CN218321198U

CN218321198U - Rapid preparation device for monoclonal antibody

Info

Publication number: CN218321198U
Application number: CN202221368101.0U
Authority: CN
Inventors: 贾兆强; 康晓文; 李忠文; 程立瀛; 卢灿华
Original assignee: Shanghai Shuoying Biotechnology Co ltd
Current assignee: Shanghai Shuoying Biotechnology Co ltd
Priority date: 2022-06-01
Filing date: 2022-06-01
Publication date: 2023-01-17
Anticipated expiration: 2032-06-01

Abstract

The utility model relates to an antibody preparation field discloses a quick preparation facilities of monoclonal antibody, the power distribution box comprises a box body, the fixed two casees of placing that are provided with in box top, place the fixed discharging pipe that is provided with on the case, be provided with the solenoid valve on the discharging pipe, serum and normal saline are equipped with respectively to the difference splendid attire in two casees, it has the kickboard to float in the box, place and seted up the apical trough on the roof portion inner wall, the apical trough internal fixation is provided with the diaphragm, two perpendicular holes have been seted up at the diaphragm top, it has the riser to erect downthehole sliding contact, riser bottom and kickboard fixed connection, two fixed horizontal plates that are provided with in riser top, all fixed the conducting strip that is provided with on horizontal plate top and the apical trough top inner wall, it is fixed the inlet pipe that is provided with to place the case side. The utility model has the advantages of it is following and effect: serum and normal saline can be conveniently and rapidly quantitatively added into the box body, and the working strength is reduced.

Description

Rapid preparation device for monoclonal antibody

Technical Field

The utility model relates to an antibody preparation technical field, in particular to quick preparation facilities of monoclonal antibody.

Background

Monoclonal antibodies are highly homogeneous antibodies produced by a single B cell clone, directed against only a particular epitope. Usually, the antibody is prepared by hybridoma technique, and after the antibody preparation is completed, the antibody is generally extracted by salting out method, and a certain amount of physiological saline and serum solution is added each time to precipitate the antibody.

When adding normal saline and serum among the prior art antibody preparation facilities, need the volume of artifical measurement serum and normal saline at every turn, add in the box after the measurement is accomplished, so can not add serum and normal saline toward the box fast quantitative, improve working strength, consequently, need design one kind can make things convenient for fast quantitative to add serum and normal saline toward the box in, reduce working strength's monoclonal antibody's quick preparation facilities.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a monoclonal antibody's quick preparation facilities has the effect that can make things convenient for quick ration to add serum and normal saline in the box, reduce working strength.

The above technical purpose of the present invention can be achieved by the following technical solutions: the improved blood-pressure-reducing infusion bottle comprises a box body, the box top is fixedly provided with two placing boxes, the placing boxes are fixedly provided with discharging pipes, electromagnetic valves are arranged on the discharging pipes, serum and normal saline are respectively and greatly contained in the two boxes, a floating plate floats in the box body, a top groove is formed in the inner wall of the top of the placing box, a transverse plate is fixedly arranged in the top groove, two vertical holes are formed in the top of the transverse plate, vertical holes are provided with vertical plates in sliding contact, the bottoms of the vertical plates are fixedly connected with the floating plate, two vertical plates are fixedly provided with a horizontal plate, conducting strips are fixedly arranged on the top inner walls of the top groove and the top groove, an inlet pipe is fixedly arranged on the side surface of the placing box, a control valve is arranged on the inlet pipe, a moving groove is formed in the side wall of the top groove, a positioning hole is formed in the side surface of one vertical plate, a positioning plate clamped with the positioning hole is formed in the sliding contact in the moving groove, a screw groove is formed in the side surface of the positioning plate, a rotating shaft is connected with a rotating shaft, and external threads are connected with the rotating shaft.

The utility model discloses a further set up to: the two conducting strips are electrically connected with the control valve.

The utility model discloses a further set up to: the box side is fixed to be provided with row material pipe, is provided with the valve on arranging the material pipe.

By adopting the technical scheme, the mixed liquid is convenient to discharge.

The utility model discloses a further set up to: the end part of the rotating shaft is fixedly provided with a rotating button.

