CN218944166U - Cell division suppressing device and cell division suppressing system - Google Patents

Abstract

The embodiment of the application provides a cell division suppression device and a cell division suppression system. The cell division suppressing device includes: electrode structure, coolant substrate and filling structure. The electrode structure is used for outputting an electric field to the target biological tissue; the cooling liquid substrate is connected with one side of the electrode structure and at least partially used for carrying out heat exchange with the electrode structure; the filling structure is connected with one side of the coolant substrate close to the electrode structures and is used for at least partially filling gaps between the electrode structures. According to the embodiment of the application, on one hand, the medical adhesive tape is replaced by the cooling liquid substrate in the cell division suppression device, so that heat generated in the working process of the device can be absorbed, and the comfort level of a patient is improved; on the other hand, the filling structure is added in the cell division suppression device, and the thickness drop is reduced, so that the foreign body sensation on the surface of biological tissues can be reduced, and the comfort of patients and the fitting degree of the cell division suppression device are improved.

Description

Cell division suppressing device and cell division suppressing system

Technical Field

The present application relates to the technical field of medical devices, and in particular, to a cell division suppression device and a cell division suppression system.

Background

Since 1980, electric fields have been commonly used in the biological and medical fields, including therapeutic approaches to kill microorganisms, cell fusion, gene conversion, and tumor therapy. Foreign researchers in 2004 have found that tumor cell division proliferation can be selectively inhibited under the action of an alternating electric field with low electric field strength (1-2 volts per cm) and medium-low frequency (100-300 khz), and this action mechanism is called tumor therapeutic electric field (Tumor Treating Fields, TTF) action mechanism. As a novel treatment method, the tumor electric field treatment has a plurality of advantages compared with the traditional drug treatment, operation treatment, radiotherapy and chemotherapy treatment and the like.

In combination with literature reports, it has been found that the mechanism of action of electric field therapy of tumors is to utilize the proliferation and division processes of tumor cells more frequently than normal cells, thereby applying an electric field to tumor cells, acting on tubulin of tumor proliferation cells, destroying the mitosis and apoptosis of tumor cells. The specific action modes are two, one is that an uneven external electric field is applied in the pre-mitosis stage of tumor cells to enable microtubules composed of polar molecules to turn to polarization and move along the direction with stronger field intensity, so that the microtubules cannot be gathered into spindle filaments, and the mitosis of the tumor cells is stopped; the other is that an electric field with the direction of the electric field lines parallel to the long axis of the dividing cells is applied to the tumor cells at the end stage of the division of the tumor cells, so that the density of the electric field lines and cytoplasm at the narrow cleavage groove of the tumor cells is the highest, and the cleavage groove is broken under the action of the electric field force, so that the tumor cells can not normally divide to cause apoptosis.

At present, a tumor therapeutic apparatus based on TTF technology mainly acts on a human body by means of a pair of cell division suppression devices, wherein the cell division suppression devices mainly realize output electric fields by arranging round electrode plates on medical adhesive tapes. However, when the cell division suppressing device is adhered to the surface of human skin tissue, a side effect of the tumor electric field treatment is that the temperature of the internal structure of the cell division suppressing device is continuously increased as the field intensity output by the cell division suppressing device is continuously increased. Great inconvenience is brought to the life and experience of patients under the condition of hot summer heat. Under high temperature conditions, abnormal changes in physiological functions of humans, particularly in thermoregulation, water and salt metabolism, blood circulation, etc., occur, such as a large amount of sweating, which places a burden on the cardiovascular system. Once the high temperature exceeds the tolerance of the human body, the working efficiency is reduced if the high temperature is light, the thinking judgment is affected if the high temperature is heavy, even heatstroke is directly caused, and potential safety hazards are brought to the human body of the patient.

In addition, when the cell division suppressing device is attached to the body surface of a patient using an adhesive medical tape, the cell division suppressing device is not breathable enough and also limits the physical activity of the patient to some extent. The cell division suppressing device reduces the viscosity of the medical tape after repeated use, and thus cannot be firmly attached to the skin. The cell division suppression device also causes certain damage to the skin when torn.

Furthermore, because the circular electrode plate has certain thickness, when laminating on patient skin tissue surface, because the thickness fall between electrode plate self and the medical sticky tape, consequently lead to the patient to produce stronger foreign matter sense, lack certain comfort level.

