CN218989244U

CN218989244U - Multichannel bioreactor

Info

Publication number: CN218989244U
Application number: CN202223518256.0U
Authority: CN
Inventors: 刘伟; 鄢晓君; 郝钒宇; 刘欣
Original assignee: Tianjin Huakan Intelligent Technology Co ltd
Current assignee: Tianjin Huakan Intelligent Technology Co ltd
Priority date: 2022-12-28
Filing date: 2022-12-28
Publication date: 2023-05-09
Anticipated expiration: 2032-12-28

Abstract

The utility model relates to the technical field of bioreactors, in particular to a multichannel bioreactor, which comprises a sealing shell, wherein the sealing shell comprises a workbench and a positioning assembly, the positioning assembly is positioned on the upper surface of the workbench, the positioning assembly comprises a positioning cylinder, a limit groove is formed in the inner wall of the positioning cylinder, a coil spring shaft is connected to the inner wall of the limit groove, a hinge rod is sleeved outside the coil spring shaft, the other end of the hinge rod is connected with a clamping wheel, a telescopic rod is connected between the hinge rod and the positioning cylinder, and a guide rod is connected to the inner wall of the positioning cylinder. The utility model realizes the auxiliary positioning of the reaction bottle through the arrangement of the positioning component, ensures the high stability of stirring operation of the reaction bottle, can adapt to the reaction bottles with different diameters to carry out clamping positioning, has wide application range and good integral sealing performance, and is convenient to use in a high-humidity environment.

Description

Multichannel bioreactor

Technical Field

The utility model relates to the technical field of bioreactors, in particular to a multichannel bioreactor.

Background

The bioreactor is specially designed for the suspension culture of adherent cells, the device enhances the fluidity of the culture solution around the cells by a suspension culture mode of ultra-low speed stirring, and is suitable for the suspension culture of adherent cells and microcarriers, the suspension culture of single suspension cells, the balling suspension culture of special cells, the virus infection research, the cell expansion culture, the fermentation and other processes.

When the existing bioreactor is used for stirring the cell culture solution in the reaction bottle, the reaction bottle is directly placed above the operation panel, and the existing bioreactor is not provided with a certain auxiliary positioning structure, so that the reactor is impacted on the reaction bottle due to the flow of the liquid in the reaction bottle when the reactor is used for stirring at a low speed, the reaction bottle moves in position, and the accuracy of stirring treatment is reduced, and therefore, a multichannel bioreactor is needed to be designed to solve the problems.

Disclosure of Invention

The utility model aims to provide a multichannel bioreactor, which solves the problem that the prior bioreactor proposed in the background art does not have a certain auxiliary positioning structure, so that the reactor causes the position movement of a reaction bottle when the reactor is subjected to low-speed stirring treatment.

In order to achieve the above purpose, the present utility model provides the following technical solutions: a multi-channel bioreactor, comprising:

the sealing shell comprises a workbench, wherein the bottom of the workbench is connected with a second shell, two sides of the workbench are connected with a first shell, and the bottoms of the second shell and the first shell are connected with rubber pads;

the positioning assembly is positioned on the upper surface of the workbench and comprises a positioning barrel, a limit groove is formed in the inner wall of the positioning barrel, a coil spring shaft is connected to the inner wall of the limit groove, a hinge rod is sleeved outside the coil spring shaft, a clamping wheel is connected to the other end of the hinge rod, a telescopic rod is connected between the hinge rod and the positioning barrel, and a guide rod is connected to the inner wall of the positioning barrel.

Preferably, a sealing gasket is arranged on one side of the workbench, which is in contact with the first shell, a sealing gasket is arranged on one side of the workbench, which is in contact with the second shell, and the first shell and the second shell are connected with the workbench through screws.

Preferably, the lower surface of rubber pad is provided with anti-skidding line, the rubber pad passes through the lower surface of screw connection at the second casing, the second casing is in same horizontal line with the bottom of first casing.

Preferably, the positioning assembly is matched with the positioning lines on the upper surface of the workbench, the positioning lines and the positioning cylinder are positioned on the same axis, and the positioning cylinder is connected to the upper surface of the workbench.

Preferably, six groups of limit grooves are uniformly formed in the positioning cylinder, the internal structures of the six groups of limit grooves are the same, a through hole is formed in the limit groove, a coil spring shaft is inserted in the through hole, the positioning cylinder is rotationally connected with the coil spring shaft, and coil springs are arranged at two ends of the coil spring shaft.

