CN204034020U - A kind of different plane microneedle array - Google Patents
A kind of different plane microneedle array Download PDFInfo
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- CN204034020U CN204034020U CN201420319587.8U CN201420319587U CN204034020U CN 204034020 U CN204034020 U CN 204034020U CN 201420319587 U CN201420319587 U CN 201420319587U CN 204034020 U CN204034020 U CN 204034020U
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- micropin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Abstract
This utility model relates to a kind of different plane microneedle array, comprise isoplanar micropin and substrate, isoplanar micropin comprises more than one and one needle point and the base being connected needle point, and needle point and base are in same plane, and isoplanar micropin more than two panels is assembled on substrate.The beneficial effects of the utility model are: the needlepoint form of isoplanar micropin easily controls, and tips quality is good, and the microneedle array utilizing multi-disc isoplanar micropin assembled side-by-side to become can ensure that needle point, aciculiform, pin are long, can meet micropin density requirements again.The technique used in microneedle array manufacturing process is all comparatively ripe, easily realizes.
Description
Technical field
This utility model relates to medical beauty treatment instrument and medicine injection micropin technical field, particularly a kind of different plane microneedle array.
Background technology
Microneedle cutaneous is a kind of emerging medicine-feeding technology, produces a large amount of micron-sized duct, in a large amount of blood vessels that medicine is penetrated to the skin in skin corium by these ducts, thus realize transdermal administration by pressing micropin at keratodermatitis and epidermal area.Micropin can realize the features such as integrated, portable, painless and accurate, efficient administration over the course for the treatment of, in treating diabetes, chemotherapy, vaccination etc., have unrivaled advantage.In addition, because micropin needle point is sharp, size is little, can not produce pain and bleeding during administration, Wicresoft's aperture of row can heal very soon, is extremely suitable for beauty treatment fields.
Conventional machining methods is difficult to the micropin making micro-meter scale, and current microneedle configuration makes based on microelectron-mechanical technique (MEMS) mostly.Micropin is as a kind of device for transdermal administration, and its needle point is less, density is higher, concordance is more strong better, and its manufacturing process is simpler, yield rate is higher, cost is more low better.Microneedle array is a kind of three dimensional structure of typical high-aspect-ratio, and MEMS technology develops from the IC technique of plane, still has certain difficulty for the microneedle array making high-aspect-ratio.
According to the difference of structure, micropin is divided into isoplanar micropin and different plane micropin.The axis being parallel of isoplanar micropin is in base plane, and the axes normal of different plane micropin is in base plane.The advantage of isoplanar micropin is that processing technology is simple, and aciculiform, needle point, pin length can accurately control, and shortcoming is that micropin number is less.Different plane micropin is then on the contrary, and micropin number is many, but is highly restricted, and technics comparing is complicated.Current research emphasis utilizes various comparatively complicated technology directly to process different plane micropin, but think to obtain excellent aciculiform, needle point, pin length and high density simultaneously, the unavoidable equipment using complicated technique and costliness, is unfavorable for reducing costs, and yield rate is also difficult to ensure.
Utility model content
Technical problem to be solved in the utility model is: existing different plane micropin tip height is restricted, and complex manufacturing technology.
This utility model solves the technical scheme that its technical problem adopts: a kind of different plane microneedle array, comprise isoplanar micropin and substrate, isoplanar micropin comprises more than one and one needle point and the base being connected needle point, needle point and base are in same plane, and isoplanar micropin more than two panels is assembled on substrate.
Further restriction, arranges elastic buffer cushion block between the micropin of isoplanar.
By the first string that isoplanar micropin is assembled on substrate be:
Substrate has the groove coordinated that to match with base, the base of isoplanar micropin and elastic buffer cushion block are assembled on substrate by the mounting means embedding groove.
Further restriction, filling adhesive between base and the groove of substrate.
Second scheme be assembled in by isoplanar micropin on substrate is:
Substrate is the substrate of band jig, comprise substrate body and jig, substrate body have at least two positioning convex strips, jig has the draw-in groove coordinated with positioning convex strip one_to_one corresponding, jig is arranged in substrate body, positioning convex strip is embedded in draw-in groove, clamping gap is left between draw-in groove and positioning convex strip, the base of isoplanar micropin is placed in clamping gap, arrange between jig and substrate body and promote jig to the elastic component of side translation reducing clamping gap, to clamp the base of isoplanar micropin.
Further restriction, positioning convex strip is elastic buffer cushion block.