Therefore, a new cell division suppression device is needed to solve the above-mentioned problems.

Disclosure of Invention

The application provides a cell division suppression device and a cell division suppression system aiming at the defects of the existing mode, and aims to solve the technical problems that in the prior art, the internal temperature of the cell division suppression device is too high or the internal structure thickness of the cell division suppression device is poor, so that comfort level of patients is not high when the cell division suppression device is attached to the skin surface of a human body.

In a first aspect, embodiments of the present application provide a cell division suppression device comprising: electrode structure, coolant substrate and filling structure.

An electrode structure for outputting an electric field to a target biological tissue;

the cooling liquid substrate is connected with one side of the electrode structure and at least partially used for carrying out heat exchange with the electrode structure;

and the filling structure is connected with one side of the cooling liquid substrate, which is close to the electrode structures, and is used for at least partially filling gaps between the electrode structures.

Optionally, the coolant substrate comprises;

a cooling liquid chamber for accommodating a cooling liquid;

the cooling liquid input pipe is communicated with the cooling liquid cavity and is used for inputting cooling liquid into the cooling liquid cavity;

and the cooling liquid output pipe is communicated with the cooling liquid cavity and is used for outputting cooling liquid in the cooling liquid cavity, cooling the cooling liquid through the cooling system and then refluxing the cooling liquid into the cooling liquid cavity through the cooling liquid input pipe.

Optionally, the thickness of the filling structure in the first direction is not greater than the thickness of the electrode structure in the first direction, and the first direction is perpendicular to a plane in which the coolant substrate is in a flat state.

Optionally, the thickness of the filling structure in the first direction is equal to the thickness of the electrode structure in the first direction.

Optionally, the filling structure is specifically a first filling structure, the first filling structure being in the form of a mesh, the first filling structure having a mesh for accommodating the electrode structure.

Optionally, the filling structures are specifically second filling structures, the second filling structures are strip-shaped, and gaps between the second filling structures are used for accommodating the electrode structures;

optionally, the filling structure is specifically a third filling structure, and the third filling structure is in a block shape.

Optionally, the second filling structures and the electrode structures are distributed on the same side of the coolant substrate at uniform intervals;

optionally, the third filling structure and the electrode structure are distributed at uniform intervals on the same side of the coolant substrate.

Optionally, an adhesive structure is disposed on a side of the filling structure away from the coolant substrate.

Optionally, the filling structure employs an insulating gas permeable material.

In a second aspect, embodiments of the present application provide a cell division suppression system comprising: a host and at least one pair of cell division suppression devices as provided in the first aspect, the cell division suppression devices being electrically connected to the host.

The beneficial technical effects that technical scheme that this application embodiment provided brought include:

according to the cell division suppression device provided by the application, the cooling liquid substrate is adopted to replace the medical adhesive tape, so that on one hand, the inconvenience that the adhesive strength is reduced and the service life of the electrode patch is shortened due to the fact that the medical adhesive tape needs to be repeatedly adhered and torn can be avoided; on the other hand, set up the coolant liquid basement that has the cooling effect in the device for the inside radiant heat that produces of electrode paster, electrode paster is inside to be provided with thermistor, is used for detecting the inside temperature of electrode paster. The reflux rate in the cooling liquid circulation structure can be adjusted according to the temperature change detected by the thermosensitive element, so that the temperature of the electrode patch acting on the surface of the target biological tissue is reduced, the comfort of a human body is further improved, and the side effect on a patient is reduced while the treatment effect is ensured.

In addition, the cell division suppression device provided by the application adopts a mode of arranging a filling structure between the cooling liquid substrate and the electrode structure to at least partially fill the gap between the electrode structures, so that the thickness drop between the electrode structure and the cooling liquid substrate is reduced or even eliminated, the foreign body sensation generated when the cell division suppression device is attached to the surface of human skin tissue is reduced, and the comfort level of a patient is improved.

Additional aspects and advantages of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the application.

Drawings

The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings, in which:

FIG. 1 is an exploded view of a first cell division suppression device according to an embodiment of the present application;

FIG. 2 is a first side cross-sectional view of the cell division suppression device of FIG. 1 after assembly;

FIG. 3 is a second side cross-sectional view of the cell division suppression device of FIG. 1 after assembly;

FIG. 4 is a third side cross-sectional view of the cell division suppression device of FIG. 1 after assembly;

FIG. 5 is an exploded view of a second cell division suppression device according to an embodiment of the present disclosure;

FIG. 6 is a schematic structural diagram of a third cell division suppression device according to an embodiment of the present disclosure;

FIG. 7 is a schematic structural diagram of a fourth cell division suppression device according to an embodiment of the present disclosure;

fig. 8 is a schematic structural diagram of a cell division suppression system according to an embodiment of the present application.

