CN211825812U - High-precision blood glucose detection device - Google Patents
High-precision blood glucose detection device Download PDFInfo
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- CN211825812U CN211825812U CN202020542027.4U CN202020542027U CN211825812U CN 211825812 U CN211825812 U CN 211825812U CN 202020542027 U CN202020542027 U CN 202020542027U CN 211825812 U CN211825812 U CN 211825812U
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Abstract
The invention provides a high-precision blood sugar detection device, which executes detection based on an electrochemical method and introduces a system error correction term and a temperature compensation mechanism, thereby overcoming the influence of system errors and temperature changes on a detection result to a certain extent. Specifically, the bridge with the positive and negative temperature coefficient thermistor sensors is adopted for temperature measurement, and the detection result is compensated according to the temperature value in the data processing process; meanwhile, based on a double-path input mode, two detection results can be obtained simultaneously by only collecting blood once, and random errors are eliminated and the detection precision is improved through weighted average of the two results. In addition, in the aspect of data processing, the invention introduces a two-way error overlarge feedback mechanism, and when the system deviation is overlarge, the calibration can be fed back in time. The invention effectively improves the detection precision, has higher temperature sensitivity, and has the technical advantages of convenient carrying, convenient use, low cost and the like.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a high-precision blood sugar detection device.
Background
Blood glucose detection is an important technical means for monitoring the state of an illness of a diabetic patient, so that a glucometer is very widely applied to daily life of the diabetic patient and hyperglycemia population. In terms of detection principle, the glucometers commonly found in the market at present are mainly divided into two categories, namely electrochemical method testing and light reflection technology testing. Wherein the electrochemical method is based on the reaction of enzyme and glucose to generate electricity, and the glucose concentration value is obtained through the magnitude of current; its advantages are low cost, easy influence from environmental factors, easy pollution to electrode, and high error rate.
According to the current national standards: when the blood glucose concentration detected by the blood glucose meter is less than or equal to 4.2nmol/L, the accuracy requirement allowable deviation is not more than +/-0.83 nmol/L; when the blood glucose meter detects that the blood glucose concentration is more than 4.2nmol/L, the accuracy requirement allows the deviation not to exceed +/-20%. At present, the testing precision of the household blood glucose meter is generally not high. On one hand, according to the existing standard, the household blood glucose meter has the condition of larger random error; on the other hand, the glucometer is greatly influenced by the environment, and particularly, the temperature has obvious influence on the blood sugar test result.
In order to reduce the detection error of the glucometer and improve the detection accuracy, researchers in the prior art have made many attempts. Among them, the chinese patent "a signal processing circuit, MCU and blood glucose meter" (publication No. CN210041762U) provides a signal processing circuit, a Micro Control Unit (MCU) and a blood glucose meter. Wherein, signal processing circuit is applied to blood glucose meter, includes: the operational amplifier closed-loop feedback circuit converts a current signal generated by the blood glucose test paper into an analog voltage signal; an analog-to-digital converter (ADC); a digital-to-analog converter (DAC); the ADC is used for converting an analog voltage signal output by the operational amplifier closed-loop feedback circuit into a digital voltage signal by using a first reference voltage and outputting the digital voltage signal to the DAC; the DAC is used for generating bias voltage by using the digital voltage signal output by the ADC and the first reference voltage and inputting the bias voltage to the non-inverting input end of the operational amplifier in the operational amplifier closed-loop feedback circuit. By adopting the technical scheme, the influence of low-frequency noise on the output signal can be reduced, the precision of the output signal is improved, and the precision of the detection result of the glucometer is further improved. However, the technical solution mainly adopts the object of processing to eliminate the influence of the reference voltage on the precision of the analog-to-digital converter, and does not consider the influence of the environmental temperature and the system random error on the blood glucose meter test.
Chinese patent "a blood glucose meter high accuracy measurement circuit" (publication No. CN205879765U) provides a blood glucose meter high accuracy measurement circuit, which includes: an optical measurement unit including a light emitting element and a light receiving element; a measuring device main body; wherein the measuring device main body part comprises an analog-to-digital converter which is connected with the optical measuring part and converts the analog signal detected by the optical measuring part into a digital signal; the control storage part is connected with the analog-to-digital converter, receives the digital signal and the state display signal and stores the digital signal and the state display signal in the storage part; a common mode integrator connected to the control storage unit and outputting a first reference value after integration after integrating the digital signal and/or the state display signal; the circuit can measure the blood sugar value signals with high precision through the common mode integrator and the counter circuit so as to obtain accurate numerical values. Although this technical scheme adopts the light reflex technical mode to carry out the measuring of blood sugar, compare with the electrochemistry mode of this patent, its structure is comparatively complicated, is unfavorable for the control of cost.
