CN218165648U - Preparation for maintaining activity of probiotics - Google Patents
Preparation for maintaining activity of probiotics Download PDFInfo
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- CN218165648U CN218165648U CN202220914638.6U CN202220914638U CN218165648U CN 218165648 U CN218165648 U CN 218165648U CN 202220914638 U CN202220914638 U CN 202220914638U CN 218165648 U CN218165648 U CN 218165648U
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- capsule shell
- probiotic
- probiotics
- dietary fiber
- hollow capsule
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Abstract
The utility model discloses a preparation for keeping probiotic activity, which belongs to the technical field of probiotics, and comprises a capsule main body, wherein the capsule main body consists of a capsule shell, probiotic pellets and a soluble dietary fiber filling layer, an upper hollow capsule shell and a lower hollow capsule shell are embedded with each other, the upper hollow capsule shell and the lower hollow capsule shell are internally provided with the probiotic pellets and the soluble dietary fiber filling layer, and the soluble dietary fiber filling layer is filled in the upper hollow capsule shell and the lower hollow capsule shell; during the storage process, the grain beta-glucan in the probiotic enteric-coated pellets can keep the activity of the probiotics; the enteric coating layer film on the pellet outer layer, the soluble dietary fiber filling layer in the capsule shell and the capsule shell form a multilayer protective barrier, so that the damage of oxygen and moisture to the probiotics is isolated, and the activity of the probiotics in the storage process is comprehensively maintained.
Description
Technical Field
The utility model belongs to the technical field of the probiotics, concretely relates to keep active preparation of probiotics.
Background
Probiotics are active microorganisms which are beneficial to a host and change the composition of flora at a certain part of the host by colonizing in a human body. The health of the intestinal tract is kept by promoting the absorption of nutrients by regulating the immune function of the host mucous membrane and the system or by regulating the balance of flora in the intestinal tract, so that single microorganisms or mixed microorganisms with definite compositions which are beneficial to the health are generated.
The probiotic bacteria in the probiotic bacteria preparation are extremely volatile and inactive in the storage and oral administration process, especially in the gastrointestinal tract after oral administration, and are inactivated by the hydrolysis of gastric acid and digestive enzymes. At present, conventional probiotic preparations are powder, capsules, tablets and the like, and the protection effect on the activity of probiotics is difficult to realize.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a preparation that keeps probiotic activity to propose current probiotic in solving above-mentioned background art and storing and the problem of oral in-process utmost point volatile deactivation.
In order to achieve the above object, the utility model provides a following technical scheme: a preparation for keeping probiotic activity comprises a capsule main body, wherein the capsule main body comprises a capsule shell, probiotic pellets and a soluble dietary fiber filling layer, an upper hollow capsule shell and a lower hollow capsule shell are embedded with each other, the probiotic pellets and the soluble dietary fiber filling layer are arranged in the upper hollow capsule shell and the lower hollow capsule shell, the soluble dietary fiber filling layer is filled in the upper hollow capsule shell and the lower hollow capsule shell, and the probiotic pellets comprise pellet cores and enteric coating films, wherein the pellet cores are composed of grain beta-glucan and probiotic, and the enteric coating films are wrapped on the outer surfaces of the grain beta-glucan and the pellet cores of the probiotic pellets.
As a preferred embodiment, the cereal beta-glucan is oat beta-glucan or barley beta-glucan or a mixture of both in any proportion.
In a preferred embodiment, the probiotic bacteria refer to lactic acid bacteria, bifidobacteria, yeasts or any mixture of the three.
As a preferred embodiment, the weight ratio of cereal beta-glucan to probiotic is 1:5-5:1.
As a preferred embodiment, the diameter of the pellet core of the pellet is 0.5mm-2.5mm.
In a preferred embodiment, the material of the enteric coating film is acrylic resin or hydroxypropyl methyl cellulose phthalate.
As a preferred embodiment, the enteric coating layer film has a coating weight gain of 2% to 20%.
As a preferred embodiment, the soluble dietary fiber filling layer is specifically referred to as resistant dextrin or fructo-oligosaccharide or inulin or any mixture of the three in any ratio.
