CN219126312U

CN219126312U - Pain measuring frame

Info

Publication number: CN219126312U
Application number: CN202222253723.5U
Authority: CN
Inventors: 陈诚; 袁云云; 陈春麟
Original assignee: Medicorp Bio Pharmaceutical Technology Shanghai Co ltd; Shanghai Medicilon Inc
Current assignee: Medicorp Bio Pharmaceutical Technology Shanghai Co ltd; Shanghai Medicilon Inc
Priority date: 2022-08-26
Filing date: 2022-08-26
Publication date: 2023-06-06
Anticipated expiration: 2032-08-26

Abstract

The application relates to the technical field of experimental devices, in particular to a pain measuring frame, which is particularly suitable for a pain measuring frame of a related experiment for mechanical pain measurement. The utility model provides a survey pain frame for place the animal of survey in order to test its pain threshold, includes first support and support post, first support can place the animal of survey, first support liftable setting is in on the support post.

Description

Pain measuring frame

Technical Field

The application relates to the technical field of experimental devices, in particular to a pain measurement frame, which is particularly suitable for related experiments of mechanical pain measurement.

Background

In the field of biomedical research, "pain threshold" research is of paramount importance, and its research directly affects the dosage and implementation of the relevant drugs, based on which a large number of pain threshold test trials on animals are required. Pain studies in experimental animals have focused mainly on the determination of two pain thresholds: one is a temperature pain threshold, also called cold and hot pain threshold, and the main equipment for detecting the hot pain threshold is a thermal stabbing pain instrument, which irradiates the plantar skin of a rodent with infrared light beams with certain intensity, and measures the time from the beginning of irradiation to the occurrence of foot lifting and avoiding actions of the animal due to pain; the other is a mechanical pressure pain threshold, which is called a pressure pain threshold for short, the tip of the equipment can apply pressure to the bottom surface of the hind paw of a large mouse above a filter screen with meshes with proper sizes from the lower part, and the pressure value recorded by the equipment is used for the foot contraction action caused by pain. In the pain threshold measurement of animals, it is generally necessary to place an animal to be measured, such as a mouse, in a designated space and to perform pain measurement on the sole of the mouse by using pain measurement equipment after the emotion of the mouse is stabilized.

In the existing pain measurement frame, the height of the pain measurement frame is not adjustable, so that when the pain threshold of an animal is measured, an operator is required to bend down to the lower part of the first bracket, and then a pain measurement instrument is penetrated into the sole of the animal to acquire experimental data, so that the tester bends down to lift the head to penetrate into the sole of the animal in a very strange gesture, and the pain measurement test is not facilitated for the tester.

Disclosure of Invention

The application provides a pain measurement frame to solve the technical problem that current pain measurement frame is not adjustable in height.

The application provides a survey pain frame for place to survey animal in order to test its pain threshold, a serial communication port, including first support and support post, first support is used for placing survey animal, first support liftable ground sets up on the support post.

In one embodiment, the pain measurement rack further comprises a second bracket fixedly connected with the bracket column and arranged below the first bracket.

In one embodiment, the pain measurement rack further comprises an adjusting screw which is in threaded fit with the first bracket, the second bracket is in supporting connection with the adjusting screw to ensure that the relative position of the adjusting screw and the bracket column is unchanged,

the adjusting screw can adjust the relative position of the first bracket and the adjusting screw through threads to realize that the first bracket is arranged on the bracket column in a lifting manner.

In one embodiment, the adjusting screw comprises a threaded section and a polished rod section which are connected with each other, the threaded section is in threaded fit with the first bracket, the polished rod section penetrates through the second bracket and is in rotatable fit with the second bracket, and the relative position of the adjusting screw and the second bracket is unchanged.

In one embodiment, the end of the polish rod Duan Yuan from the threaded section is provided with a turning knob.

In one embodiment, the pain measurement rack further comprises a fastening bolt, the first bracket is sleeved on the bracket column, the fastening bolt can pass through the first bracket to be abutted with the bracket column,

the fastening bolt can realize the movement or the fixation of the first bracket relative to the bracket post by changing the abutting pressure.

