CN114344715A - Active temperature-adjusting electrode patch and cell division inhibition device - Google Patents

Abstract

The embodiment of the application provides an active temperature-adjusting electrode patch and a cell division inhibition device. This active electrode patch that adjusts temperature includes: a substrate, a conductive structure and a heat exchange tube. Wherein the substrate is adapted to be at least partially applied to a target biological tissue surface. The conductive structure is connected with one side of the substrate and is used for being coupled with the conductive structure in the other corresponding active temperature-adjusting electrode patch and outputting a target electric field to target biological tissues. The heat exchange tube is at least partially in heat conduction connection with the conductive structure and is used for being connected with the heat circulation assembly, guiding the circulation of a heat exchange medium and realizing the heat exchange between the heat exchange medium and the conductive structure. The embodiment of the application realizes that the heat exchange pipe is additionally arranged in the electrode patch, the heat exchange medium is introduced into the heat exchange pipe, the heat exchange between the heat exchange medium and the conductive structure can adjust the temperature of the surface of the skin tissue of the human body by acting on the electrode patch, and therefore the comfort of a patient can be improved, and the potential safety hazard can be reduced.

Description

Active temperature-adjusting electrode patch and cell division inhibition device

Technical Field

The application relates to the technical field of medical equipment, in particular to an active temperature-adjusting electrode patch and a cell division inhibiting device.

Background

Since 1980, electric fields have been commonly used in the fields of biology and medicine to kill microorganisms, cell fusion, gene transformation, and tumor therapy. According to research, the alternating current electric field with low electric field intensity (1-2 volts per centimeter) and medium-low frequency (100-300 kilohertz) can selectively inhibit division and proliferation of Tumor cells, and the action mechanism is called Tumor therapy electric field (TTF) action mechanism. As a novel treatment method, the tumor electric field treatment has many advantages compared with the traditional medicine treatment, the operation treatment, the radiotherapy and chemotherapy treatment and the like.

The action mechanism of tumor electric field treatment is that the physiological characteristic that the proliferation and division process of tumor cells is more frequent than that of normal cells is utilized, an electric field is applied to the tumor cells, the electric field acts on the tubulin of the tumor proliferation cells, the mitosis of the tumor cells is destroyed, and the tumor cells are apoptotic. Or applying an uneven external electric field at the mitosis prophase of the tumor cells to make the microtubules consisting of polar molecules turn to polarization and move along the direction with stronger field intensity, so that the microtubules can not be gathered into spindle yarns, and the mitosis of the tumor cells is stopped; or an electric field in a specific direction is applied at the terminal stage of tumor cell division, so that the density of electric field lines and cytoplasm at the narrow cleavage groove of the tumor cell is highest, and the cleavage groove is broken under the action of the electric field force and cannot normally divide, thereby causing the apoptosis of the tumor cell.

At present, a tumor therapeutic apparatus based on a tumor electric field therapy technology is mainly pasted on the surface of a target biological tissue by means of a pair of electrode patches which are matched with each other, and an electric field is applied to act on tumor cells to enable the tumor cells to die. A large amount of heat can be generated in the electrode patch during action, the heat is transferred to the surface of the skin, the comfort level of a patient can be reduced, the physiological functions of the patient such as thermoregulation, water and salt metabolism and blood circulation are affected, and the physiological phenomena such as a large amount of sweating, dysphoria and heatstroke of the patient are caused. Even scald, burn and other injuries can be caused to the skin when the heat is too high, and hidden danger is caused to the personal safety of patients.

Disclosure of Invention

The application provides an active temperature-adjusting electrode patch and a cell division suppression device aiming at the defects of the existing mode, and is used for solving the technical problem that the electrode patch cannot actively adjust the temperature in the prior art.

In a first aspect, embodiments of the present application provide an active temperature regulating electrode patch, including:

a substrate for at least partial application to a target biological tissue surface.

And the conductive structure is connected with one side of the substrate and is used for being coupled with the conductive structure in the other corresponding active temperature-regulating electrode patch and outputting a target electric field to target biological tissues.

And at least part of the heat exchange tube is in heat conduction connection with the conductive structure and is used for being connected with the heat circulation assembly, guiding the circulation of a heat exchange medium and realizing the heat exchange between the heat exchange medium and the conductive structure.

Optionally, the heat exchange tube is connected to a side of the electrically conductive structure remote from the substrate.

Optionally, the conductive structure comprises: a flexible circuit board, and an electrode structure connected to the flexible circuit board.

The heat exchange tube is connected to the flexible circuit board and surrounds at least a portion of the electrode structure.

Optionally, the heat exchange tube comprises a first end, a heat exchange portion and a second end connected in series.

The first end and the second end are each for connection to a thermal cycle assembly.

The heat exchange part is connected with the flexible circuit board, and the orthographic projection of the plane of the heat exchange part in the substrate tiled state is positioned within the orthographic projection of the plane of the flexible circuit board in the substrate tiled state.

Optionally, the heat exchange tube comprises at least two heat exchange legs, at least one heat exchange leg surrounding part of the electrode structure.

Optionally, the active tempering electrode patch further comprises: a heat sensitive element.

The thermosensitive element is connected with the flexible circuit board and used for detecting the surface temperature of the target biological tissue.

Optionally, the active tempering electrode patch further comprises: a dielectric structure.

The dielectric structure is connected to the side of the electrode structure remote from the substrate.

The electrode structure and the heat exchange tube are connected with one side of the flexible circuit board far away from the substrate.