As a preferred embodiment, the weight ratio of the probiotic pellets to the soluble dietary fiber filling layer is 1:5-5:1.
As a preferred embodiment, the upper and lower hollow capsule shells are food or pharmaceutical grade gelatin or vegetable hollow capsules for oral administration.
Compared with the prior art, the beneficial effects of the utility model are that:
during the storage process of the preparation for maintaining the activity of the probiotics, the grain beta-glucan in the probiotic enteric-coated pellets can maintain the activity of the probiotics; the enteric coating layer film on the pellet outer layer, the soluble dietary fiber filling layer in the capsule shell and the capsule shell form a multilayer protective barrier, so that the damage of oxygen and moisture to the probiotics is isolated, and the activity of the probiotics in the storage process is comprehensively maintained.
After the preparation keeping the activity of the probiotics is orally taken, the capsule is dissolved in the stomach and then releases the probiotics pellet and the soluble dietary fiber filling layer, the probiotics pellet ensures that the probiotics are not contacted with gastric acid and digestive enzyme to be hydrolyzed, the probiotics pellet disintegrates after reaching the small intestine and releases the probiotics and the grain beta-glucan, the grain beta-glucan forms a viscous colloidal substance after contacting with water to wrap the probiotics in the grain beta-glucan, the probiotics is isolated from being contacted with the digestive enzyme, the probiotics are prevented from being hydrolyzed, and the in-vivo activity of the probiotics is ensured. In addition, the grain beta-glucan and the soluble dietary fiber filling layer are both foods of probiotics, so that the dormant probiotics can be reactivated, the proliferation of the probiotics is promoted, and the in-vivo activity of the probiotics is enhanced.
Drawings
Fig. 1 is a schematic structural view of the present invention;
fig. 2 is a schematic structural diagram of the probiotic pellet of the present invention.
In the figure: 1. a capsule preparation body; 2. an upper hollow capsule shell; 3. a lower hollow capsule shell; 4. probiotic pellets; 5. a soluble dietary fiber filling layer; 6. a pellet core; 7. enteric coating films.
Detailed Description
Referring to fig. 1-2, the utility model provides a keep preparation of probiotic activity, including the capsule main part, the capsule main part comprises capsule shell, probiotic pellet 4 and soluble dietary fiber filling layer 5, and upper hollow capsule shell 2 and lower hollow capsule shell 3 set up each other, be provided with probiotic pellet 4 and soluble dietary fiber filling layer 5 in upper hollow capsule shell 2 and the lower hollow capsule shell 3, soluble dietary fiber filling layer 5 is filled in upper hollow capsule shell 2 and lower hollow capsule shell 3, probiotic pellet 4 comprises pellet core 6 and the enteric coating rete 7 of parcel at cereal beta-glucan and probiotic pellet 4 pellet core surface that constitute by cereal beta-glucan and probiotic.
The cereal beta-glucan refers to oat beta-glucan or barley beta-glucan or a mixture of the two in any proportion.
The probiotics refers to lactic acid bacteria, bifidobacteria, yeast or a mixture of the three in any ratio.
The weight ratio of cereal beta-glucan to probiotic is 1:5-5:1.
The diameter of the pellet core 6 is 0.5mm-2.5mm.
The material of the enteric coating film 7 is acrylic resin or hydroxypropyl methyl cellulose phthalate.
The coating weight gain of the enteric coating layer film 7 is 2-20%.
The soluble dietary fiber filling layer 5 specifically refers to resistant dextrin, fructo-oligosaccharide, inulin or any mixture of the three in any ratio.
The weight ratio of the probiotic pellet 4 to the soluble dietary fiber filling layer 5 is 1:5-5:1.
The upper hollow capsule shell 2 and the lower hollow capsule shell 3 are food or medicinal gelatin hollow capsules or plant hollow capsules for oral administration.
Wherein the pellet core 6 is prepared by mixing 1 part of lactobacillus, 1 part of bifidobacterium, 2 parts of oat beta-glucan and 1 part of barley beta-glucan, adding proper purified water for wetting to prepare a soft material, preparing the soft material into pellets with the diameter of 1-2 mm by using an extrusion spheronization machine, and drying the pellets by using a fluidized bed.
