CN218272088U - Collecting device for detecting glucose concentration - Google Patents

Abstract

The utility model describes a detection glucose concentration's collection system, include: the temperature acquisition device comprises a current sensing module, a first analog-to-digital conversion module, a first amplifier, a first voltage module, a second amplifier, a second voltage module, a temperature acquisition module and a micro-processing unit module, wherein the first amplifier is coupled to the current sensing module and the first voltage module, the second amplifier is coupled to the current sensing module and the second voltage and is coupled to the current sensing module, the output end of the second amplifier is coupled to the first analog-to-digital conversion module through a low-pass filtering module, the temperature acquisition module is provided with the second analog-to-digital conversion module and the temperature sensing module, and the micro-processing unit module controls the acquisition frequency of the acquisition device and controls the on-off state of the first analog-to-digital conversion module. Through the utility model discloses, the concentration of detection glucose that can be long-time, accurate.

Description

Collection device for detecting glucose concentration

Technical Field

The utility model relates to a detect collection system of glucose concentration.

Background

In the process of the rapid development of social and economic life, the quality of life of people is also developed, and the attention on body health is increasingly raised, wherein diabetes and chronic complications thereof become one of the diseases which seriously affect the health of people at present. In order to delay and reduce chronic complications of diabetes, the disease can be better judged by monitoring the glucose concentration in blood, and corresponding measures can be taken to control the glucose concentration, so that monitoring needs to be realized by devices or systems capable of collecting glucose information.

In the prior art, a dynamic blood glucose detector and a glucose sensor are mostly adopted to detect glucose in interstitial fluid or blood, in order to improve the accuracy of blood glucose detection, an electrode is often required to be arranged in the blood glucose detector to work in a matching manner, and an enzyme capable of reflecting with glucose is arranged on the electrode, so that the enzyme reacts with glucose to generate particle concentration change, and further current change occurs. Thus, the glucose concentration in the blood can be inferred by measuring the magnitude of the current. However, the existing blood glucose meter has difficulty in maintaining the stability of the voltage of the measurement environment during measurement, so that the accuracy of current measurement is difficult to ensure during measurement, and the glucose concentration in interstitial fluid or blood cannot be well detected.

Disclosure of Invention

The present invention has been made in view of the above-mentioned state of the art, and an object of the present invention is to provide a collecting device capable of accurately detecting glucose concentration for a long time.

Therefore, the utility model provides a detection glucose concentration's collection system, include: a current sensing module, a first analog-to-digital conversion module, a first amplifier, a first voltage module, a second amplifier, a second voltage module, a temperature acquisition module, and a micro-processing unit module, the first amplifier having a first input configured to couple to the current sensing module via a first resistance and a second input coupled to the first voltage module and having a first output coupled to the current sensing module, the second amplifier having a third input configured to couple to the current sensing module and a fourth input coupled to the second voltage module and having a second output coupled to the current sensing module via a second resistance, the second output coupled to the first analog-to-digital conversion module via a low pass filter module, the temperature acquisition module having a second analog-to-digital conversion module coupled to the second voltage module via a third resistance and a temperature sensing module connected to the second analog-to-digital conversion module, the micro-processing unit module having a switch analog-to-digital conversion module that controls an acquisition frequency of the acquisition device and controls an on-off state of the first analog-to-digital conversion module.

Through the utility model discloses, when the glucose in interstitial fluid or blood reacts, when the concentration of glucose also can change, through measuring the weak electric current that glucose concentration produced when changing and then handle it, infer and can obtain the concentration of glucose. The current sensing module is used for capturing the change of the current, the analog signal of the collected current can be converted into a digital signal through the first analog-to-digital conversion module, the sensitivity of measurement is guaranteed through the temperature collected signal, and the working duration of the collecting device can be guaranteed by controlling the collecting frequency of the collecting device through the micro-processing unit module. Therefore, the concentration of the glucose can be accurately collected for a long time.