The utility model discloses a further set up to: the side surface of the placing box is provided with a mounting hole, a bearing is fixedly arranged in the mounting hole, and the rotating shaft is fixedly connected with the inner ring of the bearing.

Through adopting above-mentioned technical scheme, make things convenient for the rotation of pivot.

The utility model discloses a further set up to: the solenoid valve is located and places the incasement.

The utility model has the advantages that:

1. the utility model discloses a turn button, pivot, locating plate and locating hole that set up only need rotate the turn button, can make the locating plate shift out the locating hole, relieve the spacing to the riser, the kickboard moves down this moment, two conducting strips separate, and then can make the control valve start, carry out the liquid feeding processing automatically in the box, in the liquid feeding process, the kickboard moves up, until two conducting strips contact, the control valve closes this moment, stop the fluid infusion, can automatic quantitative liquid feeding processing, this moment rethread locating plate card goes into in the locating hole, carry out spacing processing to the riser;

2. the utility model discloses a discharging pipe, solenoid valve, valve and the row of setting material pipe only need open the solenoid valve for in serum and the normal saline flow in the box, normal saline mixes the completion back with serum solution, opens the valve, mixes in liquid gets into collection device along arranging the material pipe, can make things convenient for quick ration to add serum and normal saline in the box, reduce working strength.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

FIG. 1 is a schematic structural diagram of a rapid monoclonal antibody preparation apparatus according to the present invention.

Fig. 2 is a schematic sectional structural diagram of an apparatus for rapid preparation of monoclonal antibody according to the present invention.

Fig. 3 is a schematic view of a portion a of fig. 2.

In the figure, 1, a box body; 2. placing a box; 3. a discharge pipe; 4. an electromagnetic valve; 5. a floating plate; 6. a top groove; 7. a transverse plate; 8. a vertical plate; 9. a horizontal plate; 10. a conductive sheet; 11. positioning a plate; 12. positioning holes; 13. a rotating shaft; 14. a feed pipe; 15. and a control valve.

Detailed Description

The technical solution of the present invention will be clearly and completely described below with reference to specific embodiments. It is obvious that the described embodiments are only some of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative efforts belong to the protection scope of the present invention.

Referring to fig. 1, 2 and 3, the utility model provides a rapid preparation device of monoclonal antibody, which comprises a box body 1, wherein a material discharging pipe is fixedly arranged on the side surface of the box body 1, a valve is arranged on the material discharging pipe, two placing boxes 2 are fixedly arranged on the top of the box body 1, a material discharging pipe 3 is fixedly arranged on the placing boxes 2, a solenoid valve 4 is arranged on the material discharging pipe 3, the solenoid valve 4 is positioned in the placing boxes 2, the solenoid valve 4 is controlled by a controller, serum and physiological saline are respectively contained in the two box bodies 1, a floating plate 5 floats in the box body 1, a top groove 6 is arranged on the inner wall of the top of the placing box 2, a transverse plate 7 is fixedly arranged in the top groove 6, two vertical holes are arranged on the top of the transverse plate 7, a vertical plate 8 is in sliding contact in the vertical holes, the bottom of the vertical plate 8 is fixedly connected with the floating plate 5, a horizontal plate 9 is fixedly arranged on the top of the two vertical plates 8, conductive sheets 10 are fixedly arranged on the top of the horizontal plate 9 and the inner wall of the top groove 6, a feeding pipe 14 is fixedly arranged on the side surface of the placing box 2, the two feeding pipes 14 are respectively connected with an external material pipe, so that serum and physiological saline respectively improve the two feeding pipes 14 to enter the placing box 2, a control valve 15 is arranged on the feeding pipe 14, a moving groove is arranged on the side wall of the top groove 6, a positioning hole 12 is arranged on the side surface of one vertical plate 8, a positioning plate 11 clamped with the positioning hole 12 is in sliding contact in the moving groove, a screw groove is arranged on the side surface of the positioning plate 11, a rotating shaft 13 is rotatably connected to the side surface of the placing box 2, a rotating button is fixedly arranged at the end part of the rotating shaft 13, the rotating shaft 13 is driven to rotate by the rotating button, an external thread is arranged on the outer side of the rotating shaft 13, the external thread on the rotating shaft 13 is connected with the screw groove thread, two electromagnetic valves 4 are started, and then the serum and the physiological saline in the two placing boxes 2 flow into the box body 1, after the completion of the mixing of the normal saline and the serum solution, the valve is opened, the mixed liquid enters the collecting device along the discharging pipe, the electromagnetic valve 4 is closed in the process, the rotating button is rotated, the rotating shaft 13 rotates, the external thread and the screw groove are arranged, the positioning plate 11 can be moved out of the positioning hole 12 transversely, the limit of the vertical plate 8 is removed, the vertical plate 8 and the horizontal plate 9 move downwards due to self gravity at the moment, two conducting plates 10 are separated, the control valve 15 is opened at the moment, liquid adding treatment is carried out in the placing box 2 along with the rising of the liquid level, the floating plate 5 moves upwards until the two conducting plates 10 are contacted, the control valve 15 is automatically closed at the moment, the rotating button is reversely rotated, the positioning plate 11 can be clamped into the positioning hole 12, the electromagnetic valve 4 is opened later, the circulation is realized, the serum and the normal saline can be conveniently and quickly added into the box in a quantitative manner, and the working strength is reduced.

