CN218245370U

CN218245370U - Quick-freezing cabinet for adipose-derived mesenchymal stem cells

Info

Publication number: CN218245370U
Application number: CN202222624672.2U
Authority: CN
Inventors: 程远辉; 孙新伟
Original assignee: Shandong Xinbaili Biotechnology Co ltd
Current assignee: Shandong Xinbaili Biotechnology Co ltd
Priority date: 2022-10-07
Filing date: 2022-10-07
Publication date: 2023-01-10
Anticipated expiration: 2032-10-07

Abstract

The utility model discloses a fat mesenchymal stem cell quick-freeze cabinet, the intelligent cabinet temperature adjusting device comprises a cabinet body and a top cap, the top cap articulates the rear side border at cabinet body upper surface through the round pin axle, logical groove has been seted up to the lower part of cabinet body front side, it places the box to lead to sliding connection has upper end open-ended liquid nitrogen in the groove, the front side that the box was placed to the liquid nitrogen is fixed with the closing plate, the upper portion of internal wall of cabinet is fixed with the fixed plate, the upper surface array of fixed plate has been seted up and has been placed freezing pipe and place logical groove, freezing pipe places the outside on leading to the groove top and has been seted up the seal groove, movable joint has sealed lid in the seal groove, this fat mesenchymal stem cell quick-freeze cabinet, rational in infrastructure practicality, the operation is convenient for place fixedly and take out freezing pipe, can carry out quick effectual freezing to the fat mesenchymal stem cell of waiting to freeze in freezing pipe, and have good leakproofness, can effectively avoid air conditioning to reveal the influence that causes freezing, the nitrogen gas air circumstance influence that also can try to avoid simultaneously, and then cause the injury to the staff.

Description

Quick-freezing cabinet for adipose-derived mesenchymal stem cells

Technical Field

The utility model relates to a cell cryopreserving technical field specifically is a fat mesenchymal stem cell quick-freeze cabinet.

Background

Mesenchymal stem cells are pluripotent stem cells that have all of the commonalities of stem cells, namely self-renewal and multipotential differentiation capacity. The application is most in clinical application, and the combined application with hematopoietic stem cells can improve the success rate of transplantation and accelerate hematopoietic reconstruction. After a patient receives a large dose of chemotherapy, the mesenchymal stem cells and the hematopoietic stem cells are input together, so that the recovery time of the blood cells of the patient can be obviously accelerated, and the chemotherapy is safe and has no adverse reaction.

Publicly known, mesenchymal stem cells need to be stored in liquid nitrogen at low temperature, and Chinese patent with the publication number of CN216834921U and publication number of 2022.06.28 discloses a fat mesenchymal stem cell refrigerating box, which comprises a box body and a box door, wherein a longitudinal partition plate is fixed in the box body, and sliding grooves are fixed on the longitudinal partition plate and two sides of the inner wall of the box body; a plurality of transverse placing plates are further arranged in the box body to divide the box body into a plurality of layers; each layer is internally provided with a detachable air conditioning device, each air conditioning device (11) comprises an air inlet pipe and a pipeline grating, the air inlet pipe is communicated with the air inlet grating, the air inlet pipe and the pipeline grating are arranged, the air inlet pipe comprises a first air inlet pipe, a second air inlet pipe and a third air inlet pipe which are sequentially communicated, two ends of the second air inlet pipe are positioned in the first air inlet pipe and the third air inlet pipe and are in sliding connection with the two air inlet pipes, the air inlet grating comprises two longitudinal air inlet pipes and a plurality of transverse air inlet pipes, two ends of each transverse air inlet pipe are respectively connected with one longitudinal air inlet pipe, and each transverse air inlet pipe is provided with a plurality of air outlet holes; the adipose-derived mesenchymal stem cell refrigerator serving as a cell cryopreservation device still has the following defects:

at first, this fridge structure is more complicated, the operation is inconvenient, need frequent dismantlement and installation to air conditioning device, and, this fridge places through placing the board and freezes the deposit, be not convenient for place fixedly and take out freezing the deposit pipe, be not convenient for also freeze the intraductal fat mesenchymal stem cell that treats that freezes the deposit and the abundant contact of liquid nitrogen air conditioning, and then be not convenient for with its quick effectual freezing deposit, furthermore, this fridge is at every turn put and is got when opening, all can expose the box wholly outside, and then expose outside liquid nitrogen and the interior air conditioning of box in the liquid nitrogen standing groove, lack good leakproofness, the influence that can't avoid air conditioning to reveal and cause freezing, the influence of the nitrogen gas air environment also can't be avoided simultaneously, also cause the injury to the staff easily.

