CN218213030U - Intelligent medical detection device for combined detection of bladder cancer and multiple diseases - Google Patents

Abstract

The utility model discloses an intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect includes host system, micro-fluidic biochip, inside reagent injection module, rotatory mixing module, magnetism is inhaled and is filtered control module and signal detection module, be provided with a plurality of rubber bag wares on the micro-fluidic biochip, the inside reagent injection module of host system control punctures the rubber bag ware according to predetermined order so that the reagent in the rubber bag ware flows in the reaction cell, the objective table of the fixed micro-fluidic biochip of rotatory mixing module control is rotatory so that different reagent misce bene and fully react with the blood sample, magnetism is inhaled and is filtered the magnetism nanoparticle that is equipped with specific marker in the solution after the control module separation reaction, signal detection module detects in order to obtain the testing result to the solution that has the magnetism nanoparticle after the separation. The utility model discloses combine high sensitivity reagent component and micro-fluidic biochip technique, can realize quick, accurate, low-cost, intelligent detection.

Description

Intelligent medical detection device for combined detection of bladder cancer and multiple diseases

Technical Field

The utility model relates to a medical science detects technical field, especially relates to an intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect.

Background

Bladder cancer is one of the most common tumors of the urinary system, and is the first malignant tumor of the urinary system. In recent years, with the acceleration of the industrial process of China and the change of the life rhythm and the eating habit of people, the incidence rate of bladder cancer of China is increased year by year, which makes people realize the importance of early diagnosis of bladder cancer. Bladder cancer, one of the high-grade neoplasms of the urinary system, has a misdiagnosis rate of 27% to 62% due to lack of specificity of clinical manifestations. In addition, fever, cough and the like are common symptoms which are easy to occur in ordinary life and are caused by cold, mycoplasma pneumoniae infection and the like, but doctors are very difficult to accurately judge and screen the symptoms, and the phenomenon of mutual cross infection among different individuals occurs. The symptoms cause a plurality of uncomfortable states such as dizziness, brain distension, nasal obstruction, hypodynamia, intolerance of cold and the like, and cause serious uncomfortable symptoms such as high fever, severe cold, mycoplasma pneumonia and the like which need hospitalization, and even need ICU rescue.

Therefore, the method has important significance for quickly and accurately detecting and analyzing the mycoplasma pneumoniae caused by bladder cancer, rickets, colds, coughs and other symptoms at low cost, realizing early screening and diagnosis of the diseases and realizing intelligent early accurate detection of the diseases.

The current methods for diagnosing the above-mentioned disorders/diseases are basically done individually by the doctor, one by one. At present, pathological examination is mainly carried out by methods of examining blood routine, urine routine, C reactive protein, strengthening CT tumor marker detection, B ultrasonic, cystoscope, bronchofiberscope examination and the like one by one, the procedures are complicated, a plurality of times of frequent detection are carried out, the cost is high, the process is complicated, diseases/diseases are a dynamically changing process, valuable treatment time is easily missed, or cross repeated infection is caused, so that the early detection result cannot be used for subsequent treatment, bladder cancer cannot be detected at the first time, and the optimal treatment time is delayed. In addition, in the conventional blood testing method by blood drawing, about 5mL of whole blood is usually needed, the detection time is long, blood is usually collected in the morning, the result can be obtained in the afternoon, the rapid detection and diagnosis are difficult to realize, methods such as enhanced CT tumor marker inspection and the like are influenced by electromagnetic radiation, a certain damage is caused to health by multiple detections, B ultrasonic can be displayed only when the diameter of a focus tissue is larger than 0.5cm, the detection time of the methods is difficult to achieve rapid, timely and accurate detection, secondary confirmation still needs to be carried out by a cystoscope in the follow-up process, the detection time is long, and the detection cost is relatively high.

Therefore, there is a need for a device that can be used for rapid, inexpensive, accurate, large-scale, multi-sample batch testing, and for intelligent medical rapid testing of a variety of different pathologies (bladder cancer, mycoplasma pneumoniae, rickets with bone density, etc.).

SUMMERY OF THE UTILITY MODEL

The utility model discloses a main aim at to prior art's defect, provide one kind to above-mentioned disease/disease carry on respectively/synchronous minimal access collection, low cost, high accuracy, short-term test be used for bladder cancer and many diseases to jointly detect intelligent medical detection device.

