CN218239932U

CN218239932U - Medicine composition content detection mechanism

Info

Publication number: CN218239932U
Application number: CN202222237151.1U
Authority: CN
Inventors: 任方龙; 索明; 特木热
Original assignee: Shanghai Lingwo Kangfei Medical Technology Co ltd
Current assignee: Shanghai Lingwo Kangfei Medical Technology Co ltd
Priority date: 2022-08-25
Filing date: 2022-08-25
Publication date: 2023-01-06
Anticipated expiration: 2032-08-25

Abstract

The utility model discloses a medicine detection device technical field, in particular to a medicine component content detection mechanism, which comprises a crushing and mixing mechanism, wherein a discharge port of the crushing and mixing mechanism is connected with a feed port of a concentration mechanism through a conduit, and a discharge port of the concentration mechanism is connected with a feed port of a detection mechanism through a conduit; smash mixing mechanism includes the compounding jar, the beneficial effects of the utility model are that: through arranging the crushing and mixing mechanism, the concentration mechanism and the detection mechanism which are sequentially arranged from top to bottom and have height difference, the medicine to be detected is crushed firstly, then concentrated and finally detected in the detection mechanism, intermediate materials do not need to be taken out in the whole process, and the steps are consecutive, so that the detection speed can be greatly increased; the proportion of reagent is facilitated, and through the arrangement of the filter screen and the microporous filter membrane, impurity removal can be effectively carried out, so that the detection accuracy can be improved.

Description

Medicine composition content detection mechanism

Technical Field

The utility model relates to a medicine detection device technical field specifically is a medicine composition content detection mechanism.

Background

Heavy metal refers to metal elements with atomic density of more than 5g/cm, about 45 kinds, such as copper, lead, zinc, manganese, iron, mercury, tungsten, aluminum, etc.; although heavy metals such as manganese, copper and zinc are trace elements required by life activities, most of heavy metals such as lead and mercury are not required by life activities, and all heavy metals are toxic to human bodies when exceeding a certain concentration; the medicine can be used for treating diseases, and if the medicine contains excessive heavy metal components, the medicine can affect human health.

In the prior art, the heavy metal content in the medicine components is detected by instruments such as an atomic fluorescence spectrometer, an atomic absorption spectrometer, an inductively coupled plasma mass spectrometer and the like, so that the defects of high price and inconvenient operation exist; and stir the bits of broken glass through the super little rubbing crusher earlier, then take out the material and put into the evaporimeter and evaporate, take out the material again and put into the atomic fluorescence, detect in atomic absorption spectrometer or the inductively coupled plasma mass spectrometer, because whole process need get the material many times and put into the material, lead to detecting speed slow.

SUMMERY OF THE UTILITY MODEL

In view of the problem that exists in the current medicine composition content detection mechanism, provided the utility model discloses.

Therefore, the utility model aims at providing a medicine composition content detection mechanism, through, the problem of having solved.

For solving the technical problem, according to the utility model discloses an aspect, the utility model provides a following technical scheme:

a medicine component content detection mechanism comprises a crushing and mixing mechanism, wherein a discharge port of the crushing and mixing mechanism is connected with a feed port of a concentration mechanism through a guide pipe, and a discharge port of the concentration mechanism is connected with a feed port of a detection mechanism through a guide pipe;

the crushing and mixing mechanism comprises a mixing tank, and the mixing tank is provided with a stirring rod and a filter screen.

As a medicine composition content detection mechanism's an optimal selection scheme, wherein: super little rubbing crusher and first reagent storehouse are installed to compounding jar top, the export of first reagent storehouse bottom passes through the first measuring pump of pipe connection, the discharge gate of super little rubbing crusher passes through pipe intercommunication compounding jar inner chamber.

As a medicine composition content detection mechanism's an optimal selection scheme, wherein: mixing tank top fixed mounting has servo motor, servo motor's output shaft fixed connection vertical axis, install through the bolt on the vertical axis the puddler, the equidistance is equipped with vertical puddler on the puddler.

As a preferred scheme of a medicine composition content detection mechanism, wherein: the blades are arranged on the stirring rod at equal distances, and the blades and the vertical stirring rod are mutually distributed in a staggered manner at equal distances.

As a medicine composition content detection mechanism's an optimal selection scheme, wherein: the material mixing tank is characterized in that a first discharge port is formed in the bottom end of the material mixing tank, a material mixing stop valve is fixedly mounted on the first discharge port, and a first discharge pipe is fixedly connected to the bottom end of the first discharge port.

