CN218938210U

CN218938210U - Chromatographic column sample collection device

Info

Publication number: CN218938210U
Application number: CN202220476296.4U
Authority: CN
Inventors: 赵武新; 史佳豪
Original assignee: Zhejiang Boyi Biotechnology Co ltd
Current assignee: Zhejiang Boyi Biotechnology Co ltd
Priority date: 2022-03-04
Filing date: 2022-03-04
Publication date: 2023-04-28
Anticipated expiration: 2032-03-04

Abstract

The utility model provides a chromatographic column sample collection device, which relates to the technical field of chromatographic columns and comprises a supporting seat and a collecting pipe supporting plate, wherein a driving part is arranged on one side of the top of the supporting seat, a pneumatic cylinder is movably arranged on the driving part, an adjusting column is arranged at the output end of the pneumatic cylinder, an adjusting block is movably installed on the adjusting column, an adjusting part is arranged in the adjusting column, the adjusting part drives the adjusting block to move, a clamping claw is hinged below one end of the adjusting block, an electric telescopic rod is hinged above one end of the adjusting block, a hinge part is arranged at the top of the clamping claw, and the output end of the electric telescopic rod is hinged with the hinge part; according to the utility model, the chromatographic column is clamped by the clamping claws, the sample is led into the chromatographic column to separate components, and in the process of leading in the sample, the clamping claws are pulled by the electric telescopic rod to rotate, so that the angle is changed, the chromatographic column is inclined, the sample is conveniently adhered to the wall to conduct material guiding, the generation of bubbles is avoided, and convenience is provided for the collection of subsequent samples.

Description

Chromatographic column sample collection device

Technical Field

The utility model relates to the technical field of chromatographic columns, in particular to a chromatographic column sample collection device.

Background

The column chromatography technology is also called column chromatography technology, the main principle is that according to the different distribution coefficients of each component in a sample mixture in a stationary phase and a mobile phase, the components are separated through repeated distribution for a plurality of times, when the column chromatography operation is performed, gel is filled in a chromatographic column, a single gel bead is like a sieve, the sizes of sieve holes of different types of gel are different, if the gel is filled in a column which is long enough, a gel column is formed, when a sample containing proteins with different sizes is added to the gel column, the proteins with smaller average pore diameters than the gel beads continuously penetrate into the beads, the movement path of the small molecules is long, the resistance from the interiors of the gel beads is large, so that the smaller proteins take longer to elute from the column, the gel has small pore diameters and can accept large proteins, therefore, the large proteins directly pass through gaps among the gel beads to be eluted first, the separation of the components is realized, the column chromatography technology has the advantages that the used gel belongs to inert carrier, the adsorption force is weak, the adsorption force is relatively wide, the operation condition can be performed under a quite wide temperature range, and the split solvent is not required to be separated physically and physically separated;

in the prior art, for example, an authorized publication number CN 211905242U discloses a chromatographic column sample collection device, which comprises a chromatographic column fixing platform, a chromatographic column platform supporting rod, a base, a chromatographic column, a collecting test tube and a collecting test tube mounting seat, and by moving the collecting test tube mounting seat, the positions of the collecting test tube and the chromatographic column correspond to each other, the collecting test tube is accurately positioned to collect the separated sample.

Disclosure of Invention

In view of the above problems, the utility model provides a chromatographic column sample collection device, which is convenient for sample adherence to conduct material guiding, avoids generation of bubbles and provides convenience for collection of subsequent samples.

In order to achieve the purpose of the utility model, the utility model is realized by the following technical scheme: the utility model provides a chromatographic column sample collection device, includes supporting seat and collecting pipe layer board, one side at supporting seat top is equipped with drive division, and the activity is equipped with the pneumatic cylinder on the drive division, the output of pneumatic cylinder is equipped with the adjusting column, and movable mounting has the regulating block on the adjusting column, be equipped with the adjusting part in the adjusting column, and the regulating part drives the regulating block and remove, the below of regulating block one end articulates there is the gripper jaw, and the top of regulating block one end articulates there is electric telescopic handle, the top of gripper jaw is equipped with articulated portion, electric telescopic handle's output is articulated with articulated portion, the inboard clamp of gripper jaw has the chromatographic column;

the collecting pipe layer board is established on the supporting seat, and the top of collecting pipe layer board is equipped with the collecting pipe groove, the collecting pipe groove equidistance is equipped with the multiunit, and the collecting pipe groove is used for holding the collecting pipe, every group collecting pipe groove one end position department all be equipped with infrared reflector plate on the collecting pipe layer board, the below of gripper jaw is equipped with the infrared location probe with infrared reflector plate looks adaptation.