In one embodiment, the first bracket and/or the second bracket are/is a concave structure with four high sides, the first bracket comprises a first frame structure and a first bracket bottom plate, the second bracket comprises a second frame structure and a second bracket bottom plate, and the first bracket bottom plate and the second bracket bottom plate are respectively accommodated in the first frame structure and the second frame structure.

In one embodiment, the first bracket bottom plate is provided with a plurality of through holes to facilitate the pain measuring instrument to detect the animal to be tested, and the second bracket bottom plate can be placed with a non-porous tray to collect excreta of the animal to be tested.

In one embodiment, the pain measurement rack further comprises a test cage disposed on the first support and forming a test cavity with the first support to house the animal under test.

In one embodiment, the test cage sides are made of an opaque material.

The beneficial effects of the utility model are as follows:

the first bracket and the bracket column are arranged in a lifting manner, so that the technical problem that the existing pain measuring frame cannot be adjusted in height can be well solved;

by additionally arranging the second bracket, the second bracket is arranged below the first bracket, so that the second bracket can receive excreta of an animal to be tested on the first bracket or can be used for placing other laboratory vessels, and the utilization rate is improved;

the support columns are arranged behind the first support and the second support, so that the operation space for the testers can be provided as much as possible, and the operation efficiency is improved;

through setting up the test cage, can be better realize the detection to the animal that is surveyed.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly introduced below, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

Fig. 1 is a schematic structural view of a pain measurement rack provided in the present application.

Reference numerals:

110, a first bracket; 111, a first frame-shaped structure; 112, a first bracket floor;

120, a second bracket; 121, a second frame-shaped structure; 122, a second bracket base;

130, a support column; 131, support bars; 132, a base;

140, adjusting a screw; 141, a threaded section; 142, a polish rod segment; 143, turning the handle;

150, testing the cage;

160, fastening bolts.

Detailed Description

The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all, of the embodiments of the present application. All other embodiments, based on the embodiments herein, which are within the scope of the protection of the present application, will be within the skill of the art without inventive effort. Furthermore, it should be understood that the detailed description is presented herein for purposes of illustration and explanation only and is not intended to limit the present application. In this application, unless otherwise indicated, terms of orientation such as "upper", "lower", "left" and "right" are generally used to refer to the directions of the drawings in which the device is actually used or in an operating state.

It should be noted that the following description order of the embodiments is not intended to limit the preferred order of the embodiments of the present application. In the following embodiments, the descriptions of the embodiments are focused on, and for the part that is not described in detail in a certain embodiment, reference may be made to the related descriptions of other embodiments.

Example 1

Referring to fig. 1, a pain measuring rack is shown in the drawing, which comprises a first rack 110, a second rack 120, a rack column 130 and an adjusting screw 140, wherein the second rack 120 is arranged below the first rack 110, the rack column 130 is provided with two racks, the racks are arranged at two ends of the first rack 110 and the second rack 120, the second rack 120 is fixedly connected with the rack column 130, the first rack 110 is sleeved with the rack column 130 in a sliding manner, the first rack 110 and the second rack 120 are in a plate-shaped structure, the adjusting screw 140 comprises a thread section 141 and a polished rod section 142, the adjusting screw 140 penetrates through the second rack 120 to be in threaded connection with the first rack 110, the polished rod section 142 of the adjusting screw 140 is in rotary connection with the second rack 120, because the adjusting screw 140 is relatively fixed with the second rack 120 in height, the second rack 120 is fixedly connected with the rack column 130, when the adjusting screw 140 is rotated, the first rack 110 moves up and down along the direction of the adjusting screw 140 under the action of the threads of the adjusting screw 140 and the first rack 110, and the height of the first rack 110 is adjustable. The adjusting screw 140 bottom is circular handle, and convenience of customers rotates adjusting screw 140 in order to adjust first support 110, makes things convenient for the experimenter to operate.

Thus, by providing the first bracket 110, the second bracket 120, the bracket post 130, and the adjusting screw 140, the height adjustment of the first bracket 110 with respect to the bracket post 130 and the second bracket 120 can be well achieved.