In order to realize the above-mentioned purpose, the utility model provides an intelligent medical detection device for bladder cancer and many diseases jointly detect, including host system, micro-fluidic biochip, inside reagent injection module, rotatory mixing module, magnetism inhale filtration control module and signal detection module, be provided with a plurality of rubber bag wares on the micro-fluidic biochip, host system is used for control inside reagent injection module punctures according to predetermined order the rubber bag ware is so that reagent in the rubber bag ware flows into the reaction tank, rotatory mixing module is used for control to fix the objective table of micro-fluidic biochip is rotatory so that different reagent misce bene and fully react with blood sample, magnetism inhale the magnetism nanoparticle that is equipped with specific marker in the solution after filtration control module is used for the separation reaction, signal detection module is used for detecting the solution that has the magnetism nanoparticle after the separation in order to obtain the testing result.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, still including connect in host system with micro-fluidic biochip's outside reagent injection module is used for puncture the rubber bag ware that is equipped with outside reagent under host system's the control to pour into the outside reagent into the reaction tank.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, signal detection module includes weak signal detecting element, connect in weak signal detecting element with host system's conversion amplifying unit, connect in conversion amplifying unit with host system's the unit that steps up, weak signal detecting element is arranged in converting the light signal of the different wavelength in the solution into the signal of telecommunication, conversion amplifying unit be used for with the signal of telecommunication through voltage conversion and amplify the operation after send to host system, the unit that steps up is used for stepping up the low voltage power supply and is handled and obtain suitablely weak signal detecting element's high pressure.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, still including connect in host system's photomultiplier probe control module that stretches out and draws back is used for control under host system's the control weak signal detecting element aims at the detection window.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, still include battery and power management and the module of charging, power management and the module of charging are right through general Type-C interface the battery charges, still is used for converting battery voltage into system's mains voltage and peripheral equipment voltage system mains voltage and peripheral equipment voltage.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, still include with touch display control screen and the button module that host system connects, touch display control screen is used for the input to be surveyed user's information and shows the weak fluorescence information of being surveyed user's blood sample, the button module is used for the switch-on or cuts off power management and the input voltage and the switching on and shutting down function and the switching on and shutting down LED of the module of charging instruct.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, still including connecting in host system's data storage module and wireless communication module, wireless communication module is used for detecting data transmission to backend server, data storage module is used for wireless communication module can't connect during the backend server, the storage detect data.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, still include with the constant temperature module that host system connects is used for right through infrared mode micro-fluidic biochip heats and stabilizes the temperature at preset temperature.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, still include with the waste liquid discharge control module that host system connects, waste liquid discharge control module includes the magnetic path and sets up the rubber portion on the magnetic path surface, rubber portion seals the contact with the waste liquid discharge that sets up on the waste liquid collecting pit or waste liquid collecting pit side, realizes through waste liquid discharge control module that magnetism inhales the waste liquid after the filtration control module separation whether discharge to prevent the anti-backflow waste liquid collecting pit.

The utility model provides an among the intelligent medical detection device that is used for bladder cancer and many diseases to jointly detect, magnetism is inhaled filtration control module and is included iron core, the coil of winding on the iron core.

The utility model provides an intelligent medical detection device and system for bladder cancer and many diseases jointly detect has following beneficial effect: the utility model provides an intelligent medical detection device for bladder cancer and multi-disease joint detection, which adopts an internal reagent injection module to orderly puncture a rubber sac device arranged on a microfluidic biochip, so that a reagent put in the rubber sac device flows into a reaction tank under the action of gravity; the rotating and mixing module controls the objective table to accelerate, decelerate or move at a constant speed step by step, so that different reagents are mixed, meanwhile, the different reagents in different rubber bag devices can flow into the reaction tank step by step under the action of the same internal reagent injection module, and the reaction of a plurality of reagents before and after and the selective separation of target molecules and the selective flow of waste liquid into the waste liquid collecting tank under the action of the waste liquid discharge control module can be realized under the action of the magnetic suction and filtration control module with the coil and the iron core; therefore, the detection of different diseases (bladder cancer, mycoplasma pneumoniae, rickets and the like) is realized in the detector by changing the reagent components in the rubber capsule in the microfluidic biochip; moreover, the diagnosis is not needed to be made one by a doctor, the diseases are not needed to be diagnosed one by one, and the frequent detection is avoided for many times, so the cost is low, the repeated detection is not easy to cause, the optimal treatment time is not easy to delay, and the early screening of various diseases such as bladder cancer, mycoplasma pneumoniae, rickets with bone density and the like can be diagnosed quickly, accurately and at low cost.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts:

fig. 1 is a schematic diagram of an intelligent medical detection device for combined detection of bladder cancer and multiple diseases according to an embodiment of the present invention;

fig. 2 is a schematic structural diagram of an intelligent medical detection device for bladder cancer and multi-disease joint detection according to an embodiment of the present invention.