The further improvement is that: the driving part comprises an electromagnetic guide rail and an electromagnetic slide block, the electromagnetic guide rail is arranged on one side of the top of the supporting seat, the electromagnetic slide block is movably mounted on the electromagnetic guide rail, and the pneumatic cylinder is arranged on the electromagnetic slide block.

The further improvement is that: the inside of adjusting the post is equipped with the mounting groove, the adjusting part includes screw thread lead screw and first motor, screw thread lead screw rotates to be installed the inside of mounting groove, first motor is established one side of adjusting the post, and the output of first motor with screw thread lead screw connects, the middle part of regulating block extends into the mounting groove, screw thread lead screw runs through the middle part and the screw thread adaptation of regulating block.

The further improvement is that: the clamping claw comprises a claw disc and claw arms, wherein the claw arms are provided with two groups, the two groups of claw arms are respectively and rotatably installed on two sides of the inside of the claw disc, gears are respectively arranged at the rotating positions of the two groups of claw arms, and rubber pads are respectively arranged on the inner sides of the two groups of claw arms.

The further improvement is that: the middle position inside the claw dish department rotates and is equipped with the worm, worm and two sets of gear looks adaptations, the inside one end of claw dish is equipped with the drive chamber, and the drive intracavity portion is equipped with the second motor, the output of second motor with the worm is connected.

The further improvement is that: the infrared positioning probe is connected with the control terminal and transmits positioning signals, and the control terminal drives the driving part and the adjusting part to open and close according to the positioning signals.

The further improvement is that: the two ends of the inside of the supporting seat are respectively provided with a driving roller in a rotating mode, the driving rollers are driven to rotate by a motor, the driving rollers are wound with a conveying belt, and the collecting pipe supporting plates are placed on the conveying belt.

The beneficial effects of the utility model are as follows:

1. according to the utility model, the chromatographic column is clamped by the clamping claws, the sample is led into the chromatographic column to separate components, and in the process of leading in the sample, the clamping claws are pulled by the electric telescopic rod to rotate, so that the angle is changed, the chromatographic column is inclined, the sample is conveniently adhered to the wall to conduct material guiding, the generation of bubbles is avoided, and convenience is provided for the collection of subsequent samples.

2. According to the utility model, the sample collecting pipe is placed through the collecting pipe groove on the collecting pipe supporting plate, the electromagnetic guide rail drives the electromagnetic slide block to move so as to change the left and right positions of the chromatographic column, the threaded screw rod is used for rotationally driving the adjusting block to move along the adjusting column so as to change the front and back positions of the chromatographic column, and the height of the chromatographic column can be adjusted through the pneumatic cylinder, so that the multi-axis adjusting position of the chromatographic column is convenient, and the output end corresponds to different sample collecting pipes.

3. When the position of the chromatographic column is adjusted, the infrared reflecting sheet is identified by the infrared positioning probe, the infrared positioning probe is connected with the control terminal and transmits positioning signals, and the control terminal drives the driving part and the adjusting part to be opened and closed according to the positioning signals, so that the position of the chromatographic column is accurately controlled, and the positioning and collecting are automated.

4. The collecting pipe supporting plate is placed on the conveying belt, and the conveying belt can be driven to run through the driving roller, so that the collecting pipe supporting plate is conveyed, the feeding and discharging of the collecting pipe supporting plate are facilitated, and the functions are diversified.

Drawings

FIG. 1 is a front view of the present utility model;

FIG. 2 is a schematic diagram of a chromatographic column of the utility model;

fig. 3 is a schematic view of a gripper jaw of the present utility model.

