CN218944415U

CN218944415U - Chromatographic column with fast-assembling lid

Info

Publication number: CN218944415U
Application number: CN202223089010.6U
Authority: CN
Inventors: 颜武华; 邓良斌; 谭祖开
Original assignee: Fuzhou Fa Mo You Ke Mechanical Science And Technology Co ltd
Current assignee: Fuzhou Fa Mo You Ke Mechanical Science And Technology Co ltd
Priority date: 2022-11-16
Filing date: 2022-11-16
Publication date: 2023-05-02
Anticipated expiration: 2032-11-16

Abstract

The utility model relates to a chromatographic column with a quick-mounting cover, belonging to the field of chromatographic columns; the chromatographic column comprises a chromatographic column body, an upper end cover, a lower end cover, an upper nipple and a lower nipple, wherein the upper end and the lower end of the chromatographic column body are respectively connected with the upper nipple and the lower nipple, and one ends of the upper nipple and the lower nipple, which are far away from the chromatographic column body, are respectively connected with the upper end cover and the lower end cover; the upper end cover is provided with a feed inlet and an exhaust outlet, the lower end cover is of a conical structure and is provided with a discharge outlet, and the discharge outlet is provided with a discharge valve; a filtering device is arranged between the lower end cover and the lower nipple, and a current carrier is arranged in the upper nipple; the upper end cover and the lower end cover are respectively connected with the chromatographic column through the upper nipple and the lower nipple, so that the condition that the glass tube is easy to break due to frequent disassembly of the upper end cover and the lower end cover is reduced; the filtering device can meet the filtering requirements of materials with different particle sizes, and the application range of the chromatographic column is enlarged.

Description

Chromatographic column with fast-assembling lid

Technical Field

The utility model relates to a chromatographic column with a quick-mounting cover, belonging to the technical field of building construction.

Background

With the development of science and technology, chromatographic methods are used in medicine, natural products, biological fields and the like to separate and purify products.

The utility model with the application number of CN202023094240.2 discloses a chromatographic column with a quick-assembly cover, which comprises a chromatographic column body, a fixing frame and a clamp, wherein the chromatographic column body comprises a glass tube, an upper cover, a lower cover and a quick-assembly nipple, two ends of the glass tube are respectively connected with two quick-assembly nipple through two flanges, and the two quick-assembly nipple is respectively connected with the upper cover and the lower cover through two clamps. The upper cover includes lid, distributor, sintering net, distributor and sintering net are in proper order the range upon range of install in the lid inboard, the lower cover includes sintering net, guide plate, lid, and sintering net and guide plate are in proper order the range upon range of install in the lid inboard, and the glass pipe is not directly connected with upper cover, lower cover, through fixable's fast-assembling nipple connection, reduces because the glass pipe easy broken condition that frequently dismantles the upper cover lower cover and cause, and fast-assembling nipple passes through flange and upper cover, lower cover connection, reduces the dismantlement time, solves the easy locking problem of stainless steel bolt, and the inhomogeneous, the incomplete area problem of play liquid is solved to upper cover, lower cover integral type structure.

The problems of the prior art are: the sintering net is integrally connected with the upper cover and the lower cover, the size of the filtering holes in the sintering net is determined before sintering, and the filtering holes cannot be changed after sintering into a finished product; if the pore diameter of the filter holes of the sintering net is changed or other filter materials need to be replaced, the whole upper cover or the whole lower cover needs to be replaced; the application range of the glass chromatographic column is narrow, and the production cost of the glass chromatographic column is increased intangibly.

When the sample is injected, the sample solution directly flows into the chromatographic column from the top end of the chromatographic column, so that the filler in the chromatographic column is easy to splash onto the inner wall of the chromatographic column, and the filler splashed onto the inner wall is not fully utilized in the chromatography, so that the chromatographic effect is affected.

Disclosure of Invention

In order to solve the problems in the prior art, the utility model provides a chromatographic column with a quick-mounting cover.

The technical scheme of the utility model is as follows:

the chromatographic column with the quick-assembly cover comprises a chromatographic column body, an upper end cover, a lower end cover, an upper nipple and a lower nipple, wherein the upper end and the lower end of the chromatographic column body are respectively connected with the upper nipple and the lower nipple, and one ends of the upper nipple and the lower nipple, which are far away from the chromatographic column body, are respectively connected with the upper end cover and the lower end cover; the upper end cover is provided with a feed inlet and an exhaust outlet, the lower end cover is of a conical structure and is provided with a discharge outlet, and the discharge outlet is provided with a discharge valve; a filtering device is arranged between the lower end cover and the lower nipple, and a current-guiding body is arranged in the upper nipple.