Further restriction, isoplanar micropin is the isoplanar micropin of wedge shape, the isoplanar micropin of wedge shape narrows to needle point side, and one of them side of two sides in described formation clamping gap is vertical, and another side is the inclined plane of agreeing with the isoplanar micropin of wedge shape.
The 3rd scheme be assembled in by isoplanar micropin on substrate is:
In substrate, there is pouring basin, the base of isoplanar micropin is placed in pouring basin, be spaced from each other by cushion block between the micropin of isoplanar and locate, the degree of depth of pouring basin is greater than the height of the base of isoplanar micropin, pouring liquid castable in the pouring basin being fit into isoplanar micropin, makes isoplanar micropin become to be integrated with substrate after castable solidification.
Further restriction, cushion block is elastic buffer cushion block.
For convenience of the assembling of isoplanar micropin, limit further, pouring basin has the lateral opening being convenient to put into isoplanar micropin and cushion block from the side of substrate in the side of substrate, and lateral opening carries out shutoff by groove link stopper.
Further restriction, have the locating dowel extended to lateral opening in pouring basin, the base of isoplanar micropin and cushion block have the locating hole coordinated with locating dowel, and base and the cushion block of isoplanar micropin are set in locating dowel.
The 4th scheme be assembled in by isoplanar micropin on substrate is:
Substrate adopts curable liquid baseplate material fixedly to form, and isoplanar micropin is implanted before liquid baseplate material solidification, by the mode of solidification, isoplanar micropin is assembled on substrate thereafter.
The beneficial effects of the utility model are: the needlepoint form of isoplanar micropin easily controls, and tips quality is good, and the microneedle array utilizing multi-disc isoplanar micropin assembled side-by-side to become can ensure that needle point, aciculiform, pin are long, can meet micropin density requirements again.
The technique such as isoplanar micropin processing technology, substrate, template machining, female mold reverse mould used in microneedle array manufacturing process is all comparatively ripe, and cost is lower, easily realizes.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, this utility model is further illustrated;
Fig. 1 is the manufacturing process schematic diagram of isoplanar of the present utility model micropin;
Fig. 2 is the structural representation of the different plane microneedle array in scheme 1 of the present utility model;
Fig. 3 is the sectional view of the different plane microneedle array in scheme 2 of the present utility model;
Fig. 4 is the axonometric chart of the different plane microneedle array in scheme 2 of the present utility model;
Fig. 5 is the manufacturing process schematic diagram of the different plane microneedle array of scheme 3 of the present utility model;
Fig. 6 is the manufacture process schematic diagram using elastic buffer cushion block in scheme 3 of the present utility model;
Fig. 7 is the structural representation of the transhipment template in scheme 4 of the present utility model;
Fig. 8 is the structural representation of wherein a kind of different plane microneedle array in scheme 4 of the present utility model;
Fig. 9 is the structural representation of the different plane microneedle array of another kind in scheme 4 of the present utility model;
The structural representation of Figure 10 female mold for making different plane microneedle array of the present utility model;
The structural representation of Figure 11 different plane microneedle array by reverse mould preparation formation of the present utility model; In figure, 1. isoplanar micropin, 2. substrate, 3. groove, 4. jig, 5. positioning convex strip, 6. elastic component, 7. pouring basin, 8. cushion block, 9. groove link stopper, 10. locating dowel, 11. transhipment templates, 12. notch cuttype grooves, 13. female mold, 14. mask plates, 15. substrate of glass, 16. crome metals, 17. positive photo glue, 18.SU-8 photoresist, 19. elastic buffer cushion blocks.
Detailed description of the invention
A kind of different plane microneedle array, comprise isoplanar micropin 1 and substrate 2, isoplanar micropin 1 comprises more than one and one needle point and the base being connected needle point, needle point and base are in same plane, isoplanar micropin 1 more than two panels is assembled on a substrate 2, arranges elastic buffer cushion block 19 between isoplanar micropin 1.
Elastic buffer cushion block 19 has following effect: one, can distance between isolated controlling isoplanar micropin 1; Two, in injection process, play buffering and adjust the effect of thrusting skin depth, by controlling the degree of deformation of different pressing dynamics adjustment elastic buffer cushion blocks 19, and then controlling the length that micropin needle body protrudes elastic buffer cushion block 19, the degree of depth of skin is thrust in adjustment.
This utility model is intended to the advantage merging isoplanar micropin and different plane micropin, and the advantage of conjugated polymer micropin technique low cost.
