CN201993361U - Reagent device used for detecting anticardiolipin antibody immunoglobulin (IgM) - Google Patents
Reagent device used for detecting anticardiolipin antibody immunoglobulin (IgM) Download PDFInfo
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- CN201993361U CN201993361U CN201020695971XU CN201020695971U CN201993361U CN 201993361 U CN201993361 U CN 201993361U CN 201020695971X U CN201020695971X U CN 201020695971XU CN 201020695971 U CN201020695971 U CN 201020695971U CN 201993361 U CN201993361 U CN 201993361U
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- anticardiolipin antibody
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Abstract
The utility model provides a reagent device used for detecting anticardiolipin antibody immunoglobulin (IgM). The reagent device comprises a rectangular base body and a handle positioned at one end of the base body, wherein eight hole positions are arranged on the base body; a sealing thin film is also adhered to the reagent device and is covered on a reagent hole; a label used for detecting a reagent barcode is stuck on the handle of the reagent device; and the numerical value of the barcode comprises a detection item code corresponding to each detection, a detection reagent production code, a reagent validity period, a qualitative correction value/quantitative determination standard curve parameter, an enzyme-linked immuno reaction type, a reagent and the information of the serial number of an analyzing device. The reagent device can perform fully automatic analytic detection with a matched automatic detection device and is simple and convenient to operate; an operation error is not easy to cause; and then the accuracy of the detection result is guaranteed.
Description
Technical field
The utility model application relates to a kind of reagent device of measuring anticardiolipin antibody IgM, belongs to the biological detection equipment technical field.
Background technology
Antiphospholipid antibody syndrome (anti-phospholipid syndrome is newfound in recent ten years a kind of non-organ specific autoimmune disease APS), and its clinical symptoms complexity is various, and symptom both can single appearance also can be a plurality of and deposit.The patient have middle and high titre anticardiolipin antibody (anticardiolipidantibody, ACA) and long-term continuing exist, detect therefore that ACA is the important evidence of diagnosis APS in patient's serum.
ACA is a kind of with the autoantibody of cuorin electronegative on blood platelet and the endothelial cell membrane as target antigen, be common in systemic loupus erythematosus (systemic lupus erythematosus, SLE) and other autoimmune diseases.This antibody and thrombosis, decrease of platelet, spontaneous abortion or FDIU are in close relations.ACA is divided into two classes, and a class is the autoimmune type or the originality antibody of pretending illness, and is relevant with autoimmune disease, relies on β
2Glycoprotein I (β
2GPI) could combine better with cuorin, strong with the affinity of electronegative phosphatide; Another kind of antibody is non-autoimmune type or the antibody that claims avirulence, this antibody-like is irrelevant and relevant as syphilis, third liver, human immunodeficiency virus, Leptospira, cytomegalovirus and Q heat etc. with some infection with autoimmune disease, and this antibody-like does not rely on β
2GPI is low with the affinity of electronegative phospholipids incorporate.Adopt in the detection method to wrap earlier and used β behind the cuorin again
2GPI wraps quilt again, then can significantly improve the susceptibility of detection.
A lot of in addition diseases can detect ACA, and during such as detection syphilis, available cuorin is as one of antigen coated thing, and other also have acquired immune deficiency syndrome (AIDS), hepatitis C, tuberculosis, parvovirus and cytomegalovirus infection, and the healthy philtrum of part also can detect.And in the diagnosis of APS, high titer antibody just is called the positive and diagnostic significance is arranged in having only, for fear of the false positive testing result, just need all stronger detection method of susceptibility and specificity and reagent device, can make things convenient for the cuorin IgM antibody (ACA-IgM) that detects accurately in the test serum.
Summary of the invention
In order to solve the weak point that exists in the existing detectable installation method of anticardiolipin antibody IgM analyzing and testing, the utility model application provides a kind of new detectable device.This reagent device is sought a kind of simpler, accurate and effective method and is carried out detection by quantitative to satisfy the needs of clinical diagnosis based on the enzyme linked immunosorbent detection technology.
