CN218561454U

CN218561454U - Mycobacterium tuberculosis detection device

Info

Publication number: CN218561454U
Application number: CN202222505620.3U
Authority: CN
Inventors: 张洪英; 朱银银; 乔梦凯; 吴咏梅
Original assignee: NANJING MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION
Current assignee: NANJING MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION
Priority date: 2022-09-21
Filing date: 2022-09-21
Publication date: 2023-03-03
Anticipated expiration: 2032-09-21

Abstract

The application provides a tubercle bacillus detection device, which relates to the field of medical equipment and comprises a processing unit, wherein the processing unit comprises a sputum box, a first storage piece and a second storage piece; the first storage part is connected with the first storage part and used for storing the first trough; the second is stored the piece and is equipped with the second groove, and the notch in second groove is connected and closed to first storage piece and second storage piece, and first storage piece can form the second through-hole that communicates the second groove in second intercommunication department in advance. In the sputum processing procedure, the corresponding liquid of sputum box, first storage piece and second storage piece storage are utilized to utilize respectively, have the effect of quantization, are convenient for control the liquid volume, are convenient for improve the accuracy and the reliability of testing result. Meanwhile, in the sputum phlegm reduction and buffering treatment processes, the sputum is in a closed environment and is not directly contacted with an external environment, and the biological safety risk is not easy to occur.

Description

Mycobacterium tuberculosis detection device

Technical Field

The utility model relates to the field of medical equipment, particularly, relate to a tubercle bacillus detection device.

Background

Mycobacterium tuberculosis (m. Tuberculosis), commonly known as mycobacterium tuberculosis, is the causative agent of tuberculosis. The current methods for detecting tubercle bacillus mainly include etiological method, immunological method and molecular biological method. The etiology detection is the only tuberculosis diagnosis method at present, and the etiology method such as the sputum smear method is a quick, cheap and feasible method for clinical diagnosis, and the sputum is collected, processed, smeared and detected. At present, the sputum smear method mainly depends on manual experience to add sputum into sputum for liquefaction, the detection result is greatly influenced by the experience and responsibility of medical workers, and the accuracy and reliability of the detection result are low.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a tubercle bacillus detection device, it can effectively reduce the adverse effect of human factor to the testing result, and the accuracy and the reliability of the testing result who acquires are higher.

The embodiment of the utility model is realized like this:

the utility model provides a tubercle bacillus detection device, include:

a processing unit comprising a sputum cassette, a first storage member and a second storage member; the sputum box is provided with a closed cavity for storing sputum to be detected, and the sputum box is provided with a first pre-communicating part; the first storage part is provided with a second pre-communicating part and a first groove for storing sputum, the sputum box is connected with the first storage part and closes the notch of the first groove, and a first through hole communicated with the first groove can be formed in the first pre-communicating part of the sputum box; the second storage part is provided with a second groove for storing buffer solution, the first storage part is connected with the second storage part and closes the notch of the second groove, and a second through hole communicated with the second groove can be formed in the second pre-communication part of the first storage part.

In an alternative embodiment, the sputum cassette, the first storage member or the second storage member is provided with graduations.

In an alternative embodiment, the first storage member is threadably connected to the sputum cartridge.

In an optional embodiment, a first cutter head is arranged on the first storage member, and the first cutter head is used for puncturing the first pre-communicating part in the process that the first storage member is screwed with the sputum box, so that the first through hole is formed in the first pre-communicating part of the sputum box, and the first through hole is an arc-shaped through hole extending in the circumferential direction of the sputum box.

In an alternative embodiment, the first storage member is threadedly coupled to the second storage member.

In an optional embodiment, a second cutter head is disposed on the second storage member, and the second cutter head is configured to pierce the second pre-communicating portion in a process of screwing the second storage member to the sputum box, so that the first storage member forms the second through hole at the second pre-communicating portion, and the second through hole is an arc-shaped through hole extending in a circumferential direction of the first storage member.

In an optional embodiment, the sputum box comprises a box body, a filter element and a box cover, the box body is provided with a closed end and an open end, the first pre-communicating part is arranged at the closed end, the filter element is arranged in the box body, the box cover is detachably connected with the box body and used for opening or closing the open end, and the box cover and the box body define the closed cavity together when the box cover closes the open end; the box body is connected with the first storage part.