Additionally, in the collecting device of the present invention, optionally, the current sensing module includes a working electrode, a reference electrode for maintaining a stable potential difference with the working electrode, and a counter electrode forming a loop with the working electrode. This enables a circuit to be formed between the three electrodes and the current flowing through the working electrode to be measured.

Additionally, in the acquisition device of the present invention, optionally, the low pass filter module has a fourth resistor coupled to the second output and a first capacitor coupled to ground, and the low pass filter module has an output coupled to the first analog-to-digital conversion module. Therefore, the output signal can be transmitted to the analog-to-digital conversion module through the low-pass filtering module.

Additionally, in the collecting device of the present invention, optionally, the collecting device further comprises a power module, the power module includes a constant voltage chip, the constant voltage chip has an input end coupled to the third voltage module and an output end coupled to the second voltage module, and the first voltage module is coupled to the constant voltage chip via a fifth resistor. Thus, a relatively stable voltage can be output through the constant voltage chip.

Additionally, in the collecting device of the present invention, optionally, the first voltage module outputs a first constant voltage, and the second voltage module outputs a second constant voltage. Thus, a stable voltage can be output by the first voltage module and the second voltage module.

Additionally, in an acquisition device as claimed in the present invention, optionally, the first amplifier and the second amplifier are powered by the third voltage module.

Additionally, in the collection device of the present invention, optionally, the temperature sensing module includes a thermistor. Therefore, the temperature sensing module can have high sensitivity.

Additionally, in the collecting device of the present invention, optionally, the resistance of the third resistor is equal to the nominal resistance of the thermistor.

Additionally, in the collection system of the present invention, optionally, the first analog-to-digital conversion module has a reference voltage, and the first analog-to-digital conversion module has a plurality of voltage ranges set based on the reference voltage. In this case, different measurement ranges can be obtained by setting different voltage ranges based on the reference voltage, and thus, an appropriate measurement range can be selected to obtain accurate data.

Additionally, in the collecting device of the present invention, optionally, the low pass filter module is a first-order low pass filter. Therefore, high-frequency noise can be filtered, and noise interference can be reduced.

Additionally, the utility model relates to an in the collection system, optionally, the microprocessing unit module still has right collection system burns the serial communication unit of burning the calibration and transmits the bluetooth communication unit of information collection, from this, can transmit the data information that collection system gathered through bluetooth communication unit.

According to the utility model discloses a detection glucose concentration's collection system, concentration that can be long-time, accurate detection glucose.

Drawings

The invention will now be explained in further detail by way of example only with reference to the accompanying drawings, in which:

fig. 1 is a circuit diagram showing a part of elements of an acquisition apparatus according to an embodiment of the present disclosure.

Fig. 2 is a circuit diagram showing a temperature acquisition module according to an embodiment example of the present invention.

Fig. 3 is a circuit diagram showing a low-pass filter module according to an exemplary embodiment of the present invention.

Fig. 4 is a circuit diagram showing a constant voltage chip according to an exemplary embodiment of the present invention.

Reference numerals:

1, 8230and an acquisition device,

10, 8230and a current sensing module,

21 \ 8230, a first voltage module, 22 \ 8230, a second voltage module, 23 \ 8230and a third voltage module,

30, 8230and a low-pass filtering module,

40, 8230and a first analog-to-digital conversion module,

50, 8230and a second analog-to-digital conversion module,

60 \ 8230, 70 \ 8230and constant voltage chip.

R1 \8230, a first resistor R2 \8230, a second resistor R3 \8230, a third resistor R4 \8230, a fourth resistor C1 \8230, and a first capacitor.

U1 (8230), a first amplifier U2 (8230), and a second amplifier.

Detailed Description

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description, the same components are denoted by the same reference numerals, and redundant description thereof is omitted. The drawings are schematic and the ratio of the dimensions of the components and the shapes of the components may be different from the actual ones.