Isoplanar micropin 1 can utilize existing processing technology to make, as dry etching silicon, plated metal processing technology.
Isoplanar micropin 1 can also profit make in the following method, as shown in Figure 1, provides an embodiment making the isoplanar micropin 1 of SU-8 material with photoetching process:
1) draw two-dimentional micropin figure with AUTOCAD, make mask plate 14.Needle body is high 300 μm, wide 200 μm, 500 μm, gap, and monolithic isoplanar micropin 1 comprises 10 needle bodies, base height 2mm.
2) prepare a slice K9 glass wafer as substrate of glass 15, substrate of glass 15 sputters the thick crome metal of one deck 300nm 16;
3) the BP212-37s positive photo glue 17 of spin coating one deck 2 micron thickness subsequently, expose with the mask plate 14 that step 1 makes, with the sodium hydroxide developing liquid developing of 0.5%, 100 DEG C of after bake 5min obtain patterned photoresist mask;
4) CR-14 corrosive liquid corroding metal chromium 16 is then used, remove photoresist with acetone subsequently and obtain chromium mask plate, thus the chromium mask plate of photoetching SU-8 is transferred in substrate of glass 15, CR-14 corrosive liquid is formulated by 5g ammonium ceric nitrate, 20mL acetic acid and 100mL water;
5) be spun in substrate of glass 15 by SU-8 photoresist 18, thickness is 100 μm;
6) 90 DEG C dry after from substrate of glass 15 back-exposure; Dry rear developing liquid developing, obtain isoplanar microneedle configuration;
7) isoplanar microneedle configuration is placed in the sodium hydroxide solution of 20%, isoplanar micropin 1 is peeled off from substrate of glass 15.
For improve needle point penetrate effect, when the SU-8 photoresist 18 of the isoplanar micropin 1 to SU-8 material exposes, from the back side canted exposure of substrate of glass 15, inclination angle is 70 °, formed tilt needle point, to increase the acutance of needle point.
As shown in Figure 2, by the first string that isoplanar micropin 1 is assembled on a substrate 2 be:
Substrate 2 has the groove 3 coordinated that to match with base, in groove 3, fill the binding agent being used for bonding micropin base, the groove 3 on substrate 2 is consistent with the base shape of isoplanar micropin 1, and groove 3 degree of depth is a little more than base.The isoplanar micropin 1 made by existing processing technology generally comprises dozens of needle body, and base length can reach several millimeters, and the degree of depth can be designed to micron dimension.Groove 3 on substrate 2 can realize by the MEMS processing technique of traditional machining or lower accuracy, and many row isoplanars micropin 1 vertically embeds the mounting means assembling of groove 3 on a substrate 2 by base, obtains different plane microneedle array.
The embodiment of a scheme 1 is provided below:
Utilization is laser-ablated in lucite (PMMA) and makes the groove 3 corresponding with the base shape of micropin on the surface, as the substrate 2 connecting isoplanar micropin 1.Drip as the PDMS performed polymer of the binding agent of bonding micropin base and the mixing material of cross-linking agent on substrate 2 surface and smoothen, standing 5min makes part PDMS bonding agent infiltrate groove 3, then dries remaining PDMS bonding agent.With the base of the SU-8 isoplanar micropin 1 of tweezers gripping monolithic, put into groove 3 respectively, and compress base portion.After micropin 1 installation of whole isoplanars, dry 10min for 100 DEG C and PDMS bonding agent is solidified, obtain Embedded different plane microneedle array side by side.
As shown in Figures 3 and 4, second scheme of being assembled by isoplanar micropin 1 is on a substrate 2:
Substrate 2 is the substrate 2 of band jig 4, comprise substrate body and jig 4, substrate body have at least two positioning convex strips 5, jig 4 has the draw-in groove coordinated with positioning convex strip 5 one_to_one corresponding, jig 4 is arranged in substrate body, positioning convex strip 5 is embedded in draw-in groove, clamping gap is left between draw-in groove and positioning convex strip 5, the base of isoplanar micropin 1 is placed in clamping gap, arrange between jig 4 and substrate body and promote jig 4 to the elastic component 6 of side translation reducing clamping gap, to clamp the base of isoplanar micropin 1.
When the isoplanar micropin 1 that isoplanar micropin 1 is wedge shape, and the isoplanar micropin 1 of wedge shape narrows to needle point side, and one of them side forming two sides in clamping gap is vertical, and another side is the inclined plane of agreeing with the isoplanar micropin 1 of wedge shape.