The utility model application provides a kind of detectable device of measuring anticardiolipin antibody IgM, this reagent device comprises matrix that is provided with position, 8 holes and the handle that is positioned at matrix one end, it by special-purpose particular analysis instrument the various particular agent solution between each hole of reagent device is annotated and suction is abandoned, sample and reagent are reacted, measure the numerical value of the back solution color and luster that reacts then, finally obtain testing result by the numerical value of measuring is handled.
Specifically, the described a kind of reagent device of measuring anticardiolipin antibody IgM of the utility model application is characterized in that: described reagent device comprises rectangular matrix and is positioned at the handle of matrix one end that matrix is provided with position, 8 holes.
Described a kind of reagent device of measuring anticardiolipin antibody IgM is characterized in that: the labeling that is pasted with the detectable bar code on the handle of described reagent device.
The numerical value of described bar code comprises every information that detects the sequence number of pairing test item code, detectable product batch number, the reagent term of validity, qualitative corrected value/quantitative measurement typical curve parameter, enzyme linked immunoassay type, reagent and analytical equipment.
Described a kind of reagent device of measuring anticardiolipin antibody IgM is characterized in that: position, described hole comprises a reacting hole, a sample well, a dilution holes and five reagent wells, wherein,
1) sample well is contained and is held solution to be measured;
2) dilution holes is used for dilution of sample;
3) be used for contain holding test sample and detectable, and be flat and have very high light source/light path permeability with the reacting hole of these samples and reagent generation enzyme linked immunoassay;
4) each reagent wells is loaded with euzymelinked immunosorbent assay (ELISA) and detects the required a kind of reagent of anticardiolipin antibody IgM or vacant.
Described a kind of reagent device of measuring anticardiolipin antibody IgM is characterized in that: also be pasted with sealing film on the described reagent device, described sealing film is covered on the reagent wells.
Described a kind of reagent device of measuring anticardiolipin antibody IgM is characterized in that: the section shape of position, described hole comprises square, V-shape or U font.
The required reagent of institute's splendid attire enzyme linked immunosorbent detection comprises required immune response inhibitor/neutralizing agent/blocking agent/adsorbent, enzyme conjugates solution, chromogenic substrate solution, colour developing stop buffer, increased response agent/promoter, the diluted sample solution of enzyme linked immunoassay that detects anticardiolipin antibody IgM in the described reagent device that is used to measure anticardiolipin antibody IgM of the utility model application, described reagent wells.
Described analytical reagent device be a kind of measure anticardiolipin antibody IgM independently, single part, the disposable enzyme-linked immuno assay reagent device that is exclusively used in the particular analysis instrument.
The device of the described mensuration anticardiolipin antibody of the utility model application IgM has following advantage:
1, utilization enzyme-linked immuno assay principle, utilize specific analytical instrument, adopt the detectable device and the analytical reagent device of supporting special use, automatically realize qualitative/quantitative measurement of anticardiolipin antibody IgM, be a kind of brand-new, that be suitable for, practical, detect the scheme of anticardiolipin antibody IgM efficiently, fast;
2, be a kind of independently, single part detectable and analytical equipment, need not as general ELISA method, to use 12 * 8 types, 8 * 12 types or complete plate 96 hole special enzyme-linked immune microwell plates as antigen or antibody sandwich articles for use and reaction vessel, there is not the waste of reagent as long as there is a duplicate samples can carry out the detection of respective items purpose in use, if the quantity of sample surpasses a, use this reagent and analytical equipment to get final product by the actual sample number;
3, it all has a special-purpose bar code to each analytical reagent device, the numerical value of bar code comprises the information such as sequence number that detect pairing test item code, detectable product batch number, the reagent term of validity, quantitative measurement typical curve parameter, concrete enzyme linked immunoassay type, reagent and analytical equipment, can not arbitrarily be changed, strictness is controlled during use, especially when using above term of validity detectable, to be identified and stop and send examining report, thereby can guarantee the accuracy that detects;
4, it is effectively separated each detectable and seals, and can not cause the cross pollution between all ingredients and influences testing result;
5, no matter be qualitative detection or detection by quantitative, it detects necessary reagent with each and is contained in the reagent wells position of an analytical reagent device, detectable need not be come splendid attire with different reagent bottles respectively, not only operation is very easy, and be not easy to cause bust, thereby guarantee the correctness of testing result.
