KR102483912B1 - Method for producing soft capsule type functional health food - Google Patents

Abstract

Disclosed is a method for producing a health functional food in which the ingredients are exposed in the small intestine as a soft capsule containing a probiotics strain. A method for manufacturing a soft capsule-type health functional food includes mixing raw materials of the measured health functional food in an atmosphere with a relative humidity of 65% or less and a temperature of 20 ° C to 24 ° C for 30 to 50 minutes; Forming a coating layer by forming a capsule, and spraying a liquid coating material on the soft capsule, wherein the coating material is fat, fatty acid, wax, shellac, cellulose phthalate, hydroxypropyl methylcellulose phthalate , HPMC), and the raw material is from the group consisting of lactobacillus, lactococcus, enterococcus, streptococcus and bifidobacterium. It includes any one or more probiotics strains selected.

Description

Manufacturing method of soft capsule type health functional food {METHOD FOR PRODUCING SOFT CAPSULE TYPE FUNCTIONAL HEALTH FOOD}

The present invention relates to health functional food, and more particularly, to a method for manufacturing a health functional food as a soft capsule containing probiotics strains and exposing the constituents in the small intestine.

Health functional food refers to a tablet, capsule, pill, granule, powder, liquid, or flake form (tablet, capsule, pill, powder, etc.) It refers to food manufactured (including processing) in the form of flake, paste, syrup, gel, jelly, bar, film, etc. Here, raw materials refer to substances used in the manufacture of health functional foods and are included in the final product, and ingredients refer to separate single substances or substances contained in raw materials and contained in the final product.

Health functional foods have functional levels of nutrient function, physiological activity function, and disease risk reduction function. Nutrient function refers to the physiological action of nutrients for the growth promotion and normal function of the human body using vitamin C, etc., and physiological activity function refers to a specific function for the normal function or biological activity of the human body using lutein or coenzyme Q10. It refers to a function that shows contribution to health, function improvement, health maintenance, or improvement, and disease risk reduction function refers to a function related to disease occurrence or health condition risk reduction by using calcium or vitamin D.

Probiotics, one of the representative health functional foods, is a general term for beneficial bacteria that live in the intestinal tract and help health, and refers to lactic acid bacteria typically used in yogurt fermentation. They are known to exhibit various physiological activities such as inhibition of oral cavity bacteria, regulation of the body's immune system (promoting anti-inflammatory response, reduction of allergic symptoms, etc.), alleviation of irritable bowel syndrome, and intestinal function.

Recently, a lot of research and development is being conducted to powder probiotics and prepare them as health functional foods. Probiotics powder is useful as a material that can improve the health function of food as it can be easily applied to various foods such as bread, confectionery, chocolate, cream, sauce, gum, and beverages, and is easier to store and handle than liquid. It has the advantage of commercialization. Therefore, various researches and developments are being conducted to increase the efficiency of the powder manufacturing process, control the characteristics of the powder, and improve the survival rate and efficacy of probiotics during manufacturing and storage or ingestion.

Registered Patent No. 10-1973333 (2019.04.29)

The present invention was derived to improve the problems of the prior art, and an object of the present invention is to manufacture a soft capsule-type health functional food that contains lactic acid bacteria, maintains the formulation in the stomach, and exposes the contained ingredients in the small intestine. to provide a way

In order to solve the above technical problem, the method for manufacturing a soft capsule-type health functional food according to an aspect of the present invention, the raw material of the measured health functional food is heated for 30 minutes in an atmosphere with a relative humidity of 65% or less and a temperature of 20 ° C to 24 ° C. mixing for 50 minutes, creating soft capsules filled with the blended raw materials, and spraying a liquid coating material on the soft capsules at a temperature of 55°C to 65°C for 1 hour to 2 hours to obtain a soft capsule capacity of 500 mg. Forming a coating layer of 2 mg per dose. The coating material includes at least one selected from the group consisting of fat, fatty acid, wax, shellac, cellulose phthalate acetate, and hydroxymethyl cellulose phthalate (HPMC).