In an optional embodiment, the processing unit further comprises a collecting member detachably connected to the box body, the collecting member being configured to communicate with the open end when the box cover opens the box body.

In an optional embodiment, the mycobacterium tuberculosis detection apparatus further includes a centrifuge, and the processing unit is connected to the centrifuge and is configured to drive the processing unit to rotate.

In an optional embodiment, the centrifuge includes a motor and a positioning tube, the positioning tube is fixedly connected to an output shaft of the motor, and the processing unit is inserted into the positioning tube.

The embodiment of the utility model provides a beneficial effect is:

to sum up, this embodiment provides a tubercle bacillus detection device, utilizes the sputum box to collect the sputum, will store the first piece of storing that has the appropriate amount of phlegm solution and couple together with the sputum box to make first intercommunication portion in advance form first through-hole, so, the sputum box communicates through first through-hole with first piece of storing, through make a round trip to reverse sputum box and first piece of storing, makes sputum and the abundant mixture of phlegm solution, carries out the flow of reducing phlegm. When the phlegm reducing is completed, the second storage piece storing a proper amount of buffer solution is connected with the first storage piece, the second pre-connecting part forms a second through hole, the first storage piece and the second storage piece are communicated through the second through hole, and the liquid after the phlegm reducing is fully mixed with the buffer solution by reversing the sputum box, the first storage piece and the second storage piece back and forth. And finally, the sputum box can be opened, the processed liquid is poured out, and the smear is performed after centrifugal processing. In the sputum processing procedure, the corresponding liquid of sputum box, first storage piece and second storage piece storage are utilized to utilize respectively, have the effect of quantization, are convenient for control the liquid volume, are convenient for improve the accuracy and the reliability of testing result. Meanwhile, in the sputum phlegm reducing and buffering treatment processes, the sputum is in a closed environment and is not directly contacted with an external environment, so that the biological safety risk is not easy to occur.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention, and therefore should not be considered as limiting the scope, and that those skilled in the art can also obtain other related drawings based on these drawings without inventive efforts.

FIG. 1 is a schematic structural diagram of a Mycobacterium tuberculosis detection apparatus according to an embodiment of the present invention;

FIG. 2 is an exploded view of the Mycobacterium tuberculosis detection apparatus according to an embodiment of the present invention;

fig. 3 is a schematic structure of a centrifuge according to an embodiment of the present invention.

Icon:

100-a processing unit; 110-sputum box; 111-a cartridge; 112-a filter element; 113-box cover; 114-first pre-communication; 120-a first storage; 121-a first slot; 122-a second pre-communication section; 123-a first cutting head; 130-a second storage; 131-a second groove; 132-a second cutting head; 140-a collecting member; 200-a centrifuge; 210-a motor; 220-positioning the tube.

Detailed Description

To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the attached drawings in the embodiments of the present invention are combined to clearly and completely describe the technical solution in the embodiments of the present invention, and obviously, the described embodiments are part of the embodiments of the present invention, rather than all embodiments. The components of embodiments of the present invention, as generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the accompanying drawings, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate the position or positional relationship based on the position or positional relationship shown in the drawings, or the position or positional relationship which is usually placed when the product of the present invention is used, and are only for convenience of description and simplification of the description, but do not indicate or imply that the device or element referred to must have a specific position, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal", "vertical" and the like do not imply that the components are required to be absolutely horizontal or pendant, but rather may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood as a specific case by those skilled in the art.

At present, when tubercle bacillus detected, need prepare a plurality of bottles, a plurality of bottles are independent settings, the liquid that the storage corresponds in every beaker, for example, first bottle in a plurality of bottles is used for collecting the sputum, the second bottle is used for storing the sputum, the third bottle is used for storing buffer solution etc. during the use, the manual work is poured the sputum into the first bottle that collects there is the sputum, pour buffer solution into first bottle after stirring a period again, whole operation process is artifical the realization, the interpolation of liquid all relies on operator's experience to judge, the liquid addition is wayward. Meanwhile, the bottle body is open and directly contacts with the external environment, so that the biological safety risk is easy to occur.

