CN218967469U

CN218967469U - Multi-project joint inspection kit and detection device

Info

Publication number: CN218967469U
Application number: CN202223483643.5U
Authority: CN
Inventors: 黎丽曼; 陈明
Original assignee: Shenzhen Jinrui Biotechnology Co ltd
Current assignee: Shenzhen Jinrui Biotechnology Co ltd
Priority date: 2022-12-21
Filing date: 2022-12-21
Publication date: 2023-05-05
Anticipated expiration: 2032-12-21

Abstract

The utility model discloses a multi-item joint inspection kit, which is characterized by comprising the following components: support plate group and reagent nest of tubes, the support plate group includes: the device comprises a sample tube carrier plate, a component carrier plate detachably connected with the sample tube carrier plate and a detection tube carrier plate detachably connected to the other end of the component carrier plate relative to the sample tube carrier plate, wherein the component carrier plate comprises a plurality of component carrier plates which are mutually detachably connected, and corresponding hole sites are formed in a carrier plate group; the reagent tube set includes: sample pipe, component pipe, washing pipe and detection tube, sample pipe installs in the sample downthehole, and the component pipe is equipped with a plurality ofly, and a plurality of component pipes are installed in the component downthehole, and the washing pipe is installed in the washing downthehole, and the detection tube is equipped with a plurality ofly, and a plurality of detection tubes are installed in a plurality of detection downthehole. By additionally arranging the component holes and the detection holes for the reaction components of the object to be detected, synchronous detection of a plurality of target objects to be detected is realized, the use amount of samples is reduced, and the detection efficiency is improved.

Description

Multi-project joint inspection kit and detection device

Technical Field

The utility model relates to the field of automatic determination kits, in particular to a multi-item joint inspection kit and a detection device.

Background

Along with the development of science and technology and the rapid promotion of medical technology, full-automatic detection device has been widely used in hospitals, clinics and epidemic prevention departments because of its advantages of fast measurement speed and high accuracy, and correspondingly, various detection type kits matched with the full-automatic detection device have also been developed.

In the prior art, most of common detection kits are single target to-be-detected kits, the obtained analyzable data are single and incomplete, detection of multiple composite indexes cannot be dealt with, when multiple projects are detected, a large sample size is needed, and multiple kits are needed for detection, so that more troubles are brought to operation, and the transportation and storage costs of the kits are increased.

Meanwhile, in some situations where peripheral blood detection is needed, such as detecting inflammation indexes of children's physical examination or infants, because the sample size is extremely rare, and often when multiple items are needed to be detected, a joint detection device is particularly needed to realize as few sample dead volumes as possible and as many detection items as possible.

Disclosure of Invention

The utility model provides a multi-project joint inspection kit, which aims to solve the related technical problems, and solves the technical problems of how to influence the detection efficiency, waste of sample size and detection cost due to the need of using a plurality of kits and how to conveniently operate the kit in the joint inspection of different projects under the field of automatic detection of multi-project joint inspection.

The technical scheme of the utility model is as follows:

a multi-project joint inspection kit comprising: the support plate group, the support plate group includes: the device comprises a sample tube carrier plate, a component carrier plate detachably connected with the sample tube carrier plate and a detection tube carrier plate detachably connected with the other end of the component carrier plate relative to the sample tube carrier plate, wherein one or more component carrier plates are arranged, a plurality of component carrier plates are mutually detachably connected, sample holes are formed in the sample tube carrier plate, a plurality of component holes are formed in one or more component carrier plates, and washing holes and a plurality of detection holes are formed in the detection tube carrier plate;

a reagent tube set, the reagent tube set comprising: sample pipe, component pipe, washing pipe and detection tube, the sample pipe is installed in the sample hole, the component pipe is provided with a plurality of, a plurality of the component pipe is installed in the component hole, the washing pipe is installed in the washing hole, the detection tube is provided with a plurality of, a plurality of the detection tube is installed in a plurality of the detection hole.

Further, the plurality of component tubes include a marker tube, a magnetic bead tube, and a reaction tube, which are respectively installed in the plurality of component holes on the plurality of component carrier plates.

Still further, the label tube includes a biotin tube for placing biotin, and the label tube, the biotin tube, the magnetic bead tube, the reaction tube, and the washing tube are all provided in plurality.