In one embodiment, the method for producing the health functional food contains a coating material under the coating conditions of 6 to 10% by weight of HPMC, 7.5 to 15.0 g / min of coating liquid injection, and 28 ° C to 40 ° C of intake air temperature in the coating step. In the process of using air spray so that a coating liquid is sprayed and adhered to the surface of the soft capsule and dried in powder form as soon as it is sprayed, the coating liquid is soft until it is sprayed and adhered to the soft capsule surface. It is preferable to maintain a coating environment so that a uniform coating solution is uniformly attached to the surface of the capsule and dried.

In one embodiment, the raw material includes one or more probiotic strains selected from the group consisting of lactobacillus, lactococcus, enterococcus, streptococcus and bifidobacterium. .

In the case of using the above-mentioned manufacturing method of the soft capsule type health functional food, lactobacillus, lactococcus, enterococcus, streptococcus and bifidobacterium consisting of As a tablet or granule containing at least one probiotics strain selected from the group, it is possible to provide a health functional food soft capsule that remains in the stomach and exposes the contents in the small intestine.

In addition, according to the present invention, as an enteric soft capsule-type health functional food coated with hypromellose or hydroxypropyl methylcellulose (HPMC), it has the advantage of effectively securing reliability and efficacy. there is.

1 is a flowchart of a method for manufacturing a soft capsule type health functional food according to an embodiment of the present invention.

Since the present invention can apply various modifications and have various embodiments, specific embodiments will be illustrated in the drawings and described in detail in the detailed description. However, this is not intended to limit the present invention to specific embodiments, and should be understood to include all conversions, equivalents, or substitutes included in the spirit and scope of the present invention. In describing the present invention, if it is determined that a detailed description of related known technologies may obscure the gist of the present invention, the detailed description will be omitted.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a flowchart of a method for manufacturing a soft capsule type health functional food according to an embodiment of the present invention.

Referring to Figure 1, the manufacturing method of the soft capsule type health functional food, the raw material of the measured health functional food is blended for 30 minutes to 50 minutes in an atmosphere of 20 ℃ to 24 ℃ relative humidity of 65% or less (S11) , It includes a series of steps of creating a soft capsule filled with the blended raw materials (S12), and forming a coating layer by spraying a liquid coating material on the soft capsule (S13). The coating material includes at least one selected from the group consisting of fat, fatty acid, wax, shellac, cellulose phthalate acetate, and hydroxymethyl cellulose phthalate (HPMC).

The raw material includes one or more probiotic strains selected from the group consisting of lactobacillus, lactococcus, enterococcus, streptococcus and bifidobacterium.

That is, in the present embodiment, a microorganism consisting of the above-described probiotics strain or a mixture thereof and a culture medium and a protective agent for culturing the bacteria or culture body may be used as raw materials.

For example, probiotics are defined as living microorganisms that, when ingested in adequate amounts, confer health benefits to the host, and are relatively safe and non-toxic. Probiotics lactic acid bacteria are also excellent in killing or suppressing Helicobacter, the cause of chronic gastritis. In addition, Lactoracillus Plantarum HY7714 was recognized for skin damage caused by ultraviolet rays and skin moisturizing.

In addition, Lactobacillus includes Lactobacillus plantarum CJLP133 (L.plantarum CJLP133), a lactobacillus derived from fruits and vegetables, which means a bacterium named CJLP133 of the genus Lactobacillus and Plantarum species. Depending on the strain, probiotics have effects such as improving cholesterol levels, improving immune diseases, improving intestinal diseases and constipation or diarrhea, improving atopic diseases, and improving lactose intolerance.

Example 1

The shell of the soft capsule filled with probiotics strains was composed of 40% gelatin, 40% glycerin, and 20% purified water. Hydroxymethylcellulose (HPMC), an enteric base, was used as a coating agent, and acetylated monoglyceride (AMG) was used as a plasticizer to increase the flexibility of the film coating. And as a coating solvent, a mixture of fermented alcohol (95%) and purified water was used.

The coating solution was prepared with a total weight of 500 g, and the coating layer was formed by changing the amount of HPMC used in the solid content to 6%, 8%, and 10%, respectively, based on the weight of the total solution. As a solvent, a mixture of fermented alcohol and purified water at a weight ratio of 85:15 was used.

To prepare the coating solution, while stirring the mixed solvent of fermented alcohol and purified water with a homogenizer, HPMC and AMG were added and further stirred at 2500 rpm for about an hour to prepare a homogeneous coating solution.