Detailed Description

In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the accompanying drawings. Exemplary embodiments of the present invention are shown in the drawings. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

The conventional bladder cancer screening method mainly comprises a B-ultrasonic-assisted cystoscope method or a CT-assisted cystoscope method for definite diagnosis, as B-ultrasonic and CT have long operation flows, non-POCT detection is carried out, the price is high, the bladder cancer focus tissue below 0.5cm is difficult to detect, only when the focus tissue reaches a certain size degree, primary judgment can be carried out through B-ultrasonic or CT, then secondary confirmation is carried out through a cystoscope on the basis of primary diagnosis of the focus tissue, whether a patient suffers from bladder cancer can be judged, the whole detection flow is long, the detection cost of the patient is high, multiple departments are required for detection, the detection time generally exceeds 7 days, and early accurate and rapid detection on the bladder cancer cannot be carried out. In addition to the above-mentioned methods for diagnosing bladder cancer, there is no method for clinically significant diagnosis of bladder cancer, i.e., the existing methods have the problems of difficulty in early diagnosis, high cost, low accuracy, inability of quantitative detection, etc. Therefore, aiming at the problems, if blood can be taken through fingertips, accurate quantitative detection of bladder cancer by minimally invasive trace can be greatly helpful for accurate medication of doctors and treatment of patients. For this reason, for solving above problem, the utility model discloses a low-power consumption power management technique, touch control display technology, weak signal detection and intelligent photoelectric detection technique, multisensor gathers and step-by-step accurate control technique, internet of things, remote communication, micro-fluidic biochip technique, techniques such as magnetic nanometer control to utilize micro-fluidic biochip's advantage, combine the characteristics that diseases such as bladder cancer, rickets, pneumonia mycoplasma arouse, propose an intelligent medical detection device and system that is used for above-mentioned disease quick, accurate, low cost, intellectuality, digital management.

In order to better understand the technical solutions, the technical solutions will be described in detail below with reference to the drawings and the specific embodiments of the specification, and it should be understood that the specific features in the embodiments and examples of the present invention are detailed descriptions of the technical solutions of the present application, but not limitations of the technical solutions of the present application, and the technical features in the embodiments and examples of the present invention can be combined with each other without conflict.

Fig. 1 shows the schematic diagram of the intelligent medical detection device for bladder cancer and multi-disease joint detection provided by an embodiment of the present invention, and fig. 2 shows the structure schematic diagram of the intelligent medical detection device for bladder cancer and multi-disease joint detection provided by an embodiment of the present invention. Referring to fig. 1 and 2, the intelligent medical detection device for bladder cancer and multi-disease joint detection comprises a main control module 1, a microfluidic biochip 2, an internal reagent injection module 3, a rotary blending module 4, a magnetic absorption and filtration control module 5, a signal detection module 6, an external reagent injection module 7, a PMT (photomultiplier tube) probe stretching control module 8, a power management and charging module 9, a battery 10, a key module 11, a touch control display screen 12, a data storage module 13, a wireless communication module 14 and a constant temperature module 15.

Specifically, in an embodiment of the present invention, the microfluidic biochip 2 includes a blood filling hole, a detection window, and a plurality of mounting grooves for accommodating the rubber capsule device. The blood sample is dripped into the microfluidic biochip through the blood filling hole and then flows into the reaction tank. A plurality of rubber bag devices are arranged in the mounting groove, and different reagents for detecting different diseases are arranged in each rubber bag device. After the bottom of the rubber capsule device is punctured, a reagent put in the rubber capsule device flows into the reaction tank under the action of gravity through the um-level micro conduit. The prior art and the method mostly detect single diseases and are difficult to carry out combined rapid detection on a plurality of diseases, namely, a plurality of diseases and diseases are difficult to detect simultaneously, and the application can change the reagent components in the rubber capsule device in the microfluidic biochip, thereby realizing the detection on different diseases (bladder cancer, mycoplasma pneumoniae, rickets and the like) in the detector; and no one-by-one order is required by doctors, no one-by-one definite diagnosis and examination of diseases are required, and multiple frequent detections are avoided, so the cost is low, repeated detections are not easy to cause, the optimal treatment time is not easy to delay, and the early screening of various diseases such as bladder cancer, mycoplasma pneumoniae, rickets with bone density and the like can be quickly, accurately and cheaply diagnosed.