Optionally, a heat exchange tube is connected to a side of the substrate remote from the electrically conductive structure.

The orthographic projection of the plane of the heat exchange tube in the substrate tiled state is at least partially overlapped with the orthographic projection of the plane of the conductive structure in the substrate tiled state.

Alternatively, the heat exchange tube is arranged in a winding manner in the range of the orthographic projection of the conductive structure on the plane of the substrate in the tiled state.

Optionally, the heat exchange tube comprises at least two heat exchange branch tubes, and an orthographic projection of a plane where at least one heat exchange branch tube is located in the substrate tiled state at least partially overlaps with an orthographic projection of a plane where the conductive structure is located in the substrate tiled state.

Optionally, the conductive structure comprises: a flexible circuit board and an electrode structure. The electrode structure is connected with one side of the flexible circuit board far away from the substrate.

The active temperature-regulating electrode patch further comprises: a heat sensitive element and a dielectric structure. The thermosensitive element is connected with the flexible circuit board and used for detecting the surface temperature of the target biological tissue. The dielectric structure is connected to the side of the electrode structure remote from the substrate.

Optionally, the substrate is a medical tape.

In a second aspect, embodiments of the present application provide a cell-division inhibiting device, comprising: at least one pair of active temperature regulating electrode patches as provided in the first aspect, and a thermal cycling assembly.

And the heat exchange tube in the active temperature-regulating electrode patch is connected with the thermal circulation component.

Optionally, the thermal cycling assembly comprises:

and the container is connected with the heat exchange tube and is used for storing the heat exchange medium.

And the power pump is arranged in the heat exchange tube and used for driving the heat exchange medium to flow in the heat exchange tube.

Optionally, the cell-division suppressing device further comprises: a host.

The conductive structure of the active temperature-regulating electrode patch and the power pump are respectively electrically connected with the host machine.

The beneficial technical effects brought by the technical scheme provided by the embodiment of the application comprise:

compare in prior art not set up the electrode paster that adjusts the temperature structure, the active electrode paster that adjusts the temperature that this application provided increases the heat exchange tube structure of active temperature regulation, is connected heat exchange tube and conducting structure heat-conduction, is favorable to realizing the heat exchange between the heat transfer medium of hot exchange tube mesocycle flow and the conducting structure in the active electrode paster that adjusts the temperature. The temperature of the active temperature-adjusting electrode patch acting on the surface of the skin can be adjusted when the active temperature-adjusting electrode patch applies an electric field to a patient, so that the application area of the active temperature-adjusting electrode patch is in a proper temperature state, the comfort level of the patient is improved, and potential safety hazards are reduced. Specifically, the heat exchange medium in the heat exchange tube can absorb the heat generated by the electrode patch so as to avoid the active temperature adjustment electrode patch from being in a high-temperature heating state for a long time, so that the risk of damage to other internal structures in the electrode patch by the heat generated by the conductive structure in the active temperature adjustment electrode patch is reduced, and the service life of the active temperature adjustment electrode patch is prolonged.

Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.

Drawings

The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:

fig. 1 is a schematic structural tiling diagram of a first active temperature adjustment electrode patch provided in an embodiment of the present application;

fig. 2 is a schematic structural tiling diagram of a second active temperature adjustment electrode patch provided in an embodiment of the present application;

fig. 3 is a schematic structural tiling diagram of a third active temperature adjustment electrode patch provided in an embodiment of the present application;

FIG. 4 is a schematic view of a tiled arrangement of the substrate of the active temperature regulating electrode patch of FIG. 3 on a side away from the heat exchange tube;

FIG. 5 is a side view of the active temperature regulating electrode patch of FIG. 4;

fig. 6 is a schematic diagram of a structure of a cell division suppressing device according to an embodiment of the present disclosure.

In the figure:

1-a conductive structure; 11-a flexible circuit board; 12-an electrode structure;

2-a heat exchange tube; 21-a first end portion; 22-a heat exchange section; 23-a second end;

3-a substrate; 4-a thermo-sensitive element; 5-a dielectric structure; 6-a transmission line; 7-patch interface;

100-a cell division inhibiting device; 110-active temperature regulating electrode patch;

120-a thermal cycling assembly; 121-a container; 122-a power pump;

130-host.

Detailed Description

Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.

It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. As used herein, the term "and/or" includes all or any element and all combinations of one or more of the associated listed items.

The research and development idea of the application comprises:

when the electrode patch acts on target biological tissues, the internal conductive structure can generate a large amount of heat. In the existing electrode patch, a heat dissipation structure is not arranged under the common condition, and heat generated during the action of the electrode patch is blocked by a medical adhesive tape and is difficult to dissipate to the external environment in time. However, when the electrode patch is worn on a patient for a long time, the heat generated by the conductive structure for a long time is accumulated, so that the ambient temperature near the conductive structure is increased, and the heat exchange between the conductive structure and the external environment is blocked, so that the heat dissipation effect is poor. Moreover, the electrode patch can also shorten the service life of the electrode patch itself when the electrode patch is in a high-temperature state for a long time.

In addition, when the ambient temperature is low, the temperature of the electrode patch itself may be lower than the temperature of the skin tissue surface. At this time, since the conventional electrode patch has no heating structure, when the electrode patch is applied to the surface of skin tissue, certain cold stimulation is caused to the skin, which causes contraction of blood vessels of the skin and brings discomfort to a patient.