Wherein: 1. a support base; 2. a collecting pipe pallet; 3. a pneumatic cylinder; 4. an adjusting column; 5. an adjusting block; 6. an electric telescopic rod; 7. a chromatographic column; 8. a collecting tube tank; 9. an infrared reflecting sheet; 10. an infrared positioning probe; 11. an electromagnetic guide rail; 12. an electromagnetic slide block; 13. a mounting groove; 14. a threaded screw rod; 15. a first motor; 16. a claw disk; 17. a claw arm; 18. a gear; 19. a worm; 20. a second motor; 21. a driving roller; 22. and (3) a conveyor belt.

Detailed Description

The present utility model will be further described in detail with reference to the following examples, which are only for the purpose of illustrating the utility model and are not to be construed as limiting the scope of the utility model.

Example 1

According to fig. 1, 2 and 3, this embodiment provides a chromatographic column sample collection device, which comprises a supporting seat 1 and a collecting pipe supporting plate 2, wherein a driving part is arranged on one side of the top of the supporting seat 1, a pneumatic cylinder 3 is movably arranged on the driving part, an adjusting column 4 is arranged at the output end of the pneumatic cylinder 3, an adjusting block 5 is movably arranged on the adjusting column 4, an adjusting part is arranged in the adjusting column 4, the adjusting part drives the adjusting block 5 to move, a clamping claw is hinged below one end of the adjusting block 5, an electric telescopic rod 6 is hinged above one end of the adjusting block 5, a hinge part is arranged at the top of the clamping claw, the output end of the electric telescopic rod 6 is hinged with the hinge part, and a chromatographic column 7 is clamped at the inner side of the clamping claw;

the collecting pipe layer board 2 is established on supporting seat 1, and the top of collecting pipe layer board 2 is equipped with collecting tube slot 8, collecting tube slot 8 equidistance is equipped with the multiunit, and collecting tube slot 8 is used for holding the collecting pipe, every group collecting tube slot 8 one end position department all be equipped with infrared reflector plate 9 on the collecting pipe layer board 2, the below of gripper jaw is equipped with the infrared location probe 10 with infrared reflector plate 9 looks adaptation. During the use, start gripper jaw gripping chromatographic column 7, import sample through chromatographic column 7 carries out the component separation, at the in-process of leading-in sample, electric telescopic handle 6 pulling gripper jaw rotates, thereby change the angle, make things convenient for sample adherence to lead the material, simultaneously, put the collecting tube groove 8 on collecting tube layer board 2 with the sample collecting tube, the position about the drive division changes chromatographic column 7, regulation portion drive regulating block 5 moves the front and back position that changes chromatographic column 7 along adjusting column 4, the height of chromatographic column 7 is adjusted to pneumatic cylinder 3, thereby drive chromatographic column 7 multiaxis adjustment position, make the output correspond different sample collecting tubes, sample collection that separates out.

The driving part comprises an electromagnetic guide rail 11 and an electromagnetic slide block 12, the electromagnetic guide rail 11 is arranged on one side of the top of the supporting seat 1, the electromagnetic slide block 12 is movably arranged on the electromagnetic guide rail 11, and the pneumatic cylinder 3 is arranged on the electromagnetic slide block 12. When in use, the electromagnetic guide rail 11 drives the electromagnetic slide block 12 to move and the pneumatic cylinder 3 to move, thereby changing the left and right positions of the chromatographic column 7.

The inside of adjusting post 4 is equipped with mounting groove 13, the adjusting part includes screw thread lead screw 14 and first motor 15, screw thread lead screw 14 rotates to be installed the inside of mounting groove 13, first motor 15 is established one side of adjusting post 4, and the output of first motor 15 with screw thread lead screw 14 is connected, mounting groove 13 is gone into in the middle part extension of regulating block 5, screw thread lead screw 14 runs through the middle part of regulating block 5 and screw thread adaptation. When in use, the first motor 15 drives the threaded screw rod 14 to rotate, and the adjusting block 5 is driven to move along the adjusting column 4 by utilizing the threaded action, so that the front and back positions of the chromatographic column 7 are changed.