According to the drawings of fig. 2 and fig. 3, the two conducting strips 10 are electrically connected with the control valve 15, when the two conducting strips 10 are in contact, the control valve 15 can be closed, when the two conducting strips 10 are separated, the control valve 15 is opened, the side surface of the placing box 2 is provided with the mounting hole, a bearing is fixedly arranged in the mounting hole, the rotating shaft 13 is fixedly connected with the inner ring of the bearing, and the stability of the rotating shaft 13 during rotation is improved.

The above details describe the device for rapidly preparing monoclonal antibody provided by the present invention. The principles and embodiments of the present invention have been explained herein using specific embodiments, which are merely used to help understand the method and its core ideas of the present invention. It should be noted that, for those skilled in the art, without departing from the principle of the present invention, the present invention can be further modified and modified, and such modifications and modifications also fall within the scope of the appended claims.

Claims

1. The rapid preparation device for the monoclonal antibody is characterized by comprising a box body (1), wherein two placing boxes (2) are fixedly arranged at the top of the box body (1), a discharging pipe (3) is fixedly arranged on each placing box (2), a solenoid valve (4) is arranged on each discharging pipe (3), serum and normal saline are respectively filled in each two box bodies (1), a floating plate (5) floats in each box body (1), a top groove (6) is formed in the inner wall of the top of each placing box (2), a transverse plate (7) is fixedly arranged in each top groove (6), two vertical holes are formed in the top of each transverse plate (7), a vertical plate (8) is in sliding contact with each vertical hole, the bottom of each vertical plate (8) is fixedly connected with the floating plate (5), a horizontal plate (9) is fixedly arranged at the tops of the two vertical plates (8), positioning holes (10) are fixedly arranged on the top of each horizontal plate (9) and the inner wall of the top of each top groove (6), a positioning plate (14) is fixedly arranged on the side of each placing box (2), a control valve (15) is arranged on each feeding pipe (14), a moving plate (8) is arranged on the side wall, and a positioning hole (12) is in each vertical plate (12) and is in each positioning plate (12), the thread groove has been seted up to locating plate (11) side, it is connected with pivot (13) to place case (2) side rotation, the external screw thread has been seted up in pivot (13) outside, external screw thread and thread groove threaded connection on pivot (13).

2. The apparatus for rapid preparation of monoclonal antibodies according to claim 1, wherein the two conductive strips (10) are electrically connected to the control valve (15).

3. The apparatus for rapid preparation of monoclonal antibodies according to claim 1, wherein the side of the housing (1) is fixedly provided with a discharge pipe, and the discharge pipe is provided with a valve.

4. The apparatus for rapid preparation of monoclonal antibodies according to claim 1, wherein the end of the rotating shaft (13) is fixedly provided with a knob.

5. The rapid preparation device of a monoclonal antibody according to claim 1, wherein the side of the placing box (2) is provided with a mounting hole, a bearing is fixedly arranged in the mounting hole, and the rotating shaft (13) is fixedly connected with an inner ring of the bearing.

6. The rapid monoclonal antibody preparation apparatus according to claim 1, wherein the solenoid valve (4) is located in the placing box (2).