It will be appreciated that the pain measurement rack is particularly suitable for use as a mechanical pain measurement rack: the utility model provides a first support 110 height-adjustable of pain measurement frame, be the rack that is to put the rodent of being surveyed with first support 110, when being the rack of putting the mouse for example, can make things convenient for the tester to measure through the pain measurement instrument, if carry out pain threshold test operation to the plantar of mouse through von Frey test probe, because when carrying out the measurement of animal pain threshold, need operating personnel to bend to first support 110 below, then stab the pain measurement instrument into animal plantar and acquire experimental data, when the height-unadjustable of pain measurement frame, the pain measurement frame can't be adjusted to the position that lets all testers feel comfortable, require the tester to bend to raise the head and stab the animal plantar with a very "strange" gesture simultaneously, and through this application, the tester can not need bend, can directly raise the head to stab the animal plantar after adjusting to specific height with first support 110, improve the test experience of tester in the test process.

It should be noted that, the number of the support columns 130 is preferably two, but it does not mean that the number of the support columns 130 is only two, in some specific embodiments, 1 support column 130 is disposed on the rear long sides of the first support 110 and the second support 120, at this time, the support columns 130 and the adjusting screw 140 are integrally disposed, the adjusting screw 140 is sleeved in the support columns 130, and the handle of the adjusting screw 140 is disposed at the top end of the support columns 130, the support columns 130 and the first support 110 are movably connected so that the first support 110 can move up and down relative to the support columns 130, the adjusting screw 140 is connected with the first support 110 by bolts, and the height of the first support 110 is adjustable by rotating the adjusting screw 140 to adjust the up and down positions of the first support 110; in still other embodiments, the plurality of support columns 130 may be provided on the rear long sides of the first and

second supports

110 and 120, and thus, the number and fixing positions of the support columns 130 should not be construed as limitations of the present application.

Further, the polished rod section 142 is provided with the rotation handle 143 far away from the one end of screw section 141, can better help the tester realize adjusting.

Further, the support column 130 further comprises a base 132, the support group is fixedly connected with the base 132, pulleys are arranged on the base 132 to facilitate the movement of the pain measuring frame, specifically, two universal wheels are arranged at the front two ends of the base 132, two directional wheels are arranged at the rear two ends of the base 132, and the moving efficiency of the pain measuring frame is improved while the cost is reduced.

Further, in a specific embodiment, the universal wheel includes wheel body, bogie and gag lever post, and the wheel body is installed on the bogie, gag lever post and bogie swing joint, and gag lever post can be optional with the bogie butt for the gag lever post is located when first state, gag lever post and wheel body butt for the wheel body can't rotate, near realizing fixed, when the gag lever post is located the second state, gag lever post and wheel body contactless, the wheel body free rotation realizes full angle motion function.

Still further, the base 132 is of a "U" shape, that is, the base 132 omits the transverse metal plate on the front surface of the lifting platform, and compared with the "U" shape of the base 132, the "U" shape ensures that the supporting effect of the whole pain measuring frame is not reduced, and meanwhile, the mode can further save the space occupation of the whole pain measuring frame and adapt to more application scenes.

Further, the support columns 130 are disposed at the connection points between the two sides of the first support 110 and the second support 120 and the rear long side, and the support columns 130 are formed by bending metal plates respectively connected with the sides of the support group and the rear long side, so that the support columns 130 and the first support 110 and the second support 120 can be better fixed.

It should be noted that, the connection points between the two sides of the first support 110 and the second support 120 and the rear long side are of specific significance, as described above, the tester needs to measure the sole of the animal by using the pain measurement device, if the support 130 is arranged between the front long side or the two sides, the tester is affected by using the pain measurement device to test the sole of the animal to different extent, so as to affect the testing efficiency, and therefore, the support rod of the whole testing frame needs to be moved backwards as much as possible, so that the influence of the pain measurement frame on the pain measurement experiment process is reduced.

Still further, be provided with a plurality of support bars 131 on the support post 130, can connect the reinforcement to a plurality of parts, please refer to fig. 1, in a specific embodiment, the support bar is provided with six, first support bar and second support bar one end are connected with the back long limit of second support 120, the other end is connected with support post 130, third year support bar and fourth support bar are used for fixing the back long limit of support post 130 and base 132, fourth support bar and fifth support bar are used for fixing the both sides limit of support post 130 and base 132, improve the steadiness of survey pain frame.