In the figure:

1-a coolant base; 2-filling the structure; 3-electrode structure;

11-a cooling liquid cavity; 12-a cooling liquid input pipe; 13-a coolant outlet pipe;

21-a first filling structure; 22-a second filling structure; 23-a third filling structure;

4-an adhesive structure;

a 100-cell division suppression system; 110-cell division suppression means;

120-mainframe; 121-a voltage generator; 122-controller.

Detailed Description

Examples of embodiments of the present application are illustrated in the accompanying drawings, in which like or similar reference numerals refer to like or similar elements or elements having like or similar functionality throughout. Further, if detailed description of the known technology is not necessary for the illustrated features of the present application, it will be omitted. The embodiments described below by referring to the drawings are exemplary only for the purpose of illustrating the present application and are not to be construed as limiting the present application.

It will be understood by those skilled in the art that all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs unless defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless expressly stated otherwise, as understood by those skilled in the art. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. The term "and/or" as used herein includes all or any element and all combination of one or more of the associated listed items.

The development thinking of the application comprises:

the prior cell division suppression device adopts a metal electrode plate to apply uneven alternating electric field to a focus area, thereby realizing tumor electric field treatment. The temperature of the electrode patch can be gradually increased along with the continuous enhancement of the field intensity in the process of outputting the electric field. However, only the heat dissipation structure in the existing electrode patch can only realize passive heat dissipation, but the passive heat dissipation structure cannot timely dissipate heat after absorbing the heat, so that the heat dissipation cannot be continuously and effectively realized.

In addition, because the metal electrode plate has a certain thickness, when the cell division suppression device is attached to the surface of a target biological tissue, a certain gap is generated between the cell division suppression device and the skin tissue of a human body due to the thickness of the metal electrode plate, so that a patient can feel uncomfortable due to stronger foreign body feeling; on the other hand, the cell division suppressing device is not adhered to the skin tissue of the patient with high degree.

The application provides a cell division suppression device and a cell division suppression system, which aim to solve the technical problems in the prior art.

The following describes the technical solutions of the present application and how the technical solutions of the present application solve the above technical problems in detail with specific embodiments.

An embodiment of the present application provides a cell division suppression device 110, where a schematic structural diagram of the cell division suppression device 110 is shown in fig. 1, and includes: electrode structure, coolant substrate and filling structure.

An electrode structure 3 for outputting an electric field to a target biological tissue;

a coolant substrate 1 connected to one side of the electrode structure 3, at least partially for heat exchange with the electrode structure 3;

and a filling structure 2 connected with one side of the coolant substrate 1 near the electrode structures 3 for at least partially filling the gaps between the electrode structures 3.

In this embodiment, the medical adhesive tape in the existing cell division suppression device 110 is replaced by the cooling liquid substrate 1, wherein the cooling liquid substrate 1 is disposed on one side of the electrode structure 3, so that it can be realized that the electrode structure 3 is continuously enhanced in output field intensity and the temperature is continuously increased in the working process of the electrode patch, which is easy to bring adverse effects to the treatment of patients. When the coolant is injected into the coolant substrate 1, the heat exchange between the coolant substrate 1 and the electrode structure 3 can reduce the temperature inside the cell division suppression device 110, so as to avoid damage to patients caused by overhigh temperature.

In addition, a filling structure 2 is added to the conventional cell division suppressing device 110, and the filling structure 2 and the electrode structure 3 are disposed on the same side of the coolant substrate 1. It can be realized that when the cell division suppressing device 110 is applied to the surface of the target biological tissue, the filling structure 2 can fill the gap between the electrode structures 3 inside the cell division suppressing device 110, so that the thickness drop formed between the electrode structures 3 and the coolant substrate 1 can be reduced to some extent, the foreign body sensation on the surface of the biological tissue can be reduced, and the comfort of a patient and the fitting degree of the cell division suppressing device 110 can be improved.

Alternatively, the cooling liquid base 1 may be a wearable waistcoat or a waistband or armband with velcro.

