CN218700634U

CN218700634U - 3D prints stromatolite micropin mould

Info

Publication number: CN218700634U
Application number: CN202221742308.XU
Authority: CN
Inventors: 贾梦虹; 范丽敏; 王欢
Original assignee: Shanghai Chuanghua Material Technology Co ltd
Current assignee: Shanghai Chuanghua Material Technology Co ltd
Priority date: 2022-07-05
Filing date: 2022-07-05
Publication date: 2023-03-24
Anticipated expiration: 2032-07-05

Abstract

The utility model provides a 3D prints stromatolite micropin mould, include: the male die is composed of a male die with a convex groove structure, and comprises: a microneedle mould is arranged at the top of the convex groove, a substrate is arranged below the microneedle mould, a composite layer is arranged below the substrate, and the substrate is positioned between the microneedle mould and the composite layer; the substrate is configured to deliver a material to a microneedle mold, wherein the substrate further comprises: the upper part of the matrix body is connected with the microneedle mould; the flow guide holes are formed in the matrix body. The device is convenient for die backing by adopting the die as the male die, avoids bubbles which are difficult to remove when liquid is poured, and has simple structure, easy function, convenient integration and good application value.

Description

3D prints stromatolite micropin mould

Technical Field

The utility model relates to the field of medical technology, especially, relate to 3D prints stromatolite micropin mould.

Background

The micro-needle is a novel physical permeation promoting means which is considered to have a promising application prospect in recent years, and is a physical permeation promoting technology with high technical content, which is developed along with the development of the micro-processing technology in the future. The size of the micro-needles and the space between the micro-needles are micron-sized, and the micro-needles can easily pass through the stratum corneum without touching subcutaneous nerves, so that the micro-needles do not cause pain. Microneedles are mainly administered by solidifying the drug in the microneedle and then inserting it into the skin, or dissolving it directly in the skin. The microneedle technology can also be used together with other penetration-promoting means such as iontophoresis and the like to realize better effect. A great number of researchers have conducted transdermal research on a plurality of drugs, especially macromolecular drugs (such as protein-level deoxyribonucleic acid) with the assistance of microneedles, and the results prove that the microneedles have the unique advantages of promoting transdermal absorption of the macromolecular drugs. With the gradual and intensive research on safety and the unification of relevant standards, the microneedles will become a novel transdermal drug delivery mode. The microneedle array needs to be designed most appropriately according to skin diseases or skin conditions, and development and provision of various microneedle arrays are required. The new process of negative mould is of great importance for the growing demand of microneedle arrays.

The filling of the female die is easy to have bubbles due to the small aperture of the pinhole, the bubbles need to be extracted by repeated vacuum pumping, and the times of vacuum pumping are increased along with the increase of the density of the solution, so that a large amount of production time is consumed in the die-reversing process, and the production efficiency is greatly reduced.

SUMMERY OF THE UTILITY MODEL

Aiming at the problems existing in the prior art when the microneedle mould works, the 3D printing laminated microneedle mould is simple in structure, easy to operate in function, convenient to integrate, good in application value, capable of improving production efficiency and saving cost.

The specific technical scheme is as follows:

3D prints stromatolite micropin mould comprises the formpiston mould that has the tongue structure, includes: a microneedle mould is arranged at the top of the convex groove, a substrate is arranged below the microneedle mould, a composite layer is arranged below the substrate, and the substrate is positioned between the microneedle mould and the composite layer;

the substrate is configured to deliver a material to a microneedle mold, wherein the substrate further comprises:

the upper part of the matrix body is connected with the microneedle mould;

and the flow guide hole is formed in the substrate body.

Preferably, the composite layer is located below the substrate body, the composite layer further comprising:

a first connection layer connected with the substrate body;

and the upper part of the second connecting layer is connected with the first connecting layer.

Preferably, the diversion hole is positioned at the bottom of the microneedle mould.

Preferably, the number of the microneedle mould is several, and the microneedle mould is uniformly distributed above the substrate in an array.

