CN218794015U

CN218794015U - Silica gel chromatographic column

Info

Publication number: CN218794015U
Application number: CN202223134745.6U
Authority: CN
Inventors: 邓礼良; 王跃; 姚金美; 赵林川
Original assignee: Suzhou Comin Biotechnology Co ltd
Current assignee: Suzhou Comin Biotechnology Co ltd
Priority date: 2022-11-24
Filing date: 2022-11-24
Publication date: 2023-04-07
Anticipated expiration: 2032-11-24

Abstract

The utility model discloses a silica gel chromatographic column, the test paper comprises a cylinder, the cylinder is used for packing, the upper end of cylinder is provided with the charge door, the lower tip of cylinder is provided with the discharge gate, be provided with the stock solution ball between cylinder and the charge door, the diameter of stock solution ball is greater than the diameter of cylinder still includes the liquid level alarm, the liquid level alarm with the connection can be dismantled to the cylinder, and is located the cylinder is close to the one end of stock solution ball. Through the arrangement of the liquid storage ball, more eluent can be supplemented once, the frequency of eluent supplement is reduced, the workload is reduced, and the probability of 'dry column' caused by untimely eluent supplement is reduced. Through the arrangement of the liquid level alarm, when the main inner liquid level is lower than the preset position, the liquid level alarm gives an alarm to remind a worker to supplement the washing and dehydrating machine, so that the phenomenon of 'dry column' is prevented.

Description

Silica gel chromatographic column

Technical Field

The utility model relates to a purification and separation device applied in the fields of pharmacy, food, chemical industry and the like, in particular to a silica gel chromatographic column.

Background

Silica gel chromatography has been widely used for purification and separation of natural products and synthetic products as one of the highly efficient purification and separation methods. The separation principle of silica gel chromatography is to separate substances according to different adsorption forces of the substances on silica gel, in general, substances with larger polarity are easy to be adsorbed by the silica gel, substances with weaker polarity are not easy to be adsorbed by the silica gel, and the whole chromatography process is the adsorption, desorption, re-adsorption and re-desorption processes. In the chemical synthesis process, a silica gel chromatography is commonly used for separating substances, in the separation process, an elution machine needs to be continuously added into a silica gel column, the existing silica gel chromatography column does not have a liquid level alarm function, and when no one keeps watch or eluent is not added in time, the phenomenon of 'dry column' is easy to occur, so that the separation effect is influenced.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defects, the utility model aims to provide a silica gel chromatographic column which is provided with an alarm device and prevents the phenomenon of 'dry column'.

In order to achieve the above purpose, the utility model discloses a technical scheme is: the utility model provides a silica gel chromatographic column, includes the cylinder, the cylinder is used for packing, the upper end of cylinder is provided with the charge door, the lower tip of cylinder is provided with the discharge gate, be provided with the liquid storage ball between cylinder and the charge door, the diameter of liquid storage ball is greater than the diameter of cylinder still includes the liquid level alarm, the liquid level alarm with the connection can be dismantled to the cylinder, and is located the cylinder is close to the one end of liquid storage ball. Through the arrangement of the liquid storage ball, more eluent can be supplemented once, the frequency of eluent supplement is reduced, the workload is reduced, and the probability of 'dry column' caused by untimely eluent supplement is reduced. Through the arrangement of the liquid level alarm, when the main inner liquid level is lower than the preset position, the liquid level alarm gives an alarm to remind a worker to supplement the washing and dehydrating machine, so that the phenomenon of 'dry column' is prevented.

Further, the liquid level alarm is an optical fiber sensing liquid level alarm.

Further, still include the clamp spare, the clamp spare with liquid level alarm fixed connection, the clamp spare can the clamp be in on the cylinder. The liquid level alarm and the column body are detachably connected through the clamp piece.

Further, one end, close to the liquid storage ball, of the column body is provided with an annular protruding portion protruding outwards in the radial direction. Through the setting of annular bellying, play the supporting role to the liquid level alarm, prevent that clamp spare is not hard up to lead to the liquid level alarm to slide along the cylinder.

Further, the annular convex part is provided with a plurality of, and a plurality of the annular convex parts are equidistantly distributed. Through the setting of a plurality of annular bellying, the clamp spare can select can be connected with the not co-altitude department of cylinder, and then the height of liquid level when changing the liquid level alarm and reporting to the police, and during the staff used, can be according to the height of silica gel in the cylinder during the separation and select the minimum height of liquid level when reporting to the police.

