of the biological sample on the sample slide 200, and so on, so that when the image scanning device 40 performs image scanning operation on the same sample slide 200, specific operations and specific parameters of the image scanning operation may be adjusted according to the above information, for example, parameters such as adjusting scan field, scan focus, exposure, and so on.

For example, the panoramic scanning of the sample slide 200 may be to scan sub-images of a plurality of sub-regions spaced by a preset distance on the sample slide 200 to obtain a plurality of corresponding sub-images, and then stitch the plurality of sub-images to obtain a panoramic image corresponding to the sample slide 200, so as to realize the panoramic scanning of the sample slide 200.

For example, the image scanning device 40 may adjust the focus of scanning by the image scanning device 40 according to the coating position determined during the pre-scanning operation, so that the camera field of view of the CMOS camera assembly is aligned with the biological sample coated on the sample slide 200.

In some embodiments, pre-scanning device 30 includes an imaging assembly. The imaging assembly is used for imaging the sample slide 200 under the condition that the distance between the imaging assembly and the first station A is in a preset focal length range or the displacement distance of the imaging assembly towards the first station A is in a preset focusing range so as to acquire a pre-scanning result.

It should be understood that the pre-scanning operation of the pre-scanning assembly on the sample slide 200 specifically includes imaging the sample slide 200 by the imaging assembly, and before imaging the sample slide 200, it is further necessary to determine whether the pre-scanning assembly reaches a condition for effectively imaging the sample slide 200 according to a distance between the imaging assembly and the first station a or a displacement distance of the imaging assembly in a direction of the first station a, and after determining that the condition has been reached, imaging the sample slide 200 by the imaging assembly, thereby effectively improving a scanning effect of the pre-scanning operation.

It should also be appreciated that the sample image scanning apparatus 100 provided in the present application may perform the operations of transferring and inverting the next sample slide 200 by the transferring device 10 and the transferring device 20 and the pre-scanning the next sample slide 200 by the pre-scanning device 30 simultaneously in the process of performing the image scanning operation on the previous sample slide 200 by the image scanning device 40, and after the image scanning operation on the previous sample slide 200 is completed, feed the next sample slide 200 to the image scanning device 40 to perform the image scanning operation, so as to significantly increase the processing speed of performing the microscopic scanning on the batch of sample slides 200.

In summary, embodiments of the present application provide a sample image scanning apparatus 100, including: a transfer device 10 and a transfer device 20, the transfer device 10 is used for transferring the sample slide 200 to the transfer device 20, the transfer device 20 is used for turning over the sample slide 200, and at least one of the transfer device 10 and the transfer device 20 is also used for transferring the turned over sample slide 200 to the scanning position C; a pre-scanning device 30 for performing a pre-scanning operation on the specimen slide 200 positioned at the transfer device 20; the image scanning device 40 is configured to perform an image scanning operation on the sample slide 200 transferred to the scanning position C to obtain a scanned image, so that the structure of the sample image scanning device 100 is simplified and the speed of performing multiple operations on the sample slide 200 is increased, and the technical problems that in the process of scanning the sample slide 200 by using the existing scheme and device, when different operations are performed on the sample slide 200, the scheme of transferring and adjusting the sample slide 200 is complicated, the device mechanism is complex, the time required for performing health analysis on the sample slide 200 is long, and the efficiency is low are solved.

It should be understood that the block diagrams depicted in the figures are exemplary only, and do not necessarily include all structures to structure connections. In the description of the present application, unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.

It is also to be understood that the terminology used in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

It should also be understood that the term "and/or" as used in this specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.

It should also be understood that the term "and/or" as used in this specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations. It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or system that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or system. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or system that comprises the element.

The foregoing embodiment numbers of the present application are merely for describing, and do not represent advantages or disadvantages of the embodiments. While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims (10)

1. A sample image scanning apparatus, comprising:

a transfer device for transferring a sample slide to the transfer device, the transfer device for flipping the sample slide, at least one of the transfer device and the transfer device further for transferring the flipped sample slide to a scanning position;

a pre-scanning device for performing a pre-scanning operation on the sample slide located in the transfer device;

and the image scanning device is used for carrying out image scanning operation on the sample slide transferred to the scanning position so as to acquire a scanning image.