Description of drawings
Fig. 1 is the cross-sectional view of an embodiment of the reagent device of the described mensuration anticardiolipin antibody of the utility model application IgM;
Fig. 2 is the top plan view of an embodiment of the reagent device of the described mensuration anticardiolipin antibody of the utility model application IgM;
Fig. 3 is the cross-sectional view of another embodiment of the reagent device of the described mensuration anticardiolipin antibody of the utility model application IgM;
Fig. 4 is the top plan view of another embodiment of the reagent device of the described mensuration anticardiolipin antibody of the utility model application IgM;
Fig. 5 and Fig. 6 are the cross-sectional view of other embodiment of the reagent device of the described mensuration anticardiolipin antibody of the utility model application IgM;
Wherein, 1 is that sample well, 2,3,4,5,6 is that reagent wells, 7 is that reacting hole, 8 is that dilution holes, 9 is that handle, 10 is that sealing film, 11 is that matrix, 90 is a labeling.
Embodiment
Below in conjunction with concrete pick-up unit and implementation step the described reagent device of the utility model application is further described, purpose is for the public better understands technical scheme described in the utility model, rather than to the restriction of described technical scheme.In fact; in spirit of the present utility model; to the improvement that comprises increase and decrease, replacement and the structure of position, hole in the described reagent device structure all is that those of ordinary skills need not performing creative labour and can obtain, therefore all within the utility model application technical scheme required for protection.
Fig. 1 and Fig. 2 are the structural representations of an embodiment of a kind of reagent device of measuring anticardiolipin antibody IgM described in the utility model, comprise matrix 11, on described matrix 11, be provided with position, 1～8 hole (from 1 to 8), its mesopore position 1 is the sample well that is used for the splendid attire testing sample, and at the bottom of its bottom surface is " V " font groove, all the other positions, hole are reacting holes 7, reagent wells 2,3,4,5,6 and dilution holes 8, on described reagent wells (2-6), be pasted with one deck sealing film 10, described reacting hole 7 is to be used to receive test sample and detectable and as the container of enzyme linked immunoassay and colorimetric, this reacting hole 7 is penetrating holes of light source/light path, end at described matrix 11 is provided with handle 9, is pasted with the labeling 90 that detects anticardiolipin antibody IgM reagent information bar code on described handle 9.
Fig. 3-the 6th, the synoptic diagram of other embodiment of a kind of reagent device of measuring anticardiolipin antibody IgM described in the utility model, as seen from the figure, the section shape of position, described hole (comprising sample well, reagent wells, dilution holes and reacting hole) comprises square, V-shape or U font.The xsect of position, hole comprises different shape, for example can be for circular or square.
A kind of reagent device of measuring anticardiolipin antibody IgM described in the utility model can carry out full automatic analyzing and testing with supporting automatic detection device, and it is easy and simple to handle, is not easy to cause bust, thereby guarantees the correctness of testing result.
Claims (5)
1. reagent device of measuring anticardiolipin antibody IgM is characterized in that: described reagent device comprises rectangular matrix and is positioned at the handle of matrix one end that matrix is provided with position, 8 holes.
2. a kind of reagent device of measuring anticardiolipin antibody IgM according to claim 1 is characterized in that: the labeling that is pasted with the detectable bar code on the handle of described reagent device.
