CN218684842U - Rat lumbosacral part injection drug administration device - Google Patents
Rat lumbosacral part injection drug administration device Download PDFInfo
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- CN218684842U CN218684842U CN202221758140.1U CN202221758140U CN218684842U CN 218684842 U CN218684842 U CN 218684842U CN 202221758140 U CN202221758140 U CN 202221758140U CN 218684842 U CN218684842 U CN 218684842U
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- rat
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- lumbosacral
- rod
- platform
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- 238000002347 injection Methods 0.000 title claims abstract description 34
- 239000007924 injection Substances 0.000 title claims abstract description 34
- 238000001647 drug administration Methods 0.000 title description 2
- 238000003780 insertion Methods 0.000 claims abstract description 5
- 230000037431 insertion Effects 0.000 claims abstract description 5
- 238000012377 drug delivery Methods 0.000 claims description 10
- 230000002457 bidirectional effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 9
- 238000007913 intrathecal administration Methods 0.000 abstract description 6
- 210000003692 ilium Anatomy 0.000 abstract description 4
- 210000000576 arachnoid Anatomy 0.000 abstract 1
- 210000003007 myelin sheath Anatomy 0.000 abstract 1
- 238000010171 animal model Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000008499 blood brain barrier function Effects 0.000 description 3
- 210000001218 blood-brain barrier Anatomy 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000001621 ilium bone Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004781 brain capillary Anatomy 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 210000002987 choroid plexus Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 210000004749 ligamentum flavum Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002330 subarachnoid space Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model discloses a rat lumbosacral portion injection device of dosing, include the supporting platform who comprises trapezoidal rest platform and base, the left top of base is provided with the fixed subassembly of regulation truck, the top of adjusting the fixed subassembly of truck is provided with places the platform, the fixed injection needle inlet tube groove of having seted up in top of placing the platform, the utility model relates to a biological medicine's experimental device technique technical field. This rat lumbosacral portion injection device of dosing, through adjusting the fixed subassembly of trunk, place the platform, trapezoidal rest platform and base combination use, can fully expose rat lumbar vertebrae and sacral vertebra and the cross department of controlling the ilium, the injection needle tube groove needle insertion through the device reaches the arachnoid cavity of resorption, reaches the purpose of intrathecal direct administration, and the contrast tradition buries the pipe through occipital macropore to spinal myelin sheath in to rat's mortality and the disability rate when showing to reduce intrathecal administration, and reduce the operation degree of difficulty.
Description
Technical Field
The utility model relates to the technical field of experimental equipment of biological medicine, in particular to a rat lumbosacral part injection drug delivery device.
Background
Animal experiments are an important part of modern life science research, are important media for human beings to directly know life phenomena, and play an irreplaceable role in other research techniques and means for people to know various laws in the organic world. The anthropomorphic disease animal model constructed by the treatment of experimental animals in a corresponding induction mode is the most common experimental tool for researching disease pathogenesis, screening intervention strategies and evaluating the curative effect of medicaments.
The blood-brain barrier is the barrier between the plasma formed by the walls of the brain capillaries and the glial cells and the brain cells and the barrier between the plasma formed by the choroid plexus and the cerebrospinal fluid. The blood brain barrier has selective permeability, and has important function and biological significance for maintaining independent and stable environment in brain and spinal cord tissues. But also brings great challenges to the construction of experimental animal models simulating central nervous system diseases and the blood-brain barrier permeation of water-soluble substances and macromolecules, and is not beneficial to the drug research of the central nervous system.
Intrathecal injection can directly transport the medicine to the central nervous system, can rapidly and safely achieve effective blood concentration, and has been applied and developed in the clinical treatment of some diseases. Intrathecal administration for animal experiments is generally carried out by inserting a catheter from the macropore of the occiput of a rat to the tail and injecting the drug through the catheter. The space in the spinal cord is small, and the insertion of a catheter inevitably compresses and damages nerves, so that the death and the disability of experimental animals are caused, the success rate of the operation is low, and the development of research is restricted.