It is noted that the terms "comprises," "comprising," and "having," and any variations thereof, in the present disclosure, such that a process, method, system, article, or apparatus that comprises or has a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include or have other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

In addition, the headings and the like referred to in the following description of the present invention are not intended to limit the content or scope of the present invention, but only serve as a reminder for reading. Such a subtitle should neither be understood as a content for segmenting an article, nor should the content under the subtitle be limited to only the scope of the subtitle.

The utility model relates to a detect collection system of glucose concentration. The "collection device for detecting glucose concentration" may be simply referred to as "glucose collection device" or "collection device". Through the utility model relates to a detection glucose concentration's collection system, concentration information that can be long-time, accurate collection glucose detects the concentration that obtains glucose at last.

The following describes an acquisition device according to the present embodiment with reference to the drawings.

In some examples, when glucose in blood glucose reacts under the action of enzyme, the concentration of ions changes and weak current is generated, and then the glucose concentration in interstitial fluid or blood can be obtained by collecting current and temperature and performing calculation processing on the collected data through a computer. In some examples, "concentration information of glucose" may refer to the current and temperature required in obtaining the glucose concentration. In some examples, the weak current may range from 1 to 100nA.

Fig. 1 is a circuit diagram showing some elements of an acquisition apparatus 1 according to an embodiment of the present disclosure. Fig. 2 is a circuit diagram showing a temperature acquisition module 60 according to an exemplary embodiment of the present invention. Fig. 3 is a circuit diagram showing a low-pass filter module 30 according to an exemplary embodiment of the present invention.

In some examples, the acquisition device 1 may include a current sensing module 10, a first analog-to-digital conversion module 40, a first amplifier U1, a first voltage module 21, a second amplifier U2, a second voltage module 22 (see fig. 1). In some examples, the acquisition device may further include a temperature acquisition module 60 and a micro-processing unit module (not shown).

In some examples, the current sensing module 10 may be implanted in the subcutaneous tissue of a user and generate an electrical current. The first amplifier U1 may provide a regulated voltage. The second amplifier U2 may receive the current signal output by the current sensing module 10 and convert and amplify the current signal into a larger voltage. The first analog-to-digital conversion module 40 may convert the received analog signal into a digital signal. The first voltage module 21 and the second voltage module 22 input voltages to the first amplifier U1 and the second amplifier U2, respectively. The temperature acquisition module 60 may acquire an ambient temperature.

In some examples, the first amplifier U1 may have a first input, a second input, and a first output, the first input and the second output may be coupled with the current sensing module 10, and the first input may be coupled with the current sensing module 10 via a first resistor R1, and the second input may be coupled with the first voltage module 21. Thus, a part of the input voltage of the current sensing module 10 can be controlled by the first amplifier U1.

In some examples, the second amplifier U2 may have a third input terminal that may be coupled to the current sensing module 10, a fourth input terminal that may be coupled to the second voltage module 22, and a second output terminal that may be coupled to the current sensing module 10 via a second resistor R2. In some examples, the second output may also be coupled with the first analog-to-digital conversion module 40 via the low pass filtering module 30. Thus, the signal output from the second output terminal of the second amplifier U2 can be filtered and analog-to-digital converted by the low pass filter module 30.

In some examples, the micro-processing unit module may control the acquisition frequency of the acquisition device 1. In some examples, the micro-processing unit module may control an open and closed state of the first analog-to-digital conversion module 40. In particular, the micro-processing unit module may control the first analog-to-digital conversion module 40 to be in a turned-off state so as to enable the acquisition apparatus 1 to be in a low power consumption state. This increases the energy storage capacity of the collecting device 1 and increases its service life.

In some examples, the temperature acquisition module 60 may include the second analog-to-digital conversion module 50 and a temperature sensing module. In some examples, the temperature sensing module may be a thermistor. In some examples, the third resistor R3 may have a resistance equal to the nominal resistance of the thermistor. The nominal resistance value may be the resistance of the thermistor at an actual ambient temperature of 25 deg..

The second analog-to-digital conversion module 50 may be coupled to the second voltage module 22 via a third resistor R3, and the temperature sensing module may be connected to the second analog-to-digital conversion module 50 (see fig. 2). In this case, the second voltage module 22 may provide voltage for the temperature acquisition module 60, and the analog signal measured by the temperature sensing module may be converted into a digital signal by the second analog-to-digital conversion module 50.