In view of this, designers have devised a mycobacterium tuberculosis detection apparatus that can mix liquids in a closed environment, is highly safe, and can improve the accuracy and reliability of detection results by facilitating the control of the amount of liquid.

Referring to fig. 1-2, in the present embodiment, the mycobacterium tuberculosis detection apparatus includes a processing unit 100, where the processing unit 100 includes a sputum box 110, a first storage component 120, and a second storage component 130; the sputum box 110 is provided with a closed cavity for storing sputum to be detected, and the sputum box 110 is provided with a first pre-communicating part 114; the first storage member 120 is provided with a second pre-communicating part 122 and a first groove 121 for storing the sputum, the sputum box 110 is connected with the first storage member 120 and closes the notch of the first groove 121, and the sputum box 110 can form a first through hole communicated with the first groove 121 at the first pre-communicating part 114; the second storage member 130 is provided with a second groove 131 for storing a buffer solution, the first storage member 120 is connected with the second storage member 130 and closes a notch of the second groove 131, and the first storage member 120 can form a second through hole communicating with the second groove 131 at the second pre-communication portion 122.

The using method of the tubercle bacillus detection device provided by the embodiment comprises the following steps:

utilize phlegm box 110 to collect the sputum earlier, the first piece 120 that stores the first storage that has the appropriate amount of phlegm solution is connected with phlegm box 110, and make first intercommunication portion 114 form first through-hole in advance, thus, the airtight chamber of phlegm box 110 communicates through first through-hole with the first recess of first storage piece 120, and the notch of first recess is sealed by phlegm box 110, the inside liquid of phlegm box 110 and first storage piece 120 is difficult for contacting with the external environment, then, through making a round trip to reverse phlegm box 110 and first storage piece 120, make phlegm solution and phlegm solution intensive mixing, carry out phlegm reduction flow. After the sputum is completely reduced, the second storage member 130 storing a proper amount of buffer solution is connected with the first storage member 120, and the second pre-connecting part forms a second through hole, the first groove of the first storage member 120 and the second groove of the second storage member 130 are communicated through the second through hole, and the notch of the second groove is closed by the first storage member 120, so that the sputum box 110, the first storage member 120 and the second storage member 130 are reversed back and forth, and the liquid after the sputum is completely mixed with the buffer solution. Finally, the sputum cassette 110 can be opened and the processed fluid poured out for centrifugation and then smear. In the sputum processing process, the sputum box 110, the first storage part 120 and the second storage part 130 are used for storing corresponding liquid, so that the quantitative effect is achieved, the liquid amount is convenient to control, and the accuracy and the reliability of detection results are convenient to improve. Meanwhile, in the sputum phlegm reducing and buffering treatment processes, the sputum is in a closed environment and is not directly contacted with an external environment, so that the biological safety risk is not easy to occur.

In this embodiment, the sputum box 110 optionally includes a box body 111, a filter element 112 and a box cover 113. The box body 111 is arranged to be a rotating body, the box body 111 is provided with a closed end and an open end in the axial direction, the closed end is arranged on the first pre-communicating part 114, the first pre-communicating part 114 is arranged to be an arc-shaped groove, the groove extends along the circumferential direction of the box body 111, and the length of the groove can be set as required. By providing the first pre-communicating portion 114 as a groove, the thickness of the groove bottom wall of the groove is smaller than the thickness of the other positions of the closed end, for example, the thickness of the closed end at the groove bottom wall of the groove is about 2mm, which facilitates breaking the groove to form the first through hole due to the small wall thickness at the groove. The filter element 112 may be configured as a cellulose membrane, the filter element 112 is fixed in the case 111 and is designed to be close to the open end of the case 111, the cover 113 is detachably connected to the case 111, the cover 113 is used to open or close the open end, and when the cover 113 closes the open end, the cover 113 and the case 111 jointly define a sealed cavity.

Optionally, the box body 111 is provided with a first external thread and a second external thread, the first external thread and the second external thread are respectively close to the open end and the closed end of the box body 111, the box cover 113 is provided with a threaded hole, and the threaded hole in the box cover 113 is in threaded connection with the first external thread, so that the box cover 113 is detachably connected with the box body 111. It should be appreciated that a gasket may be provided between the cover 113 and the body 111 to improve sealing.