The chinese patent "a blood glucose meter with high precision temperature compensation" (publication No. CN202903801U) provides a blood glucose meter with high precision temperature compensation, which includes a temperature sensor, wherein the sensor is in contact with the position right below the test paper reflection area during measurement, so as to rapidly sense the temperature of the test paper reflection area. The temperature sensor comprises a thermistor, wherein heat-conducting epoxy resin is packaged on the surface of the thermistor, and the thermistor is arranged at the front end of the test paper slot. The utility model discloses to the drawback of current blood glucose meter, consider the test paper on structural design can with temperature sensor heat conduction contact, can reflect the temperature of test paper like this in real time, when measuring, insert the test paper after, the temperature of sensor meeting perception test paper, the volume of awaiting measuring is measured out after the test paper temperature, and the suggestion user drips the blood and measures. According to the technical scheme, the ordinary thermistor is used for detecting the temperature of the blood glucose test paper so as to reduce the influence of the temperature on the measurement result, however, the temperature sensitivity of the mode is low, and the feedback correction of system errors is lacked, so that the detection precision is still to be improved.
In summary, although some prior arts alleviate the problem of large error of the blood glucose meter to some extent, overall, the detection accuracy is still to be improved, the influence factors on the temperature are difficult to overcome, and the technical implementation manner is to be improved.
Disclosure of Invention
The invention aims to provide a high-precision blood glucose detection device aiming at the technical defects of the prior art, and aims to solve the technical problem that the detection precision of a conventional blood glucose meter needs to be improved in the prior art.
The invention also aims to solve the technical problem of how to reduce the influence of temperature factors on the detection result as much as possible.
The invention further solves the technical problem of how to fully consider the portability and the product cost of the glucometer while improving the detection precision.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
a high-precision blood sugar detection device comprises a temperature detection system, a two-way input system, a signal processing system and a control output system;
the temperature detection system comprises a positive temperature coefficient thermistor sensor, a negative temperature coefficient thermistor sensor, 2 high-precision resistors and a Hall sensor, wherein the positive temperature coefficient thermistor sensor, the negative temperature coefficient thermistor sensor and the 2 high-precision resistors form a bridge circuit, and the Hall sensor detects the current value of the bridge circuit;
the double-path input system comprises a blood sampling point, a path A bioelectrode, a path B bioelectrode and 2 Hall sensors, wherein the 2 Hall sensors respectively detect current values from the path A bioelectrode and the path B bioelectrode and transmit the current values to the signal processing system;
the signal processing system comprises an I-V conversion circuit, an operational amplifier, a negative feedback circuit and an AD converter, wherein the I-V circuit converts current into a voltage value, the operational amplifier amplifies small voltage, the negative feedback circuit stabilizes the circuit performance, and the AD converter converts an analog voltage value into a digital quantity and transmits the digital quantity to the control output system;
the control output system comprises a single chip microcomputer and a display screen, wherein the single chip microcomputer receives a detection value from the temperature detection system, a ROM in the single chip microcomputer checks a table to obtain a temperature value, and a temperature influence factor is adjusted according to the temperature value; the singlechip receives data from the two AD converters, and a blood sugar detection result is obtained after weighted average; the singlechip controls the display screen to display.
Preferably, the control output system further comprises a speaker module, and the single chip controls the speaker module to play.
Preferably, the mountain-climbing control system further comprises a system setting module, and the system setting module is used for setting the time of the blood glucose meter or retrieving and reading stored data.
Preferably, the test strip is contacted with a positive temperature coefficient thermistor sensor and a negative temperature coefficient thermistor sensor of the temperature detection system at the same time, and the temperature value obtained by looking up the table is the test strip surface temperature value.
Preferably, the singlechip is an STC89C51 singlechip.
Preferably, the display screen is an LCD12864 liquid crystal display screen.