In some examples, when the temperature of the environment in which the thermistor is located changes, the resistance value of the thermistor also changes. Therefore, the ambient temperature of the thermistor, namely the body surface temperature of a human body, can be judged by measuring the resistance value of the thermistor. In addition, in some examples, the sensitivity of the acquisition device 1 and the temperature of the acquisition device 1 (i.e., the body surface temperature of the human body) may be in a direct relationship. In this case, it can be judged whether the sensitivity acquired by the acquisition device 1 is satisfactory or not by measuring the temperature, and for example, the higher the sensitivity is, the higher the validity of the data is. Therefore, the accuracy of the acquisition device 1 in measuring the glucose concentration information can be effectively improved.

Referring to fig. 1, in some examples, current sensing module 10 can include a working electrode WE, a reference electrode RE, and a counter electrode CE. The working electrode WE can perform an oxidation-reduction reaction with glucose oxidase or dehydrogenase and glucose in interstitial fluid or blood, and forms a loop with the counter electrode CE to generate a current signal. The reference electrode RE can maintain a stable potential difference with the working electrode WE. Thus, it is possible to implant the subcutaneous tissue of the user through the current sensing module 10 and generate an electric current.

In some examples, the low pass filtering module 30 may be a first order low pass filter. Referring to fig. 1 and 3, in some examples, the low pass filtering module 30 may have a fourth resistor R4 and a first capacitor C1, the fourth resistor R4 being coupled to the second output terminal, the first capacitor C1 being coupled to ground. An output of the low pass filtering module 30 is coupled to a first analog to digital conversion module 40. In this case, high frequency noise in the output signal of the second amplifier U2 can be filtered. Therefore, the anti-interference performance of the signal can be improved, and the possibility that the signal input by the second analog-to-digital conversion module 50 oscillates due to the high-frequency noise doping can be reduced.

Fig. 4 is a circuit diagram showing a constant voltage chip 70 according to an exemplary embodiment of the present invention.

In some examples, the acquisition device 1 may further comprise a power module. In some examples, the power supply module may include a constant voltage chip 70. The constant voltage chip 70 has an input terminal coupled to the third voltage block 23 and an output terminal coupled to the second voltage block 22 (see fig. 4). The first voltage block 21 may be coupled to the constant voltage chip 70 via a fifth resistor. Thereby, a stable voltage can be obtained across the fifth resistor, which may range from 10 mv to 1000 mv.

In some examples, the third voltage module 23 may provide the battery voltage VDD3. In this case, the battery voltage may obtain a stable voltage through the constant voltage chip 70, and both the first voltage module 21 and the second voltage module 22 may output the stable voltage.

In some examples, the first voltage module 21 may output a first constant voltage and the second voltage module 22 may output a second constant voltage. In this case, when the first voltage module 21 and the second voltage module 22 input constant voltages from the first amplifier U1 and the second amplifier U2, respectively, and the first amplifier U1 or the second amplifier U2 is coupled to the electrodes of the current sensing module 10, the stability of the potential difference between the electrodes can be maintained. Thus, the current generated by the glucose when the reaction occurs can be accurately measured.

In some examples, the first amplifier U1 and the second amplifier U2 may be powered by a third voltage module 23. This enables stable voltage to be supplied to the first amplifier U1 and the second amplifier U2.

In some examples, the first analog-to-digital conversion module 40 may have a reference voltage, and the first analog-to-digital conversion module 40 may have a plurality of voltage ranges set based on the reference voltage. Specifically, the first analog-to-digital conversion module 40 has different gain factors, and since the range of the input voltage is equal to the reference voltage divided by the gain of the first analog-to-digital conversion module 40, different voltage ranges can be obtained when different gain factors are selected. In this case, different measurement ranges can be obtained by setting different voltage ranges based on the reference voltage, and thus, an appropriate measurement range can be selected to obtain accurate data.