Preferably, one end of the hinging rod far away from the coil spring shaft is connected with two clamping wheels through a rotating pin, the outer wall of each clamping wheel is provided with a soft rubber pad, two guide rods are arranged in total, the two guide rods are respectively positioned on two sides of the hinging rod, and the hinging rod is in sliding connection with the guide rods.

Compared with the prior art, the utility model has the beneficial effects that: this multichannel bioreactor passes through positioning component's setting, realizes the assistance-localization real-time to the reaction bottle, guarantees its stirring work's high stability, can adapt to the reaction bottle of different diameters simultaneously and carry out the centre gripping location, and application scope is wide, and the whole leakproofness of device is good, is convenient for use under the high humidity environment.

(1) According to the utility model, the auxiliary limit can be carried out on the reaction bottles placed above the workbench through the arrangement of the positioning assembly, so that the placement stability of the reaction bottles is ensured, the position movement of the reaction bottles during working is avoided, and meanwhile, the positioning assembly adopts a hinged clamping mode and can be suitable for clamping and limiting the reaction bottles with different diameters.

(2) According to the utility model, through the arrangement of the sealing shell and the extrusion positioning of the sealing gaskets among the connecting plates, the overall sealing performance of the reactor is greatly improved, so that the reactor can be suitable for use in a high-humidity environment.

Drawings

FIG. 1 is a schematic diagram of the overall structure of the present utility model;

FIG. 2 is a schematic view of the explosion structure of the seal housing of the present utility model;

FIG. 3 is a schematic cross-sectional view of a positioning assembly of the present utility model;

fig. 4 is a schematic view of a hinge rod connection structure according to the present utility model.

In the figure: 1. a seal housing; 11. a work table; 12. a first housing; 13. a second housing; 14. a rubber pad; 2. a positioning assembly; 21. a positioning cylinder; 22. a limit groove; 23. a coil spring shaft; 24. a hinge rod; 25. a clamping wheel; 26. a guide rod; 27. a telescopic rod.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to fig. 1-4, an embodiment of the present utility model is provided: a multi-channel bioreactor, comprising: the work table 11, the telescopic rod 27, the coil spring shaft 23 and the external coil springs used in the present application are all commercially available products, and the principle and the connection manner thereof are all well known to those skilled in the art, so that they are not described in detail herein,

the sealing shell 1, the sealing shell 1 comprises a workbench 11, the bottom of the workbench 11 is connected with a second shell 13, two sides of the workbench 11 are connected with a first shell 12, the bottoms of the second shell 13 and the first shell 12 are connected with rubber pads 14, and the sealing shell 1 adopts a spliced structure, so that the overhaul of internal parts is facilitated;

the locating component 2, locating component 2 is in the upper surface of workstation 11, locating component 2 includes positioning tube 21, spacing groove 22 has been seted up to the inner wall of positioning tube 21, the inner wall of spacing groove 22 is connected with wind spring axle 23, the articulated pole 24 has been cup jointed to the outside of wind spring axle 23, the other end of articulated pole 24 is connected with centre gripping wheel 25, be connected with telescopic link 27 between articulated pole 24 and the positioning tube 21, the inner wall of positioning tube 21 is connected with guide bar 26, through the setting of this structure, can realize carrying out the assistance-localization real-time to the reaction bottle, guarantee the stability of its work, simultaneously through articulated cooperation of articulated pole 24 and centre gripping wheel 25, the reaction bottle of different diameters of can adaptation uses.

Further, the sealing gaskets are arranged on the side, which is in contact with the first shell 12, of the workbench 11, the sealing gaskets are arranged on the side, which is in contact with the second shell 13, of the workbench 11, the first shell 12 and the second shell 13 are connected with the workbench 11 through screws, and the sealing gaskets are arranged, so that the sealing performance of the workbench after being connected and extruded with each other is improved, and the reactor can be used in a high-humidity environment in a matching mode.

Further, the lower surface of rubber pad 14 is provided with anti-skidding line, and rubber pad 14 passes through the lower surface of screw connection at second casing 13, and second casing 13 is in same horizontal line with the bottom of first casing 12, and the setting of anti-skidding line can improve its frictional force with the desktop, improves the stability that the reactor desktop was placed.

Further, the positioning assembly 2 is matched with the positioning lines on the upper surface of the workbench 11, the positioning lines are located on the same axis with the positioning cylinder 21, the positioning cylinder 21 is connected to the upper surface of the workbench 11, and the mutual matching of the positioning assembly 2 and the placement point above the workbench 11 is ensured.