As a medicine composition content detection mechanism's an optimal selection scheme, wherein: the concentrating mechanism comprises a rotary evaporator, a first discharge pipe of a feed inlet of the rotary evaporator is fixedly connected, a first valve is installed on the feed inlet, a second discharge pipe of a second discharge port of the rotary evaporator is fixedly connected with a second discharge pipe, a second valve is installed on the second discharge pipe, the second discharge pipe is far away from the feed inlet of a filter box fixedly connected with one end of the second discharge port, and at least two groups of microporous filter membranes are arranged in the filter box.

As a preferred scheme of a medicine composition content detection mechanism, wherein: the bottom end of the filter box is provided with a third discharge pipe, a third valve is fixedly mounted on the third discharge pipe, and the bottom end of the third discharge pipe is fixedly connected with a second reagent bin.

As a medicine composition content detection mechanism's an optimal selection scheme, wherein: detection mechanism includes liquid chromatograph, second reagent storehouse and third reagent storehouse, the feed inlet of liquid chromatograph passes through pipe connection second measuring pump, the second measuring pump passes through pipe connection second reagent storehouse, the discharge gate in third reagent storehouse passes through pipe connection liquid chromatograph's feed inlet.

As a preferred scheme of a medicine composition content detection mechanism, wherein: the stirring rod and the filter screen are all provided with three groups, three groups of stirring rod and three groups of filter screen are in staggered distribution from top to bottom in sequence.

As a medicine composition content detection mechanism's an optimal selection scheme, wherein: the utility model discloses a crushing and mixing mechanism, including the mixing tank, puddler and filter screen, smash mixing mechanism still includes scrapes the wall pole, it installs through the bolt to scrape the wall pole on the vertical axis, scrape wall pole outer wall sliding connection compounding jar inner wall.

Compared with the prior art:

1. through arranging the crushing and mixing mechanism, the concentration mechanism and the detection mechanism which are sequentially arranged from top to bottom and have height difference, the medicine to be detected is crushed firstly, then concentrated and finally detected in the detection mechanism, intermediate materials do not need to be taken out in the whole process, and the steps are consecutive, so that the detection speed can be greatly increased;

2. through setting up first measuring pump and second measuring pump, help the proportion ratio of reagent to through setting up filter screen and millipore filtration, can filter the edulcoration effectively, thereby can improve the accuracy that detects.

Drawings

Fig. 1 is a schematic structural diagram provided in embodiment 1 of the present invention;

fig. 2 is an enlarged cross-sectional view of the pulverizing and mixing mechanism provided in embodiment 1 of the present invention;

fig. 3 is a cross-sectional view of a filter box provided in embodiment 1 of the present invention;

fig. 4 is an enlarged cross-sectional view of the pulverizing and mixing mechanism provided in embodiment 2 of the present invention.

In the figure: the system comprises a grinding and mixing mechanism 1, a material mixing stop valve 10, a material mixing tank 11, a first reagent bin 12, a first metering pump 121, an ultrafine grinder 13, a servo motor 14, a vertical shaft 15, a stirring rod 16, a vertical stirring rod 161, a blade 162, a filter screen 17, a first discharge port 18, a first discharge pipe 19, a wall scraping rod 100, a concentration mechanism 2, a feed port 21, a first valve 211, a second discharge port 22, a second valve 221, a second discharge pipe 23, a filter box 24, a third discharge pipe 25, a third valve 251, a microporous filter membrane 26, a rotary evaporator 27, a detection mechanism 3, a second reagent bin 31, a second metering pump 311, a third reagent bin 32 and a liquid chromatograph 33.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention clearer, embodiments of the present invention will be described in further detail with reference to the accompanying drawings.

Example 1:

the utility model provides a medicine component content detection mechanism, please refer to fig. 1-3, comprising a crushing and mixing mechanism 1, wherein a discharge port of the crushing and mixing mechanism 1 is connected with a feed port of a concentration mechanism 2 through a conduit, and a discharge port of the concentration mechanism 2 is connected with a feed port of a detection mechanism 3 through a conduit;

the crushing and mixing mechanism 1 comprises a mixing tank 11, and the mixing tank 11 is provided with a stirring rod 16 and a filter screen 17.