SUMMERY OF THE UTILITY MODEL

The to-be-solved technical problem of the utility model is to overcome current defect, provide a fat mesenchymal stem cell quick-freeze cabinet, be convenient for deposit the pipe to freezing and place fixedly and take out, can deposit intraductal fat mesenchymal stem cell of treating to freeze and deposit to freezing and carry out quick effectual freezing, have good leakproofness moreover, can effectively avoid air conditioning to reveal the influence that causes to freezing, can effectively solve the problem in the background art.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a fat mesenchymal stem cell quick-freeze cabinet, includes the cabinet body and top cap, the top cap articulates the back side edge at cabinet body upper surface through the round pin axle, logical groove has been seted up to the lower part of cabinet body front side, it places the box to lead to sliding connection has upper end open-ended liquid nitrogen, the front side that the box was placed to the liquid nitrogen is fixed with the closing plate, the upper portion of internal wall of cabinet is fixed with the fixed plate, the upper surface array of fixed plate has been seted up and has been freezed to deposit the pipe and place logical groove, it places the outside on logical groove top and has seted up the seal groove to freeze to deposit the pipe, activity joint has sealed lid in the seal groove, it places the both sides that lead to the groove bottom to freeze to deposit the pipe and is fixed with fixed frame, all is fixed with the guide arm between the top of two fixed frame inner walls and the bottom, is equipped with the lifting disk between two fixed frame, the both sides of lifting disk all are fixed with the slider, two guide arms correspond sliding connection with the slide opening on two slider upper surfaces respectively, be fixed with the bottom of fixed frame inner wall between the bottom of fixed frame wall and be fixed frame, the outside of guide arm, the upper surface of lifting disk has been seted up and has been frozen to deposit the pipe standing groove, the laminating of lifting disk, the upper surface of lifting disk, the laminating of lifting disk is located the bottom of freezing tube.

As a preferred technical scheme of the utility model, freeze and deposit the pipe and place the both sides on logical groove top and all set up threaded hole, two threaded hole equal threaded connection have a threaded rod, the top of threaded rod is equipped with the rotation depression bar, the outside of rotation depression bar bottom and the top fixed connection of threaded rod, the inboard of rotation depression bar bottom and the one side laminating of sealed upper surface of covering.

As an optimized technical proposal of the utility model, a handle is fixed at the middle part of the upper surface of the sealing cover.

As a preferred technical scheme of the utility model, the spout has all been seted up to the both sides that lead to the inslot wall, the equal share in both sides that the box was placed to the liquid nitrogen is fixed with the draw runner with spout sliding connection.

As a preferred technical scheme of the utility model, the annular seal groove has been seted up in the outside that leads to the groove front end, the rear side of closing plate is fixed with the annular seal strip with annular seal groove activity joint, the front side of closing plate is fixed with the handle.

As an optimized technical scheme of the utility model, the lower part of the internal wall of cabinet is fixed with and is located fixed frame and liquid nitrogen and places the partition otter board between the box.

Compared with the prior art, the beneficial effects of the utility model are that: this adipose mesenchymal stem cell quick-freeze cabinet, rational in infrastructure practicality, the simple operation is convenient for place fixedly and take out cryopreserved pipe, can carry out quick effectual cryopreserving to the adipose mesenchymal stem cell of the intraductal waiting cryopreserved of cryopreserved, has good leakproofness moreover, can effectively avoid air conditioning to reveal the influence to cryopreserving and cause, also can avoid nitrogen gas air environment's influence simultaneously as far as possible, and then causes the injury to the staff.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is the internal structure schematic diagram of the cabinet body of the utility model.

Fig. 3 is the structural schematic diagram of the liquid nitrogen placing box of the present invention.

Fig. 4 is a schematic view of the local structure of the present invention.

Fig. 5 is a partial side view of the present invention.