Then, the prepared coating solution was sprayed onto the soft capsules to form a coating layer on the soft capsules. 2 mg of the coating solution for the coating layer was used per soft capsule of 500 mg capacity.

A film coater (Hi-coater, Freund Corporate) was used to examine the effect of the HPMC concentration of the coating layer, the intake air temperature, and the amount of coating injection liquid on the coating surface of the soft capsule. The quality of the coating layer was evaluated by adjusting the intake air temperature to 32, 35, and 38 ℃, respectively, and the coating spraying liquid amount to 7.5, 11.25, and 15.0 g / min with a pump, respectively, for HPMC concentrations of 6, 8, and 10%. .

In order to confirm the uniform state of the coating layer, gold-ion was coated with an ion sputter coater, and then the cross section was observed at 100 magnification using a scanning electron microscope. As a result, it was confirmed that the spray liquid amount of the coating liquid has a significant effect on causing the white phenomenon that deteriorates the coating quality.

The disintegration test was measured by the disintegration test method described in the Health Functional Food Codex. That is, the prepared soft capsules were put into artificial gastric juice and artificial intestinal fluid, 6 each, and then the artificial gastric fluid was moved up and down for 120 minutes and the artificial intestinal fluid was moved up and down for 60 minutes, and then the dissolution of the soft capsule was observed. The used artificial gastric juice was prepared by dissolving 7.0 ml of hydrochloric acid and water in 2.0 g of sodium chloride to make 1 L (pH 1.2). prepared (pH 6.8).

As a result of the experiment, in order to prevent the white phenomenon from occurring, that is, to increase the transparency of the surface when coating the surface of the soft capsule, while stirring the mixed solvent of fermented alcohol and purified water with a homogenizer, HPMC and AMG were added at 2500 rpm After stirring for an additional hour to prepare a homogeneous coating liquid, the coating liquid spray amount is 7.5 ~ 15.0 g / min, the intake temperature is room temperature (28 ℃) to 40 ℃ (preferably 32 ~ 38 ℃), HPMC concentration 6 ~ 10% In the process of using air spray to spray the coating liquid under coating conditions of (preferably 6-8%) and attach it to the surface of the soft capsule, dry it in powder form as soon as it is sprayed and attach it to the surface of the soft capsule, It was confirmed that it is important to ensure that a uniform coating solution is uniformly attached to the surface of the soft capsule and dried until the coating solution is sprayed or adhered to the surface of the soft capsule.

Although the above has been described with reference to preferred embodiments of the present invention, those skilled in the art can variously modify and change the present invention without departing from the spirit and scope of the present invention described in the claims. You will understand.

Claims (1)

As a method for producing a soft capsule type health functional food,
Blending the raw material of the measured health functional food in an atmosphere with a relative humidity of 65% or less and a temperature of 20 ° C to 24 ° C for 30 minutes to 50 minutes;
Generating a soft capsule filled with the blended raw materials; and
Forming a coating layer by spraying a liquid coating material on the soft capsule,
The coating material includes hydroxypropyl methylcellulose phthalate (hereinafter referred to as HPMC), and in the coating step, 6 to 8% by weight of HPMC based on the total weight of the liquid coating material, the amount of spraying the coating liquid is 7.5 to 15.0 g. /min and air intake temperature of 32 ° C to 38 ° C, the coating liquid containing the coating material is sprayed and adhered to the surface of the soft capsule, and air spray is used so that it is attached to the surface of the soft capsule immediately after being sprayed and dried in the form of powder. In the process of maintaining the coating environment so that the coating liquid is uniformly adhered to the surface of the soft capsule and dried until the coating liquid is sprayed and adhered to the surface of the soft capsule,
The coating solution was prepared by stirring a solvent in which fermented alcohol and purified water were mixed at a weight ratio of 85:15 with a homogenizer, then adding HPMC and acetylated monoglyceride (AMG) and stirring at 2500 rpm for an additional hour,
2mg of the coating solution is used per soft capsule of 500mg capacity,
The raw material includes any one or more probiotic strains selected from the group consisting of lactobacillus, lactococcus, enterococcus, streptococcus and bifidobacterium
Manufacturing method of health functional food.

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