CN218969208U

CN218969208U - Prothrombin complex adsorption separation device

Info

Publication number: CN218969208U
Application number: CN202223504810.XU
Authority: CN
Inventors: 欧长军; 言启全; 曾梅琴
Original assignee: Hunan Yige Pharmaceutical Co ltd
Current assignee: Hunan Yige Pharmaceutical Co ltd
Priority date: 2022-12-27
Filing date: 2022-12-27
Publication date: 2023-05-05
Anticipated expiration: 2032-12-27

Abstract

The utility model relates to a prothrombin compound adsorption and separation device which comprises a separation cylinder, wherein the top of the separation cylinder is fixedly connected with a motor, the bottom of a stirring support is fixedly connected with a coupler, and the bottom of the coupler is fixedly connected with a stirring rotating shaft. This prothrombin complex adsorbs separator, through setting up the motor, the start-up of motor drives stirring support, stirring support and drive stirring pivot and stirring bull stick simultaneously in the inside stirring of separating tube, realize carrying out absorptive process to plasma, and through pumping the passageway, other jars pump in different eluents, elute prothrombin complex from absorptive medium, accomplish prothrombin complex's adsorption separation operation, whole process can realize prothrombin complex's adsorption separation power and accomplish in the inside of separating tube simultaneously, operating time has been practiced thrift, and the risk of the pollution that produces in the adsorption separation process has been reduced, realize closed adsorption separation operation.

Description

Prothrombin complex adsorption separation device

Technical Field

The utility model relates to the technical field of biochemical engineering, in particular to a prothrombin complex adsorption separation device.

Background

Thrombin powder is a white or off-white freeze-dried cake or powder, thrombin as a bioactive substance is a bioactive protein having an important role in the coagulation cascade of anticoagulation and coagulation acceleration in humans, thrombin is a serine protease, and is also the main effector protease in the blood coagulation cascade, exhibiting coagulation acceleration and anticoagulation properties, and thrombin aggregates on tissue when circulating coagulation factors contact tissue factors in exposed extravascular tissues, and thrombin catalyzes conversion of fibrinogen to fibrin by activating platelets.

Compared with the traditional workshop mode, which is used for most of the industries, the adsorption filler and the extracting solution of the former process are mixed, filtered by a screen, and then stirred, eluted and filtered to obtain the eluent, the mode has the defects of unchanged operation, high labor intensity and low working efficiency, and part of factories adopt a chromatographic column mode to replace the traditional workshop mode, and the operation time is longer and the efficiency is lower due to the characteristic of the adsorption filler although the labor intensity is improved, so that the prothrombin compound adsorption and separation device is necessary to solve the problems.

Disclosure of Invention

Aiming at the defects of the prior art, the utility model provides a prothrombin compound adsorption and separation device which has the advantages of simple operation, capability of improving the adsorption and separation efficiency and the like, and solves the problems of complex adsorption and separation operation and low working efficiency in the prior art.

In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides a prothrombin complex adsorbs separator, includes the separating drum, the top fixedly connected with motor of separating drum, the output shaft department fixedly connected with reduction gear of motor, the bottom fixedly connected with stirring support of reduction gear, the bottom fixedly connected with shaft coupling of stirring support, the bottom fixedly connected with stirring pivot of shaft coupling, the surface fixedly connected with stirring bull stick of stirring pivot, the manhole has been seted up to the left surface of separating drum, the absorption filler entry has been seted up at the top of separating drum, the top fixedly connected with pump pipeline of separating drum.

Further, the bottom joint of separating tube has the joint board, movable mounting has the buckle structure between the bottom of joint board and separating tube.

Further, a filter bag is installed at the inner bottom of the separating cylinder, and a rotating plate is fixedly connected to the bottom of the stirring rotating shaft.

Further, the rotating plate is positioned at the top of the filter bag, and the distance between the rotating plate and the filter bag is two millimeters.

Further, be detachable structure between stirring bull stick, stirring pivot and the shaft coupling, the top fixedly connected with inlet pipe of separating drum.