Preferably, the single chip receives data from the two paths of AD converters, and when the absolute value of the difference value between the two paths of blood sugar values is smaller than the channel error constraint value, the blood sugar detection result is compensated according to the following formula:
P＝(A+B)/2+αT+ΔS
wherein, A is the blood sugar value of the channel A, B is the blood sugar value of the channel B, T is the temperature value, alpha is the temperature influence factor, and Delta S is the system error correction.
Preferably, the singlechip receives data from the two paths of AD converters, counts for 1 time when the absolute value of the difference value between the two paths of blood glucose values is larger than the channel error constraint value, and repeatedly acquires data of the bioelectrode in the path A and the bioelectrode in the path B; and when the counting times are more than 3, sending out a prompt and correcting the error.
Preferably, the blood sampling device further comprises a test strip, the test strip is simultaneously attached to the blood sampling point, the A-path bioelectrode and the B-path bioelectrode, and blood flows to the A-path bioelectrode and the B-path bioelectrode through the blood sampling point respectively.
Preferably, the portable electronic device further comprises a machine body, the display screen is fixedly connected to the front end of the machine body, and the machine body is further provided with a loudspeaker, a switch, a setting key, an increasing key and a decreasing key respectively.
The invention provides a high-precision blood sugar detection device, which executes detection based on an electrochemical method and introduces a random error elimination, a system error correction term and a temperature compensation mechanism, thereby overcoming the influence of random errors, system errors and temperature change on a detection result to a certain extent. Specifically, the bridge with the positive and negative temperature coefficient thermistor sensors is adopted for temperature measurement, and the detection result is compensated according to the temperature value in the data processing process; meanwhile, based on a double-path input mode, two detection results can be obtained simultaneously by only collecting blood once, and random errors are eliminated and the detection precision is improved through weighted average of the two results. In addition, in the aspect of data processing, the invention introduces a two-way error overlarge feedback mechanism, and when the system deviation is overlarge, the calibration can be fed back in time. The invention effectively improves the detection precision, has higher temperature sensitivity, and has the technical advantages of convenient carrying, convenient use, low cost and the like.
The invention is essentially different in terms of temperature measurement and current measurement techniques compared to the prior art exemplified in the background. The invention adopts the thermistor sensors with positive and negative temperature coefficients to form the bridge to improve the sensitivity of the system to temperature change, and can effectively eliminate the influence of temperature on the test result; the blood sugar is measured based on an electrochemical method, so that the price is low and the use and the carrying are convenient; the bridge formed by the thermistor sensors with positive and negative temperature coefficients has higher temperature sensitivity.
In summary, the present invention is directed to a high-precision blood glucose monitor, which solves the problem of large error in measuring blood glucose by most of the conventional blood glucose meters. The device has small volume and convenient use and operation. The beneficial effects are concentrated in the following aspects:
1. the temperature sensor bridge with positive and negative temperature coefficients is adopted to measure the temperature of the blood glucose test paper, so that the measurement precision is improved.
2. And a double-path input system is adopted, namely, two times of detection can be simultaneously carried out by only adopting one sample, and the weighted average of the results of the two times of detection is beneficial to eliminating random errors and improving the detection precision.
3. Temperature compensation and system error correction are introduced, and detection precision is further improved.
4. And a double-path error overlarge feedback mechanism is introduced, and when the system has overlarge deviation, the calibration is fed back in time.
Drawings
FIG. 1 is a circuit diagram of a temperature sensing system in accordance with the present invention;
FIG. 2 is a block diagram of a two-way input system of the present invention;
FIG. 3 is a connection diagram of the hardware system of the whole machine of the present invention;
FIG. 4 is a flow chart of the present invention processing of sensed data; wherein A is the blood sugar value of the channel A, B is the blood sugar value of the channel B, C is the counter value, T is the temperature value, P is the final output result, Delta S is the system error correction, alpha is the temperature influence factor, and is the channel error constraint;
FIG. 5 is an external configuration diagram of the present invention;
in the figure:
1. test strip 2, blood sampling point 3, A-way bioelectrode 4 and B-way bioelectrode