The chromatographic column body is characterized in that flanges are arranged on the outer walls of the upper end and the lower end of the chromatographic column body, the outer wall of one end of the upper nipple, the outer wall of the upper end and the lower end of the lower nipple and the outer wall of one end of the lower end cover.

Wherein the chromatographic column body is connected with the upper nipple, and the chromatographic column body is connected with the lower nipple through a flange; one end of the upper nipple, which is far away from the chromatographic column, is connected with the upper end cover through threads, and a sealing gasket is arranged between the upper nipple and the upper end cover.

The guide body comprises a circular ring-shaped bracket, a guide cover and a connecting rod, wherein the guide cover and the connecting rod are positioned below the circular ring-shaped bracket, and the circular ring-shaped bracket is fixed with the inner wall of the upper nipple in an adhering manner; the air guide sleeve is a conical hollow sleeve body with a small upper end and a large lower end, and the diameter of the lower end of the air guide sleeve is smaller than the inner diameter of the upper nipple; three connecting rods are uniformly and symmetrically arranged in the annular support, one ends of the three connecting rods are respectively fixed with the inner wall of the annular support, and the other ends of the three connecting rods are positioned at the center of the annular support and fixed at the upper end of the air guide sleeve.

The outer wall of the flow guiding body is sleeved with a sealing ring, and the flow guiding body is in sealing connection with the upper nipple through the sealing ring.

The filtering device comprises a filter disc, a filtering tray and a filtering fixing ring, wherein the upper end of the filtering tray is opened, the lower end of the filtering tray is closed, holes are uniformly arranged at the bottom of the filtering tray, and internal threads are arranged on the inner side wall of the filtering tray; the filtering fixing ring is of a cylindrical structure, the bottom and the upper end are both open ends, and the outer wall of the filtering fixing ring is provided with external threads matched with the internal threads; the filter piece is arranged between the filter tray and the filter fixing ring.

Grooves are formed in the upper end and the lower end of the side wall of the filter tray along the circumferential direction of the side wall of the filter tray respectively, and O-shaped rings are arranged in the grooves; the upper end of the filtering tray is connected with a flange at one end of the lower nipple far away from the chromatographic column, and the lower end of the filtering tray is connected with a flange on the lower end cover.

The filter piece is one of a glass filter piece, a filter cloth, a stainless steel filter screen and a polytetrafluoroethylene membrane.

The utility model has the following beneficial effects:

1. according to the chromatographic column with the quick-mounting cover, the chromatographic column body is not directly connected with the upper end cover and the lower end cover, but is connected through the fixable upper short pipe and the fixable lower short pipe, so that the condition that the chromatographic column is easy to break due to frequent disassembly of the upper end cover and the lower end cover is reduced, and the use safety is improved.

2. According to the chromatographic column with the quick-mounting cover, the filtering requirements of the same chromatographic column on materials with different particle diameters can be met by replacing the filter plates in the filtering device, and the application range of the chromatographic column is enlarged.

3. According to the chromatographic column with the quick-mounting cover, during sample injection, a sample solution flows downwards along the inner wall of the chromatographic column under the flow guiding effect of the outer wall of the flow guide cover, so that the filler in the chromatographic column is not splashed, and the chromatographic effect is improved.

Drawings

FIG. 1 is a schematic diagram of a chromatographic column with a quick-fit cap according to the present utility model;

FIG. 2 is a schematic diagram of a filtration device in a chromatography column with a quick-fit cap according to the utility model;

FIG. 3 is a schematic view of a flow guide cover in a chromatographic column with a quick-fit cover.

The reference numerals in the drawings are as follows:

1-chromatographic column, 2-upper end cover, 21-feed inlet, 22-exhaust port, 3-lower end cover, 31-discharge port, 32-discharge valve, 41-upper nipple, 42-lower nipple, 5-current conductor, 51-annular bracket, 52-air guide cover, 53-connecting rod, 6-filter device, 61-filter sheet, 62-filter tray, 621-internal screw thread, 622-hole, 623-filter tray side wall, 624-O-shaped ring, 63-filter fixing ring, 631-external screw thread, 7-flange.