Further, sealing rings are arranged between the filter bag and the bottom of the separating cylinder, and the clamping plates and the sealing rings are connected with the fixing plate of the separating cylinder through clamping structures.

Further, the manhole is welded with the left side surface of the separating cylinder, and a compression pipeline and an outflow pipeline are welded at the bottom of the separating cylinder.

Compared with the prior art, the technical scheme of the application has the following beneficial effects:

this prothrombin complex adsorption separation device through setting up the motor, when using, directly add plasma through the inlet pipe, and throw into the adsorption packing through the adsorption packing entry, the start of motor drives stirring support, stirring support and drive stirring pivot and stirring bull stick simultaneously in the inside stirring of separating tube, realize carrying out the absorbing process to plasma, and pump into different eluents through pumping channel, other jars, elute prothrombin complex from absorbing medium, accomplish prothrombin complex's adsorption separation operation, whole process can realize prothrombin complex's adsorption separation power and accomplish in the inside of separating tube simultaneously, operating time has been practiced thrift, and the risk of the pollution that produces in the adsorption separation process has been reduced, closed adsorption separation operation has been realized, reduce the loss of adsorption medium.

Drawings

FIG. 1 is a perspective view of the structure of an adsorption separation device of the present utility model;

FIG. 2 is a front cross-sectional view of the adsorption separation device of the present utility model;

FIG. 3 is a schematic diagram of the adsorption separation device according to the present utility model.

In the figure: 1. a separation cylinder; 2. a clamping plate; 3. a buckle structure; 4. a manhole; 5. an adsorptive filler inlet; 6. pumping into a pipeline; 7. a motor; 8. a speed reducer; 9. stirring the support; 10. a coupling; 11. a stirring rotating shaft; 12. a stirring rotating rod; 13. compressing the pipeline; 14. an outflow conduit; 15. a rotating plate; 16. and (5) filtering the bag.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

Referring to fig. 1-3, a prothrombin complex adsorption and separation device in this embodiment includes a separation barrel 1, a motor 7 is fixedly connected to the top of the separation barrel 1, a speed reducer 8 is fixedly connected to an output shaft of the motor 7, a stirring support 9 is fixedly connected to the bottom of the speed reducer 8, a coupling 10 is fixedly connected to the bottom of the stirring support 9, a stirring rotating shaft 11 is fixedly connected to the bottom of the coupling 10, a stirring rotating rod 12 is fixedly connected to the outer surface of the stirring rotating shaft 11, a manhole 4 is provided on the left side surface of the separation barrel 1, an adsorption filler inlet 5 is provided on the top of the separation barrel 1, and a pumping pipeline 6 is fixedly connected to the top of the separation barrel 1.

In the specific implementation, the motor 7 is arranged, the plasma is directly added through the feed pipe, the adsorption filler is input through the adsorption filler inlet 5, the stirring support 9 is driven by the starting of the motor 7, the stirring support 9 drives the stirring rotating shaft 11 and the stirring rotating rod 12 to stir in the separating cylinder 1 at the same time, the process of adsorbing the plasma is realized, different eluents are pumped into other tanks through the pumping channel 6, the prothrombin complex is eluted from the adsorbed medium, the adsorption separation operation of the prothrombin complex is completed, the adsorption separation force of the prothrombin complex is completed in the separating cylinder 1 at the same time in the whole process, the operation time is saved, the pollution risk generated in the adsorption separation process is reduced, the closed adsorption separation operation is realized, and the loss of the adsorption medium is reduced;

through setting up stirring pivot 11 and stirring bull stick 12 and all being assembled formula stirring structure, can more facilitate the user to can assemble at any time and dismantle the process to can be fixed in stirring pivot 11 the bottom of stirring support 9 through shaft coupling 10, have two millimeters through the interval between rotor plate 15 and filter bag 16, rotor plate 15 can make the medium thickness at filter bag 16 top thin, influences the filter effect of filter bag 16, avoids rotor plate 15 to cause the injury to filter plate 16 surface simultaneously;

can throw into the inside of separating drum 1 with the adsorption packing through adsorption packing entry 5, through the setting of manhole 4, can be after finding that adsorption packing has the damage, can press compressed air earlier and fall water, come out the adsorption packing blowing from manhole 4 again, when the condition of jam appears, can compress air through compression pipe 13, realize at last that the blowback avoids the condition of jam to take place, through buckle structure 3's setting, the convenience is changed the dismantlement of filter bag 16.

