CN219290433U

CN219290433U - 3D prints hollow microneedle of stromatolite

Info

Publication number: CN219290433U
Application number: CN202221746282.6U
Authority: CN
Inventors: 李永勇; 贾梦虹; 范丽敏; 王欢
Original assignee: Shanghai Chuanghua Material Technology Co ltd
Current assignee: Shanghai Chuanghua Material Technology Co ltd
Priority date: 2022-07-05
Filing date: 2022-07-05
Publication date: 2023-07-04
Anticipated expiration: 2032-07-05

Abstract

The present utility model provides a 3D printed laminated hollow microneedle comprising: the micro-needle is arranged above the substrate, hollow shafts are arranged in the substrate and the micro-needle at the central line of the micro-needle, the top ends of the hollow shafts are connected with the inner wall of the top of the micro-needle, and the bottom ends of the hollow shafts extend to the bottom of the substrate; the microneedle is used for medicine to carry, wherein, the microneedle still includes: the lower part of the microneedle body is connected with the matrix; the microneedle spray head is arranged at the top end of the microneedle body. The structure is conical through the micro needle, the hollow shaft is cylindrical, and the micro needle is pyramid-shaped, the hollow shaft is prismatic, so that different needle types correspond to different hollow structures, the micro needle type is consistent with the hollow structure, the micro needle has good mechanical structure stability, and the practical application value is enhanced.

Description

3D prints hollow microneedle of stromatolite

Technical Field

The utility model relates to the technical field of medical treatment, in particular to a 3D printing laminated hollow microneedle.

Background

The hollow microneedle can be used for a blood collection system and a drug delivery system, has the function of accurately controlling drug dosage delivery, and can also be used for preparing a blood pressure sensor, a surgical display device of a trace body fluid analyzer and the like. In the drug delivery device, the interface of the hollow microneedle array should be able to withstand mechanical stress caused by uneven patches, and a needle-type structure should be designed before preparation.

In recent years, with the development of biomedical and medical devices, many multi-shaped, multi-functional microneedles having different physical properties using metals, polymers and gelatin have been developed. The traditional microneedle preparation technology mainly comprises the steps of preparing by using a mould, removing hollow parts of the solid microneedles prepared in advance by means of laser, RIE and the like, preparing the microneedles by directly etching on a silicon-based material substrate and the like. However, these methods are not only very fragile when the microneedle is released from the mold or peeled off; the preparation cost is high, the efficiency is low, and the preparation process is complex.

Disclosure of Invention

Aiming at the problems existing in the prior art when the microneedle works, the 3D printing laminated hollow microneedle which aims at simple structure, easy function, convenient integration, good application value, stable structure and good mechanical consistency is provided.

The specific technical scheme is as follows:

a 3D printed laminated hollow microneedle comprising:

the micro-needle device comprises a substrate, wherein a micro-needle is arranged above the substrate, hollow shafts are arranged in the substrate and the micro-needle at the central line of the micro-needle, the top ends of the hollow shafts are connected with the inner wall of the top of the micro-needle, and the bottom ends of the hollow shafts extend to the bottom of the substrate;

the microneedle is used for drug delivery, wherein, the microneedle further includes:

the microneedle body is connected with the substrate below;

the microneedle spray head is arranged at the top end of the microneedle body.

Preferably, the hollow shaft is located inside the matrix and the microneedles, the hollow shaft further comprising:

a shaft positioned inside the matrix and the microneedles;

the feed inlet is arranged at the bottom of the shaft body;

the discharge port is arranged at the top of the shaft body.

Preferably, the feed inlet is positioned at the bottom of the substrate, and the feed inlet is uniformly annular.

Preferably, the discharge hole is positioned at the top of the micro-needle, and the discharge hole and the micro-needle spray head are positioned at the same position.

Preferably, the number of the microneedles is a plurality, and the plurality of the microneedles are uniformly distributed over the substrate in an array.

Preferably, the hollow shafts are uniformly distributed in the matrix and the microneedles in a one-to-one correspondence.

Preferably, the microneedle is conical, the microneedle nozzle of the microneedle is arranged at the tip of the conical shape, and the hollow shaft is cylindrical.