Super little rubbing crusher 13 and first reagent storehouse 12 are installed on 11 tops of blendor, the first measuring pump 121 of pipe connection is passed through in the export of 12 bottoms in first reagent storehouse, the discharge gate of super little rubbing crusher 13 passes through pipe intercommunication blendor 11 inner chambers, 11 tops of blendor fixed mounting has servo motor 14, servo motor 14's output shaft fixed connection vertical axis 15, install puddler 16 through the bolt on the vertical axis 15, the equidistance is equipped with vertical puddler 161 on the puddler 16, blade 162 is installed to the equidistance on the puddler 16, blade 162 and vertical puddler 161 are to the equidistance staggered distribution each other, 11 bottoms in blendor are equipped with first discharge gate 18, fixed mounting has compounding stop valve 10 on first discharge gate 18, first discharge pipe 18 bottom fixed connection first discharge pipe 19, puddler 16 and filter screen 17 all are equipped with three groups, three groups of puddler 16 and three groups of filter screen 17 are from the top to bottom staggered distribution in proper order.

The concentration mechanism 2 comprises a rotary evaporator 27, a feed inlet 21 of the rotary evaporator 27 is fixedly connected with a first discharge pipe 19, a first valve 211 is installed on the feed inlet 21, a second discharge port 22 of the rotary evaporator 27 is fixedly connected with a second discharge pipe 23, a second valve 221 is installed on the second discharge pipe 23, one end, far away from the second discharge port 22, of the second discharge pipe 23 is fixedly connected with a feed inlet of a filter box 24, at least two groups of microporous filter membranes 26 are arranged in the filter box 24, a third discharge pipe 25 is arranged at the bottom end of the filter box 24, a third valve 251 is fixedly installed on the third discharge pipe 25, and the bottom end of the third discharge pipe 25 is fixedly connected with a second reagent bin 31.

The detection mechanism 3 comprises a liquid chromatograph 33, a second reagent bin 31 and a third reagent bin 32, a feed inlet of the liquid chromatograph 33 is connected with a second metering pump 311 through a conduit, the second metering pump 311 is connected with the second reagent bin 31 through a conduit, and a discharge outlet of the third reagent bin 32 is connected with a feed inlet of the liquid chromatograph 33 through a conduit.

When the reagent feeding device is used specifically, a set amount of medicine to be detected falls into the material mixing tank 11 after being crushed by the ultrafine crusher 13, ionized water, citric acid and disodium ethylene diamine tetraacetate are added into the two first reagent bins 12, the ionized water, the citric acid and the disodium ethylene diamine tetraacetate are respectively added into the material mixing tank 11 according to a set amount, the servo motor 14 is started to drive the vertical shaft 15 to rotate, the medicine is crushed and uniformly stirred by the vertical stirring rod 161 and the blades 162, and the medicine is filtered by the three groups of filter screens 17 to form a mixed solution; opening the material mixing stop valve 10 and the first valve 211, and enabling the mixed solution to flow into the rotary evaporator 1 to be concentrated into concentrated solution; and opening the second valve 221, enabling the concentrated solution to enter the filter box 24, filtering the concentrated solution through the microporous filter membrane 26 to obtain a solution to be detected, opening the third valve 251 to enable the solution to be detected to enter the second reagent bin 31 on the left side, adding deionized water into the third reagent bin 32, metering the deionized water through a metering pump, injecting the deionized water into the liquid chromatograph 2 for detection, and determining the content of heavy metals in the medicine components.

Example 2:

referring to fig. 4, the difference from embodiment 1 is: puddler 16 and filter screen 17 all are equipped with one, smash mixing mechanism 1 and still include and scrape wall pole 100, scrape wall pole 100 and pass through the bolt and install on vertical axis 15, scrape wall pole 100 outer wall sliding connection compounding jar 11 inner wall.

When the device is used specifically, a set amount of medicine to be detected falls into the mixing tank 11 after being crushed by the ultrafine crusher 13, ionized water, citric acid and disodium ethylene diamine tetraacetate are added into the two first reagent bins 12, the ionized water, the citric acid and the disodium ethylene diamine tetraacetate are respectively added into the mixing tank 11 according to a set amount, the servo motor 14 is started to drive the vertical shaft 15 to rotate, the vertical stirring rod 161 and the blade 162 are used for crushing and uniformly stirring, the rotating wall scraping rod 100 scrapes the inner wall of the mixing tank 11 simultaneously, and materials attached to the inner wall of the mixing tank 11 are scraped off, so that a detection structure is more real and accurate, and the materials are filtered by the filter screen 17 to form a mixed solution; opening the material mixing stop valve 10 and the first valve 211, and enabling the mixed solution to flow into the rotary evaporator 1 to be concentrated into concentrated solution; and opening the second valve 221, enabling the concentrated solution to enter the filter box 24, filtering the concentrated solution through the microporous filter membrane 26 to obtain a solution to be detected, opening the third valve 251 to enable the solution to be detected to enter the second reagent bin 31 on the left side, adding deionized water into the third reagent bin 32, metering the solution by using a metering pump, injecting the solution into the liquid chromatograph 2 for detection, and determining the content of heavy metals in the medicine components.