Alternatively, the material of the filling structure 2 may be selected from organic insulating materials and inorganic insulating materials.

Specifically, the filling structure 2 may be made of synthetic resin.

The electrode structure 3 comprises a stacked arrangement of a conductive structure and a dielectric structure, the dielectric structure being arranged on a side of the conductive structure remote from the coolant substrate 1.

Alternatively, the material of the conductive structure may be any one of a metal material (e.g., titanium, platinum, gold, etc.), an inorganic nano-conductive material (e.g., graphene, zinc oxide, zinc sulfide, etc.), and an organic conductive material (e.g., polyaniline, polythiophene, etc.); the dielectric structure can be a ceramic plate with high dielectric constant or a high-molecular coating with high dielectric constant; a pair of oppositely stacked conductive structures, dielectric structures, may be coupled to equivalent a capacitor.

Specifically, the conductive structure can be a round titanium plate with the diameter of 20 mm and the thickness of 1 mm, and the dielectric structure can be a round ceramic plate with the diameter of 20 mm and the thickness of 0.5 mm.

The number of electrode structures 3 that can be provided in one cell division suppressing device 110 is 1, 2, 3, 4, 5, 6, … …, n, etc., where n is a positive integer. The number of electrode structures 3 may be set as required according to the scope of action of the tumor region and the size of the coolant base 1, and is not particularly limited herein.

The development idea of the application also includes that the cooling liquid substrate 1 needs to be specifically provided with a pipe to achieve the effect of circulating cooling. To this end, as shown in fig. 1, the present application provides the cell division suppression device 110 with one possible implementation as follows:

the coolant base 1 includes;

a cooling liquid chamber 11 connected to one side of the substrate 1 for accommodating a cooling liquid;

a cooling liquid input pipe 12 communicating with the cooling liquid cavity 11 for inputting cooling liquid into the cooling liquid cavity 11;

and the cooling liquid output pipe 13 is communicated with the cooling liquid cavity 11 and is used for outputting the cooling liquid in the cooling liquid cavity 11, cooling the cooling liquid by the cooling system and then refluxing into the cooling liquid cavity 11 through the cooling liquid input pipe 12.

In this embodiment, the cooling liquid is injected into the cooling liquid cavity 11 from the cooling liquid input pipe 12, and after the cooling liquid performs indirect heat exchange with the electrode structure 3 in the cooling liquid cavity 11, the cooling liquid is output through the cooling liquid output pipe 13, so that a cooling circulation system of the cooling liquid input pipe 12-the cooling liquid cavity 11-the cooling liquid output pipe 13-the cooling system-the cooling liquid input pipe 12 can be established, the electrode structure 3 in the electrode patch 110 is cooled, and damage to patients caused by overhigh temperature is avoided.

Alternatively, the cooling fluid chamber 11 may be in a pouch or pot type.

The development idea of the present application also includes that the electrode structure 3 needs to be in contact with the surface of the biological tissue in order to achieve electric field therapy. To this end, as shown in fig. 2, the present application provides the cell division suppression device 110 with one possible implementation as follows:

the thickness of the filling structure 2 in the first direction is not greater than the thickness of the electrode structure 3 in the first direction, and the first direction is perpendicular to the plane where the coolant substrate 1 is in a flat state.

In this embodiment, the thickness of the filling structure 2 is not greater than the thickness of the electrode structure 3 to ensure that when the cell division suppression device 110 is applied to the target biological tissue surface, the electrode structure 3 can contact the target biological tissue surface to release an electrical signal to the focal region. Meanwhile, when the thickness of the filling structure 2 is smaller than that of the electrode structure 3, a certain gap inside the cell division suppressing device 110 can be maintained while reducing the thickness difference therebetween. Thereby, the foreign body sensation on the body surface of the patient can be reduced, the comfort can be improved, and the cell division suppressing device 110 can be provided with a certain air permeability.

Alternatively, the thickness of the filling structure 2 is equal to one third of the thickness of the electrode structure 3.

Alternatively, the thickness of the filling structure 2 is equal to one half of the thickness of the electrode structure 3.

Alternatively, the thickness of the filling structure 2 is equal to two thirds of the thickness of the electrode structure 3.

Specifically, when the thickness of the electrode structure 3 is 1 mm, the thickness of the filling structure 2 may be 0.33 mm, 0.5 mm or 0.66 mm.