Detailed Description

The utility model will now be described in detail with reference to the drawings and to specific embodiments.

Referring to fig. 1-3, a chromatographic column with a quick-assembly cover comprises a chromatographic column body 1, an upper end cover 2, a lower end cover 3, an upper nipple 41 and a lower nipple 42, wherein the upper end and the lower end of the chromatographic column body 1 are respectively connected with the upper nipple 41 and the lower nipple 42, and one ends of the upper nipple 41 and the lower nipple 42, which are far away from the chromatographic column body 1, are respectively connected with the upper end cover 2 and the lower end cover 3; the upper end cover 2 is provided with a feed inlet 21 and an exhaust outlet 22, the lower end cover 3 is of a conical structure and is provided with a discharge outlet 31, and the discharge outlet 31 is provided with a discharge valve 32; a filtering device 6 is arranged between the lower end cover 3 and the lower nipple 42, and a current carrier 5 is arranged in the upper nipple 41.

Referring to fig. 1, flanges 7 are disposed on the outer walls of the upper and lower ends of the chromatographic column 1, the outer wall of one end of the upper nipple 41, the outer wall of the upper and lower ends of the lower nipple 42, and the outer wall of one end of the lower end cover 3.

Further, the chromatographic column 1 is connected with the upper nipple 41, and the chromatographic column 1 is connected with the lower nipple 42 through the flange 7; the end, far away from the chromatographic column 1, of the upper nipple 41 is connected with the upper end cover 2 through threads, and a sealing gasket is arranged between the upper nipple 41 and the upper end cover 2.

As shown in fig. 3, the flow guiding body 5 includes a circular bracket 51, a flow guiding cover 52 and a connecting rod 53 which are positioned below the circular bracket 51, and the circular bracket 51 is fixed to the inner wall of the upper nipple 41 in an adhering manner; the air guide sleeve 52 is a conical hollow sleeve body with a small upper end and a large lower end, and the diameter of the lower end of the air guide sleeve 52 is smaller than the inner diameter of the upper nipple 41; three connecting rods 53 are uniformly and symmetrically arranged in the annular support 51, one ends of the three connecting rods 53 are respectively fixed with the inner wall of the annular support 51, and the other ends of the three connecting rods 53 are positioned at the center of the annular support 51 and fixed at the upper end of the air guide sleeve 52.

Further, a sealing ring is sleeved on the outer wall of the diversion body 5, and the diversion body 5 is in sealing connection with the upper nipple 41 through the sealing ring.

As shown in fig. 2, the filtering device 6 includes a filter 61, a filtering tray 62 and a filtering fixing ring 63, the upper end of the filtering tray 62 is opened, the lower end is closed, holes 622 are uniformly arranged at the bottom, and internal threads 621 are provided on the inner side wall; the filtering fixing ring 63 has a cylindrical structure, the bottom and the upper end are both open ends, and the outer wall of the filtering fixing ring 63 is provided with external threads 631 matched with the internal threads 621; the filter sheet 61 is disposed between the filter tray 62 and the filter fixing ring 63.

Further, grooves are respectively formed at the upper and lower ends of the filter tray side wall 623 along the circumferential direction of the filter tray side wall 623, and O-rings 624 are arranged in the grooves; the upper end of the filter tray 62 is connected with the flange 7 at one end of the lower nipple 42 far away from the chromatographic column 1, and the lower end is connected with the flange 7 on the lower end cover 3; the filter 61 is one of a glass filter, a filter cloth, a stainless steel filter screen, and a polytetrafluoroethylene membrane.

The working principle of the utility model is as follows:

(1) The upper end cover 2 and the lower end cover 3 are not directly connected with the two ends of the chromatographic column 1, but the upper nipple 41 and the lower nipple 42 are respectively fixed on the chromatographic column 1 through the flange 7 and are respectively connected with the upper end cover 2 and the lower end cover 3, so that the problem that the chromatographic column 1 is easy to break due to frequent disassembly of the upper end cover 2 and the lower end cover 3 is solved; the guide body 5 is arranged in the nipple, the sample solution flows downwards along the inner wall of the chromatographic column 1 through the guide effect of the outer wall of the guide cover 5, so that the filler in the chromatographic column 1 is not splashed, the chromatographic effect is improved, the sealing ring is arranged on the outer wall of the guide body 5, and the sealing ring can effectively prevent the pollution brought by the outside.