The application provides an active temperature-adjusting electrode patch and a cell division inhibiting device, and aims to solve the technical problems in the prior art.

The following describes the technical solutions of the present application and how to solve the above technical problems with specific embodiments.

The embodiment of the present application provides an active temperature adjustment electrode patch 110, as shown in fig. 1, including: a substrate 3, an electrically conductive structure 1 and a heat exchange tube 2. Wherein the content of the first and second substances,

the substrate 3 is used for at least partially applying on the surface of target biological tissue;

the conductive structure 1 is connected with one side of the substrate 3 and is used for being coupled with the conductive structure 1 in the other corresponding active temperature-regulating electrode patch 110 and outputting a target electric field to target biological tissues;

the heat exchange tube 2 is at least partially in heat-conducting connection with the electrically conductive structure 1, and is configured to be connected to the thermal circulation assembly 120, to guide the circulation of a heat exchange medium, and to realize heat exchange between the heat exchange medium and the electrically conductive structure 1.

In this embodiment, the heat exchange tube 2 is disposed in the active temperature adjustment electrode patch 110 and is in heat conduction connection with the conductive structure 1, a heat exchange medium is introduced into the heat exchange tube 2 from the container 121 in the thermal circulation assembly 120, and after flowing through the heat exchange tube 2, the heat exchange medium absorbing heat further flows out of the heat exchange tube 2 and finally enters the container 121 in the thermal circulation assembly 120 to realize the circulation flow of the heat exchange medium. When the active temperature-adjusting electrode patch 110 acts on a patient, a heat exchange medium with the temperature lower than that of the conductive structure 1 during heat generation is introduced into the heat exchange tube 2, the heat exchange medium is enabled to exchange heat with the conductive structure 1 through the tube wall of the heat exchange tube 2 by utilizing the temperature difference between the heat exchange medium and the conductive structure 1, and the heat exchange medium continuously and actively absorbs heat generated by the conductive structure 1, so that the temperature of the active temperature-adjusting electrode patch 110 acting on the surface of a target biological tissue is reduced, and the comfort level of the patient is improved.

In addition, when the environmental temperature is lower than the temperature of the surface of the target biological tissue, the temperature of the active temperature adjustment electrode patch 110 is also lower, and at this time, before the active temperature adjustment electrode patch 110 is attached to the surface of the target biological tissue, a heat exchange medium with the temperature higher than that of the conductive structure 1 is introduced into the heat exchange tube 2 of the active temperature adjustment electrode patch 110, so that the temperature of the active temperature adjustment electrode patch 110 is increased, the temperature difference between the conductive structure 1 and the surface of the target biological tissue is reduced, and the cold stimulation to a patient when the active temperature adjustment electrode patch is attached to the surface of the target biological tissue is reduced.

Optionally, the target biological tissue is human skin tissue.

Alternatively, the conductive structure 1 may be made of a metal material or a conductive non-metal material.

Optionally, the conductive structure 1 is connected to a side of the substrate 3 close to the target biological tissue.

Alternatively, the heat exchange medium may be water below a set temperature, an ice-water mixture, a non-toxic, harmless liquid below a set temperature, air below a set temperature, or an inert gas below a set temperature. It should be noted that the set temperature can be specifically set according to the season and the ambient temperature. For example, when the room temperature (ambient temperature) is 25 ℃, the set temperature may be set to 15 ℃.

Alternatively, the material of the heat exchanging tube 2 may employ silica gel, polyvinyl chloride (PVC), or Polyurethane (PU).

The research and development concept of the present application also includes that the heat exchange tube 2 needs to be close to the heat generating structure in the active temperature regulating electrode patch 110 to improve the heat exchange efficiency. To this end, as shown in fig. 1, the present application provides one possible implementation manner for the active temperature adjustment electrode patch 110 as follows:

the heat exchanger tube 2 is connected to the side of the electrically conductive structure 1 remote from the substrate 3.

In this embodiment, the heat exchange tube 2 is connected with the side of the conductive structure 1 far away from the substrate 3, and not only can be connected with the conductive structure 1 in a heat conduction manner, but also is favorable for realizing the heat conduction connection with the skin tissue of the human body, so that the heat exchange media in the heat exchange tube 2 can exchange heat with the conductive structure 1 and the skin tissue surface of the human body respectively, and the temperature regulation efficiency of the electrode patch is further improved.

The research and development concept of the present application also includes that the conductive structure 1 in the active thermoregulation electrode patch 110 is required for outputting an electric field to perform electric field treatment on a patient. To this end, as shown in fig. 1, the present application provides one possible implementation manner for the active temperature adjustment electrode patch 110 as follows:

the conductive structure 1 includes: a flexible circuit board 11, and an electrode structure 12 connected to the flexible circuit board 11;

the heat exchanger tube 2 is connected to a flexible circuit board 11 and surrounds at least part of the electrode structure 12.

In the present embodiment, the conductive structure 1 includes a flexible circuit board 11 and an electrode structure 12, and the electrode structure 12 and a flexible lead wire communicating with the electrode structure 12 are fixed on the flexible circuit board 11. The heat exchange tube 2 surrounds the electrode structure 12, and can absorb heat emitted from the 360-degree direction on the periphery of the electrode structure 12, so that the heat can be uniformly and quickly absorbed, and the comfort level of the skin tissue surface of a patient can be improved.

Alternatively, the flexible circuit board 11 may employ a single-sided flexible circuit board, a double-sided flexible circuit board, a multi-sided flexible circuit board, or a rigid-flex combined type flexible circuit board.