Specifically, in the utility model discloses an in the embodiment, under main control module's control, inside reagent injection module 3 can control the order that different reagents injected into the reaction tank, punctures the bottom of different rubber bag wares promptly according to the bottom butt joint back of predetermined order and different rubber bag wares to under the effect of same inside reagent injection module, realize in the different rubber bag wares that the substep of different reagents flows in the reaction tank in proper order. The internal reagents are injected into the reaction tank in order, so that the mutual pollution of various reagents can be avoided, and the accuracy of a detection result can be ensured. The internal reagent is a common reagent for detecting a certain disease or a general reagent for detecting several diseases according to the experience summarized in the actual operation process, and the internal reagent is placed in a rubber capsule device of the microfluidic biochip in advance, so that the operation process can be simplified, the detection efficiency can be improved, and the misoperation can be reduced.

Specifically, in an embodiment of the present invention, the external reagent injection module 7 is configured to puncture the rubber capsule device filled with the external reagent under the control of the main control module, so as to inject the external reagent into the reaction tank, i.e., puncture the bottom of the rubber capsule device after docking with the bottom of the rubber capsule device filled with the external reagent under the control of the main control module. Wherein, the external reagent refers to a special reagent which needs to be added according to special conditions. The method of puncturing the rubber capsule device by the pinhole and injecting the external reagent can realize the injection of a certain external special reagent, thereby prolonging the preservation time of different reagents in the microfluidic biochip, prolonging the validity period of the microfluidic biochip, and greatly saving the instrument cost by sharing the same injection system.

Specifically, in an embodiment of the present invention, the rotating and mixing module 4 is used to control and fix the stage of the microfluidic biochip to rotate so as to mix different reagents uniformly and fully react with the blood sample. Furthermore, the rotating and uniformly mixing module is a stepping motor arranged on the objective table, and the PWM wave generated by the main control module controls the stepping motor to do uniform speed, acceleration or deceleration movement, so that different reagents flowing into the reaction tank are fully mixed, the reaction time is shortened, and the detection time is shortened. Through mutually supporting with inside reagent injection module for inside reagent injection module docks with the bottom of different rubber capsules ware according to predetermined order, thereby makes different reagents inject the reaction tank in order, realizes the orderly injection and the orderly reaction of different kinds of reagents in the rubber capsules ware. Through mutually supporting with external reagent injection module for external reagent injection module docks with the bottom of the rubber bag ware that corresponds, realizes external reagent's accurate injection.

Specifically, in an embodiment of the present invention, the magnetic absorption and filtration control module 5 is used for separating magnetic nanoparticles containing specific markers in the reacted solution, leaving the specific markers, and allowing irrelevant waste liquid to flow out to the anti-reverse flow waste liquid collecting tank. Further, magnetism is inhaled and is filtered control module and is included the iron core, the coil of winding on the iron core, and the electric current size that flows into the coil through main control module control carries out accurate the controlling to the magnetism nanometer particle in the solution after the separation, can realize that magnetism nanometer particle is according to the accurate motion of specified direction to make specific particle realize the separation. The movement of the micro-nano particles can be accurately controlled, so that the detection accuracy can be greatly improved, the nano-scale full mixing is realized, the reaction time is shortened, the chemical reaction speed is accelerated, and the aim of rapid detection is fulfilled. Further, be provided with a waste liquid discharge and seal bottom, above-mentioned or the side in the waste liquid collecting pit, realize through the control that waste liquid discharge seals this waste liquid whether the waste liquid flows into the anti-backflow waste liquid collecting pit, this waste liquid discharge seal whether sealed receive with the waste liquid discharge control module control that main control module is connected. The waste liquid discharge control module comprises a magnetic block and a rubber part arranged on the surface of the magnetic block, and the rubber part is in contact with a waste liquid discharge seal arranged on the waste liquid collecting pool or on the side face of the waste liquid collecting pool. The main control module controls the on-off of the current in the magnetic block, so that a rubber part of the waste liquid discharge control module can be used for blocking a waste liquid discharge seal on the waste liquid collecting pool or on the side surface of the waste liquid collecting pool, and therefore waste liquid in the waste liquid collecting pool is prevented from flowing into the waste liquid collecting pool; when the solution in the reaction tank needs to flow into the waste liquid collecting tank, the main control module controls the waste liquid discharge control module to enable the waste liquid discharge seal on the waste liquid collecting tank or on the side surface to be separated from the rubber part of the waste liquid discharge control module so that the waste liquid flows into the waste liquid collecting tank.