SUMMERY OF THE UTILITY MODEL
To the deficiency of the prior art, the utility model provides a rat lumbosacral part injection device of dosing has solved mortality and the high problem of disability rate to the previous rat intrathecal tube administration method.
In order to achieve the above purpose, the utility model discloses a following technical scheme realizes: the utility model provides a rat lumbosacral portion injection device of dosing, includes the supporting platform of compriseing trapezoidal rest platform and base, the left top of base is provided with adjusts the fixed subassembly of truck, the top of adjusting the fixed subassembly of truck is provided with places the platform, the top of placing the platform is fixed to be seted up and is injected the needle tube way.
The adjustable trunk fixing assembly comprises two fixing rods, a screw rod and a sliding rod are sleeved on one side, opposite to the fixing rods, of the fixing rods in a rotating mode, the sliding rod is fixedly connected with the opposite side of the fixing rods, clamping plates and two fixing rods are symmetrically arranged on the surfaces of the sliding rod and the screw rod, telescopic rods are fixedly connected with the surfaces of the fixing rods, and bolts are sleeved on surface threads of the telescopic rods.
Preferably, the two fixing rods are sleeved on the left top of the base in a sliding manner, and the clamping plate is sleeved on the surface of the screw rod in a threaded manner and sleeved on the surface of the sliding rod in a sliding manner.
Preferably, the surface of the screw rod is symmetrically provided with two-way threads, and one end of the screw rod penetrates through the fixing rod on one side and extends out of the surface of the fixing rod on one side.
Preferably, the ladder rest is fixedly connected to the right top of the base.
Preferably, the bottom of the placing table is fixedly connected to the top of the fixing rod, and an injector is placed in the inner cavity of the injection needle insertion tube groove.
Preferably, the telescopic rod is fixedly connected to the top of the base.
Preferably, the placing table is positioned on the adjusting trunk fixing assembly, and the placing table, the adjusting trunk fixing assembly and the trapezoidal placing table are combined for use, so that the injection needle directly reaches the intersection of the exposed lumbar vertebra, sacral vertebra and left and right iliac bones of the rat, and enters the subarachnoid space after the needle is pushed.
Preferably, the adjustable torso fixing assembly is horizontally adjustable inward to fix the lateral torso of the rat.
Preferably, the adjustable torso-adjustable mounting assembly is positioned on the base, is slidable along the base, and is used in combination with the trapezoidal rest to secure a rat.
Preferably, the platform for supporting the rat consists of a trapezoidal rest table and a base, wherein the trapezoidal rest table is positioned on the base and is used for supporting the rat after anesthesia.
Preferably, the trunk adjusting fixing assembly, the placing table, the trapezoidal placing table and the base are combined for use, so that an anesthetized rat can be fixed, an injection needle can reach the crossing position of the lumbar vertebra, the sacral vertebra and the left and right ilia of the rat through the needle inserting tube groove, and intrathecal injection administration is completed.
Advantageous effects
The utility model provides a rat lumbosacral part injection drug delivery device. Compared with the prior art, the method has the following beneficial effects:
1. the rat lumbosacral part injection drug delivery device has the advantages that the fixed rod is enabled to slide at the top of the base by pushing the fixed rod, the bolt is also retracted to realize horizontal inward sliding, the placing table can move along with the fixed rod, the clamping plate is enabled to be positioned at the two sides of a rat, the bolt is enabled to fix the telescopic rod, the fixed rod is fixed, the screw rod is rotated, the clamping plate on the surface of the screw rod can move relative to the two-way thread on the surface of the screw rod under the limiting sleeve joint of the sliding rod, so that the clamping plate can slowly fix the lateral trunk of the rat, at the moment, the injection needle inlet pipe groove arranged at the top of the placing table can be aligned with the intersection of the lumbar vertebra, the sacral vertebra and the left and right ilium of the rat, then the injector is placed in the injection needle-inserting tube groove, and the injector is pushed, so that the injector reaches the crossing position of the lumbar vertebra, the sacral vertebra and the left and right iliac bones of the rat along with sliding, the injection needle penetrates through the muscle to the ligamentum flavum and continues to be inserted into the cavity, namely the subarachnoid cavity is reached, and finally the medicine-inserting push rod of the injector is slowly pushed to inject the liquid medicine into the sheath.