5. Body 6, liquid crystal screen 7, loudspeaker 8, switch and setting key
9. Add key 10, subtract key.
Detailed Description
Hereinafter, specific embodiments of the present invention will be described in detail. Well-known structures or functions may not be described in detail in the following embodiments in order to avoid unnecessarily obscuring the details. Approximating language, as used herein in the following examples, may be applied to identify quantitative representations that could permissibly vary in number without resulting in a change in the basic function. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
A high-precision blood sugar detection device comprises a temperature detection system, a two-way input system, a signal processing system and a control output system;
temperature detection system: the temperature detection system is mainly used for detecting the surface temperature of the test paper of the glucometer. The sensor consists of 2 thermistor sensors with different temperature coefficients, two high-precision resistors and a Hall sensor. The four resistors R1-R4 form a bridge in which the thermistor sensor R1 has a positive temperature coefficient and the thermistor sensor R3 has a negative temperature coefficient. R2 and R4 are high precision resistors. The hall sensor S1 is used to detect the magnitude of the current in the bridge. According to the current, the surface temperature value of the test paper is obtained, the temperature influence factor is corrected, and the detection precision is improved. The temperature measurement on the thermistor sensor adopting the positive and negative temperature coefficients is higher than the measurement precision of a single thermistor sensor. As shown in fig. 1.
A two-way input system: the two-way input system connects the blood collected by the blood collecting point to A, B two pairs of biosensing electrodes for signal processing respectively. S2 and S3 are A, B hall sensors with two inputs for current sensing, respectively. The currents detected at S2 and S3 are input to a signal processing system, respectively. The system can realize two-path detection and analysis by one-time blood sampling, and avoids the inconvenience of multiple blood sampling. As shown in fig. 2.
A signal processing system: the system is composed of an I-V conversion circuit, an operational amplifier, a negative feedback circuit and an AD converter. The I-V circuit is used to convert the current to a voltage value. The operational amplifier amplifies the small voltage, the negative feedback circuit is used for stabilizing the circuit performance, and the AD converter converts the analog voltage value into digital quantity for the singlechip to further process.
The control output system: the system consists of an STC89C51 single chip microcomputer, an LCD12864 liquid crystal display screen, a loudspeaker module and a system setting module. The STC89C51 singlechip obtains a temperature value through the table lookup of the ROM in the singlechip according to the detection value of the temperature detection system, and adjusts the temperature influence factor. In order to further improve the detection precision of the blood sugar, the blood sugar values obtained by the two AD converters are weighted and averaged to obtain the final blood sugar value. The singlechip controls the liquid crystal display to display and reminds a user of the blood sugar value through the loudspeaker module. The system setting module is mainly used for setting the time of the blood glucose meter or retrieving and reading stored data and the like.
The connection relationship of the hardware system of the whole blood glucose meter is shown in fig. 3, the data processing flow of the blood glucose meter is shown in fig. 4, and the external structure of the blood glucose meter is shown in fig. 5.
The working principle is as follows: the blood glucose meter is set through a power-on/setting button. The increase key and the decrease key can increase or decrease the numerical value and record for browsing. When the blood glucose test paper is put into the blood glucose meter, the blood glucose meter is automatically started. The temperature detection module detects the temperature, and the single chip microcomputer adjusts the temperature influence factor after acquiring the test paper temperature value. Blood is collected at the blood collection point. The blood flows to the A-way bioelectrode and the B-way bioelectrode in two ways. The signal processing module processes A, B two paths of signals, and the single chip microcomputer receives the two paths of signals and then judges whether errors of A, B two paths of blood sugar detection results exceed or not, if not, the two paths of signals are subjected to P ═ A + B)/2+ alpha T + delta S, wherein random errors can be eliminated by (A + B)/2, the alpha T can be subjected to temperature compensation, and the delta S is used for correcting system errors. The final detection value P is output and displayed on a liquid crystal screen, and the blood sugar value of the person to be detected is informed through a loudspeaker. When the errors of the A, B two-path blood sugar detection results exceed, the error counter C is judged, and if the errors reach 3 times, a prompt is sent out to correct the errors. The whole system adopts the electric bridge with positive and negative temperature coefficients to measure the temperature, so the measurement of the test paper temperature is more accurate. Secondly, the final blood sugar value is obtained by adopting two-way input weighting and averaging, and the random error of the system can be eliminated. The system error can be overcome by introducing a system error correction term, and the influence of temperature change on an output result can be overcome by introducing a temperature compensation mechanism. Meanwhile, the blood glucose meter can perform two times of detection (double-path input) on the blood glucose meter only by collecting blood once, so that the blood glucose meter has higher measurement precision.