Specifically, in an embodiment of the present invention, the signal detection module 6 is used to detect the separated solution with magnetic nanoparticles to obtain a detection result. The signal detection module is mainly realized through a photomultiplier tube, converts light signals with different wavelengths such as weak fluorescence and the like into current signals, then carries out current-voltage conversion and operational amplification pretreatment, and then sends the current signals to an ADC (analog-to-digital converter) in the main control module for analog-to-digital acquisition, so that weak multi-band fluorescence photon multiplication detection is realized, and high-sensitivity pathological detection is realized. The signal detection module includes:

a weak signal detection unit 61 for converting optical signals of different wavelengths in a solution into electrical signals, and detecting photon signals emitted from a self-luminescent substance in a process of returning from an excited state to a ground state under a specific condition to generate the electrical signals, wherein in the present application, a multi-pin multi-stage amplification PMT photomultiplier 978 or 931A manufactured by Hamamatsu corporation of japan is used as a weak signal detection unit to realize detection of weak fluorescent signals of different wavelengths;

the conversion and amplification unit 62 is used for transmitting the electric signal to the main control module after voltage conversion and amplification operation, performing voltage conversion on a weak fluorescent current signal (anode photocurrent signal) received by the PMT photomultiplier, and then performing voltage amplification and pretreatment through multi-pole operational amplification to finally realize the output of a 0-3.3V voltage signal;

the boosting unit 63 is used for boosting the low-voltage power supply to obtain a high voltage suitable for the weak signal detection unit, amplifying the 12V direct-current voltage, and controlling the internal DAC to output a 0-3.3V voltage signal through the main control module, so as to control the boosting unit to output a high-voltage direct-current voltage (400-1500V) for the high voltage required by the weak signal detection unit (photomultiplier), wherein the 12V direct-current voltage is obtained by performing DC-DC conversion on the battery voltage mainly through the power management and charging module.

Specifically, in an embodiment of the present invention, the PMT probe telescoping control module 8 is configured to control the weak signal detection unit to align with the detection window under the control of the main control module. Through the mutual matching with the rotary blending module, the PMT probe is aligned to the detection window of the microfluidic biochip, so that the detection of the PMT on weak fluorescent signals is realized.

Specifically, in an embodiment of the present invention, the power management and charging module 9 obtains the voltage for charging the 3.3V battery through the universal Type-C interface (5-12V), and simultaneously, the charging interface voltage can be changed into the system power voltage and the peripheral device voltage through the power management and charging module, when the battery is not charged, the battery voltage is changed into the required system power voltage and the required peripheral device voltage by the power management and charging module, and the control mode thereof realizes the connection and the closing of the corresponding power supply through the control of the main control module to control whether the triode is connected or not.

Specifically, in an embodiment of the present invention, the touch display control screen 11 is used for inputting the information of the tested user and displaying the weak fluorescence information of the blood sample of the tested user. During the intelligent medical quick detection, a worker/a detected user inputs information such as the name, age, telephone, sex and the like of the detected user through touch of the touch display control screen, and the weak fluorescence information with different wavelengths of the detected user is displayed through the touch display control screen. Different pieces of pathological information are reflected by different pieces of fluorescence information, so that the disease/pathological reason of the tested user is displayed, and then a report is generated to inform medical staff or the tested user.

Specifically, in an embodiment of the present invention, the key module 12 is used to switch on or off the input voltage of the power management and charging module and the on/off function and the on/off LED indication.

Specifically, in an embodiment of the present invention, the wireless communication module 13 is configured to transmit the detection data to the backend server, and the data storage module 14 is configured to store the detection data when the wireless communication module cannot connect to the backend server. The utility model discloses a Flash memory chip or SD card are as data storage module. When the main control module detects that the wireless communication module is abnormal in communication, information such as user information, sex, age, weak fluorescent voltage signals and system working state is stored in the data storage module and is uploaded to the background server through the wireless communication module until the main control module detects that the wireless communication module is normal in communication.

Specifically, in an embodiment of the present invention, the constant temperature module 15 is connected to the main control module, and the illumination providing specific wavelength for the microfluidic biochip through infrared means is catalyzed and heated, and the temperature is stabilized at the preset temperature. The reaction time can be shortened by providing a proper constant temperature, the reaction speed is accelerated, and the aim of rapid detection is fulfilled.