The development idea of the present application further includes that the smaller the thickness drop between the filling structure 2 and the electrode structure 3, the smaller the gap generated between the electrode structures 3 of the cell division suppressing device 110. To this end, as shown in fig. 3, the present application provides the cell division suppression device 110 with one possible implementation as follows:

the thickness of the filling structure 2 in the first direction is equal to the thickness of the electrode structure 3 in the first direction.

In this embodiment, when the thickness of the filling structure 2 is equal to the thickness of the electrode structure 3, the thickness between the filling structure 2 and the electrode structure 3 is completely adapted, and the two structures together form a combined structure which is almost flat, and the surface close to the biological tissue is almost completely smooth, so that the foreign body sensation generated on the cell division suppression device 110 by the electrode structure 3 can be completely eliminated, and the fit degree between the cell division suppression device 110 and the target biological tissue can be improved.

In one example, the electrode structure 3 is a metal disc of diameter 20 mm and thickness 1 mm, and the filling structure 2 is also a material of thickness 1 mm.

Alternatively, the filling structure 2 is provided with a through hole, the shape of which fits with the shape of the electrode structure 3.

In one example, the electrode structure 3 is in the form of a wafer of diameter 20 mm and thickness 1 mm, the filling structure 2 has a thickness 1 mm and the diameter of the through hole is slightly larger than 20 mm.

Optionally, the filling structure 2 is provided with a blind hole, the inner surface of the blind hole is provided with adhesiveness, and the shape of the blind hole is embedded with the electrode structure 3.

In one example, the electrode structure 3 is in the form of a wafer of diameter 20 mm and thickness 1 mm, the filling structure 2 has a thickness of 1.5 mm, the blind hole has a thickness of 1 mm and the diameter is slightly greater than 20 mm.

Optionally, each through hole or blind hole in the filling structure 2 accommodates at least 2 electrode structures 3.

In one example, the diameter of the through holes or blind holes of the filling structure 2 is 50 mm, and 4 circular electrode structures 3 with diameters of 20 mm are uniformly distributed in each through hole or blind hole.

The development concept of the present application also includes the consideration of saving material costs as much as possible in manufacturing the cell division suppressing device 110. To this end, the present application provides three possible implementations of the cell division suppression device 110:

as shown in fig. 5, in a first implementation:

the filling structure 2 is in particular a first filling structure 21, the first filling structure 21 being in the form of a mesh, the first filling structure 21 having a mesh for accommodating the electrode structure 3.

In the present embodiment, the first filling structure 21 is designed as a mesh, and the electrode structure 3 is placed in the mesh. On the one hand, the structural characteristics of the mesh structure itself can reduce the material costs of the filling structure 2 while at the same time reinforcing the solidity of the first filling structure 21. On the other hand, the manufacturing process of the net structure is simpler, and is beneficial to mass production and application. The mesh of the mesh structure is used for accommodating the electrode structures 3, so that the thickness drop between the electrode structures 3 can be reduced, the foreign body sensation generated by the internal structure of the cell division suppression device 110 can be reduced, and the comfort of a human body can be improved.

Optionally, the mesh is any one of triangle, square, diamond, and regular hexagon.

As shown in fig. 6, in a second implementation:

the filling structure 2 is specifically a second filling structure 22, the second filling structure 22 is in a strip shape, and the gaps between the second filling structures 22 are used for accommodating the electrode structures 3.

In this embodiment, when the second filling structure 22 is designed to be strip-shaped, the area occupied by the filling structure 2 on the coolant substrate 1 can be reduced to a certain extent, and correspondingly, the adhesion area between the coolant substrate 1 and the target biological tissue is also increased, so as to improve the adhesion degree of the coolant substrate 1 on the target biological tissue. When the electrode structures 3 are distributed in an array, the second filling structures 22 are also distributed among the row-column gaps of the array of the electrode structures 3, and the second filling structures 22 increase the contact area between the internal structure of the cell division suppression device 110 and the target biological tissue, so that the pressure of the electrode structures 3 on the target biological tissue is reduced, the foreign body sensation of a patient is reduced, and the comfort of a human body is improved.

As shown in fig. 7, in a third implementation:

the filling structure 2 is specifically a third filling structure 23, and the third filling structure 23 is in a block shape.