2. The rat lumbosacral part injection drug delivery device can be applied to other rat experiments directly acting on a central nervous system, and is strong in universality and operation safety.
Drawings
FIG. 1 is a side view of the structure of the present invention;
FIG. 2 is a top view of the present invention;
FIG. 3 is a rear view of the structure of the present invention;
FIG. 4 is a view of the structure-adjustable trunk fixing assembly of the present invention;
fig. 5 is a side view of the structure-adjustable trunk fixing component of the present invention.
In the figure: 1. a torso-adjusting fixation assembly; 11. fixing the rod; 12. a screw rod; 13. a slide bar; 14. a telescopic rod; 15. a bolt; 16. a clamping plate; 2. a placing table; 21. injecting needle tube groove; 3. a trapezoidal rest; 4. a base.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1-3, the present invention provides a technical solution: the utility model provides a rat lumbosacral portion injection device of dosing, includes the supporting platform who comprises trapezoidal rest 3 and base 4, the left top of base 4 is provided with adjusts the fixed subassembly 1 of truck, the top of adjusting the fixed subassembly 1 of truck is provided with places platform 2, the fixed injection needle inlet tube groove 21 of having seted up in top of placing platform 2, trapezoidal rest 3 fixed connection of platform on the right top of base 4, the bottom fixed connection of placing platform 2 is at the top of dead lever 11, and the syringe has been placed to the inner chamber of injection needle inlet tube groove 21.
Referring to fig. 4-5, the adjustable trunk fixing assembly 1 includes two fixing rods 11, a screw rod 12 is rotatably sleeved on one side of each of the two fixing rods 11, a sliding rod 13 is fixedly connected to one side of each of the two fixing rods 11, clamping plates 16 are symmetrically arranged on the surfaces of the sliding rod 13 and the screw rod 12, telescopic rods 14 are fixedly connected to the surfaces of the two fixing rods 11, bolts 15 are sleeved on surface threads of the telescopic rods 14, the two fixing rods 11 are slidably sleeved on the left top of the base 4, the clamping plates 16 are sleeved on the surface of the screw rod 12 in a threaded manner and slidably sleeved on the surface of the sliding rod 13, bidirectional threads are symmetrically arranged on the surface of the screw rod 12, one end of the screw rod 12 penetrates through one side fixing rod 11 and extends out of the surface of the fixing rod 11 on one side, and the telescopic rods 14 are fixedly connected to the top of the base 4.
When the rat anesthesia device works, firstly, after the rat is anesthetized, the hairs at the intersection of the lumbar vertebra, the sacrum and the left and right ilia of the rat are cut off, the skin is clamped by a pair of tweezers, a 0.5cm incision is longitudinally cut by the scissors, the rat is placed on the trapezoidal placing table 3, the rear part of the rat can be lifted up through the trapezoidal placing table 3, then one bolt 15 of the two telescopic rods 14 in the trunk fixing assembly 1 is rotated and adjusted, the bolt 15 loosens the telescopic rods 14, then the fixed rod 11 is pushed, the fixed rod 11 slides on the top of the base 4, meanwhile, the bolt 15 retracts, the horizontal inward sliding is realized, secondly, the placing table 2 can also move along with the rotation, the clamping plates 16 are positioned at the two sides of the rat, the bolts 15 are reversed, the bolts 15 fix the telescopic rods 14, and the fixed rod 11 is fixed, then the screw rod 12 is rotated, and the screw threads which are in two directions with the surface of the screw rod 12 are sleeved under the limit of the sliding rod 13, so that the clamping plate 16 on the surface of the screw rod 12 can move towards one side, the clamping plate 16 can slowly fix the lateral trunk of a rat, at the moment, the injection needle inlet pipe groove 21 arranged at the top of the placing table 2 can be aligned with the crossing part of the lumbar vertebra, the sacrum and the left and right ilium of the rat, then the injector is placed in the injection needle inlet pipe groove 21 and pushed to reach the crossing part of the lumbar vertebra, the sacrum and the left and right ilium of the rat along with the sliding, the injection needle can continuously enter the cavity through the muscle to the yellow ligament, namely, the subarachnoid cavity is reached, and finally, the medicine inlet push rod of the injector is slowly pushed to inject the medicine liquid into the sheath.