2. The sample image scanning apparatus of claim 1, wherein said relay device comprises:

A housing seat mechanism for housing the sample slide;

the turnover mechanism is connected with the containing seat mechanism and is used for driving the containing seat mechanism to turn over so as to drive the contained sample slide to be converted between a horizontal state and a vertical state.

3. The sample image scanning apparatus of claim 2, wherein said relay device further comprises a movement mechanism that drives said receptacle mechanism between a first station and a second station;

wherein the transfer device is used for transferring the sample slide to the first station; the moving mechanism is used for driving the containing seat mechanism to move to the first station to receive the sample slide and driving the containing seat mechanism containing the sample slide to move to the second station;

the turnover mechanism is used for driving the accommodating seat mechanism positioned at the second station to drive the accommodating sample slide to turn over so as to convert the sample slide from a vertical state to a horizontal state; the moving mechanism is also used for driving the overturned accommodating seat mechanism to move to the first station.

4. A sample image scanning apparatus according to claim 3, wherein the transfer device comprises a first transfer mechanism for transferring the sample slide in a vertical state to the first station and a second transfer mechanism for feeding the sample slide in a horizontal state to the scanning position.

5. A sample image scanning device according to claim 3, wherein the movement mechanism is further adapted to drive the receptacle mechanism at the first station and flipped to move towards the scanning position to feed the sample slide received in the receptacle mechanism to the scanning position.

6. The sample image scanning apparatus of claim 5, wherein the scanning position, the first station and the second station are arranged in a straight line, and the turnover mechanism is configured to drive the receptacle mechanism located at the second station to turn over in the direction of the scanning position, so that the sample slide is converted from a vertical state to a horizontal state.

7. A sample image scanning apparatus according to claim 3, wherein said pre-scanning means is provided in correspondence with said first station and is adapted to perform a pre-scanning operation on said sample slide which is not flipped and is located at said first station; and/or the number of the groups of groups,

the sample image scanning device further comprises a first identification device arranged corresponding to the first station, wherein the first identification device is used for identifying the direction of one surface of the sample slide, which is positioned at the first station and is coated with the biological sample; and/or the number of the groups of groups,

The transfer device also comprises a rotating mechanism connected with the containing seat mechanism, the rotating mechanism is used for driving the containing seat mechanism to drive the sample slide to rotate by a preset angle and/or when the surface of the sample slide coated with the biological sample faces away from the preset direction,

the sample image scanning device further comprises a code scanning device arranged corresponding to the first station, wherein the code scanning device is used for scanning the sample slide which is positioned at the first station and is not turned over so as to obtain bar code information corresponding to the sample slide.

8. The specimen image scanning apparatus of any one of claims 1-7, wherein the pre-scanning device is configured to perform a pre-scanning operation on the specimen slide to obtain at least a coating state of the biological specimen on the specimen slide, wherein the pre-scanning device includes one of a low power mirror imaging assembly and a CMOS camera assembly,

the image scanning device is used for performing an image scanning operation associated with at least one of the coating state and the pre-scanning device.

9. The specimen image scanning apparatus of claim 8, wherein the image scanning device is configured to perform a high-power mirror scan on the specimen slide when the pre-scanning device includes a low-power mirror imaging assembly; when the pre-scanning device includes a CMOS camera assembly, the image scanning device is configured to perform an image scanning operation on the specimen slide that matches the coating state.

10. A sample image scanning device according to any of claims 3-7, wherein the pre-scanning means comprises an imaging assembly;

the imaging assembly is used for imaging the sample slide under the condition that the distance between the imaging assembly and the first station is in a preset focal length range or the condition that the displacement distance of the imaging assembly towards the direction of the first station is in a preset focusing range so as to obtain a pre-scanning result.

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