Optionally, the active electrode patch further comprises a transmission line 6. One end of the transmission line 6 is connected with the flexible circuit board 11, and the other end is connected with the patch interface 7. The transmission line 6 is used for transmitting electrical pulse signals.

Alternatively, the electrode structure 12 may be a metal disc having a diameter of 20 mm and a thickness of 1 mm.

Alternatively, the material of the electrode structure 12 may employ copper, silver, or zinc.

Alternatively, the electrode structure 12 may be bonded or soldered on the flexible circuit board 11.

Optionally, the side of the electrode structure 12 remote from the substrate 3 is provided with a conductive gel for attachment to a human skin tissue surface.

Alternatively, the heat exchange tube 2 may be adhered to the flexible circuit board 11.

The research and development concepts of the present application also include that the heat exchange tubes 2 need to be in communication with a means for providing a heat exchange medium and secured around the electrode structure 12 for proper operation. To this end, as shown in fig. 1, the present application provides one possible implementation manner for the active temperature adjustment electrode patch 110 as follows:

the heat exchange tube 2 comprises a first end portion 21, a heat exchange portion 22 and a second end portion 23 which are connected in sequence;

the first end 21 and the second end 23 are respectively used for connecting the thermal cycle assembly 120;

the heat exchanging portion 22 is connected to the flexible circuit board 11, and an orthogonal projection of a plane where the heat exchanging portion 22 is located in a state where the substrate 3 is laid is located within an orthogonal projection of a plane where the flexible circuit board 11 is located in a state where the substrate 3 is laid.

In this embodiment, the two ends of the heat exchange tube 2 are respectively communicated with the thermal circulation assembly 120, and the thermal circulation assembly 120 provides the heat exchange tube 2 with a heat exchange medium in a circulating flow. The heat exchange part 22 of the heat exchange tube 2 is arranged at the position of the flexible circuit board 11 close to the electrode structure 12, which is beneficial to improving the heat exchange efficiency between the heat exchange medium and the electrode structure 12.

In one example, as shown in fig. 1, the flexible circuit board 11 in the active temperature adjustment electrode patch 110 is "king" shaped, 9 circular electrode pads are uniformly distributed on the flexible circuit board 11, the first end portion 21 of the heat exchange tube 2 is led in from the upper left corner of the flexible circuit board 11, the heat exchange portion 22 of the heat exchange tube 2 sequentially surrounds the 9 electrode pads and is fixed on the flexible circuit board 11, and finally the second end portion 23 is led out from the lower right corner of the flexible circuit board 11. The first and second ends 21 and 23 respectively communicate with the thermal cycle assembly 120.

The research and development idea of the present application also includes that the specific structure of the heat exchange tube 2 needs to be adaptively designed according to the distribution characteristics of other structures inside the electrode patch. To this end, as shown in fig. 2, the present application provides one possible implementation manner for the active temperature adjustment electrode patch 110 as follows:

the heat exchange tube 2 comprises at least two heat exchange legs, at least one of which surrounds part of the electrode structure 12.

In the present embodiment, the heat exchange tube 2 may be designed with a plurality of branch tubes depending on the specific position of the electrode structure 12 on the flexible circuit board 11. Each branch pipe communicates with a main pipe, and both ends of the main pipe are respectively connected with the thermal cycle assembly 120 to achieve heat exchange between each heat exchange portion 22 of the heat exchange branch pipe and the electrode structure 12. On one hand, the design of a plurality of branch pipes can eliminate the limitation of a single heat exchange pipe 2 in the process of laying a pipeline route, and avoid the appearance of redundant or repeated pipelines, thereby saving the material cost of the heat exchange pipe 2. On the other hand, the heat exchange medium can flow in a plurality of branch pipes simultaneously and exchange heat with a plurality of electrode structures 12 simultaneously, so that the limitation that the heat exchange medium can only exchange heat with a plurality of electrode structures 12 in sequence due to the fact that the heat exchange medium flows in the heat exchange pipe 2 according to time sequence in a single heat exchange pipe 2 is avoided. Therefore, the heat exchange efficiency between the heat exchange medium and the electrode structure 12 can be improved.

In one example, as shown in fig. 2, 9 circular electrode sheets are uniformly distributed on the electrode patches in three rows and three columns, and the heat exchange tube 2 is provided with three branch tubes, each of which surrounds 3 electrode sheets of each row. The three branch pipes are all communicated with the main pipe of the heat exchange pipe 2.

The research and development idea of the present application further includes that the flow rate of the heat exchange medium in the heat exchange tube 2 in the active temperature adjustment electrode patch 110 needs to be adaptively adjusted according to the temperature acting on the surface of the skin tissue of the human body by the active temperature adjustment electrode patch 110. To this end, as shown in fig. 1, the present application provides one possible implementation manner for the active temperature adjustment electrode patch 110 as follows:

the active temperature regulating electrode patch 110 further comprises: a thermosensitive element 4;

the thermosensitive element 4 is connected to the flexible circuit board 11 for detecting the surface temperature of the target biological tissue.