Further, six groups of limit grooves 22 are evenly formed in the positioning cylinder 21, the internal structures of the six groups of limit grooves 22 are the same, through holes are formed in the limit grooves 22, the coil spring shafts 23 are inserted in the through holes, the positioning cylinder 21 is rotationally connected with the coil spring shafts 23, coil springs are arranged at two ends of the coil spring shafts 23, the hinge rod 24 can rebound towards the axis of the positioning cylinder 21 through the mutual matching of the coil spring shafts 23 and the coil springs, so that automatic clamping of the hinge rod is guaranteed, and shrinkage is realized through pressing, clamping and positioning of reaction bottles with different diameters are guaranteed, anti-skidding lines are formed in the surfaces of the clamping wheels 25, and stability after clamping is guaranteed.

Further, one end of the hinging rod 24 far away from the coil spring shaft 23 is connected with two clamping wheels 25 through a rotating pin, the outer wall of each clamping wheel 25 is provided with a soft rubber pad, two guide rods 26 are arranged on two sides of the hinging rod 24 respectively, the hinging rod 24 is in sliding connection with the guide rods 26, the hinging rotation of the hinging rod 24 can be realized through the arrangement of the guide rods 26, the auxiliary limiting is carried out, and the hinging stability of the hinging rod is guaranteed.

Working principle: when the utility model is used, the reaction bottle is inserted along the center of the positioning cylinder 21, when the reaction bottle contacts the clamping wheel 25, the reaction bottle is continuously pressed down, the hinging rotation of the hinging rod 24 and the clamping wheel 25 can be realized, and then the clamping wheel 25 is pressed and clamped on the outer wall of the reaction bottle when the reaction bottle is pressed down, so that the auxiliary positioning of the reaction bottle is completed, and the stable work of the reactor can be realized.

It will be evident to those skilled in the art that the utility model is not limited to the details of the foregoing illustrative embodiments, and that the present utility model may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the utility model being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. A multi-channel bioreactor, comprising:

the sealing device comprises a sealing shell (1), wherein the sealing shell (1) comprises a workbench (11), the bottom of the workbench (11) is connected with a second shell (13), two sides of the workbench (11) are connected with a first shell (12), and rubber pads (14) are connected with the bottoms of the second shell (13) and the first shell (12);

positioning component (2), positioning component (2) are in the upper surface of workstation (11), positioning component (2) are including positioning tube (21), spacing groove (22) have been seted up to the inner wall of positioning tube (21), the inner wall of spacing groove (22) is connected with wind spring axle (23), articulated pole (24) have been cup jointed to the outside of wind spring axle (23), the other end of articulated pole (24) is connected with clamping wheel (25), be connected with telescopic link (27) between articulated pole (24) and positioning tube (21), the inner wall of positioning tube (21) is connected with guide bar (26).

2. A multi-channel bioreactor as claimed in claim 1, wherein: sealing gaskets are arranged on the sides, which are in contact with the first shell (12), of the workbench (11), sealing gaskets are arranged on the sides, which are in contact with the second shell (13), of the workbench (11), and the first shell (12) and the second shell (13) are connected with the workbench (11) through screws.

3. A multi-channel bioreactor as claimed in claim 1, wherein: the anti-skid rubber pad is characterized in that anti-skid patterns are formed in the lower surface of the rubber pad (14), the rubber pad (14) is connected to the lower surface of the second shell (13) through screws, and the bottoms of the second shell (13) and the first shell (12) are located on the same horizontal line.

4. A multi-channel bioreactor as claimed in claim 1, wherein: the positioning assembly (2) is matched with positioning lines on the upper surface of the workbench (11), the positioning lines and the positioning cylinder (21) are positioned on the same axis, and the positioning cylinder (21) is connected to the upper surface of the workbench (11).

5. A multi-channel bioreactor as claimed in claim 1, wherein: six groups of limit grooves (22) are uniformly formed in the positioning cylinder (21), the internal structures of the six groups of limit grooves (22) are identical, a through hole is formed in the limit groove (22), a coil spring shaft (23) is inserted into the through hole, the positioning cylinder (21) is rotationally connected with the coil spring shaft (23), and coil springs are arranged at two ends of the coil spring shaft (23).

6. A multi-channel bioreactor as set forth in claim 5, wherein: one end of the hinging rod (24) far away from the coil spring shaft (23) is connected with two clamping wheels (25) through a rotating pin, soft rubber mats are arranged on the outer walls of the clamping wheels (25), two guide rods (26) are arranged in total, the two guide rods (26) are respectively arranged on two sides of the hinging rod (24), and the hinging rod (24) is in sliding connection with the guide rods (26).