Specifically, in an embodiment of the present invention, a DSP, FPGA or ARM core-M series chip is adopted as the main control module 1 for performing output control on the power management and charging module; the voltage regulation circuit is used for carrying out feedback regulation control on the voltage output of the boosting unit and accurately controlling the output high voltage for the photomultiplier to use; the device is used for controlling the high-speed rotation and uniform mixing of the objective table, and is matched with the internal reagent injection module and the external reagent injection module to realize the orderly injection of the reagents in the microfluidic biochip or the accurate injection operation of the external reagent; the analog-to-digital converter is used for carrying out analog-to-digital converter (ADC) acquisition on the voltage signal after the weak photoelectric signal received by the weak signal detection unit is subjected to voltage conversion and operational amplification; for controlling the PMT probe extension and retraction operations; the system is used for receiving the input of the touch control display screen and displaying corresponding output results and information such as the working state of the detection device and the system through the display screen; the system comprises a background server, a database and a wireless communication module, wherein the background server is used for encrypting and compressing data of received weak fluorescent signals, system working states, user information and the like, then sending the data to the background server of a remote specified IP address and port number through the wireless communication module, decompressing and decrypting received data blocks through the background server, and then storing the data blocks in the database of the background server; the magnetic suction filter control module is used for separating specific particles; the device is used for controlling the high-speed rotation and uniform mixing of the objective table, realizes the sufficient mixing of nano-scale particles, accelerates the chemical reaction speed and achieves the aim of rapid detection. In addition, the main control module can automatically turn on or turn off the power supply of the peripheral circuit according to the current state information, in most of the time, the intelligent medical detection device and the intelligent medical detection system are in a low-power consumption standby mode, at the moment, the main control module can control the power management and battery charging module to turn off the wireless communication module, the magnetic absorption filtering control module, the PMT probe stretching control module, the weak signal detection unit, the conversion amplification unit, the data storage module, the rotary blending module, the boosting unit, the internal reagent injection module, the external reagent injection module and other modules, and the touch control display screen enters a low-power consumption touch awakening mode (screen state). The touch control display screen can be awakened to normally display only when the user touches the liquid crystal display screen again, and only when the user normally loads the microfluidic biochip and starts detection through the touch control display screen, the main control module can automatically give a control command for starting an external power supply to the power management and charging module, and then the main control module starts the output of the external power supply. The main control module can also dynamically display the received weak fluorescent signals with different wavelengths through a touch control display screen, and once the detected indexes exceed a certain threshold value, the main control module can inform a user through screen flicker and background abnormity early warning modes.

The use and working process of the device are described in detail as follows:

firstly, injecting about 20uL of fresh blood collected by fingertips into a microfluidic biochip, then taking out the microfluidic biochip from a consumable box (for detecting different diseases/diseases, the put microfluidic biochip is different) and dripping the fresh blood into the microfluidic biochip; then, according to the positions of the 2 gaps on the objective table, determining and fixing the microfluidic biochip on the objective table; then, the main control module controls the object stage to rotate, and under the coordination of the internal reagent injection module, the same set of needle holes are used for sequentially puncturing rubber capsule devices containing respective reagent components in the microfluidic biochip; after puncture, the reagent flows into the reaction tank through the um-level micro catheter under the action of gravity, and then the step motion of the objective table is controlled by the rotary blending module to realize the full blending of the reagent, namely, under the action of the same internal reagent injection (pinhole puncture) module, the step-by-step sequential flow of different reagents in different rubber capsule devices into the reaction tank is realized; and the reaction of a plurality of front and back reagents, the selective separation of target molecules and the automatic flow of waste liquid into a waste liquid collecting tank are realized under the action of a magnetic suction filtering control module with a coil and an iron core. Furthermore, if an external reagent needs to be injected in the process, a method that the rubber capsule is punctured by a pinhole and the external reagent is injected can be adopted to realize the injection of a certain external special reagent, so that the storage time of different reagents in the microfluidic biochip is prolonged, and the effective period of the microfluidic biochip is prolonged. In order to achieve the best effect, the process needs to carry out multiple coordination control on the rotating blending module, the magnetic suction filtration control module, the internal reagent injection module and the external reagent injection module, so that specific particles in blood can fully and quickly react with reagents in the microfluidic biochip, after a series of physical and chemical screening, specific markers are left by the magnetic suction filtration control module, irrelevant waste liquid flows out, and finally, the PMT probe is driven by the PMT probe telescopic control module to realize the detection of weak fluorescent signals in the photoelectric transparent window. Then the main control module controls the power management and charging module to convert 3.7/4.2V battery voltage into 5V or 12V direct current voltage, and the converted voltage is boosted to 400-1500V direct current output through the boosting unit, and the high voltage stability has great influence on weak signal detection, so that accurate feedback adjustment control is realized by specifically outputting accurate high voltage through resistor voltage division detection and DAC (digital-to-analog converter) by the main control module, and high voltage is provided for a weak signal detection unit (photomultiplier PMT). The weak signal detection unit converts weak fluorescent light signals with different wavelengths of a photoelectric detection transparent window into current signals, then performs current-voltage conversion and operational amplification pretreatment, and then sends the current signals to an ADC (analog-to-digital converter) in the main control module for analog-to-digital acquisition, the main control module receives the weak fluorescent voltage signals with different wavelengths and then performs rapid processing and analysis to obtain pathological reasons, then combines information such as user information and system working state to realize data compression and encryption, and then sends the data to a database in a designated server through the wireless communication module for data storage; when the wireless communication module cannot be networked, the main control module stores the compressed signals in the data storage module for temporary storage, and once the networking is recovered, the data in the data storage module is uploaded to the server database for further background analysis and processing. Meanwhile, the main control module can also dynamically display the received weak fluorescent signals with different wavelengths and pathological reasons through the touch control display screen, and once the detected indexes exceed a certain threshold value, the main control module informs a user through screen flicker and background abnormity early warning modes.