In the present embodiment, the third filling structures 23 are in a block shape and are staggered with the electrode structures 3 on the coolant substrate 1, so that the material cost of the third filling structures 23 can be further reduced, and the manufacturing process of the third filling structures 23 can be further simplified. The third filling structure 23 is designed to follow the principle of simplifying the cost and achieving the plane of the smooth electrode structure 3, and is uniformly distributed in the gaps of the electrode structure 3 in the cell division suppression device, so that the effect of reducing the pressure can be achieved, the foreign body sensation of skin tissues can be further reduced on the basis of reducing the material cost, and the comfort of a human body can be improved.

Optionally, the second filling structure 22 or the third filling structure 23 is distributed at even intervals with the electrode structure 3 on the side of the coolant base 1 remote from the substrate. The second filling structure 22 or the third filling structure 23 can be more uniformly distributed on the plane of the electrode structure 3, so as to improve the effective utilization rate of the second filling structure 22 or the third filling structure 23.

The development concept of the present application further includes that the surface of the cell division suppression device 110 close to the target biological tissue needs to have a certain viscosity, so that the cell division suppression device is firmly attached to the surface of the target biological tissue. To this end, as shown in fig. 4, the present application provides the following one possible implementation manner for the cell division suppression device 110:

the side of the filling structure 2 remote from the coolant substrate 1 is provided with an adhesive structure 4.

In this embodiment, the adhesive structure 4 is disposed on the side of the filling structure 2 close to the target biological tissue, so that the adhesion of the whole cell division suppression device 110 is not affected, on the basis of the foreign body sensation reduction of the electrode structure 3 by the filling structure 2 in the foregoing embodiment.

Alternatively, the material of the adhesive means 4 may be a natural or artificial adhesive which can be peeled off.

Specifically, the natural binder is derived from substances in nature. Biological adhesives such as starch, protein, dextrin, animal glue, shellac, leather glue, rosin and the like; mineral binders such as asphalt are also included. The artificial adhesive is an artificial material, and includes inorganic adhesives such as water glass, and organic adhesives such as synthetic resin and synthetic rubber.

The development idea of the present application also includes that the filling structure 2 itself cannot influence the output electric field of the electrode structure 3. To this end, the present application provides the cell division suppression device 110 with one possible implementation as follows:

the filling structure 2 is made of an insulating and breathable material.

In this embodiment, in order to avoid the influence of the filling structure 2 on the electric field output by the electrode structure 3, the material selected for the filling structure 2 itself needs to have an insulating property. The filling structure 2 does not affect the orientation and frequency of the electrode structure 3 releasing the electric field when the electrode structure 3 releases the electric field. Thereby ensuring the smooth proceeding of the electric field treatment. At the same time, the filling structure 2 needs to be made of a material with good air permeability so as to keep the skin of the patient comfortable.

Specifically, the filling structure 2 is made of a material which is insulating, breathable, flexible and elastic. For example: any one of Polyurethane (PUR), polystyrene (PS), polyvinyl chloride (PVC), polyethylene (PE), phenolic resin (PF), nylon may be used.

Based on the same inventive concept, embodiments of the present application provide a cell division suppression system 100, and a schematic structure diagram of the cell division suppression system 100 is shown in fig. 8, including but not limited to:

the host 120 and at least one pair of cell-division suppression devices 110 as set forth in the above embodiments, the cell-division suppression devices 110 are each electrically connected to the host 120.

In this embodiment, since the cell division suppression system 100 adopts any one of the cell division suppression devices 110 provided in the foregoing embodiments, the principle and technical effects thereof are shown in the foregoing embodiments, and are not described herein.

Optionally, the host 120 includes: a voltage generator 121 and a controller 122.

The controller 122 is electrically connected to the voltage generator 121.

The voltage generator 121 is electrically connected to the electrode structures 3 in at least one pair of cell division suppression devices 110, respectively, for outputting a voltage to the electrode structures 3 under the control of the controller 122.

Alternatively, the voltage generator 121 is a pulse voltage generator or an alternating voltage generator.

By applying the embodiment of the application, at least the following beneficial effects can be realized:

1. in this embodiment, the medical adhesive tape in the existing cell division suppression device 110 is replaced by the cooling liquid substrate 1, wherein the cooling liquid substrate 1 is disposed on one side of the electrode structure 3, so that it can be realized that the electrode structure 3 is continuously enhanced in output field intensity and the temperature is continuously increased in the working process of the electrode patch, which is easy to bring adverse effects to the treatment of patients. When the coolant is injected into the coolant substrate 1, the heat exchange between the coolant substrate 1 and the electrode structure 3 can reduce the temperature inside the cell division suppression device 110, so as to avoid damage to patients caused by overhigh temperature.