The embodiments of the present invention have been described in detail, but the description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention. Any modification, equivalent replacement, and improvement made within the scope of the application of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A high-precision blood sugar detection device is characterized by comprising a temperature detection system, a two-way input system, a signal processing system and a control output system;
the temperature detection system comprises a positive temperature coefficient thermistor sensor, a negative temperature coefficient thermistor sensor, 2 high-precision resistors and a Hall sensor, wherein the positive temperature coefficient thermistor sensor, the negative temperature coefficient thermistor sensor and the 2 high-precision resistors form a bridge circuit, and the Hall sensor detects the current value of the bridge circuit;
the double-path input system comprises a blood sampling point, a path A bioelectrode, a path B bioelectrode and 2 Hall sensors, wherein the 2 Hall sensors respectively detect current values from the path A bioelectrode and the path B bioelectrode and transmit the current values to the signal processing system;
the signal processing system comprises an I-V conversion circuit, an operational amplifier, a negative feedback circuit and an AD converter, wherein the I-V circuit converts current into a voltage value, the operational amplifier amplifies small voltage, the negative feedback circuit stabilizes the circuit performance, and the AD converter converts an analog voltage value into a digital quantity and transmits the digital quantity to the control output system;
the control output system comprises a single chip microcomputer and a display screen, wherein the single chip microcomputer receives a detection value from the temperature detection system, a ROM in the single chip microcomputer checks a table to obtain a temperature value, and the temperature influence factor is adjusted according to the temperature value; the singlechip receives data from the two AD converters, and a blood sugar detection result is obtained after weighted average; the singlechip controls the display screen to display.
2. The apparatus of claim 1, wherein the control output system further comprises a speaker module, and the single-chip microcomputer controls the speaker module to play.
3. The apparatus of claim 1, wherein the control output system further comprises a system setting module for setting the time of the blood glucose meter or retrieving the stored data.
4. The high-precision blood sugar detection device of claim 1, further comprising a test strip, wherein the test strip is in contact with the positive temperature coefficient thermistor sensor and the negative temperature coefficient thermistor sensor of the temperature detection system at the same time, and the temperature value obtained by looking up the table is a test strip surface temperature value.
5. The high-precision blood sugar detection device according to claim 1, wherein the single chip microcomputer is an STC89C51 single chip microcomputer.
6. The high precision blood glucose test device of claim 1, wherein the display screen is an LCD12864 liquid crystal display.
7. The apparatus of claim 1, wherein the single-chip microcomputer receives data from the two AD converters, and when the absolute value of the difference between the two blood glucose values is smaller than the channel error constraint value, the single-chip microcomputer compensates the blood glucose detection result according to the following formula:
P＝(A+B)/2+αT+ΔS
wherein, A is the blood sugar value of the channel A, B is the blood sugar value of the channel B, T is the temperature value, alpha is the temperature influence factor, and Delta S is the system error correction.
8. The high-precision blood sugar detection device according to claim 1, wherein the single chip microcomputer receives data from the two paths of AD converters, counts for 1 time when the absolute value of the difference between the two paths of blood sugar values is greater than the channel error constraint value, and repeatedly collects data of the bioelectrode in the path A and the bioelectrode in the path B; and when the counting times are more than 3, sending out a prompt and correcting the error.
9. The high-precision blood glucose detection device of claim 1, further comprising a test strip, wherein the test strip is attached to the blood sampling point, the A-way bioelectrode and the B-way bioelectrode, and blood flows to the A-way bioelectrode and the B-way bioelectrode through the blood sampling point, respectively.
10. The high-precision blood sugar detection device according to claim 1, further comprising a body, wherein the display screen is connected to the front end of the body, and the body is further provided with a speaker, a switch, a setting key, an increasing key and a decreasing key.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202020542027.4U CN211825812U (en) | 2020-04-14 | 2020-04-14 | High-precision blood glucose detection device |
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| CN202020542027.4U CN211825812U (en) | 2020-04-14 | 2020-04-14 | High-precision blood glucose detection device |
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| CN211825812U true CN211825812U (en) | 2020-10-30 |
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| CN202020542027.4U Expired - Fee Related CN211825812U (en) | 2020-04-14 | 2020-04-14 | High-precision blood glucose detection device |
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- 2020-04-14 CN CN202020542027.4U patent/CN211825812U/en not_active Expired - Fee Related
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