In the present embodiment, a thermo-sensitive element 4 is provided in the active tempering electrode patch 110 to detect the surface temperature of the target biological tissue. The temperature-sensitive element 4 can be directly contacted with the skin tissue of a human body when the active temperature-regulating electrode patch 110 is electrified to work, and the test parameters of the temperature-sensitive element 4 can be changed along with the change of the temperature, so that the temperature change of the surface of the skin tissue can be monitored in real time. The pressure and the flow velocity of the heat exchange medium conveyed by the heat circulation component 120 to the heat exchange tube 2 are controlled according to the temperature change fed back by the thermosensitive element 4, so that the heat exchange rate between the heat exchange medium and the electrode structure 12 is further adjusted, and the temperature of the active temperature-adjusting electrode patch 110 acting on the surface of the skin tissue of the human body is controlled, so that the surface of the skin tissue of the human body is in a suitable temperature state, and the comfort level of the surface of the skin tissue of the patient is improved.

Alternatively, the heat sensitive element 4 may be adhered to the side of the substrate 3 near the flexible circuit board 11.

Alternatively, the heat-sensitive element 4 may be adhered to a side of the flexible circuit board 11 near the electrode structure 12.

Alternatively, the thermosensitive element 4 may employ an NTC thermistor (negative temperature coefficient thermistor), a PTC thermistor (positive temperature coefficient thermistor), or the like.

In one example, the thermal element 4 is a circular NTC thermistor with a diameter of 6 mm, the electrode structure 12 of the active temperature-regulating electrode patch 110 is provided with mounting holes, and the thermal element 4 is disposed in the mounting holes and connected to the flexible circuit board 11.

The research and development concept of the present application also includes that the active temperature-adjusting electrode patch 110 needs to form a capacitive effect to generate a target electric field having a function of selectively acting on proliferating and dividing tumor cells. To this end, as shown in fig. 5, the present application provides one possible implementation manner for the active temperature adjustment electrode patch 110 as follows:

the active temperature regulating electrode patch 110 further comprises: a dielectric structure 5;

the dielectric structure 5 is connected to the side of the electrode structure 12 remote from the substrate 3;

the electrode structure 12 and the heat exchanger tube 2 are both connected to the side of the flexible circuit board 11 remote from the substrate 3.

In the present embodiment, a dielectric structure 5 is disposed on a side of the electrode structure 12 of the active temperature adjustment electrode patch 110 away from the substrate 3, and the dielectric structure 5 is used to cooperate with the electrode structure 12 to form a capacitance effect to apply an alternating electrical signal to a lesion area. The dielectric structure 5 can be made of a bendable and deformable material, which is beneficial for the active temperature-adjusting electrode patch 110 to be better attached to the surface of the target biological tissue, thereby improving the comfort of the patient.

Alternatively, the dielectric structure 5 may be coated or adhered to the surface of the electrode structure 12.

Alternatively, the material of the dielectric structure 5 may be a ceramic material, a polyvinyl chloride coating, or a polyamide coating.

The research and development idea of the application also includes that when the heat exchange tube 2 is connected with one side of the substrate 3 close to the target biological tissue, the position of the heat exchange tube 2 is arranged to have certain limitation due to the influence of the spatial positions of other structures inside the active temperature adjustment electrode patch 110. To this end, as shown in fig. 3, the present application provides one possible implementation of the active temperature regulating electrode patch 110 as follows:

the heat exchange tube 2 is connected with one side of the substrate 3 far away from the conductive structure 1;

the orthographic projection of the plane of the heat exchange tube 2 in the tiled state of the substrate 3 is at least partially overlapped with the orthographic projection of the plane of the conductive structure 1 in the tiled state of the substrate 3.

In this embodiment, the heat exchange tube 2 is disposed on one side of the substrate 3 away from the conductive structure 1, and the heat exchange tube 2 is close to the conductive structure 1, and an orthographic projection of a plane where the heat exchange tube 2 is located in a tiled state of the substrate 3 can cover an orthographic projection of a plane where the conductive structure 1 is located in a tiled state of the substrate 3, so that a heat exchange medium can perform uniform heat exchange with each part of the conductive structure 1, and heat dissipated from the center or the edge of the conductive structure 1 can be uniformly absorbed, so that uniformity of temperature of each part when the active temperature adjustment electrode patch 110 acts on the surface of skin tissue of a human body is improved, and comfort of a patient is improved.

The research and development idea of the present application further includes that when the conductive structure 1 in the active temperature adjustment electrode patch 110 is uniformly disposed on one side of the substrate 3 close to the skin tissue of the human body, the heat exchange tube 2 also needs to be uniformly disposed on one side of the substrate 3 away from the conductive structure 1. To this end, as shown in fig. 3, the present application provides one possible implementation of the active temperature regulating electrode patch 110 as follows:

the heat exchanger tubes 2 are arranged in a meandering manner in the area of the orthographic projection of the plane of the substrate 3 in the flat state, and the electrically conductive structures 1 are arranged in the area of the orthographic projection of the plane of the substrate 3 in the flat state.

In this embodiment, the heat exchange tube 2 is arranged on one side of the substrate 3 away from the conductive structure 1 in a roundabout manner and covers the planar area where the conductive structure 1 is located as completely as possible, so that the heat exchange medium can exchange heat with the conductive structure 1 uniformly to improve the comfort of patients.

In one example, the heat exchange tubes 2 are arranged in an "S" shaped meander on the side of the substrate 3 facing away from the electrically conductive structure 1.