2. In the conventional cell division suppressing device 110, a filling structure 2 is added, and the filling structure 2 and the electrode structure 3 are disposed on the same side of the coolant substrate 1. It can be realized that when the cell division suppressing device 110 is applied to the surface of the target biological tissue, the filling structure 2 can fill the gap between the electrode structures 3 inside the cell division suppressing device 110, so that the thickness drop formed between the electrode structures 3 and the coolant substrate 1 can be reduced to some extent, the foreign body sensation on the surface of the biological tissue can be reduced, and the comfort of a patient and the fitting degree of the cell division suppressing device 110 can be improved.

3. In this embodiment, the cooling liquid is injected into the cooling liquid cavity 11 from the cooling liquid input pipe 12, and after the cooling liquid performs indirect heat exchange with the electrode structure 3 in the cooling liquid cavity 11, the cooling liquid is output through the cooling liquid output pipe 13, so that a cooling circulation system of the cooling liquid input pipe 12-the cooling liquid cavity 11-the cooling liquid output pipe 13-the cooling system-the cooling liquid input pipe 12 can be established, the electrode structure in the electrode patch 110 is cooled, and damage to patients caused by overhigh temperature is avoided.

4. In this embodiment, the thickness of the filling structure 2 is not greater than the thickness of the electrode structure 3 to ensure that when the cell division suppression device 110 is applied to the target biological tissue surface, the electrode structure 3 can contact the target biological tissue surface to release an electrical signal to the focal region. Meanwhile, when the thickness of the filling structure 2 is smaller than that of the electrode structure 3, a certain gap inside the cell division suppressing device 110 can be maintained while reducing the thickness difference therebetween. Thereby, the foreign body sensation on the body surface of the patient can be reduced, the comfort can be improved, and the cell division suppressing device 110 can be provided with a certain air permeability.

5. In this embodiment, when the thickness of the filling structure 2 is equal to the thickness of the electrode structure 3, the thickness between the filling structure 2 and the electrode structure 3 is completely adapted, and the two structures together form a combined structure which is almost flat, and the surface close to the biological tissue is almost completely smooth, so that the foreign body sensation generated on the cell division suppression device 110 by the electrode structure 3 can be completely eliminated, and the fit degree between the cell division suppression device 110 and the target biological tissue can be improved.

6. In the present embodiment, the first filling structure 21 is designed as a mesh, and the electrode structure 3 is placed in the mesh. On the one hand, the structural characteristics of the mesh structure itself can reduce the material costs of the filling structure 2 while at the same time reinforcing the solidity of the first filling structure 21. On the other hand, the manufacturing process of the net structure is simpler, and is beneficial to mass production and application. The mesh of the mesh structure is used for accommodating the electrode structures 3, so that the thickness drop between the electrode structures 3 can be reduced, the foreign body sensation generated by the internal structure of the cell division suppression device 110 can be reduced, and the comfort of a human body can be improved.

7. In this embodiment, when the second filling structure 22 is designed to be strip-shaped, the area occupied by the filling structure 2 on the coolant substrate 1 can be reduced to a certain extent, and correspondingly, the adhesion area between the coolant substrate 1 and the target biological tissue is also increased, so as to improve the adhesion degree of the coolant substrate 1 on the target biological tissue. When the electrode structures 3 are distributed in an array, the second filling structures 22 are also distributed among the row-column gaps of the array of the electrode structures 3, and the second filling structures 22 increase the contact area between the internal structure of the cell division suppression device 110 and the target biological tissue, so that the pressure of the electrode structures 3 on the target biological tissue is reduced, the foreign body sensation of a patient is reduced, and the comfort of a human body is improved.

8. In the present embodiment, the third filling structures 23 are in a block shape and are staggered with the electrode structures 3 on the coolant substrate 1, so that the material cost of the third filling structures 23 can be further reduced, and the manufacturing process of the third filling structures 23 can be further simplified. The third filling structure 23 is designed to follow the principle of simplifying the cost and achieving the plane of the smooth electrode structure 3, and is uniformly distributed in the gaps of the electrode structure 3 in the cell division suppression device, so that the effect of reducing the pressure can be achieved, the foreign body sensation of skin tissues can be further reduced on the basis of reducing the material cost, and the comfort of a human body can be improved.