With continued reference to fig. 1, the first support 110 and the second support 120 are each in a concave structure with four sides high, and specifically, the first support 110 and the second support 120 include a frame structure and a partition, that is, the first support 110 includes a first frame structure 111 and a first support base 112, the second support 120 includes a second frame structure 121 and a second support base 122, and the heights of the first frame structure 111 and the second frame structure 121 are greater than the thicknesses of the first support base 112 and the second support base 122, so that the first support base 112 and the second support base 122 are accommodated in the first frame structure 111 and the second frame structure 121. Placing the article on the first and

second holders

110 and 120 can be better achieved.

Further, the first bracket bottom plate 112 is a plate structure with a plurality of through holes, and the second bracket bottom plate 122 is a detachable non-porous tray or a non-porous tray can be placed on the detachable non-porous tray; when the pain measuring rack is used as the pain measuring rack, the pain measuring equipment needs to be used by penetrating through the first support base plate 112, so that the first support base plate 112 is provided with a plurality of through holes, and meanwhile, when an animal to be measured is placed on the first support 110, the animal to be measured can continuously generate excrement, and the excrement of the animal to be measured can fall onto the second support 120 by arranging the through holes, so that the animal to be measured is convenient for a tester to clean.

Further, the top end of the bracket post 130 is provided with a fastening bolt 160, and the fastening bolt 160 passes through a screw hole on the bracket post 130 to be abutted with two ends of the first bracket 110, so that extrusion force is given to the first bracket 110 from two sides, and better fixing of the first bracket 110 is realized.

Still further, the first frame structure 111 has a certain height, so that the fastening bolt 160 can be adjusted in the height of the first frame structure 111, and the fastening bolt 160 can also adjust the height of the first bracket, which can also adjust the height of the first bracket 110 without the adjusting screw 140, but can only be adjusted in the range of the height of the first bracket above and below the horizontal plane in which the fastening bolt 160 is located.

Further, the pain measuring rack further comprises a test cage 150, the bottom of the test cage 150 is provided with an opening, and the test cage 150 is arranged on the first bracket 110 and then forms a test cavity for accommodating the tested animal with the first bracket 110, so that a tester can conveniently test the tested animal.

Still further, a plurality of test cages 150 are provided that can accommodate a plurality of animals under test for measurement.

Still further, the side of the test cage 150 is made of opaque material, preferably a frosted material, and the top is still made of transparent material, preferably a transparent plastic plate, so that animals can be better blocked from observing each other to influence the behavior, and meanwhile, the light penetration and the experimenter observation are not influenced, and the test accuracy is improved.

Further, the size of the rear long side of the base 132, the first support 110 and the second support 120 is preferably 165cm, the distance from the second support 120 to the horizontal plane is 90cm, the distance from the first support 110 to the horizontal plane is preferably 130-180cm, and the test cage 150 is preferably a cuboid-shaped box body with the length of 40cm, the height of 40cm and the width of 6-25 cm.

It should be understood that the test cage 150 is not necessary, and is intended to limit the movement of the animal under test, and in a specific embodiment, the first frame structure 111 is higher and has the same height as the test cage, so that the first frame structure has the function of the test cage 150, which is not limited by the present utility model.

Example 2

The difference between the present embodiment and embodiment 1 is that the present embodiment provides another lifting manner of the first bracket 110.

In this embodiment, the adjusting screw 140 is an embodiment, which is not necessary, and the fixing is mainly implemented by a locking bolt, specifically: the first bracket 110 is provided with a connecting strip at the joint with the bracket column 130, two ends of the connecting strip are contacted with two ends of the first frame-shaped structure, the middle of the connecting strip is not contacted with the first frame-shaped connecting structure to form a through cavity so that the bracket column 130 is arranged in the cavity in a penetrating way, the connecting strip is provided with a threaded hole, a fastening bolt 160 is abutted with the bracket column 130 through the threaded hole, namely the bracket column 130 is sleeved in the first bracket 110, the fastening bolt 160 passes through the first bracket 110 and is abutted with the bracket column 130, when the height of the first bracket 110 needs to be adjusted, the fastening bolt 160 is unscrewed to move the first bracket 110 up and down on the bracket column 130, and after the position of the first bracket 110 is determined, the fastening bolt 160 is screwed down so that the first bracket 110 and the bracket column 130 are relatively fixed.