Implement the utility model discloses an intelligent medical detection device has following beneficial effect:

1. by changing reagent components in a rubber capsule device in the microfluidic biochip, detection of different diseases (bladder cancer, mycoplasma pneumoniae, rickets and the like) is realized in the detector, and early screening of various diseases such as bladder cancer, mycoplasma pneumoniae, rickets in bone density and the like can be rapidly, accurately and inexpensively diagnosed;

2. get a small amount of blood below 20uL through the finger prick needle and detect, realize the few sample collection of wicresoft, do not receive the electromagnetic radiation influence, detect many times and do not harm to health, and compare with current detection method, the utility model discloses detection expense is lower relatively, the wicresoft trace, can realize low-cost short-term test.

3. After the microfluidic biochip is fixed, the rotary fusion method realizes the nanoscale sufficient mixing of various reagents, shortens the reaction time and accelerates the chemical reaction, thereby achieving the aim of rapid detection;

4. the magnetic suction type filtering mode realizes accurate separation of the targeted molecules, and the accurate collection of the waste liquid is realized through the backflow-preventing waste liquid collecting structure without polluting detection equipment;

5. different reagents are orderly reacted in the reaction tank through the internal reagent injection module, and the various reagents are not polluted mutually, so that the reliable quality of the microfluidic biochip is avoided, and the detection result is accurate;

6. under certain conditions, the external reagent is rotationally injected into the reaction tank, so that the cost of an external reagent injection device can be greatly reduced, the quality guarantee period of the reagent in the chip is prolonged, and the cost of instruments can be greatly saved by sharing the same injection system;

7. and carrying out low-power consumption management on the intelligent medical detection device and the system power supply.

8. Personal information is input at one time, a pathology report is pushed at a background, and a WeChat code scanning inquiry and receiving pathology report are realized, so that intelligent and digital health management and abnormal pathology early warning service are realized.

In the description provided herein, numerous specific details are set forth. It is understood, however, that embodiments of the invention may be practiced without these specific details. In some instances, well-known methods, structures and techniques have not been shown in detail in order not to obscure an understanding of this description.

Similarly, it should be appreciated that in the foregoing description of exemplary embodiments of the invention, various features of the invention are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure and aiding in the understanding of one or more of the various inventive aspects. However, the disclosed method should not be interpreted as reflecting an intention that: rather, the invention as claimed requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single foregoing disclosed embodiment. Thus, the claims following the detailed description are hereby expressly incorporated into this detailed description, with each claim standing on its own as a separate embodiment of this invention.

Those skilled in the art will appreciate that the modules in the device of an embodiment may be adaptively changed and arranged in one or more devices different from the embodiment. The modules or units or components in the embodiments may be combined into one module or unit or component, and furthermore, may be divided into a plurality of sub-modules or sub-units or sub-components. All of the features disclosed in this specification (including any accompanying claims, abstract and drawings), and all of the processes or elements of any method or apparatus so disclosed, may be combined in any combination, except combinations where at least some of such features and/or processes or elements are mutually exclusive. Each feature disclosed in this specification (including any accompanying claims, abstract and drawings) may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise.