The research and development idea of the present application also includes that when the heat exchanger tube 2 is connected to the side of the substrate 3 remote from the electrically conductive structure 1, the heat exchanger tube 2 can be designed to be of substantially the same type as when the heat exchanger tube 2 is connected to the side of the electrically conductive structure 1 remote from the substrate 3. To this end, when the heat exchanger tube 2 is connected to the side of the substrate 3 remote from the conductive structure 1, the present application provides one possible implementation for the active temperature regulating electrode patch 110 as follows:

the heat exchange tube 2 comprises at least two heat exchange branch tubes, and the orthographic projection of the plane of at least one heat exchange branch tube in the tiled state of the substrate 3 at least partially overlaps with the orthographic projection of the plane of the conductive structure 1 in the tiled state of the substrate 3.

In this embodiment, since the technical solution of designing the branch tubes of the heat exchange tube 2 is the same as that of the foregoing embodiment, the principle and technical effects thereof refer to the foregoing embodiment and are not described herein again.

The research and development idea of the present application further includes that, when the heat exchange tube 2 is connected to the side of the substrate 3 away from the conductive structure 1, the related technical solutions of other structures inside the active temperature adjustment electrode patch 110 are substantially the same as when the heat exchange tube 2 is connected to the side of the conductive structure 1 away from the substrate 3. To this end, when the heat exchanger tube 2 is connected to the side of the substrate 3 remote from the conductive structure 1, the present application provides one possible implementation for the active temperature regulating electrode patch 110 as follows:

the conductive structure 1 includes: a flexible circuit board 11 and an electrode structure 12; the electrode structure 12 is connected with one side of the flexible circuit board 11 far away from the substrate 3;

the active temperature regulating electrode patch 110 further comprises: a heat sensitive element 4 and a dielectric structure 5; the thermosensitive element 4 is connected with the flexible circuit board 11 and is used for detecting the surface temperature of the target biological tissue; the dielectric structure 5 is connected to the side of the electrode structure 12 remote from the substrate 3.

In this embodiment, since the technical solutions of the conductive structure 1, the thermal sensitive element 4 and the dielectric structure 5 are the same as those of the foregoing embodiment, the principle and technical effects thereof refer to the foregoing embodiment and are not described herein again.

Optionally, the substrate 3 is a medical tape.

Alternatively, the medical adhesive plaster may be any one of a pressure-sensitive medical adhesive plaster, a moisture-proof and anti-allergic medical adhesive plaster, a paper-plate and anti-allergic medical adhesive plaster, a fully transparent air-permeable medical adhesive plaster and a non-woven medical adhesive plaster.

Specifically, the pressure-sensitive medical adhesive plaster is composed of pure cotton cloth and an adhesive, the adhesive degree of the adhesive plaster can enable the adhesive plaster to be fixed on the surface of a target biological tissue, and the pressure-sensitive medical adhesive plaster can be suitable for the surface of a common skin tissue; the moistureproof and antiallergic medical adhesive plaster and the papered and antiallergic medical adhesive plaster can be suitable for the surface of allergic skin tissues; the full-transparent air-permeable medical adhesive plaster can be suitable for the surface of large-scale skin tissues; the non-woven medical adhesive plaster can be suitable for the surface of common skin tissue.

Based on the same inventive concept, the embodiment of the present application provides a cell-division inhibiting device, which is schematically shown in fig. 6 (in fig. 6, the dotted line is a circuit, and the solid line is a pipeline), including but not limited to:

at least one pair of active temperature regulating electrode patches 110, as provided in the above embodiments, and a thermal cycling assembly 120;

the heat exchange tubes 2 in the active temperature regulating electrode patch 110 are connected to a thermal cycling assembly 120.

In this embodiment, the cell division suppressing device comprises an active temperature adjusting electrode patch 110 and a thermal circulation component 120, wherein the thermal circulation component 120 is communicated with the heat exchange tube 2 and is used for providing a heat exchange medium and conveying the heat exchange medium to the heat exchange tube 2 so as to realize heat exchange between the heat exchange medium and the conductive structure 1.

Optionally, thermal cycling assembly 120 comprises: a vessel 121 and a power pump 122;

the container 121 is connected with the heat exchange tube 2 and used for storing a heat exchange medium;

a power pump 122 is disposed in the heat exchange tube 2 for driving the heat exchange medium to flow in the heat exchange tube 2.

Alternatively, the power pump 122 may employ a centrifugal pump or a vortex pump.

Optionally, the cell-division suppressing device further comprises: a host 130;

optionally, the conductive structure 1 of the active temperature-adjusting electrode patch 110 and the power pump 122 are respectively electrically connected to the host 130, and the power pump 122 is used for conveying the heat exchange medium flowing circularly to the heat exchange tube 2 under the control of the host 130.

Optionally, the host 130 further comprises: a voltage generator.

Optionally, the voltage generator is electrically connected to the conductive structures 1 in at least one pair of active cooling electrode patches, respectively, and is configured to output a voltage to the conductive structures 1 under the control of the host 130.

Optionally, the voltage generator is a pulse voltage generator or an alternating voltage generator.

By applying the embodiment of the application, at least the following beneficial effects can be realized:

1. in this embodiment, the heat exchange tube 2 is disposed in the active temperature adjustment electrode patch 110 and is in heat conduction connection with the conductive structure 1, a heat exchange medium is introduced into the heat exchange tube 2 from the container 121 in the thermal circulation assembly 120, and after flowing through the heat exchange tube 2, the heat exchange medium absorbing heat further flows out of the heat exchange tube 2 and finally enters the container 121 in the thermal circulation assembly 120 to realize the circulation flow of the heat exchange medium. When the active temperature-adjusting electrode patch 110 acts on a patient, a heat exchange medium with the temperature lower than that of the conductive structure 1 during heat generation is introduced into the heat exchange tube 2, the heat exchange medium is enabled to exchange heat with the conductive structure 1 through the tube wall of the heat exchange tube 2 by utilizing the temperature difference between the heat exchange medium and the conductive structure 1, and the heat exchange medium continuously and actively absorbs heat generated by the conductive structure 1, so that the temperature of the active temperature-adjusting electrode patch 110 acting on the surface of a target biological tissue is reduced, and the comfort level of the patient is improved.