The clamping claw comprises a claw disc 16 and claw arms 17, wherein the claw arms 17 are provided with two groups, the two groups of claw arms 17 are respectively and rotatably installed on two sides of the interior of the claw disc 16, gears 18 are respectively arranged at the rotating positions of the two groups of claw arms 17, and rubber pads are respectively arranged on the inner sides of the two groups of claw arms 17. The middle position inside the claw disk 16 is rotationally provided with a worm 19, the worm 19 is matched with the two groups of gears 18, one end inside the claw disk 16 is provided with a driving cavity, the driving cavity is internally provided with a second motor 20, and the output end of the second motor 20 is connected with the worm 19. When in use, the second motor 20 drives the worm 19 to rotate, so as to drive the two groups of gears 18 to rotate, and drive the two groups of claw arms 17 to open or close, so that chromatographic columns 7 with different calibers are adaptively clamped.

The infrared positioning probe 10 is connected with a control terminal and transmits positioning signals, and the control terminal drives the driving part and the adjusting part to open and close according to the positioning signals. When the position of the chromatographic column 7 is regulated, the infrared reflecting sheet 9 is identified by utilizing the infrared positioning probe 10, the infrared positioning probe 10 is connected with a control terminal and transmits positioning signals, and the control terminal drives the driving part and the regulating part to open and close according to the positioning signals, so that the regulating position of the chromatographic column 7 is accurately controlled, and the positioning and collecting are automated.

Example two

According to fig. 1 and 2, this embodiment provides a chromatographic column sample collection device, which comprises a supporting seat 1 and a collecting pipe supporting plate 2, wherein a driving part is arranged on one side of the top of the supporting seat 1, a pneumatic cylinder 3 is movably arranged on the driving part, an adjusting column 4 is arranged at the output end of the pneumatic cylinder 3, an adjusting block 5 is movably arranged on the adjusting column 4, an adjusting part is arranged in the adjusting column 4, the adjusting part drives the adjusting block 5 to move, a clamping claw is hinged below one end of the adjusting block 5, an electric telescopic rod 6 is hinged above one end of the adjusting block 5, a hinge part is arranged at the top of the clamping claw, the output end of the electric telescopic rod 6 is hinged with the hinge part, and a chromatographic column 7 is clamped at the inner side of the clamping claw;

The two ends inside the supporting seat 1 are rotatably provided with driving rollers 21, the driving rollers 21 are driven to rotate by a motor, a conveying belt 22 is wound on the driving rollers 21, and the collecting pipe supporting plate 2 is placed on the conveying belt 22. When the collecting pipe supporting plate 2 is used, the collecting pipe supporting plate 2 is placed on the conveying belt 22, the driving roller 21 is driven by the motor to rotate, and the conveying belt 22 is driven to run, so that the collecting pipe supporting plate 2 is conveyed, and feeding and discharging of the collecting pipe supporting plate 2 are facilitated.

This chromatographic column sample collection device holds chromatographic column 7 through the gripper jaw, comes leading-in sample to carry out the component separation through chromatographic column 7, at the in-process of leading-in sample, pulls gripper jaw through electric telescopic handle 6 and rotates to change the angle, make chromatographic column 7 slope, make things convenient for the sample wall to carry out the guide, avoid the production of bubble, facilitate for the collection of follow-up sample. And the sample collecting pipe is placed through the collecting pipe groove 8 on the collecting pipe supporting plate 2, the electromagnetic guide rail 11 drives the electromagnetic slide block 12 to move so as to change the left and right positions of the chromatographic column 7, the adjusting block 5 is rotationally driven by the threaded screw rod 14 to move along the adjusting column 4 so as to change the front and back positions of the chromatographic column 7, and the height of the chromatographic column 7 can be adjusted through the pneumatic cylinder 3, so that the multi-axis adjusting position of the chromatographic column 7 is convenient, and the output end corresponds to different sample collecting pipes. Meanwhile, when the position of the chromatographic column 7 is regulated, the infrared reflecting sheet 9 is identified by the infrared positioning probe 10, the infrared positioning probe 10 is connected with a control terminal and transmits positioning signals, and the control terminal drives the driving part and the regulating part to open and close according to the positioning signals, so that the regulating position of the chromatographic column 7 is accurately controlled, and the positioning and collecting are automated. In addition, the collecting pipe supporting plate 2 is placed on the conveying belt 22, and the conveying belt 22 can be driven to run through the driving roller 21, so that the collecting pipe supporting plate 2 is conveyed, the feeding and discharging of the collecting pipe supporting plate 2 are facilitated, and the functions are diversified.