3. a kind of reagent device of measuring anticardiolipin antibody IgM according to claim 1, position, described hole comprise a reacting hole, a sample well, a dilution holes and five reagent wells, wherein,
1) sample well is contained and is held solution to be measured;
2) dilution holes is used for dilution of sample;
3) be used for contain holding test sample and detectable, and be flat and have very high light source/light path permeability with the reacting hole of these samples and reagent generation enzyme linked immunoassay;
4) each reagent wells is loaded with euzymelinked immunosorbent assay (ELISA) and detects the required a kind of reagent of anticardiolipin antibody IgM or vacant.
4. a kind of reagent device of measuring anticardiolipin antibody IgM according to claim 1 is characterized in that: also be pasted with sealing film on the described reagent device, described sealing film is covered on the reagent wells.
5. a kind of reagent device of measuring anticardiolipin antibody IgM according to claim 1 is characterized in that: the section shape of position, described hole comprises square, V-shape or U font.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201020695971XU CN201993361U (en) | 2010-12-31 | 2010-12-31 | Reagent device used for detecting anticardiolipin antibody immunoglobulin (IgM) |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201020695971XU CN201993361U (en) | 2010-12-31 | 2010-12-31 | Reagent device used for detecting anticardiolipin antibody immunoglobulin (IgM) |
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| CN201993361U true CN201993361U (en) | 2011-09-28 |
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| CN201020695971XU Expired - Lifetime CN201993361U (en) | 2010-12-31 | 2010-12-31 | Reagent device used for detecting anticardiolipin antibody immunoglobulin (IgM) |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103185785A (en) * | 2011-12-30 | 2013-07-03 | 深圳市亚辉龙生物科技有限公司 | Reagent device and method for detecting anti-cardiolipin antibody |
| CN103185784A (en) * | 2011-12-30 | 2013-07-03 | 深圳市亚辉龙生物科技有限公司 | Reagent device and method for detecting mycoplasma pneumonia antibody |
| CN106443005A (en) * | 2016-06-30 | 2017-02-22 | 深圳市亚辉龙生物科技股份有限公司 | Anticardiolipin antibody IgM chemiluminiscence immunoassay kit and preparation method thereof |
-
2010
- 2010-12-31 CN CN201020695971XU patent/CN201993361U/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103185785A (en) * | 2011-12-30 | 2013-07-03 | 深圳市亚辉龙生物科技有限公司 | Reagent device and method for detecting anti-cardiolipin antibody |
| CN103185784A (en) * | 2011-12-30 | 2013-07-03 | 深圳市亚辉龙生物科技有限公司 | Reagent device and method for detecting mycoplasma pneumonia antibody |
| CN103185785B (en) * | 2011-12-30 | 2015-01-07 | 深圳市亚辉龙生物科技有限公司 | Reagent device and method for detecting anti-cardiolipin antibody |
| CN106443005A (en) * | 2016-06-30 | 2017-02-22 | 深圳市亚辉龙生物科技股份有限公司 | Anticardiolipin antibody IgM chemiluminiscence immunoassay kit and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: Nanshan District Nanshan street Shenzhen city Guangdong province 518000 Xing Hai Lu Lai Shan Industrial Zone 5 1-4 Patentee after: SHENZHEN YHLO BIOTECH CO., LTD. Address before: 518054, fifth, Lai Shan Industrial Zone, Shenzhen, Guangdong, Nanshan District Patentee before: Shenzhen Yhlo Biotech. Co., Ltd. |
|
| CP02 | Change in the address of a patent holder |
Address after: 518000 Shenzhen 1 Longgang biological technology plant 1, Baolong two road, Baolong street, Guangdong Patentee after: SHENZHEN YHLO BIOTECH CO., LTD. Address before: 518000 Guangdong, Shenzhen, Nanshan District Nanshan street, Xinghai Road, Li Shan Industrial Zone, 1-4 1-4 floors. Patentee before: SHENZHEN YHLO BIOTECH CO., LTD. |
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| CP02 | Change in the address of a patent holder | ||
| CX01 | Expiry of patent term |
Granted publication date: 20110928 |
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| CX01 | Expiry of patent term |