In addition, be provided with the scale mark on the box body 111, be convenient for directly perceivedly acquire the volume of the sputum of storing in the box body 111.

In this embodiment, optionally, the first storage member 120 is provided as a tube, the first storage member 120 has a first end and a second end in the axial direction thereof, the first end is an end portion of the first groove 121 where the notch is located, the second end is a closed end, the second pre-communicating portion 122 is disposed on an outer surface of the second end, the second pre-communicating portion 122 may be an arc-shaped groove, the groove extends along the circumferential direction of the first storage member 120, and the thickness of the groove bottom wall of the groove is smaller than the thickness of the rest positions of the closed end, so as to be easily damaged. The inner wall of body is provided with the internal thread near the position of first end, utilizes this internal thread can with the second external screw thread spiro union on the box body 111 to realize the dismantled connection of phlegm box 110 and first storage piece 120. And, there is the first knife head 123 in the first end, the first knife head 123 and the first storage member 120 are set up eccentrically, in the course of screwing the first storage member 120 on the box 111, the first knife head 123 abuts against the first pre-communicating part 114, and along with the increase of screwing length, the first knife head 123 pierces the trough bottom wall of the first pre-communicating part 114, thus make the first pre-communicating part 114 form the first through hole, the first through hole communicates with notch of the first recess. The first storage member 120 is provided with a third external thread at a position near the second end.

It should be noted that a sealing ring may be disposed between the box body 111 and the first storage member 120 to improve sealing performance.

In this embodiment, optionally, the second storage member 130 is configured as a tube, and the second storage member 130 has a third end and a fourth end in the axial direction, the third end is an end of the first groove 121 where the notch is located, and the fourth end is a closed end. The position that the inner wall of body is close to the third end is provided with the internal thread, utilizes this internal thread can with the third external screw thread spiro union on the first storage piece 120 to realize first storage piece 120 and the second and store the dismantlement of 130 and be connected. And, there is the second cutting head 132 at the third end, the second cutting head 132 and the second storage 130 are eccentrically arranged, in the process of screwing the second storage 130 on the first storage 120, the second cutting head 132 abuts against the second pre-communicating portion 122, and as the screwing length increases, the second cutting head 132 pierces the groove bottom wall of the second pre-communicating portion 122, so that the second pre-communicating portion 122 forms a second through hole, and the second through hole is communicated with the notch of the second groove.

It should be noted that, the first storage member 120 and the second storage member 130 are both provided with scale marks, so that the amount of the expectorant solution in the first storage member 120 and the amount of the buffer solution in the second storage member 130 can be visually obtained.

In this embodiment, optionally, the processing unit 100 further includes a collecting element 140, the collecting element 140 is detachably connected to the box body 111, and the collecting element 140 is used for communicating with the open end of the box body 111 when the box cover 113 opens the box body 111. Specifically, the collecting member 140 may be configured as a cup body, one end of the collecting member 140 is open, the other end of the collecting member 140 is closed, an inner wall of the collecting member 140 at the open end is provided with an internal thread, and the collecting member 140 can be screwed and fixed with the first external thread on the box body 111 by using the internal thread on the collecting member 140. That is, after the cover 113 is opened, the collecting member 140 is screwed to the case 111.

It should be noted that the sputum box 110, the first storage member 120, the second storage member 130 and the collection member 140 may be made of transparent materials. For example made of transparent plastic.

Referring to fig. 3, in this embodiment, optionally, the mycobacterium tuberculosis detection apparatus further includes a centrifuge 200, the processing unit 100 is connected to the centrifuge 200, and the centrifuge 200 is configured to drive the processing unit 100 to rotate, so as to generate a centrifugal motion for the liquid inside the processing unit 100, so that the tubercle bacillus is concentrated on the filter element 112, that is, the concentrated bacillus, and is used for subsequent smear, culture and nucleic acid detection and analysis.