Further, the bottom surfaces of the sample tube, the component tube and the washing tube are located on the same horizontal plane.

Furthermore, the multi-project joint inspection kit is further provided with a partition plate for preventing liquid leakage, the partition plate is relatively arranged at two sides of the sample hole, and the partition plate can be a raised partition plate or a groove type partition.

Further, the multi-item joint inspection kit further comprises a handle, and anti-skid patterns are arranged on the handle.

The utility model also provides a detection device, and the detection device comprises the multi-item joint inspection kit.

The utility model has the beneficial effects that: compared with the prior art, the kit can improve the problem that a plurality of kits are needed in multi-project joint inspection by adding the component holes and the detection holes for the reaction components of the objects to be detected and designing the component carrier plate into a structure with detachable connection and hole site amplification so as to realize synchronous detection of a plurality of objects to be detected, thereby saving the use amount of samples, improving the detection efficiency and saving the cost of the kits.

Drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a front view of a multi-project joint inspection kit of the present utility model.

FIG. 2 is a top view of a multi-project joint inspection kit of the present utility model.

FIG. 3 is a front view of another embodiment of a multi-project joint inspection kit of the present utility model.

Reference numerals illustrate:

a sample tube carrier plate 1; a component carrier plate 2; a detection tube carrier plate 3; a sample hole 4; component hole 5; a washing hole 6; a detection hole 7; a sample tube 8; a component tube 9; a marker tube 10; a biotin tube 11; a magnetic bead tube 12; a reaction tube 13; a wash pipe 14; a detection tube 15; a partition plate 16; a grip 17; anti-skid threads 18.

The achievement of the objects, functional features and advantages of the present utility model will be further described with reference to the accompanying drawings, in conjunction with the embodiments.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the utility model. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

It should be noted that, if directional indications (such as up, down, left, right, front, and rear … …) are included in the embodiments of the present utility model, the directional indications are merely used to explain the relative positional relationship, movement conditions, etc. between the components in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are correspondingly changed.

In this embodiment, referring to fig. 1 and 2, the multi-project joint inspection kit includes a carrier plate group and a reagent tube group;

the carrier plate component is divided into three parts, including: sample pipe carrier plate 1, component carrier plate 2 and detect pipe carrier plate 3, the triplex can dismantle in proper order and connect in an organic wholely, realizes the carrier plate part overall structure of kit, wherein, component carrier plate 2 is provided with a plurality ofly, and every two can dismantle each other between a plurality of component carrier plates 2 and be connected, the various reaction components that await measuring of being convenient for cooperate, the 5 quantity of component hole on a plurality of component carrier plates 2 can be amplified to satisfy the demand of different project joint inspection, for example, in an embodiment, referring to fig. 2, component carrier plate 2 is equipped with four, four all be equipped with three component holes on the component carrier plate 2 for the different thing component reactions that await measuring. Meanwhile, a sample hole 4 is formed in the sample carrier plate, and a plurality of washing holes 6 and a plurality of detection holes 7 are formed in the detection tube carrier plate 3;

in another embodiment, the component carrier plate 2 is integrally arranged, and the number of the component holes 5 on the component carrier plate 2 can be amplified to meet the requirements of joint inspection of different projects.

The reagent tube set includes: the sample tube 8 is installed in the sample hole 4 and is used for placing a sample to be tested, the component tube 9 is provided with a plurality of component tubes 9 and is used for carrying out combined reaction on components of an object to be tested and substances of corresponding reaction, the component tubes 9 are respectively installed on the component carrier plates 2 or the component carrier plates 2 in an integral mode, and the component tube 9 on each component carrier plate 2 is used for placing substances for different component partial reactions, such as antibodies, biotin, magnetic beads and the like. The washing tube 14 is installed in the washing hole 6, the detecting tube 15 is provided in plurality, and a plurality of detecting tubes 15 are installed in the detecting holes 7 for placing the conjugates and substrates of the respective items.

In an embodiment, the washing holes and the washing pipes are multiple, each washing pipe is internally provided with a washing liquid, and in the process of joint inspection of projects, before the combination generated after the reaction of each component is transferred to other reagent pipes, the combination can be washed in different reagent pipes, and the washing times are flexibly determined according to the actual conditions of the projects.