Furthermore, the liquid storage ball is provided with scale marks which mark corresponding scales.

Further, the cylinder is kept away from the one end of liquid storage ball is provided with and filters the piece, filter the piece and be quartz sand filter screen, psammitolite filter screen or the sieve that punches a hole of precision. The precision punching sieve plate has the advantages of good filtering and intercepting effects, strong pressure resistance, simple disassembly and assembly and cleaning, and the sealing washer assists in installing the punching sieve plate, so that the filtering piece is efficient and durable.

Further, the column body and the liquid storage ball are made of transparent glass, and the liquid storage ball and the column body are integrally connected. Transparent glass's setting makes things convenient for the staff to observe the interior condition of silica gel chromatography column at any time, through liquid storage ball and cylinder body coupling, has avoided the liquid leakage condition to appear in liquid storage ball and cylinder junction.

Furthermore, a liquid guide pipe is arranged at the discharge port, the diameter of the liquid guide pipe is smaller than that of the column body, and a switch valve is arranged on the liquid guide pipe.

Further, the inner wall of the feed inlet is ground glass.

The utility model has the advantages that:

1) Through the arrangement of the liquid storage ball, more eluent can be supplemented once, the frequency of eluent supplement is reduced, the workload is reduced, and the probability of 'dry column' caused by untimely eluent supplement is reduced.

2) Through the arrangement of the liquid level alarm, when the liquid level in the column is lower than a preset position, the liquid level alarm gives an alarm to remind a worker to supplement the washing and dehydrating machine, so that the phenomenon of 'column drying' is prevented.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification.

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below, and it is obvious that the drawings in the description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained without creative efforts.

Fig. 1 is a perspective view of a silica gel column according to an embodiment of the present invention;

fig. 2 is a cross-sectional view of a silica gel column according to an embodiment of the present invention;

fig. 3 is a schematic view of the connection between the clamp member and the column according to an embodiment of the present invention.

In the figure:

1. a feed inlet; 2. liquid storage balls; 21. scale lines; 3. a cylinder; 31. an annular boss; 4. a discharge port; 5. a liquid level alarm; 6. a clamp member; 61. a bolt; 7. a catheter; 8. opening and closing the valve; 9. and (4) a filter element.

Detailed Description

In order to make the above objects, features and advantages of the present invention more comprehensible, embodiments of the present invention are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, as those skilled in the art will be able to make similar modifications without departing from the spirit and scope of the present invention.

Referring to the attached drawings 1-3, the silica gel chromatographic column in the embodiment comprises a column body 3, wherein the column body 3 is used for filling silica gel, a feed inlet 1 is arranged at the upper end part of the column body 3, and the inner wall of the feed inlet 1 is ground glass so as to be conveniently connected with other equipment through the feed inlet 1. The lower end of the column body 3 is provided with a discharge hole 4, a liquid storage ball 2 is arranged between the column body 3 and the feed inlet 1, the diameter of the liquid storage ball 2 is larger than that of the column body 3, more eluent can be supplemented once through the arrangement of the liquid storage ball 2, the frequency of the eluent is supplemented less, the workload is reduced, and the probability of 'dry column' caused by untimely eluent supplement is reduced. The "dry column" phenomenon refers to a phenomenon in which the liquid level of the eluent is lower than the height of silica gel in the column, and elution is performed without an elution machine in the silica gel column. Be provided with scale mark 21 on the liquid storage ball 2 to the corresponding scale of sign makes things convenient for the staff to observe the volume of eluant in the liquid storage ball 2.

In some embodiments, a liquid level alarm 5 is further included, and the liquid level alarm 5 is a fiber optic sensing liquid level alarm 5. The liquid level alarm 5 is detachably connected with the column body 3 and is positioned at one end, close to the liquid storage ball 2, of the column body 3. Through the arrangement of the liquid level alarm 5, when the liquid level of the column is lower than the preset position, the liquid level alarm 5 gives an alarm to remind a worker to supplement the washing and dehydrating machine, so that the phenomenon of 'column drying' is prevented.

In some embodiments, the liquid level alarm further comprises a clamp member 6, wherein the clamp member 6 is fixedly connected with the liquid level alarm 5, and the clamp member 6 can be clamped on the column body 3. The liquid level alarm 5 is detachably connected with the column body 3 through a clamp part 6. The clamp member 6 is first sleeved on the corresponding position of the column body 3, and then tightened by the bolt 61, so that the clamp clamps and fixes the column body 3.