Furthermore, those skilled in the art will appreciate that although some embodiments herein include some features included in other embodiments rather than others, combinations of features of different embodiments are meant to be within the scope of the invention and form different embodiments. For example, in the following claims, any of the claimed embodiments may be used in any combination.

It should be noted that the above-mentioned embodiments illustrate rather than limit the invention, and that those skilled in the art will be able to design alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The word "comprising" does not exclude the presence of elements or steps not listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The invention can be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In the unit claims enumerating several means, several of these means may be embodied by one and the same item of hardware. The usage of the words first, second and third, etcetera do not indicate any ordering. These words may be interpreted as names.

Claims (10)

1. The utility model provides an intelligent medical detection device for bladder cancer and many diseases joint detection, a serial communication port, include host system, micro-fluidic biochip, inside reagent injection module, rotatory mixing module, magnetism inhale filtration control module and signal detection module, be provided with a plurality of rubber bag wares on the micro-fluidic biochip, host system is used for control inside reagent injection module punctures according to predetermined order the rubber bag ware is so that reagent in the rubber bag ware flows into in the reaction cell, rotatory mixing module is used for control fixed the objective table of micro-fluidic biochip is rotatory so that different reagent misce bene and fully react with blood sample, magnetism is inhaled the magnetism and is filtered the magnetic nanoparticle who is equipped with specific marker in the control module and is used for the solution after the separation reaction, signal detection module is used for detecting the solution that has magnetic nanoparticle after the separation in order to obtain the testing result.

2. The intelligent medical detection device for combined detection of bladder cancer and multiple diseases according to claim 1, further comprising an external reagent injection module connected to the main control module and the microfluidic biochip, for puncturing a rubber capsule filled with an external reagent under the control of the main control module to inject the external reagent into the reaction chamber.

3. The intelligent medical detection device for combined detection of bladder cancer and multiple diseases according to claim 1, wherein the signal detection module comprises a weak signal detection unit, a conversion and amplification unit connected to the weak signal detection unit and the main control module, and a voltage boost unit connected to the conversion and amplification unit and the main control module, the weak signal detection unit is configured to convert optical signals with different wavelengths in a solution into electrical signals, the conversion and amplification unit is configured to transmit the electrical signals to the main control module after voltage conversion and amplification operation, and the voltage boost unit is configured to boost a low-voltage power supply to obtain a high voltage suitable for the weak signal detection unit.

4. The intelligent medical detection device for combined detection of bladder cancer and multiple diseases according to claim 3, further comprising a photomultiplier probe telescoping control module connected to the main control module for controlling the weak signal detection unit to align with the detection window under the control of the main control module.

5. The intelligent medical examination device for combined detection of bladder cancer and multiple disorders of claim 1, further comprising a battery and a power management and charging module, said power management and charging module charging said battery through a generic Type-C interface and further for converting battery voltage into system supply voltage and peripheral device voltage.

6. The intelligent medical detection device for bladder cancer and multi-disease joint detection, according to claim 5, further comprising a touch display control screen and a key module connected to the main control module, wherein the touch display control screen is used for inputting information of a user to be detected and displaying weak fluorescence information of a blood sample of the user to be detected, and the key module is used for switching on or off the input voltage of the power management and charging module and the on-off function and on-off LED indication.

7. The intelligent medical detection device for combined detection of bladder cancer and multiple disorders according to claim 1, further comprising a data storage module and a wireless communication module connected to the main control module, wherein the wireless communication module is used for transmitting detection data to a background server, and the data storage module is used for storing the detection data when the wireless communication module cannot be connected to the background server.

8. The intelligent medical detection device for combined detection of bladder cancer and multiple diseases according to claim 1, further comprising a constant temperature module connected to the main control module for heating the microfluidic biochip by infrared and stabilizing the temperature at a preset temperature.

9. The intelligent medical detection device for bladder cancer and multi-disease joint detection according to claim 1, further comprising a waste liquid discharge control module connected with the main control module, wherein the waste liquid discharge control module comprises a magnetic block and a rubber part arranged on the surface of the magnetic block, the rubber part is in contact with a waste liquid discharge seal arranged on the waste liquid collection tank or on the side of the waste liquid collection tank, and the waste liquid discharge control module is used for realizing that the magnetic absorption filter control module separates the waste liquid and whether the separated waste liquid is discharged to the anti-backflow waste liquid collection tank or not.

10. The intelligent medical detection device for combined detection of bladder cancer and multiple disorders of claim 1, wherein the magnetic filter control module comprises a core and a coil wound on the core.

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