In some examples, the gain factor of the first analog-to-digital conversion module 40 may be controlled by the micro-processing unit module. The gain factor of the first analog-to-digital conversion module 40 can be adjusted according to the magnitude of the analog signal.

In some examples, the micro-processing unit module may further include a serial communication unit (not shown). In some examples, the acquisition apparatus 1 may be programmed through the serial communication unit at the time of production. In some examples, the current measurement accuracy and the temperature measurement accuracy of the acquisition apparatus 1 may also be calibrated by the serial communication unit. Therefore, the accuracy of collecting the glucose concentration information can be improved.

In some examples, the micro-processing unit module may also include a bluetooth communication unit (not shown). In some examples, the bluetooth communication unit may transmit the collected glucose concentration information. In this case, after the bluetooth communication unit is matched with the data analysis module, such as a mobile phone or a computer, the collected data information can be wirelessly received by the bluetooth communication unit and transmitted to the data analysis module, and the concentration of glucose can be checked by the data analysis module.

While the present invention has been described in detail in connection with the drawings and examples, it is to be understood that the above description is not intended to limit the invention in any way. Those skilled in the art can modify and change the present invention as needed without departing from the true spirit and scope of the present invention, and such modifications and changes are intended to fall within the scope of the present invention.

Claims (11)

1. A collection device for detecting glucose concentration, comprising:

a current sensing module, a first analog-to-digital conversion module, a first amplifier, a first voltage module, a second amplifier, a second voltage module, a temperature acquisition module, and a micro-processing unit module, the first amplifier having a first input configured to couple to the current sensing module via a first resistance and a second input coupled to the first voltage module and having a first output coupled to the current sensing module, the second amplifier having a third input configured to couple to the current sensing module and a fourth input coupled to the second voltage module and having a second output coupled to the current sensing module via a second resistance, the second output coupled to the first analog-to-digital conversion module via a low pass filter module, the temperature acquisition module having a second analog-to-digital conversion module coupled to the second voltage module via a third resistance and a temperature sensing module connected to the second analog-to-digital conversion module, the micro-processing unit module having a switch analog-to-digital conversion module that controls an acquisition frequency of the acquisition device and controls an on-off state of the first analog-to-digital conversion module.

2. The acquisition device according to claim 1, characterized in that:

the current sensing module comprises a working electrode, a reference electrode and a counter electrode, wherein the reference electrode and the working electrode keep stable potential difference, and the counter electrode and the working electrode form a loop.

3. The acquisition device according to claim 1, characterized in that:

the low pass filter module has a fourth resistor coupled to the second output terminal and a first capacitor coupled to ground, and the low pass filter module has an output terminal coupled to the first analog-to-digital conversion module.

4. The acquisition device according to claim 1, characterized in that:

also included is a power module comprising a constant voltage chip having an input coupled to a third voltage module and an output coupled to the second voltage module, the first voltage module coupled to the constant voltage chip via a fifth resistor.

5. The acquisition device according to claim 1 or 4, characterized in that:

the first voltage module outputs a first constant voltage, and the second voltage module outputs a second constant voltage.

6. The acquisition device according to claim 4, characterized in that:

the first amplifier and the second amplifier are powered by the third voltage module.

7. The acquisition device according to claim 1, characterized in that:

the temperature sensing module comprises a thermistor.

8. The acquisition device according to claim 7, characterized in that:

the resistance value of the third resistor is equal to the nominal resistance value of the thermistor.

9. The acquisition device according to claim 1, characterized in that:

the first analog-to-digital conversion module has a reference voltage, the first analog-to-digital conversion module having a plurality of voltage ranges set based on the reference voltage.

10. The acquisition device according to claim 1, characterized in that:

the low-pass filtering module is a first-order low-pass filter.

11. The acquisition device according to claim 1, characterized in that:

the micro-processing unit module is also provided with a serial port communication unit for burning and calibrating the acquisition device and a Bluetooth communication unit for transmitting acquisition information.

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