Preferably, the microneedle is in a pyramid shape, the microneedle nozzle of the microneedle is arranged at the tip of the pyramid shape, and the hollow shaft is in a prism shape.

Preferably, the microneedle height is 800 μm and the matrix height is 400 μm.

Preferably, the hollow shaft has a diameter of 4 μm.

The technical scheme has the following advantages or beneficial effects:

(1) According to the utility model, the hollow shaft is cylindrical through the conical shape of the micro needle, and the hollow shaft is prismatic through the pyramid shape of the micro needle, so that different needle types correspond to different hollow structures, and the micro needle type structure is consistent with the hollow structure, so that the micro needle has good mechanical structure stability, and the practical application value is enhanced;

(2) The substrate, the micro needle and the hollow shaft are of a 3D printing integrated structure, so that the integration is convenient, and the application value is good;

(3) The matrix of the utility model is a hollow structure, and has simple structure and easy function.

Drawings

Embodiments of the present utility model will now be described more fully with reference to the accompanying drawings. The drawings, however, are for illustration and description only and are not intended as a definition of the limits of the utility model.

FIG. 1 is a schematic diagram of a preferred embodiment of the present utility model;

FIG. 2 is a cross-sectional view of the present utility model;

FIG. 3 is an enlarged view of a portion of the present utility model A;

fig. 4 is a top view of the present utility model.

The above reference numerals denote:

1. a substrate; 2. a microneedle; 3. a hollow shaft; 201. a microneedle body; 202. a microneedle spray head; 31. a shaft body; 32. a feed inlet; 33. and a discharge port.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In the description of the present utility model, it should be noted that, directions or positional relationships indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., are based on directions or positional relationships shown in the drawings, are merely for convenience of description and simplification of description, and do not indicate or imply that the apparatus or element to be referred to must have a specific direction, be constructed and operated in the specific direction, and thus should not be construed as limiting the present utility model; the terms "first," "second," "third," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance, and furthermore, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "coupled," and the like are to be construed broadly, and may be fixedly coupled, detachably coupled, or integrally coupled, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

Referring to fig. 1-4, one embodiment provided by the present utility model is: a 3D printed laminated hollow microneedle comprising: the micro-needle device comprises a substrate 1, wherein a micro-needle 2 is arranged above the substrate 1, hollow shafts 3 are arranged in the substrate 1 and the micro-needle 2 at the central line of the micro-needle 2, the top ends of the hollow shafts 3 are connected with the inner wall of the top of the micro-needle 2, and the bottom ends of the hollow shafts 3 extend to the bottom of the substrate 1; the microneedle 2 is for drug delivery, wherein the microneedle 2 further comprises: a microneedle body 201 connected to the substrate 1 at the lower side; a microneedle spray head 202 provided at the tip of the microneedle body 201; in order to realize the integrated integration of the hollow micro-needle, the utility model comprises the integrated application of a follow-up driving device and an infusion device, wherein the matrix part is in a hollow form, and the matrix part can be integrated with the infusion device as a part of a micro-channel after being manufactured.

Further, a hollow shaft 3 is located inside the substrate 1 and the microneedles 2, and the hollow shaft 3 further includes: a shaft 31 located inside the matrix 1 and the microneedles 2; a feed inlet 32 arranged at the bottom of the shaft body 31; a discharge port 33 arranged at the top of the shaft body 31; the drug is delivered through the inlet port 32 and introduced through the outlet port 33.

Further, the feed inlet 32 is located at the bottom of the substrate 1, and the feed inlet 32 is in a uniform annular shape.

Further, a discharge port 33 is located at the top of the microneedle 2, and the discharge port 33 is located at the same position as the microneedle spray head 202.

Further, the number of the micro-needles 2 is a plurality, and the micro-needles 2 are uniformly distributed above the matrix 1 in an array manner; in order to effectively keep uniformity of the micro needle 2 in all directions, the needle type structure of the micro needle 2 is consistent with that of the hollow structure, so that the micro needle has good mechanical structure stability, and practical application value is enhanced.