In practice, the method is carried out according to the following steps:

1) Firstly, directly adding plasma through a feed pipe, and adding an adsorption filler through an adsorption filler inlet 5;

2) Then, the motor 7 is started to drive the stirring support 9, and the stirring support 9 drives the stirring rotating shaft 11 and the stirring rotating rod 12 to stir in the separating cylinder 1 at the same time;

3) Pumping different eluents into other tanks through a pumping channel 6;

4) Finally, eluting the prothrombin complex from the adsorbed medium to finish the adsorption separation operation of the prothrombin complex.

In summary, this prothrombin complex adsorption separation device, through setting up motor 7, when using, directly add plasma through the inlet pipe, and throw in the adsorption packing through adsorption packing entry 5, motor 7's start drives stirring support 9, stirring support 9 and drive stirring pivot 11 and stirring bull stick 12 simultaneously in the inside stirring of separating tube 1, realize carrying out the absorbing process to plasma, and pass through pumping channel 6, other jars pump into different eluents, elute prothrombin complex from the medium of absorption, accomplish prothrombin complex's adsorption separation operation, whole process can realize prothrombin complex's adsorption separation power and accomplish in separating tube 1's inside simultaneously, operating time has been practiced thrift, and the risk of the pollution that produces in the adsorption separation process has been realized the closed adsorption separation operation, reduce the loss of adsorption medium.

It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.

Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A prothrombin complex adsorption separation device comprising a separation cartridge (1), characterized in that: the utility model discloses a separation tube, including separating tube (1), manhole (4) have been seted up to the top fixedly connected with motor (7), output shaft department fixedly connected with reduction gear (8) of motor (7), the bottom fixedly connected with stirring support (9) of reduction gear (8), the bottom fixedly connected with shaft coupling (10) of stirring support (9), the bottom fixedly connected with stirring pivot (11) of shaft coupling (10), the surface fixedly connected with stirring bull stick (12) of stirring pivot (11), manhole (4) have been seted up to the left surface of separating tube (1), absorption filler entry (5) have been seted up at the top of separating tube (1), pipeline (6) are gone into in the top fixedly connected with pump of separating tube (1).

2. The prothrombin complex adsorption separation device according to claim 1, wherein: the bottom joint of separating tube (1) has joint board (2), movable mounting has buckle structure (3) between the bottom of joint board (2) and separating tube (1).

3. The prothrombin complex adsorption separation device according to claim 1, wherein: the filter bag (16) is installed at the inner bottom of the separating cylinder (1), and the bottom of the stirring rotating shaft (11) is fixedly connected with a rotating plate (15).

4. The prothrombin complex adsorption separation device according to claim 3, wherein: the rotating plate (15) is positioned at the top of the filter bag (16), and the distance between the rotating plate (15) and the filter bag (16) is two millimeters.

5. The prothrombin complex adsorption separation device according to claim 1, wherein: the stirring rotating rod (12), the stirring rotating shaft (11) and the coupler (10) are of a detachable structure, and the top of the separating cylinder (1) is fixedly connected with a feeding pipe.

6. The prothrombin complex adsorption separation device according to claim 1, wherein: sealing rings are arranged between the filter bags (16) and the bottom of the separating cylinder (1), and the clamping plates (2) and the sealing rings are connected with the fixing plates of the separating cylinder (1) through clamping structures (3).

7. The prothrombin complex adsorption separation device according to claim 1, wherein: the manhole (4) is welded with the left side surface of the separating cylinder (1), and a compression pipeline (13) and an outflow pipeline (14) are welded at the bottom of the separating cylinder (1).