The embodiment of a scheme 2 is provided below:
Make jig 4 with lucite, and by jig 4 and spring fitting in substrate body, jig 4 is shifted onto maximum direction, clamping gap, the base of isoplanar micropin 1 is put into clamping gap one by one, unclamp jig 4, spring automatic impaction micropin base, forms different plane microneedle array.
As shown in Figure 5, the 3rd scheme of being assembled by isoplanar micropin 1 is on a substrate 2:
There is in substrate 2 pouring basin 7, the base of isoplanar micropin 1 is placed in pouring basin 7, be spaced from each other by cushion block 8 between isoplanar micropin 1 and locate, the degree of depth of pouring basin 7 is greater than the height of the base of isoplanar micropin 1, pouring liquid castable in the pouring basin 7 being fit into isoplanar micropin 1, makes isoplanar micropin 1 be integrated with substrate 2 one-tenth after castable solidification.For convenience of the assembling of isoplanar micropin 1, pouring basin 7 has the lateral opening being convenient to put into isoplanar micropin 1 and cushion block 8 from the side of substrate 2 in the side of substrate 2, lateral opening carries out shutoff by groove link stopper 9.Have the locating dowel 10 extended to lateral opening in pouring basin 7, the base of isoplanar micropin 1 and cushion block 8 have the locating hole coordinated with locating dowel 10, and base and the cushion block 8 of isoplanar micropin 1 are set in locating dowel 10.
As shown in Figure 6, cushion block 8 also can be the elastic buffer cushion block 19 protruding substrate 2 plane, and the material of elastic buffer cushion block 19 is flexible rubber.
The embodiment of a scheme 3 is provided below:
Substrate 2 is made with lucite, substrate 2 has the pouring basin 7 corresponding with the base shape of isoplanar micropin 1, pouring basin 7 has the lateral opening being convenient to put into isoplanar micropin 1 and cushion block 8 from the side of substrate 2 in the side of substrate 2, and installs the locating dowel 10 corresponding with the locating hole of base in pouring basin 7.Pouring basin 7 degree of depth a little more than the height of base, to pour into a mould the liquid pouring material that one deck is fixed.Make pad with metal or lucite, gasket shape is consistent with the base of isoplanar micropin 1, and thickness is consistent with the spacing of isoplanar micropin 1 or determined by micropin density.Isoplanar micropin 1 is inserted into side by side in pouring basin 7, separates with pad between every two panels isoplanar micropin 1.Multi-disc isoplanar micropin 1 assembled side-by-side becomes different plane microneedle array.With the lateral opening of groove link stopper 9 shutoff pouring basin 7, with fixing isoplanar micropin 1.The mixed liquor of PDMS liquid and PDMS performed polymer and cross-linking agent is poured into a mould in pouring basin 7, concordant with substrate 2 upper surface to liquid level, then under the environment of 50-100 DEG C, heat 3-5 hour, make PDMS liquid curing.Just multiple isoplanars micropin 1 has been assembled into different plane microneedle array thus.
As Fig. 7, shown in 8 and 9, the 4th scheme of being assembled by isoplanar micropin 1 is on a substrate 2:
Substrate 2 adopts curable liquid baseplate material fixedly to form, and isoplanar micropin 1 is implanted before liquid baseplate material solidification, by the mode of solidification, isoplanar micropin 1 is assembled on a substrate 2 thereafter.
The concrete grammar that isoplanar micropin 1 is implanted before liquid baseplate material solidification is:
1) the transhipment template 11 of isoplanar micropin 1 is made, transhipment template 11 has notch cuttype groove 12, notch cuttype groove 12 comprises the inside groove of the body sections for holding isoplanar micropin 1 and the base portion water jacket for holding isoplanar micropin 1, the corresponding notch cuttype groove 12 of every sheet isoplanar micropin 1, notch cuttype groove 12 is enough to hold body sections, and the over half of base can be made to expose transhipment template 11, notch cuttype groove 12 is arranged side by side;
2) by the notch cuttype groove 12 being upside down in transhipment template 11 downward for the needle point of isoplanar micropin 1;
3) liquid baseplate material is cast in transhipment template 11, and applies pressure and liquid baseplate material is flowed and is deep in the gap between base, the base of liquid baseplate material and isoplanar micropin 1 is bonded completely;
4) liquid baseplate material is solidified;
5) transhipment template 11, the substrate 2 of solidification and isoplanar micropin 1 are peeled off from transhipment template 11.