In this embodiment, the component of the sample is not particularly limited, and may be any component of the sample as long as a substance that specifically reacts with the component is present. Examples of combinations of the component to be measured and the substance specifically reacting therewith include: antigens and antibodies, antibodies and antigens, enzymes and matrices, sugar chains and lectins. Thus, in the present utility model, the expression "specifically occurring reaction or specific reaction" refers to specific biochemical binding. The component to be measured or the substance specifically reacting therewith may be a substance whose chemical properties change before and after binding, such as a matrix. One example of such a component to be tested includes PCT antigen, and one specific example thereof includes PCT antigen and PCT antibody.

The sample may be any sample as long as it contains the above-mentioned component to be measured, or may contain the component. Examples thereof include blood, serum, plasma, and urine.

In an embodiment, referring to fig. 2, the plurality of component tubes 9 includes a marker tube 10, a magnetic bead tube 12 and a reaction tube 13, the marker tube 10 is used for placing a marker antibody, the marker tube 10 further includes a biotin tube 11 used for placing biotin, the marker tube 10, the biotin tube 11, the magnetic bead tube 12, the reaction tube 13 and the washing tube 14 are all provided with a plurality of components, and the marker tube 10, the biotin tube 11, the magnetic bead tube 12 and the reaction tube 13 are respectively installed in the plurality of component holes 5 on the plurality of component carriers 2, wherein the order of placing the plurality of component carriers 2 of the various component tubes 9 can be adjusted according to different multi-item joint inspection requirements.

For example, in one embodiment, referring to fig. 1 and 2, the component carrier plate 2 is provided with four

component carrier plates

2a, 2b, 2c and 2d, three marker tubes 10 are respectively installed in the three component holes 5 of the component carrier plate 2a, three biotin tubes 11 are respectively installed in the three component holes 5 of the component carrier plate 2b, three magnetic bead tubes 12 are respectively installed in the three component holes 5 of the component carrier plate 2c, three reaction tubes 13 are respectively installed in the three component holes 5 of the component carrier plate 2d, and a plurality of component tubes 9 for different components to be tested are respectively placed on each component carrier plate 2.

In an embodiment, referring to fig. 2, the bottom surfaces of the sample tube 8, the component tube 9 and the washing tube 14 are located on the same horizontal plane, and the reagent tubes for component reaction are all located at the same height, so that the automation of the detection device is facilitated, and the sampling, pipetting and dispensing processes can be accurately performed.

In one embodiment, the partitions 16 are disposed opposite each other on either side of the sample aperture 4, and the partitions 16 may be provided as raised partitions or as recessed partitions, preventing any cross-contamination between reagents or samples handled during preparation and handling by the pipette.

In an embodiment, referring to fig. 1, the kit further comprises a grip 17, and the grip 17 is further provided with anti-slip patterns 18, and the grip 17 may be further configured to facilitate proper insertion and positioning of the kit in the detection device. The grip 17 may also include certain identification features, such as color, bar code, RFID, etc., to facilitate identification or tracking of the individual kits.

The embodiment also provides a detection device, which comprises the multi-item joint detection kit, and the specific structure of the detection device refers to the embodiment, and because the detection device provided by the utility model comprises all schemes of all embodiments of the multi-item joint detection kit, the detection device at least has the same technical effects as the multi-item joint detection kit, and the technical effects are not described herein.

The utility model is illustrated in more detail below by way of examples. However, the following examples are illustrative only and the scope of the present utility model should not be construed as being limited by the following examples. It will be apparent to those skilled in the art that any changes, modifications or alterations may be made without departing from the spirit of the utility model.