Further, a plurality of bolt holes matched with the fastening bolts 160 are formed in the support columns 130, and when the first support 110 moves to a designated position, the fastening bolts 160 are in bolt connection with the support columns 130, so that the connection strength is improved.

It should be noted that other ways of moving the first bracket 110 up and down on the bracket post 130 in the present application also fall within the scope of protection of the present application, for example, in one embodiment, the first bracket 110 is driven by a motor to move up and down relative to the bracket post 130, and in another embodiment, the first bracket 110 is driven by a hydraulic lifting device to move up and down relative to the bracket post 130, which is not limited by the present utility model.

It can be understood that in embodiment 1, the adjusting screw 140 solves the problem of how to achieve lifting of the first bracket 110 relative to the bracket post 130, and the fastening bolt 160 may be provided or the fastening bolt 160 may not be provided, and the fastening bolt 160 solves the problem of how to better fix the first bracket 110 and the bracket post after the height of the adjusting screw 140 is adjusted; in embodiment 2, the fastening bolt 160 solves the problem of how to achieve lifting of the first bracket 110 relative to the bracket post 130, and the adjusting screw 140 may be provided or the adjusting screw 140 may not be provided, and the adjusting screw 140 solves the problem of how to better adjust and fix the first bracket 110 and the bracket post 130.

The foregoing has outlined rather broadly the more detailed description of the present application, and the detailed description of the principles and embodiments herein has been given using specific examples, which are included to provide an additional understanding of the method and concepts of the present application; meanwhile, as those skilled in the art will have modifications in the specific embodiments and application scope in accordance with the ideas of the present application, the present description should not be construed as limiting the present application in view of the above.

Claims

1. The utility model provides a survey pain frame for place and survey animal in order to test its pain threshold, its characterized in that includes first support (110) and support post (130), first support (110) can place survey animal, first support (110) liftable ground sets up on support post (130), survey pain frame still includes second support (120), second support (120) with support post (130) fixed connection, and set up the below of first support (110).

2. The pain management frame as recited in claim 1, further comprising an adjustment screw (140), the adjustment screw (140) being threadably engaged with the first bracket (110), the second bracket (120) being in supporting connection with the adjustment screw (140) to ensure that the relative position of the adjustment screw (140) to the bracket post (130) is unchanged;

the adjusting screw (140) can adjust the relative position of the first bracket (110) and the adjusting screw (140) through threads so that the first bracket (110) can be arranged on the bracket column (130) in a lifting manner.

3. The pain management frame as recited in claim 2, wherein the adjustment screw (140) includes a threaded section (141) and a polished rod section (142) connected to each other, the threaded section (141) being threadably engaged with the first bracket (110), the polished rod section (142) passing through the second bracket (120) and being rotatably engaged with the second bracket (120), the relative position of the adjustment screw (140) and the second bracket (120) being unchanged.

4. A pain management frame as claimed in claim 3, wherein the end of the polish rod section (142) remote from the threaded section (141) is provided with a turning handle (143).

5. The pain measurement rack according to claim 1 or 2, further comprising a fastening bolt (160), wherein the first bracket (110) is sleeved on the bracket post (130), the fastening bolt (160) can pass through the first bracket (110) to be abutted with the bracket post (130),

the fastening bolt (160) enables a movement or fixation of the first bracket (110) relative to the bracket post (130) by varying an abutment pressure.

6. The pain management frame as claimed in claim 2, wherein the first support (110) and/or the second support (120) are/is of a concave structure with four sides high, the first support (110) comprises a first frame structure (111) and a first support base plate (112), the second support (120) comprises a second frame structure (121) and a second support base plate (122), and the first support base plate (112) and the second support base plate (122) are respectively accommodated in the first frame structure (111) and the second frame structure (121).

7. The pain management rack as recited in claim 6, wherein the first rack (110) has a plurality of through holes formed in a bottom plate thereof for facilitating the detection of the animal by the pain management instrument, and wherein the bottom plate of the second rack (120) is capable of placing a non-porous tray for collecting excreta of the animal.

8. The pain management rack of claim 1, further comprising a test cage (150), wherein the test cage (150) is disposed on the first support (110) and forms a test cavity with the first support (110) to house the animal under test.

9. A pain management frame as claimed in claim 8, wherein the sides of the test cage (150) are made of opaque material.