In the figure: the cabinet body 1, lead to groove 2, box 3 is placed to liquid nitrogen, closing plate 4, partition otter board 5, fixed plate 6, freeze and deposit the pipe and place logical groove 7, seal groove 8, fixed frame 9, guide arm 10, lifting disk 11, freeze and deposit pipe standing groove 12, slider 13, spring 14, threaded rod 15, rotation depression bar 16, handle 17, top cap 18, spout 19, draw runner 20, annular seal groove 21, annular sealing strip 22, sealed lid 23, screw hole 24.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-5, the present invention provides a technical solution: a fat mesenchymal stem cell quick-freezing cabinet comprises a cabinet body 1 and a top cover 18, wherein the top cover 18 is hinged on the rear side edge of the upper surface of the cabinet body 1 through a pin shaft, the lower part of the front side of the cabinet body 1 is provided with a through groove 2, the through groove 2 is connected with a liquid nitrogen placing box 3 with an upper end opened in a sliding manner, two sides of the inner wall of the through groove 2 are provided with sliding grooves 20, the two sides of the liquid nitrogen placing box 3 are respectively fixed with a sliding strip 20 in a sliding manner with the sliding grooves 19, the liquid nitrogen placing box 3 is convenient to pull out and push in through the sliding strips 20 in the sliding grooves 19, the front side of the liquid nitrogen placing box 3 is fixed with a sealing plate 4, the rear side of the sealing plate 4 is fixed with an annular sealing strip 22 movably clamped with the annular sealing plate 21, the sealing effect can be achieved through the sealing plate 4 and the annular sealing strip 22 on the sealing plate, cold air generated by placing of the liquid nitrogen placing is convenient to leak, the front side of the sealing plate 4 is fixed with a handle, the top end of the liquid nitrogen placing box 3 is convenient to push-pull and pull of the top end of a rotating through the sealing strip 15, the top end of the rotating through the sealing plate 15, the top end of the rotating through the sealing strip 16, the top end of the rotating groove 16 is convenient to be connected with the top end of the rotating groove 16 of the rotating groove of the rotating pressure bar storing box, the rotating pressure storing box, the top end of the top sealing plate 16, the rotary pressure rod 16 is unscrewed to drive the threaded rod 15 to rotate, the rotary pressure rod 16 is moved away from the upper surface of the sealing cover 23, the sealing cover 23 can be opened, a lifting handle 17 is fixed in the middle of the upper surface of the sealing cover 23, the sealing cover 23 is convenient to take and place through the lifting handle 17, the two sides of the bottom end of the freezing tube placing through groove 7 are fixed with the fixed frames 9, guide rods 10 are fixed between the top and the bottom of the inner wall of each fixed frame 9, a lifting disc 11 is arranged between the two fixed frames 9, sliding blocks 13 are fixed on the two sides of the lifting disc 11 respectively, the two guide rods 10 are respectively in sliding connection with sliding holes in the upper surfaces of the two sliding blocks 13, a spring 14 is fixed between the bottom of each sliding block 13 and the bottom of the inner wall of the fixed frame 9, the spring 14 is sleeved on the outer side of each guide rod 10, a freezing tube placing groove 12 is formed in the upper surface of the lifting disc 11, the bottom end of the freezing tube containing mesenchymal stem cells to be frozen is placed in the freezing tube placing groove 12, the sealing cover 23 is placed at the top of the freezing tube, the freezing tube is pressed downwards to drive the sliding to slide downwards, the spring 14 is driven to shrink downwards until the top of the freezing tube descends into the freezing tube placing through groove 7, the rotating pressure rod 16 is screwed down to enable the bottom of the rotating pressure rod 16 to be attached to the upper surface of the sealing cover 23, the placing, sealing and fixing of the freezing tube can be completed, at the moment, the cold air released by the liquid nitrogen in the liquid nitrogen placing box 3 can rapidly and effectively freeze adipose mesenchymal stem cells in the freezing tube, when the freezing tube needs to be taken out, the sealing cover 23 is opened through reverse operation, the spring 14 elastically extrudes the lifting disc 11 upwards to drive the freezing tube to pop up, the freezing tube is convenient to take out, the position, located outside the freezing tube placing groove 12, of the upper surface of the lifting disc 11 is attached to the outside of the bottom end of the freezing tube placing through groove 7, when freezing and depositing the pipe and take out, it is sealed to accomplish the bottom that places logical groove 7 to freezing and depositing the pipe simultaneously to go up and down dish 11, can avoid air conditioning to reveal the influence that causes to freezing and deposit, and the lower part of the internal wall of cabinet 1 is fixed with the partition otter board 5 that is located fixed frame 9 and liquid nitrogen and places between the box 3, can play the effect of separating the protection through separating otter board 5.