Preferably, the flow guide holes are uniformly distributed in the matrix body in an array mode, and the number of the flow guide holes corresponds to that of the microneedle molds one by one.

Preferably, the second tie layer gauge is greater than the first tie layer gauge.

Preferably, the microneedle mould shape comprises a conical shape, a triangular pyramid shape, a quadrangular pyramid shape.

Preferably, the composite layer shape includes a square shape and a circular shape.

Preferably, the microneedle mould height is 800 μm and the matrix height is 400 μm.

Preferably, the composite layer height is 1mm.

The technical scheme has the following advantages or beneficial effects:

(1) The utility model adopts the male mold, which is convenient for reversing the mold, avoids the generation of bubbles which are difficult to remove when filling liquid, has simple structure, easy function, convenient integration and good application value;

(2) The utility model is convenient for stripping after the micro-needle is poured and molded, and a composite layer is arranged below the matrix, thereby increasing the height of the mold and facilitating the filling material;

(3) The utility model discloses the micropin mould can be for complicated structure such as conical, pyramid, improves production efficiency, saves the cost.

Drawings

Embodiments of the present invention will now be described more fully hereinafter with reference to the accompanying drawings. The drawings are, however, to be regarded as illustrative and explanatory only and are not restrictive of the scope of the invention.

Fig. 1 is a schematic structural diagram of a preferred embodiment of the present invention;

fig. 2 is a side view of the present invention;

fig. 3 is a top view of the present invention;

FIG. 4 is a partial schematic view of the substrate of the present invention.

The above reference numerals denote:

1. a male mold; 2. a substrate; 3. compounding layers; 4. a microneedle mould; 201. a matrix body; 202. a flow guide hole; 31. a first tie layer; 32. a second connection layer.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention; the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance, and furthermore, unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "connected" are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Referring to fig. 1-4, the present invention provides an embodiment: 3D prints stromatolite micropin mould comprises positive mould 1 that has the tongue structure, includes: a microneedle mould 4 is arranged at the top of the convex groove, a substrate 2 is arranged below the microneedle mould 4, a composite layer 3 is arranged below the substrate 2, and the substrate 2 is positioned between the microneedle mould 4 and the composite layer 3; the substrate 2 is used to deliver material to the microneedle mould 4, wherein the substrate 2 further comprises: the upper part of the substrate body 201 is connected with the microneedle mould 4; the flow guide holes 202 are formed in the substrate body 201; the mold is adopted as a male mold 1, the microneedle mold 4 array structure is prepared for the first time, the reverse mold is convenient, bubbles which are difficult to remove are avoided when liquid is filled, the structure is simple, the function is easy to implement, the integration is convenient, and the application value is good; in the process of repeatedly preparing the mold by reverse molding, the male mold can be vacuumized for a few times, and the large-scale replication of the mold can be completed.

Further, the composite layer 3 is located below the substrate body 201, and the composite layer 3 further includes: a first connection layer 31 connected to the substrate body 201; a second connection layer 32 connected to the first connection layer 31; by the first connection layer 31 and the second connection layer 32, the height of the mold is increased, and the filling of the required material is facilitated.

Further, the flow guide holes 202 are located at the bottom of the microneedle mould 4.

Further, the number of the microneedle mould 4 is several, and a plurality of microneedle moulds 4 are uniformly distributed above the substrate 2 in an array.

Further, the flow guide holes 202 are uniformly distributed in the matrix body 201 in an array manner, and the number of the flow guide holes corresponds to that of the microneedle molds 4 one by one; the production efficiency is accelerated by the one-to-one correspondence of the diversion holes 202 and the microneedle moulds 4.

Further, the second connection layer 32 is larger in size than the first connection layer 31.

Further, the shape of the microneedle mould 4 includes a conical shape, a triangular pyramid shape, a quadrangular pyramid shape; the microneedle mould 4 can be in a conical or pyramid structure, so that the production efficiency is improved, and the cost is saved.