The foregoing has shown and described the basic principles, principal features and advantages of the utility model. It will be understood by those skilled in the art that the present utility model is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present utility model, and various changes and modifications may be made without departing from the spirit and scope of the utility model, which is defined in the appended claims. The scope of the utility model is defined by the appended claims and equivalents thereof.

Claims

1. The utility model provides a chromatographic column sample collection device, includes supporting seat (1) and collecting pipe layer board (2), its characterized in that: one side at the top of the supporting seat (1) is provided with a driving part, the driving part is movably provided with a pneumatic cylinder (3), the output end of the pneumatic cylinder (3) is provided with an adjusting column (4), an adjusting block (5) is movably installed on the adjusting column (4), an adjusting part is arranged in the adjusting column (4), the adjusting part drives the adjusting block (5) to move, a clamping claw is hinged below one end of the adjusting block (5), an electric telescopic rod (6) is hinged above one end of the adjusting block (5), the top of the clamping claw is provided with a hinge part, the output end of the electric telescopic rod (6) is hinged with the hinge part, and a chromatographic column (7) is clamped at the inner side of the clamping claw;

the collecting pipe layer board (2) is established on supporting seat (1), and the top of collecting pipe layer board (2) is equipped with collecting tube groove (8), collecting tube groove (8) equidistance is equipped with the multiunit, and collecting tube groove (8) are used for holding the collecting pipe, every group collecting tube groove (8) one end position department all be equipped with infrared reflector plate (9) on collecting pipe layer board (2), the below of gripper jaw is equipped with infrared location probe (10) with infrared reflector plate (9) looks adaptation.

2. A chromatographic column sample collection device according to claim 1, wherein: the driving part comprises an electromagnetic guide rail (11) and an electromagnetic slide block (12), the electromagnetic guide rail (11) is arranged on one side of the top of the supporting seat (1), the electromagnetic slide block (12) is movably mounted on the electromagnetic guide rail (11), and the pneumatic cylinder (3) is arranged on the electromagnetic slide block (12).

3. A chromatographic column sample collection device according to claim 1, wherein: the inside of adjusting post (4) is equipped with mounting groove (13), adjusting part includes screw thread lead screw (14) and first motor (15), screw thread lead screw (14) rotate and install the inside of mounting groove (13), first motor (15) are established one side of adjusting post (4), and the output of first motor (15) with screw thread lead screw (14) are connected, the middle part of regulating block (5) extends into mounting groove (13), screw thread lead screw (14) run through the middle part and the screw thread adaptation of regulating block (5).

4. A chromatographic column sample collection device according to claim 1, wherein: the clamping claw comprises a claw disc (16) and claw arms (17), wherein the claw arms (17) are provided with two groups, the two groups of claw arms (17) are respectively and rotatably installed on two sides of the inside of the claw disc (16), gears (18) are respectively arranged at the rotating positions of the two groups of claw arms (17), and rubber pads are respectively arranged on the inner sides of the two groups of claw arms (17).

5. A chromatography column sample collection apparatus according to claim 4, wherein: the middle position inside claw dish (16) is located to rotate and is equipped with worm (19), worm (19) and two sets of gear (18) looks adaptation, the inside one end of claw dish (16) is equipped with the drive chamber, and is equipped with second motor (20) inside the drive chamber, the output of second motor (20) with worm (19) are connected.

6. A chromatographic column sample collection device according to claim 1, wherein: the infrared positioning probe (10) is connected with the control terminal and transmits positioning signals, and the control terminal drives the driving part and the adjusting part to open and close according to the positioning signals.

7. A chromatographic column sample collection device according to any of claims 1-6, wherein: the two ends of the inside of the supporting seat (1) are rotatably provided with driving rollers (21), the driving rollers (21) are driven to rotate by a motor, conveying belts (22) are wound on the driving rollers (21), and the collecting pipe supporting plates (2) are placed on the conveying belts (22).