The embodiment of a scheme 4 is provided below:
Transhipment template 11 also adopts laser ablation lucite to make, and the groove depth 0.2 ~ 1.5mm of the inside groove of notch cuttype groove 12, depends on that the pin of micropin is long.The notch cuttype groove 12 of transhipment template 11 is placed upward, and be oppositely placed in step trough by the isoplanar micropin 1 of the SU-8 material of monolithic respectively, base exposes 0.5mm.Then drip the mixing material of PDMS performed polymer and cross-linking agent on the surface in transhipment template 11, standing 10min makes its levelling, and thickness is about 1mm.Then its entirety is dried 10min at 100 DEG C and make PDMS liquid curing, the substrate 2 solidified by PDMS is peeled off from transhipment template 11 together with the isoplanar micropin 1 implanted, and has both obtained the different plane microneedle array of implanted.
In scheme 4, transhipment template 11 also can adopt elastomeric cushion material, as the rubber of softness.The effect elastic buffer cushion block 19 of the transhipment template 11 of quality of rubber materials is identical.Notch cuttype groove 12 in the transhipment template 11 of elastomeric cushion material is through, and the syringe needle of micropin can be made to expose, and the substrate of the isoplanar micropin 1 implanted does not need to peel off from transhipment template 11.The needle point of isoplanar micropin 1 can protrude the surface of transhipment template 11, as shown in Figure 8, or maintain an equal level with the surface of transhipment template 11, or lower than the surface of transhipment template 11, when isoplanar micropin 1 needle point protrude transhipment template 11 surperficial time, by the mode of pad cushion block below transhipment template 11, or passing through the mode of reserved groove on the platform placing transhipment template 11, stepping down to protruding the needle point transporting template 11.
As shown in FIG. 10 and 11, a kind of manufacture method of different plane microneedle array, Utilization plan 1,2,3 and 4 obtains different plane microneedle array as main mould, utilizes reverse mould technique to prepare reusable female mold 13, and then prepares different plane microneedle array by reverse mould technique.
The concrete grammar forming female mold 13 by reverse mould technique is: liquid mold materials is poured into the needle body surface of main mould under soft state, under certain vacuum or pressure environment, liquid mold materials is made to infilter space between needle body, be separated with main mould after liquid mold materials solidification, obtain female mold 13;
The concrete grammar preparing different plane microneedle array by reverse mould technique is: liquid micropin material is poured into female mold 13 under softening state, under certain vacuum or pressure environment, liquid micropin material is made to infilter and fill aciculiform groove, be separated with female mold 13 after liquid micropin material cured, obtain different plane microneedle array.
This main mould and female mold 13 can be reused, and are conducive to reducing costs.
An embodiment is provided below:
Utilization plan 1,2,3 and 4 obtains different plane microneedle array as main mould, and open containers put into by main mould, and evaporation one deck glycerol thin film on different plane microneedle array, with the PDMS releasing process of aid in later.The mixing material of cast PDMS performed polymer and cross-linking agent, standing 10min makes its levelling, is heated to 100 DEG C and keeps 10min to make it solidify.The PDMS of solidification is slowly peeled off different plane microneedle array, then reduces useless marginal portion, form different plane microneedle array female mold 13.
Lucite (PMMA) is positioned over female mold 13 upper surface, and evacuation is heated to 160 DEG C, keeps 30min, the PMMA liquid of thawing is flowed in the micropin groove of female mold 13 smoothly.Cool to room temperature with the furnace, slowly peel off female mold 13, prune useless marginal portion, namely obtain the different plane microneedle array of PMMA.
With reverse mould technique prepare different plane microneedle array liquid micropin material can adopt mixture containing skin care item or medicament effective ingredient, make different plane microneedle array both as the needle point piercing through skin, again as medicine.
Claims (12)
1. a different plane microneedle array, it is characterized in that: comprise isoplanar micropin (1) and substrate (2), described isoplanar micropin (1) comprises more than one and one needle point and the base being connected needle point, needle point and base are in same plane, and isoplanar micropin (1) more than two panels is assembled on substrate (2).
2. different plane microneedle array according to claim 1, is characterized in that: between isoplanar micropin (1), arrange elastic buffer cushion block (19).
3. different plane microneedle array according to claim 2, it is characterized in that: described substrate (2) has the groove (3) coordinated that to match with base, the base of isoplanar micropin (1) and elastic buffer cushion block (19) are assembled on substrate (2) by the mounting means embedding groove (3).