Referring to fig. 3, a multi-project joint inspection kit according to this embodiment:

the kit comprises any one of the sample tube carrier plates, the detection tube carrier plates, the sample tube, the washing tube and the detection tube of the embodiment;

before the operation, a sample of the object to be measured is added into the sample tube 8, a PCT antibody marked with alkaline phosphatase and a CRP antibody marked with alkaline phosphatase are respectively added into the marker tubes (tube R1 and tube R2), biotin marked with PCT antibody and biotin marked with CRP antibody are respectively added into the biotin tubes (tube R3 and tube R4), and SA magnetic beads for magnetic separation are added into the magnetic bead tubes (tube R5 and tube R6);

in the case of using the above-described cartridge and performing automated detection using a detection device provided with a plurality of liquid taking needles, the operation in this case will be described below:

the detection device samples in a sample tube;

dividing the sample into two parts and respectively adding the two parts into a pipe R5 and a pipe R6;

removing the marker enzyme from the tube R1 and injecting the marker enzyme into the tube R5, allowing the PCT antibody in the marker enzyme to bind to the sample PCT antigen in the tube R5, washing the conjugate through the tube R7, removing the marker enzyme from the tube R2 and injecting the marker enzyme into the tube R6, allowing the CRP antibody in the marker enzyme to bind to the sample CRP antigen in the tube R6, and washing the conjugate through the tube R8;

taking out the biotin of the labeled PCT antibody from the tube R3, injecting the biotin into the tube R5, allowing the biotin to react with the washed conjugate, taking out the biotin of the labeled CRP antibody from the tube R4, injecting the biotin into the tube R6, and allowing the biotin to react with the washed conjugate of the tube R6;

the samples in the tube R5 and the tube R6 are combined with the respective markers and the magnetic beads to form a sandwich structure, and after the magnetic separation of the combination is completed, the obtained reactants are respectively injected into the tube R9 and the tube R10;

cleaning the sandwich structure of the pipe R9 and the pipe R10 in a cleaning pipe R9 and a cleaning pipe R10 respectively to remove uncombined substances;

the combination of the tube R9 and the tube R10 and the substrate are injected into the detection tube R11 and the detection tube R12, and a signal is generated, which is proportional to the concentration value, and the concentration is detected based on the signal intensity.

According to the utility model, the synchronous detection of a plurality of target objects to be detected is realized by designing each hole site in the kit. Through setting up a plurality of detachable support plates, set up the component support plate of adjustable order and expansion hole site simultaneously, be convenient for cooperate the going on of multi-project joint inspection under the different circumstances, through the multiple component hole that is used for the component reaction of expansion to satisfy the demand of different projects, simplified the operation of joint inspection, optimized the accomodate and the cost of kit.

The foregoing description is only of the optional embodiments of the present utility model, and is not intended to limit the scope of the utility model, and all the equivalent structural changes made by the description of the present utility model and the accompanying drawings or the direct/indirect application in other related technical fields are included in the scope of the utility model.

Claims

1. A multi-project joint inspection kit, comprising:

the support plate group, the support plate group includes: the sample tube comprises a sample tube carrier plate, a component carrier plate detachably connected with the sample tube carrier plate and a detection tube carrier plate detachably connected with the other end of the component carrier plate relative to the sample tube carrier plate, wherein a plurality of component carrier plates are arranged, a plurality of component carrier plates are mutually detachably connected, sample holes are formed in the sample tube carrier plate, a plurality of component holes are formed in the component carrier plate, and washing holes and a plurality of detection holes are formed in the detection tube carrier plate;

a reagent tube set, the reagent tube set comprising: sample pipe, component pipe, washing pipe and detection tube, the sample pipe is installed in the sample hole, the component pipe is provided with a plurality ofly, a plurality of the component pipe is installed in a plurality of component holes, the washing pipe is installed in the washing hole, the detection tube is provided with a plurality of, a plurality of the detection tube is installed in a plurality of detection holes.

2. The multi-item joint inspection kit according to claim 1, wherein a plurality of the component tubes include a marker tube, a magnetic bead tube, and a reaction tube, which are respectively installed in a plurality of the component wells on a plurality of the component carrier plates.

3. The multi-item joint inspection kit according to claim 2, wherein the marker tube, the magnetic bead tube, the reaction tube, and the washing tube are each provided in plurality.

4. The multi-item joint inspection kit according to claim 1, wherein the bottom surfaces of the sample tube, the component tube, and the wash tube are on the same horizontal plane.

5. The multi-item joint inspection kit according to claim 1, further comprising a separator for preventing leakage of liquid, the separator being disposed opposite to each other at both sides of the sample hole.

6. The multi-item joint inspection kit according to claim 1, further comprising a grip with anti-slip patterns thereon.

7. A test device comprising a multi-item joint test kit according to any one of claims 1 to 6.