2. In addition, when the environmental temperature is lower than the temperature of the surface of the target biological tissue, the temperature of the active temperature adjustment electrode patch 110 is also lower, and at this time, before the active temperature adjustment electrode patch 110 is attached to the surface of the target biological tissue, a heat exchange medium with the temperature higher than that of the conductive structure 1 is introduced into the heat exchange tube 2 of the active temperature adjustment electrode patch 110, so that the temperature of the active temperature adjustment electrode patch 110 is increased, the temperature difference between the conductive structure 1 and the surface of the target biological tissue is reduced, and the cold stimulation to a patient when the active temperature adjustment electrode patch is attached to the surface of the target biological tissue is reduced.

3. In this embodiment, the heat exchange tube 2 is connected to the side of the conductive structure 1 away from the substrate 3, and can be connected to the conductive structure 1 and the human skin tissue by heat conduction, so that the heat exchange medium in the heat exchange tube 2 can exchange heat with the conductive structure 1 and the human skin tissue surface at the same time, thereby further improving the temperature adjustment efficiency of the electrode patch.

4. In the present embodiment, the conductive structure 1 includes a flexible circuit board 11 and an electrode structure 12, and the electrode structure 12 and a flexible lead wire communicating with the electrode structure 12 are fixed on the flexible circuit board 11. The heat exchange tube 2 surrounds the electrode structure 12, and can absorb heat emitted from the 360-degree direction on the periphery of the electrode structure 12, so that the heat can be uniformly and quickly absorbed, and the comfort level of the skin tissue surface of a patient can be improved.

5. In this embodiment, the two ends of the heat exchange tube 2 are respectively communicated with the thermal circulation assembly 120, and the thermal circulation assembly 120 provides the heat exchange tube 2 with a heat exchange medium in a circulating flow. The heat exchange part 22 of the heat exchange tube 2 is arranged at the position of the flexible circuit board 11 close to the electrode structure 12, which is beneficial to improving the heat exchange efficiency between the heat exchange medium and the electrode structure 12.

6. In the present embodiment, the heat exchange tube 2 may be designed with a plurality of branch tubes depending on the specific position of the electrode structure 12 on the flexible circuit board 11. Each branch pipe communicates with a main pipe, and both ends of the main pipe are respectively connected with the thermal cycle assembly 120 to achieve heat exchange between each heat exchange portion 22 of the heat exchange branch pipe and the electrode structure 12. On one hand, the design of a plurality of branch pipes can eliminate the limitation of a single heat exchange pipe 2 in the process of laying a pipeline route, and avoid the appearance of redundant or repeated pipelines, thereby saving the material cost of the heat exchange pipe 2. On the other hand, the heat exchange medium can flow in a plurality of branch pipes simultaneously and exchange heat with a plurality of electrode structures 12 simultaneously, so that the limitation that the heat exchange medium can only exchange heat with a plurality of electrode structures 12 in sequence due to the fact that the heat exchange medium flows in the heat exchange pipe 2 according to time sequence in a single heat exchange pipe 2 is avoided. Therefore, the heat exchange efficiency between the heat exchange medium and the electrode structure 12 can be improved.

7. In the present embodiment, a thermo-sensitive element 4 is provided in the active tempering electrode patch 110 to detect the surface temperature of the target biological tissue. The temperature-sensitive element 4 can be directly contacted with the skin tissue of a human body when the active temperature-regulating electrode patch 110 is electrified to work, and the test parameters of the temperature-sensitive element 4 can be changed along with the change of the temperature, so that the temperature change of the surface of the skin tissue can be monitored in real time. The pressure and the flow velocity of the heat exchange medium conveyed by the heat circulation component 120 to the heat exchange tube 2 are controlled according to the temperature change fed back by the thermosensitive element 4, so that the heat exchange rate between the heat exchange medium and the electrode structure 12 is further adjusted, and the temperature of the active temperature-adjusting electrode patch 110 acting on the surface of the skin tissue of the human body is controlled, so that the surface of the skin tissue of the human body is in a suitable temperature state, and the comfort level of the surface of the skin tissue of the patient is improved.

8. In the present embodiment, a dielectric structure 5 is disposed on a side of the electrode structure 12 of the active temperature adjustment electrode patch 110 away from the substrate 3, and the dielectric structure 5 is used to cooperate with the electrode structure 12 to form a capacitance effect to apply an alternating electrical signal to a lesion area. The dielectric structure 5 can be made of a bendable and deformable material, which is beneficial for the active temperature-adjusting electrode patch 110 to be better attached to the surface of the target biological tissue, thereby improving the comfort of the patient.