4. different plane microneedle array according to claim 3, is characterized in that: filling adhesive between the groove (3) of described base and substrate (2).
5. different plane microneedle array according to claim 1, it is characterized in that: described substrate (2) is the substrate (2) of band jig (4), comprise substrate body and jig (4), substrate body have at least two positioning convex strips (5), jig (4) has the draw-in groove coordinated with positioning convex strip (5) one_to_one corresponding, jig (4) is arranged in substrate body, positioning convex strip (5) is embedded in draw-in groove, clamping gap is left between draw-in groove and positioning convex strip (5), the base of isoplanar micropin (1) is placed in clamping gap, arrange between jig (4) and substrate body and promote jig (4) to the elastic component (6) of side translation reducing clamping gap, to clamp the base of isoplanar micropin (1).
6. different plane microneedle array according to claim 5, is characterized in that: described positioning convex strip (5) is elastic buffer cushion block (19).
7. the different plane microneedle array according to claim 5 or 6, it is characterized in that: the isoplanar micropin (1) that described isoplanar micropin (1) is wedge shape, the isoplanar micropin (1) of wedge shape narrows to needle point side, one of them side of two sides in described formation clamping gap is vertical, and another side is the inclined plane of agreeing with the isoplanar micropin (1) of wedge shape.
8. different plane microneedle array according to claim 1, it is characterized in that: in described substrate (2), there is pouring basin (7), the base of isoplanar micropin (1) is placed in pouring basin (7), be spaced from each other by cushion block (8) and locate between isoplanar micropin (1), the degree of depth of pouring basin (7) is greater than the height of the base of isoplanar micropin (1), pouring liquid castable in the pouring basin (7) being fit into isoplanar micropin (1), after castable solidification, make isoplanar micropin (1) become to be integrated with substrate (2).
9. different plane microneedle array according to claim 8, is characterized in that: described cushion block is elastic buffer cushion block (19).
10. different plane microneedle array according to claim 8 or claim 9, it is characterized in that: described pouring basin (7) has the lateral opening being convenient to put into isoplanar micropin (1) and cushion block (8) from the side of substrate (2) in the side of substrate (2), lateral opening carries out shutoff by groove link stopper (9).
11. different plane microneedle arrays according to claim 8 or claim 9, it is characterized in that: to the locating dowel (10) that lateral opening extends in described pouring basin (7), the base of isoplanar micropin (1) and cushion block (8) have the locating hole coordinated with locating dowel (10), and base and the cushion block (8) of isoplanar micropin (1) are set in locating dowel (10).
12. different plane microneedle arrays according to claim 1, it is characterized in that: described substrate (2) adopts curable liquid baseplate material fixedly to form, isoplanar micropin (1) is implanted before liquid baseplate material solidification, by the mode of solidification, isoplanar micropin (1) is assembled on substrate (2) thereafter.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104056346A (en) * | 2014-06-16 | 2014-09-24 | 游学秋 | Isoplanar microneedle array and manufacturing method thereof |
| WO2018116251A1 (en) * | 2016-12-21 | 2018-06-28 | Sabic Global Technologies B.V. | Method of making microneedles, mold assemblytherefor and microneedles array |
| CN109125914A (en) * | 2018-11-07 | 2019-01-04 | 何坛明 | A kind of antiseep micropin gatherer |
| CN110314276A (en) * | 2019-07-26 | 2019-10-11 | 清华大学 | Metal micro-needle promotees to seep seal |
| CN113952609A (en) * | 2020-11-12 | 2022-01-21 | 清华大学 | Hollow metal microneedle array and preparation method thereof, transdermal drug delivery patch and injection needle |
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2014
- 2014-06-16 CN CN201420319587.8U patent/CN204034020U/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056346A (en) * | 2014-06-16 | 2014-09-24 | 游学秋 | Isoplanar microneedle array and manufacturing method thereof |
| WO2018116251A1 (en) * | 2016-12-21 | 2018-06-28 | Sabic Global Technologies B.V. | Method of making microneedles, mold assemblytherefor and microneedles array |
| CN110234385A (en) * | 2016-12-21 | 2019-09-13 | 沙特基础工业全球技术公司 | Make method, the mold assembly and microneedle array for micropin of micropin |
| CN109125914A (en) * | 2018-11-07 | 2019-01-04 | 何坛明 | A kind of antiseep micropin gatherer |
| CN110314276A (en) * | 2019-07-26 | 2019-10-11 | 清华大学 | Metal micro-needle promotees to seep seal |
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