When in use: put into liquid nitrogen and place in the box 3, rotate depression bar 16 through unscrewing and drive threaded rod 15 and rotate, will rotate depression bar 16 and remove from the upper surface of sealed lid 23, will seal lid 23 and take out from seal groove 8 through handle 17, put into freezing the bottom of depositing the pipe that contains the adipose mesenchymal stem cell of waiting to freeze and deposit in freezing pipe standing groove 12, and place sealed lid 23 at the top of freezing the pipe, then press down freezing the pipe, fall to freezing the top of depositing the pipe and place logical groove 7 in, screw up rotation depression bar 16, make its bottom that rotates depression bar 16 and the upper surface laminating of sealed lid 23, accomplish the placing and sealed the fixing of freezing the pipe, at this moment, the air conditioning of placing the liquid nitrogen release in box 3 through the liquid nitrogen can carry out quick effectual freezing to fat mesenchymal stem cell in freezing the pipe, when needs take out freezing the pipe, as above reverse operation, open sealed lid 23, spring 14 upwards elasticity extrusion to lifting disk 11, drive freezing the pipe upwards, conveniently take out, simultaneously, take out after freezing the pipe, can influence the quick damage of freezing the environment of depositing the people who can also can cause the sealed environment to the sealed air that the freezing the bottom of depositing of freezing the pipe is placed, thereby avoid the cold to be carried out.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a quick-freeze cabinet of adipose mesenchymal stem cell, includes the cabinet body (1) and top cap (18), top cap (18) articulate the rear side border at the cabinet body (1) upper surface through the round pin axle, its characterized in that: the lower part of the front side of the cabinet body (1) is provided with a through groove (2), the through groove (2) is internally and slidably connected with a liquid nitrogen placing box (3) with an upper end opening, a sealing plate (4) is fixed on the front side of the liquid nitrogen placing box (3), a fixing plate (6) is fixed on the upper part of the inner wall of the cabinet body (1), the upper surface array of the fixing plate (6) is provided with a freezing storage pipe placing through groove (7), the outer side of the top end of the freezing storage pipe placing through groove (7) is provided with a sealing groove (8), a sealing cover (23) is movably clamped in the sealing groove (8), two sides of the bottom end of the freezing storage pipe placing through groove (7) are fixedly provided with a fixing frame (9), all be fixed with guide arm (10) between the top of two fixed frame (9) inner walls and the bottom, be equipped with between two fixed frame (9) lifting disk (11), the both sides of lifting disk (11) all are fixed with slider (13), and two guide arms (10) correspond sliding connection with the slide opening of two slider (13) upper surfaces respectively, be fixed with spring (14) between the bottom of slider (13) and the bottom of fixed frame (9) inner wall, the outside at guide arm (10) is established in spring (14) cover, freezing pipe standing groove (12) have been seted up to the upper surface of lifting disk (11), the position that the upper surface of lifting disk (11) is located freezing pipe standing groove (12) outside with freezing pipe places logical groove (12) and freezes 7) The outer side of the bottom end is jointed.

2. The adipose-derived mesenchymal stem cell quick-freezing cabinet according to claim 1, characterized in that: freezing deposit the pipe and place both sides on logical groove (7) top and all seted up threaded hole (24), equal threaded connection has threaded rod (15) in two threaded holes (24), the top of threaded rod (15) is equipped with rotation depression bar (16), the outside of rotation depression bar (16) bottom and the top fixed connection of threaded rod (15), the inboard of rotation depression bar (16) bottom is laminated with one side of sealed lid (23) upper surface.

3. The adipose-derived mesenchymal stem cell quick-freezing cabinet according to claim 2, characterized in that: a handle (17) is fixed in the middle of the upper surface of the sealing cover (23).

4. The adipose-derived mesenchymal stem cell quick-freezing cabinet according to claim 1, characterized in that: the liquid nitrogen storage box is characterized in that sliding grooves (19) are formed in two sides of the inner wall of the through groove (2), and sliding strips (20) which are connected with the sliding grooves (19) in a sliding mode are fixed to two sides of the liquid nitrogen storage box (3).

5. The adipose-derived mesenchymal stem cell quick-freezing cabinet according to claim 4, characterized in that: annular seal groove (21) have been seted up in the outside of leading to groove (2) front end, the rear side of closing plate (4) is fixed with annular seal strip (22) with annular seal groove (21) activity joint, the front side of closing plate (4) is fixed with the handle.

6. The adipose-derived mesenchymal stem cell quick-freezing cabinet according to claim 1, which is characterized in that: the lower part of the inner wall of the cabinet body (1) is fixed with a separation screen plate (5) positioned between the fixed frame (9) and the liquid nitrogen placing box (3).