(2) The filter sheet 61 in the filter device 6 is replaced to meet the filtering requirements of materials with different particle sizes; the lower end cover 3 is conical, so that the material after chromatography is better discharged, the separation purity is improved, and the production efficiency is improved.

The foregoing description is only illustrative of the present utility model and is not intended to limit the scope of the utility model, and all equivalent structures or equivalent processes or direct or indirect application in other related technical fields are included in the scope of the present utility model.

Claims

1. A chromatographic column with fast-assembling lid, its characterized in that: the chromatographic column comprises a chromatographic column body (1), an upper end cover (2), a lower end cover (3), an upper nipple (41) and a lower nipple (42), wherein the upper end and the lower end of the chromatographic column body (1) are respectively connected with the upper nipple (41) and the lower nipple (42), and one ends, far away from the chromatographic column body (1), of the upper nipple (41) and the lower nipple (42) are respectively connected with the upper end cover (2) and the lower end cover (3); the upper end cover (2) is provided with a feed inlet (21) and an exhaust outlet (22), the lower end cover (3) is of a conical structure and is provided with a discharge outlet (31), and the discharge outlet (31) is provided with a discharge valve (32); a filtering device (6) is arranged between the lower end cover (3) and the lower nipple (42), and a current guiding body (5) is arranged in the upper nipple (41).

2. A chromatography column with a quick-fit cap as claimed in claim 1, wherein: flanges (7) are arranged on the outer walls of the upper end and the lower end of the chromatographic column (1), the outer wall of one end of the upper nipple (41), the outer wall of the upper end and the lower end of the lower nipple (42) and the outer wall of one end of the lower end cover (3).

3. A chromatography column with a quick-fit cap as claimed in claim 2, wherein: the chromatographic column (1) is connected with the upper nipple (41), and the chromatographic column (1) is connected with the lower nipple (42) through a flange (7); one end of the upper nipple (41) far away from the chromatographic column body (1) is connected with the upper end cover (2) through threads, and a sealing gasket is arranged between the upper nipple (41) and the upper end cover (2).

4. A chromatography column with a quick-fit cap as claimed in claim 1, wherein: the guide body (5) comprises a circular bracket (51), a guide cover (52) and a connecting rod (53), wherein the guide cover (52) is positioned below the circular bracket (51), and the circular bracket (51) is fixed with the inner wall of the upper nipple (41) in an adherence manner; the air guide sleeve (52) is a conical hollow sleeve body with a small upper end and a large lower end, and the diameter of the lower end of the air guide sleeve (52) is smaller than the inner diameter of the upper nipple (41); three connecting rods (53) are uniformly and symmetrically arranged in the annular support (51), one ends of the three connecting rods (53) are respectively fixed with the inner wall of the annular support (51), and the other ends of the three connecting rods are positioned at the center of the annular support (51) and fixed at the upper end of the guide cover (52).

5. A chromatography column with a quick-fit cap according to claim 4, wherein; the outer wall of the guide body (5) is sleeved with a sealing ring, and the guide body (5) is connected with the upper nipple (41) in a sealing way through the sealing ring.

6. A chromatography column with a quick-fit cap as claimed in claim 2, wherein: the filtering device (6) comprises a filter disc (61), a filtering tray (62) and a filtering fixing ring (63), wherein the upper end of the filtering tray (62) is opened, the lower end of the filtering tray is closed, holes (622) are uniformly arranged at the bottom of the filtering tray, and internal threads (621) are arranged on the inner side wall of the filtering tray; the filtering fixing ring (63) is of a cylindrical structure, the bottom and the upper end are both open ends, and the outer wall of the filtering fixing ring (63) is provided with external threads (631) matched with the internal threads (621); the filter sheet (61) is arranged between the filter tray (62) and the filter fixing ring (63).

7. A chromatography column with a quick-fit cap as defined in claim 6, wherein: grooves are formed in the upper end and the lower end of the side wall (623) of the filter tray respectively along the circumferential direction of the side wall (623), and O-shaped rings (624) are arranged in the grooves; the upper end of the filter tray (62) is connected with a flange (7) at one end of the lower nipple (42) far away from the chromatographic column (1), and the lower end of the filter tray is connected with a flange (7) on the lower end cover (3).

8. A chromatography column with a quick-fit cap as defined in claim 6, wherein: the filter piece (61) is one of a glass filter piece, a filter cloth, a stainless steel filter screen and a polytetrafluoroethylene membrane.