While the invention has been described above with reference to an embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, as long as there is no structural conflict, the various features of the disclosed embodiments of the present invention can be used in any combination with each other, and the non-exhaustive description of these combinations in this specification is merely for the sake of brevity and resource conservation. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims

1. The utility model provides a medicine composition content detection mechanism, is including smashing mixing mechanism (1), its characterized in that: the discharge port of the crushing and mixing mechanism (1) is connected with the feed port of the concentration mechanism (2) through a conduit, and the discharge port of the concentration mechanism (2) is connected with the feed port of the detection mechanism (3) through a conduit;

the crushing and mixing mechanism (1) comprises a mixing tank (11), wherein the mixing tank (11) is provided with a stirring rod (16) and a filter screen (17).

2. The mechanism for detecting the content of a drug ingredient according to claim 1, wherein the top of the mixing tank (11) is provided with a superfine pulverizer (13) and a first reagent bin (12), an outlet at the bottom of the first reagent bin (12) is connected with a first metering pump (121) through a conduit, a discharge port of the superfine pulverizer (13) is communicated with an inner cavity of the mixing tank (11) through a conduit, and a discharge port of the superfine pulverizer (13) is communicated with an inner cavity of the mixing tank (11) through a conduit.

3. The mechanism for detecting the content of the pharmaceutical ingredients according to claim 2, wherein a servo motor (14) is fixedly installed at the top end of the mixing tank (11), an output shaft of the servo motor (14) is fixedly connected with a vertical shaft (15), the stirring rod (16) is installed on the vertical shaft (15) through a bolt, and vertical stirring rods (161) are equidistantly arranged on the stirring rod (16).

4. A drug component content detecting mechanism according to claim 3, wherein the stirring rod (16) is provided with blades (162) at equal distances, and the blades (162) and the vertical stirring rods (161) are staggered at equal distances from each other.

5. The mechanism for detecting the content of the drug ingredients in the drug according to any one of claims 1 to 4, wherein a first discharge hole (18) is formed at the bottom end of the mixing tank (11), and a first discharge pipe (19) is fixedly connected to the bottom end of the first discharge hole (18).

6. The medicine component content detecting mechanism according to claim 5, wherein the concentration mechanism (2) comprises a rotary evaporator (27), a feeding port (21) of the rotary evaporator (27) is fixedly connected with a first discharging pipe (19), a second discharging pipe (22) of the rotary evaporator (27) is fixedly connected with a second discharging pipe (23), one end of the second discharging pipe (23) far away from the second discharging port (22) is fixedly connected with a feeding port of a filter box (24), and at least two groups of microporous filter membranes (26) are arranged in the filter box (24).

7. The medicine component content detecting mechanism according to claim 6, wherein a third discharging pipe (25) is provided at a bottom end of the filter box (24), and a second reagent chamber (31) is fixedly connected to a bottom end of the third discharging pipe (25).

8. The drug component content detection mechanism according to claim 1, wherein the detection mechanism (3) comprises a liquid chromatograph (33), a second reagent chamber (31) and a third reagent chamber (32), the inlet of the liquid chromatograph (33) is connected with a second metering pump (311) through a conduit, the second metering pump (311) is connected with the second reagent chamber (31) through a conduit, and the outlet of the third reagent chamber (32) is connected with the inlet of the liquid chromatograph (33) through a conduit.

9. The mechanism for detecting the content of the medicine components according to claim 1, wherein three groups of stirring rods (16) and three groups of filtering nets (17) are arranged, and the three groups of stirring rods (16) and the three groups of filtering nets (17) are distributed in a staggered manner from top to bottom in sequence.

10. A mechanism for detecting the content of a drug substance according to claim 3, wherein one of the stirring rod (16) and the filtering net (17) is provided, the pulverizing and mixing mechanism (1) further comprises a wall scraping rod (100), the wall scraping rod (100) is mounted on the vertical shaft (15) through a bolt, and the outer wall of the wall scraping rod (100) is slidably connected with the inner wall of the mixing tank (11).