In some embodiments, the column body 3 is provided with an annular convex part 31 protruding radially outwards near one end of the liquid storage ball 2. Through the setting of annular convex part 31, play the supporting role to liquid level alarm 5, prevent that the not hard up liquid level alarm 5 that leads to of clamp 6 from gliding along cylinder 3. The annular convex portion 31 is provided in plurality, and the plurality of annular convex portions 31 are distributed at equal intervals. Through the setting of a plurality of annular bellying 31, the not co-altitude department of clamp 6 optional and cylinder 3 is connected, and then changes the height of the liquid level in the just right cylinder 3 of liquid level alarm 5, and then the height of liquid level when changing the warning, during the staff uses, can be according to the height of the interior silica gel of cylinder 3 when the separation and select the minimum height of liquid level when reporting to the police.

In some embodiments, the end of the cylinder 3 away from the liquid storage ball 2 is provided with a filtering member 9, and the filtering member 9 is a quartz sand filter screen, a sand core filter screen or a precision punching screen plate. The precision punching sieve plate has the advantages of good filtering and intercepting effects, strong pressure resistance, simple disassembly and assembly and cleaning, and the sealing washer assists in installing the punching sieve plate, so that the filtering piece 9 is efficient and durable.

In some embodiments, the column 3 and the liquid storage ball 2 are transparent glass, and the liquid storage ball 2 and the column 3 are integrally connected. Transparent glass's setting makes things convenient for the staff to observe the interior condition of silica gel chromatography column at any time, through

stock solution ball

2 and 3 body coupling of cylinder, has avoided

stock solution ball

2 and 3 junctions of cylinder to appear the weeping condition.

In some embodiments, a liquid guide tube 7 is arranged at the discharge port 4, the diameter of the liquid guide tube 7 is smaller than that of the column body 3, and a switch valve 8 is arranged on the liquid guide tube 7.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", and the like, indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

In the present invention, unless otherwise explicitly specified or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly, e.g., as being fixedly connected, detachably connected, or integrated; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

The above embodiments are only for illustrating the technical concept and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and implement the present invention, so as not to limit the protection scope of the present invention, and all equivalent changes or modifications made according to the spirit of the present invention should be covered in the protection scope of the present invention.

Claims

1. The utility model provides a silica gel chromatographic column, includes cylinder (3), cylinder (3) are used for packing, the upper end of cylinder (3) is provided with charge door (1), the lower tip of cylinder (3) is provided with discharge gate (4), a serial communication port, cylinder (3) with be provided with storage liquid ball (2) between charge door (1), the diameter of storage liquid ball (2) is greater than the diameter of cylinder (3) still includes liquid level alarm (5), liquid level alarm (5) with cylinder (3) can be dismantled the connection, and is located cylinder (3) are close to the one end of storage liquid ball (2).

2. The silica gel chromatographic column according to claim 1, wherein the liquid level alarm (5) is an optical fiber sensing liquid level alarm.

3. A silica gel chromatography column as claimed in claim 2, further comprising a clamp member (6), wherein said clamp member (6) is fixedly connected with said liquid level alarm (5), and said clamp member (6) can be clamped on said column body (3).

4. A silica gel chromatography column as claimed in claim 3, wherein the column body (3) is provided with an annular projection (31) projecting radially outwards at the end close to the liquid reservoir sphere (2).

5. The silica gel column according to claim 4, wherein the annular protrusion (31) is provided in plurality, and the plurality of annular protrusions (31) are distributed at equal intervals.

6. A silica gel column according to claim 5, wherein the liquid storage ball (2) is provided with scale marks (21) and corresponding scales are marked.

7. The silica gel chromatographic column according to claim 6, wherein one end of the column body (3) far away from the liquid storage ball (2) is provided with a filtering member (9), and the filtering member (9) is a quartz sand filter screen, a sand core filter screen or a precision punching sieve plate.

8. A silica gel chromatography column as claimed in claim 7, wherein said column body (3) and said liquid storage ball (2) are made of transparent glass, and said liquid storage ball (2) and said column body (3) are integrally connected.

9. The silica gel chromatographic column according to claim 8, wherein a liquid guide tube (7) is arranged at the discharge port (4), the diameter of the liquid guide tube (7) is smaller than that of the column body (3), and a switch valve (8) is arranged on the liquid guide tube (7).

10. The silica gel chromatographic column according to claim 9, wherein the inner wall of the feed port (1) is ground glass.