Optionally, the centrifuge 200 includes a motor 210 and a positioning tube 220, the positioning tube 220 is fixedly connected to an output shaft of the motor 210, and the processing unit 100 is inserted into the positioning tube 220. Specifically, after the box cover 113 is detached from the box body 111, the collecting member 140 is screwed on the box body 111, and then the whole processing unit 100 is inserted into the positioning tube 220 in an inverted manner, that is, the collecting member 140 is located below, the second storage member 130 is located above, and the whole processing unit 100 is vertically arranged, at this time, the centrifuge 200 is started, and the positioning tube 220 drives the processing unit 100 to rotate together, so as to perform the centrifugation operation.

It should be noted that, the inner wall of the positioning tube 220 may be provided with a flexible layer, such as a rubber layer, and the processing unit 100 is inserted into the positioning tube 220 to contact with the flexible layer, so as to improve the firmness of the fit between the two and prevent slipping.

In this embodiment, the sputum and the buffer solution may be any conventionally known solutions, but they are not illustrated in this embodiment. For example, the sputum is 4% sodium hydroxide solution and the buffer is PBS (Phosphate Buffered Saline).

The tubercle bacillus detection device that this embodiment provided, in the sputum processing procedure, the utilization utilizes sputum box 110, first storage 120 and second storage 130 to store corresponding liquid respectively, has the effect of quantization, is convenient for control the liquid volume, is convenient for improve the accuracy and the reliability of testing result. Meanwhile, in the sputum phlegm reducing and buffering treatment processes, the sputum is in a closed environment and is not directly contacted with an external environment, so that the biological safety risk is not easy to occur.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A tubercle bacillus detection device, characterized by comprising:

a processing unit comprising a sputum cassette, a first storage member and a second storage member; the sputum box is provided with a closed cavity for storing sputum to be detected, and the sputum box is provided with a first pre-communicating part; the first storage part is provided with a second pre-communicating part and a first groove for storing sputum, the sputum box is connected with the first storage part and closes the notch of the first groove, and a first through hole communicated with the first groove can be formed in the first pre-communicating part of the sputum box; the second storage part is provided with a second groove for storing buffer solution, the first storage part is connected with the second storage part and closes the notch of the second groove, and the first storage part can form a second through hole communicated with the second groove at the second pre-communication part.

2. The tubercle bacillus detection device according to claim 1, wherein:

the sputum box, the first storage piece or the second storage piece are provided with scale marks.

3. The tubercle bacillus detection device according to claim 1, wherein:

the first storage member is in threaded connection with the sputum box.

4. The tubercle bacillus detection device according to claim 3, wherein:

the first storage piece is provided with a first cutter head, the first cutter head is used for puncturing the first pre-communicating part in the process that the first storage piece is in threaded connection with the sputum box, so that the sputum box forms a first through hole at the first pre-communicating part, and the first through hole is an arc-shaped through hole extending in the circumferential direction of the sputum box.

5. The tubercle bacillus detection device according to claim 1, wherein:

the first storage member is in threaded connection with the second storage member.

6. The tubercle bacillus detection device of claim 5, wherein:

the second storage piece is provided with a second tool bit, the second tool bit is used for puncturing the second pre-communicating part in the process that the second storage piece is in threaded connection with the sputum box, so that the first storage piece forms a second through hole in the second pre-communicating part, and the second through hole is an arc-shaped through hole extending in the circumferential direction of the first storage piece.

7. The tubercle bacillus detection device according to claim 1, wherein:

the sputum box comprises a box body, a filter element and a box cover, wherein the box body is provided with a closed end and an open end, the first pre-communicating part is arranged at the closed end, the filter element is arranged in the box body, the box cover is detachably connected with the box body and used for opening or closing the open end, and the box cover and the box body jointly define the closed cavity when the open end is closed by the box cover; the box body is connected with the first storage part.

8. The tubercle bacillus detection device according to claim 7, wherein:

the processing unit still includes the collection piece, collect the piece with box body detachably connects, the collection piece is used for the lid is opened when the box body with open end intercommunication.

9. The tubercle bacillus detection device of claim 8, wherein:

the tubercle bacillus detection device further comprises a centrifugal machine, the processing unit is connected with the centrifugal machine, and the centrifugal machine is used for driving the processing unit to rotate.

10. The tubercle bacillus detection device of claim 9, wherein:

the centrifuge comprises a motor and a positioning pipe, the positioning pipe is fixedly connected with an output shaft of the motor, and the processing unit is inserted into the positioning pipe.