Further, the shape of the composite layer 3 includes a square shape and a circular shape.

Further, the microneedle mould 4 has a height of 800 μm and the substrate 2 has a height of 400 μm.

Further, the composite layer 3 has a height of 1mm.

The working principle is as follows: this 3D prints stromatolite micropin mould and carries out the during operation, directly pours into base member 2 back with base plate solution, makes the leading-in micropin mould 4 of base plate solution into by water conservancy diversion hole 202, and the shaping back is fixed this mould in circular culture dish, and the dish height is greater than micropin mould total height more than 0.5cm, uses the fixed mould lower surface of double faced adhesive tape, uses way kangning-184 silica gel (PDMS) according to A: liquid B10: mixing the components by mass fraction of 1 to obtain a silica gel solution, defoaming and standing the silica gel solution, pouring the solution into a dish, removing bubbles by ultra-high ultrasound and vacuum, adjusting the temperature of the thermostat to 60 ℃, and keeping the drying time for more than 2 hours. Taking out and demoulding, and facilitating direct stripping through the composite layer 3. Under an electron microscope, the microneedle array can be seen to be arranged regularly and orderly and uniformly distributed, meanwhile, the tips of the microneedles are not damaged and are all formed, and parameters such as the height, the bottom diameter, the taper, the smoothness and the like of the microneedles meet the technical requirements of products. The male die 1 is adopted as the die, so that the die is convenient to reverse, bubbles which are difficult to remove are avoided when liquid is poured, the structure is simple, the functions are easy to implement, the integration is convenient, and the application value is good; the microneedle mould 4 can be in a conical or pyramid structure, so that the production efficiency is improved, and the cost is saved.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still make modifications to the technical solutions described in the foregoing embodiments, or make equivalent substitutions and improvements to part of the technical features of the foregoing embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

3D prints stromatolite micropin mould, its characterized in that comprises positive mould (1) that has the tongue structure, includes: a micro-needle mold (4) is arranged at the top of the convex groove, a substrate (2) is arranged below the micro-needle mold (4), a composite layer (3) is arranged below the substrate (2), and the substrate (2) is positioned between the micro-needle mold (4) and the composite layer (3);

the substrate (2) is for delivering a material to a microneedle mould (4), wherein the substrate (2) further comprises:

a substrate body (201) with the upper part connected with the micro needle mold (4);

the flow guide hole (202) is formed in the matrix body (201).
2. The 3D printing laminated microneedle mould according to claim 1, wherein the composite layer (3) is located below a substrate body (201), the composite layer (3) further comprising:

a first connection layer (31) connected to the substrate body (201) at the top;

and a second connection layer (32) connected to the first connection layer (31) from above.
3. The 3D printing laminated microneedle mould according to claim 1, wherein the flow guide holes (202) are located at the bottom of the microneedle mould (4).
4. The 3D printing laminated microneedle mould according to claim 1, characterized in that the number of microneedle moulds (4) is several, and the several microneedle moulds (4) are uniformly arrayed over the substrate (2).
5. The 3D printing laminated microneedle mould according to claim 1, wherein the flow guiding holes (202) are uniformly distributed in an array inside the substrate body (201) and the number thereof corresponds to the microneedle mould (4) one by one.
6. The 3D printing laminated microneedle mold according to claim 2, wherein the second tie layer (32) gauge is larger than the first tie layer (31) gauge.
7. The 3D printing laminated microneedle mould according to claim 1, wherein the microneedle mould (4) shape comprises a conical, triangular pyramidal, quadrangular pyramidal shape.
8. The 3D printing laminated microneedle mould according to claim 1, wherein the composite layer (3) shape comprises a square, circle.
9. The 3D printing laminated microneedle mould according to claim 1, characterized in that the microneedle mould (4) has a height of 800 μ ι η and the substrate (2) has a height of 400 μ ι η.
10. The 3D printing laminated microneedle mould according to claim 1, characterized in that the composite layer (3) has a height of 1mm.