9. In this embodiment, the heat exchange tube 2 is disposed on one side of the substrate 3 away from the conductive structure 1, and the heat exchange tube 2 is close to the conductive structure 1, and an orthographic projection of a plane where the heat exchange tube 2 is located in a tiled state of the substrate 3 can cover an orthographic projection of a plane where the conductive structure 1 is located in a tiled state of the substrate 3, so that a heat exchange medium can perform uniform heat exchange with each part of the conductive structure 1, and heat dissipated from the center or the edge of the conductive structure 1 can be uniformly absorbed, so that uniformity of temperature of each part when the active temperature adjustment electrode patch 110 acts on the surface of skin tissue of a human body is improved, and comfort of a patient is improved.

10. In this embodiment, the heat exchange tube 2 is arranged on one side of the substrate 3 away from the conductive structure 1 in a roundabout manner and covers the planar area where the conductive structure 1 is located as completely as possible, so that the heat exchange medium can exchange heat with the conductive structure 1 uniformly to improve the comfort of patients.

11. In this embodiment, the cell division suppressing device comprises an active temperature adjusting electrode patch 110 and a thermal circulation component 120, wherein the thermal circulation component 120 is communicated with the heat exchange tube 2 and is used for providing a heat exchange medium and conveying the heat exchange medium to the heat exchange tube 2 so as to realize heat exchange between the heat exchange medium and the conductive structure 1.

It will be understood by those skilled in the art that in the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used for convenience of description and simplicity of description only, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be considered as limiting.

The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.

In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.

In the description herein, particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples.

The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.

Claims (15)

1. An active temperature regulating electrode patch, comprising:

a substrate for at least partial application to a target biological tissue surface;

the conductive structure is connected with one side of the substrate and is used for being coupled with the conductive structure in the other corresponding active temperature-regulating electrode patch and outputting a target electric field to target biological tissues;

and the heat exchange tube is at least partially in heat conduction connection with the conductive structure and is used for being connected with the heat circulation assembly, guiding the circulation of a heat exchange medium and realizing the heat exchange between the heat exchange medium and the conductive structure.

2. The active temperature regulating electrode patch as claimed in claim 1, wherein the thermal exchange tube is connected to a side of the electrically conductive structure remote from the substrate.

3. The active temperature regulating electrode patch of claim 2, wherein the conductive structure comprises: a flexible circuit board, and an electrode structure connected to the flexible circuit board;

the heat exchange tube is connected with the flexible circuit board and surrounds at least part of the electrode structure.

4. The active temperature regulating electrode patch as claimed in claim 3, wherein the heat exchange tube comprises a first end portion, a heat exchange portion and a second end portion connected in sequence;

the first end and the second end are respectively used for connecting a thermal circulation assembly;

the heat exchange part is connected with the flexible circuit board, and the orthographic projection of the plane of the heat exchange part in the substrate tiled state is positioned within the orthographic projection of the plane of the flexible circuit board in the substrate tiled state.

5. The active temperature regulating electrode patch as claimed in claim 3, wherein the heat exchange tube comprises at least two heat exchange legs, at least one of which surrounds a portion of the electrode structure.

6. The active temperature regulating electrode patch according to any one of claims 3-5, further comprising: a thermosensitive element;

the thermosensitive element is connected with the flexible circuit board and used for detecting the surface temperature of the target biological tissue.

7. The active temperature regulating electrode patch according to claims 3-5, further comprising: a dielectric structure;

the dielectric structure is connected with one side of the electrode structure far away from the substrate;

the electrode structure and the heat exchange tube are connected with one side, far away from the substrate, of the flexible circuit board.

8. The active temperature regulating electrode patch as claimed in claim 1, wherein the heat exchange tube is connected to a side of the substrate remote from the electrically conductive structure;

the orthographic projection of the plane of the heat exchange tube in the substrate tiled state is at least partially overlapped with the orthographic projection of the plane of the conductive structure in the substrate tiled state.

9. Active temperature regulating electrode patch according to claim 8, wherein the orthographic projection of the plane of the heat exchanger tube in the tiled substrate is circuitously arranged within the orthographic projection of the plane of the electrically conductive structure in the tiled substrate.

10. The active temperature regulating electrode patch as claimed in claim 8, wherein the heat exchange tube comprises at least two heat exchange legs, at least one of the heat exchange legs having an orthographic projection of a plane in which the substrate is laid at least partially overlapping with an orthographic projection of a plane in which the electrically conductive structure is laid in the substrate laid condition.

11. The active temperature-regulating electrode patch according to any one of claims 8 to 10,

the conductive structure includes: a flexible circuit board and an electrode structure; the electrode structure is connected with one side of the flexible circuit board, which is far away from the substrate;

the electrode patch further includes: a thermal element and a dielectric structure; the thermosensitive element is connected with the flexible circuit board and used for detecting the surface temperature of the target biological tissue; the dielectric structure is connected with one side of the electrode structure far away from the substrate.

12. The active temperature regulating electrode patch of claim 1, wherein the substrate is a medical tape.

13. A cell-division inhibiting device comprising: at least one pair of active temperature regulating electrode patches according to any of the claims 1-12, and a thermal cycling assembly;

and the heat exchange tube in the active temperature-regulating electrode patch is connected with the thermal circulation component.

14. The cell-division inhibiting device of claim 13, wherein the thermal cycling assembly comprises:

the container is connected with the heat exchange tube and is used for storing a heat exchange medium;

and the power pump is arranged in the heat exchange tube and used for driving the heat exchange medium to flow in the heat exchange tube.

15. The cell-division suppressing device according to claim 14, further comprising: a host;

and the conductive structure of the active temperature-regulating electrode patch and the power pump are respectively electrically connected with the host.

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