9. The second filling structure 22 or the third filling structure 23 and the electrode structure 3 are distributed at uniform intervals on the side of the coolant base 1 remote from the substrate. The second filling structure 22 or the third filling structure 23 can be more uniformly distributed on the plane of the electrode structure 3, so as to improve the effective utilization rate of the second filling structure 22 or the third filling structure 23.

10. In this embodiment, the adhesive structure 4 is disposed on the side of the filling structure 2 close to the target biological tissue, so that the adhesion of the whole cell division suppression device 110 is not affected, on the basis of the foreign body sensation reduction of the electrode structure 3 by the filling structure 2 in the foregoing embodiment.

11. In this embodiment, in order to avoid the influence of the filling structure 2 on the electric field output by the electrode structure 3, the material selected for the filling structure 2 itself needs to have an insulating property. The filling structure 2 does not affect the orientation and frequency of the electrode structure 3 releasing the electric field when the electrode structure 3 releases the electric field. Thereby ensuring the smooth proceeding of the electric field treatment. At the same time, the filling structure 2 needs to be made of a material with good air permeability so as to keep the skin of the patient comfortable.

It will be appreciated by those skilled in the art that in the description of the present application, it is to be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, merely to facilitate description of the present application and simplify the description, and do not indicate or imply that the devices or elements being referred to must have a specific orientation, be configured and operated in a specific orientation, and are therefore not to be construed as limiting the present application.

The terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, unless otherwise indicated, the meaning of "a plurality" is two or more.

In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.

In the description of the present specification, a particular feature, structure, material, or characteristic may be combined in any suitable manner in one or more embodiments or examples.

The foregoing is only a partial embodiment of the present application, and it should be noted that, for a person skilled in the art, several improvements and modifications can be made without departing from the principle of the present application, and these improvements and modifications should also be considered as the protection scope of the present application.

Claims (10)

1. A cell division suppression device, comprising:

at least one electrode structure for outputting an electric field to a target biological tissue;

a coolant substrate connected to one side of the electrode structure, at least partially for heat exchange with the electrode structure;

and the filling structure is connected with one side of the cooling liquid substrate, which is close to the electrode structures, and is used for at least partially filling gaps among the electrode structures.

2. The cell division suppression device of claim 1, wherein the coolant substrate comprises;

a cooling liquid chamber for accommodating a cooling liquid;

the cooling liquid input pipe is communicated with the cooling liquid cavity and is used for inputting cooling liquid into the cooling liquid cavity;

and the cooling liquid output pipe is communicated with the cooling liquid cavity and is used for outputting cooling liquid in the cooling liquid cavity and cooling the cooling liquid through a cooling system and then returning the cooling liquid to the cooling liquid cavity through the cooling liquid input pipe.

3. The cell division suppression device of claim 1, wherein a thickness of the filling structure in a first direction is not greater than a thickness of the electrode structure in the first direction, the first direction being perpendicular to a plane in which the coolant substrate is in a tiled state.

4. A cell division suppression device according to claim 3, wherein the thickness of the filling structure in the first direction is equal to the thickness of the electrode structure in the first direction.

5. A cell division suppression device according to claim 3, characterized in that the filling structure is in particular a first filling structure which is net-shaped, the first filling structure having mesh openings for accommodating the electrode structures.

6. A cell division suppression device according to claim 3, wherein the filling structures are in particular second filling structures which are strip-shaped, the interstices between the second filling structures being for accommodating the electrode structures;

or, the filling structure is specifically a third filling structure, and the third filling structure is in a block shape.

7. The cell division suppression device of claim 6, wherein the second filling structure is distributed at uniform intervals on the same side of the coolant substrate as the electrode structure;

or, the third filling structure and the electrode structure are distributed on the same side of the cooling liquid substrate at uniform intervals.

8. The cell division suppression device of any one of claims 3-7, wherein the side of the filling structure remote from the coolant substrate is provided with an adhesive structure.

9. The cell division suppression device of claim 8, wherein the filling structure is an insulating gas permeable material.

10. A cell division suppression system, comprising: a host and at least one pair of cell division suppression devices as claimed in any one of claims 1 to 9, said cell division suppression devices being electrically connected to the host.

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