Wherein, the outer layer of the pellet core is an enteric coating layer film 7, the coating material is acrylic resin Uttqi L30D-55 type, and the weight is increased by 12 percent through fluidized bed coating, thus obtaining the enteric-coated pellet.
Wherein the soluble dietary fiber filling layer 5 is prepared by mixing 2 parts of resistant dextrin and 1 part of inulin.
And (3) uniformly mixing 1 part of the enteric-coated pellets with 2 parts of soluble dietary fiber to obtain the capsule content.
The content of the capsule is evenly filled into a No. 0 gelatin hollow capsule, and the preparation for keeping the activity of the probiotics is obtained.
When in use, the grain beta-glucan in the probiotic enteric-coated pellets can keep the activity of the probiotics during the storage process; the enteric coating layer film 7 on the pellet outer layer, the soluble dietary fiber filling layer 5 in the capsule shell and the capsule shell form a multilayer protective barrier, damage of oxygen and moisture to probiotics is isolated, the activity of the probiotics in the storage process is comprehensively maintained, after the preparation for maintaining the probiotic activity is orally taken, the capsule is dissolved in the stomach, and then the probiotic pellet 4 and the soluble dietary fiber filling layer 5 are released, the probiotic pellet 4 ensures that the probiotics is not contacted with gastric acid and digestive enzyme to be hydrolyzed, the probiotic pellet 4 is disintegrated after reaching the small intestine, the probiotics and grain beta-glucan are released, sticky colloidal substances formed after the grain beta-glucan is contacted with water wrap the probiotics in, the probiotics is isolated from the digestive enzyme to prevent the probiotics from being hydrolyzed, and the in-vivo activity of the probiotics is ensured. In addition, the grain beta-glucan and the soluble dietary fiber filling layer 5 are both foods of probiotics, so that the dormant probiotics can be reactivated, the proliferation of the probiotics is promoted, and the in-vivo activity of the probiotics is enhanced.
Claims (5)
1. A formulation for maintaining probiotic activity, characterized by: the capsule comprises a capsule main body, wherein the capsule main body comprises a capsule shell, probiotic pellets (4) and a soluble dietary fiber filling layer (5), an upper hollow capsule shell (2) and a lower hollow capsule shell (3) are embedded with each other, the probiotic pellets (4) and the soluble dietary fiber filling layer (5) are arranged in the upper hollow capsule shell (2) and the lower hollow capsule shell (3), the soluble dietary fiber filling layer (5) is filled in the upper hollow capsule shell (2) and the lower hollow capsule shell (3), and the probiotic pellets (4) comprise pellet cores (6) and enteric-soluble coating films (7) coated on the outer surfaces of the pellet cores (6).
2. Formulation for maintaining probiotic activity according to claim 1, characterized in that: the diameter of the pellet core (6) is 0.5mm-2.5mm.
3. Formulation for maintaining probiotic activity according to claim 1, characterized in that: the material of the enteric coating layer film (7) is specifically acrylic resin or hydroxypropyl methyl cellulose phthalate.
4. Formulation for maintaining probiotic activity according to claim 1, characterized in that: the coating weight gain of the enteric coating layer film (7) is 2-20%.
5. Formulation for maintaining probiotic activity according to claim 1, characterized in that: the upper hollow capsule shell (2) and the lower hollow capsule shell (3) are food or medicinal gelatin hollow capsules or plant hollow capsules for oral administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220914638.6U CN218165648U (en) | 2022-04-20 | 2022-04-20 | Preparation for maintaining activity of probiotics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220914638.6U CN218165648U (en) | 2022-04-20 | 2022-04-20 | Preparation for maintaining activity of probiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218165648U true CN218165648U (en) | 2022-12-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220914638.6U Active CN218165648U (en) | 2022-04-20 | 2022-04-20 | Preparation for maintaining activity of probiotics |
Country Status (1)
| Country | Link |
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| CN (1) | CN218165648U (en) |
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2022
- 2022-04-20 CN CN202220914638.6U patent/CN218165648U/en active Active
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