Further, hollow shafts 3 are uniformly distributed inside the matrix 1 and the microneedles 2 in an array, and the number of the hollow shafts is one-to-one corresponding to that of the microneedles 2.

Further, the microneedle 2 has a conical shape, the microneedle nozzle 202 of the microneedle 2 is provided at the tip of the conical shape, and the hollow shaft 3 has a cylindrical shape.

Further, the microneedle 2 has a pyramid shape, the microneedle nozzle 202 of the microneedle 2 is provided at the tip of the pyramid shape, and the hollow shaft 3 has a prism shape.

Further, the microneedle 2 had a height of 800 μm and the matrix 1 had a height of 400 μm.

Further, the hollow shaft 3 has a diameter of 4. Mu.m.

Working principle: when the 3D printing laminated hollow microneedle works, the 3D printing laminated hollow microneedle is of a 3D printing integrated structure through the substrate 1, the microneedle 2 and the hollow shaft 3, so that medicines are conveniently transmitted to the discharge port 33 through the feed port 32 from the shaft body 31 and then are sent out by the microneedle spray head 202. Through microneedle 2 is conical, then hollow shaft 3 is cylindrical, and microneedle 2 is the pyramid, then hollow shaft 3 is prismatic for different needle types correspond different hollow structures, and microneedle type and hollow structure keep unanimous, make the microneedle have good mechanical structure stability, reinforcing practical application value.

Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present utility model, and although the present utility model has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present utility model.

Claims

A 3D printed laminated hollow microneedle comprising:

the micro-needle device comprises a substrate (1), wherein a micro-needle (2) is arranged above the substrate (1), a hollow shaft (3) is arranged in the substrate (1) and the micro-needle (2) at the central line of the micro-needle (2), the top end of the hollow shaft (3) is connected with the inner wall of the top of the micro-needle (2), and the bottom end of the hollow shaft (3) extends to the bottom of the substrate (1);

the microneedle (2) is for drug delivery, wherein the microneedle (2) further comprises:

a microneedle body (201), the lower part of which is connected with the substrate (1);

and the microneedle spray head (202) is arranged at the top end of the microneedle body (201).
2. 3D printed laminated hollow microneedle according to claim 1, characterized in that the hollow shaft (3) is located inside the matrix (1) and the microneedle (2), the hollow shaft (3) further comprising:

a shaft (31) located inside the matrix (1) and the microneedles (2);

the feed inlet (32) is arranged at the bottom of the shaft body (31);

the discharging hole (33) is arranged at the top of the shaft body (31).
3. The 3D printing laminated hollow microneedle according to claim 2, wherein the feed inlet (32) is located at the bottom of the substrate (1), and the feed inlet (32) is in a uniform ring shape.
4. The 3D printing laminated hollow microneedle according to claim 2, characterized in that the discharge port (33) is located at the top of the microneedle (2), and the discharge port (33) is located at the same position as the microneedle spray head (202).
5. 3D printed laminated hollow microneedle according to claim 1, characterized in that the number of microneedles (2) is several, the number of microneedles (2) being evenly distributed in an array over the substrate (1).
6. 3D printed laminated hollow microneedle according to claim 1, characterized in that the hollow shafts (3) are uniformly distributed inside the matrix (1) and the microneedles (2) in a one-to-one correspondence with the microneedles (2).
7. The 3D printing laminated hollow microneedle according to claim 1, wherein the microneedle (2) is conical, a microneedle spray head (202) of the microneedle (2) is provided at a tip of the conical shape, and the hollow shaft (3) is cylindrical.
8. The 3D printing laminated hollow microneedle according to claim 1, wherein the microneedle (2) has a pyramid shape, a microneedle spray head (202) of the microneedle (2) is provided at a tip of the pyramid shape, and the hollow shaft (3) has a prism shape.
9. 3D printed laminated hollow microneedle according to claim 1, characterized in that the microneedle (2) height is 800 μm and the substrate (1) height is 400 μm.
10. 3D printed laminate hollow microneedle according to claim 1, characterized in that the hollow shaft (3) has a diameter of 4 μm.