And those not described in detail in this specification are well within the skill of those in the art.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation. The use of the phrase "comprising one of the elements does not exclude the presence of other like elements in the process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A rat lumbosacral part injection drug delivery device comprises a supporting platform consisting of a trapezoidal rest (3) and a base (4), and is characterized in that: an adjustable trunk fixing component (1) is arranged at the left top of the base (4), a placing table (2) is arranged at the top of the adjustable trunk fixing component (1), and an injection needle insertion tube groove (21) is fixedly formed in the top of the placing table (2);
adjust truck fixed subassembly (1) and include two dead levers (11), two lead screw (12) have been cup jointed in the rotation of dead lever (11) relative one side, two dead lever (11) relative one side fixedly connected with slide bar (13), the surperficial symmetry of slide bar (13) and lead screw (12) is provided with grip block (16), two the fixed surface of dead lever (11) is connected with telescopic link (14), bolt (15) have been cup jointed to the surface screw thread of telescopic link (14).
2. A rat lumbosacral injection drug delivery device as defined in claim 1, wherein: the two fixing rods (11) are sleeved on the left top of the base (4) in a sliding mode, and the clamping plate (16) is sleeved on the surface of the screw rod (12) in a threaded mode and sleeved on the surface of the sliding rod (13) in a sliding mode.
3. A rat lumbosacral injection drug delivery device as defined in claim 1, wherein: the surface of the screw rod (12) is symmetrically provided with bidirectional threads, and one end of the screw rod (12) penetrates through the fixing rod (11) on one side and extends out of the surface of the fixing rod (11) on one side.
4. A rat lumbosacral injection drug delivery device as defined in claim 1, wherein: the trapezoid rest (3) is fixedly connected to the right top of the base (4).
5. A rat lumbosacral injection drug delivery device as defined in claim 1, wherein: the bottom of the placing table (2) is fixedly connected to the top of the fixing rod (11), and an injector is placed in the inner cavity of the injection needle insertion tube groove (21).
6. A rat lumbosacral injection drug delivery device as defined in claim 1, wherein: the telescopic rod (14) is fixedly connected to the top of the base (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221758140.1U CN218684842U (en) | 2022-07-08 | 2022-07-08 | Rat lumbosacral part injection drug administration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221758140.1U CN218684842U (en) | 2022-07-08 | 2022-07-08 | Rat lumbosacral part injection drug administration device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218684842U true CN218684842U (en) | 2023-03-24 |
Family
ID=85627656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202221758140.1U Active CN218684842U (en) | 2022-07-08 | 2022-07-08 | Rat lumbosacral part injection drug administration device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218684842U (en) |
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2022
- 2022-07-08 CN CN202221758140.1U patent/CN218684842U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240108 Address after: Room 1909, 19th Floor, Building 5, Building 3, No. 111 Wusongjiang Avenue, Guoxiang Street, Wuzhong District, Suzhou City, Jiangsu Province, 215124 Patentee after: Suzhou Qilin Zhijian Cell Biotechnology Co.,Ltd. Address before: 101300 No. 3, Guangming South Street, Shunyi District, Beijing Patentee before: Beijing Shunyi District Hospital |
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| TR01 | Transfer of patent right |