CN218039096U - Collision reaction tank based on ion funnel - Google Patents
Collision reaction tank based on ion funnel Download PDFInfo
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- CN218039096U CN218039096U CN202222180576.3U CN202222180576U CN218039096U CN 218039096 U CN218039096 U CN 218039096U CN 202222180576 U CN202222180576 U CN 202222180576U CN 218039096 U CN218039096 U CN 218039096U
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 30
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- 102000004310 Ion Channels Human genes 0.000 claims abstract description 62
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- 230000005684 electric field Effects 0.000 claims description 4
- 230000005405 multipole Effects 0.000 abstract description 12
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- 239000007789 gas Substances 0.000 description 8
- 238000010494 dissociation reaction Methods 0.000 description 5
- 230000005593 dissociations Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
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- 238000013461 design Methods 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
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- 230000037427 ion transport Effects 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
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Abstract
The utility model relates to a collision reaction tank based on ion funnel, include: the ion funnel and the power supply board are arranged in the airtight space, the power supply board is connected with the ion funnel, a hole used for ions to enter is formed in the inlet lens, a hole used for ions to fly out is formed in the outlet lens, a hole used for feeding collision gas is formed in the bottom of the cavity, and a hole used as an ion channel is formed in the ion funnel. The utility model discloses an ion funnel compares in present collision reaction tank common multipole pole technique, can control the ion under higher gas pressure, allows the ion to collide with bigger kinetic energy and dissociate, can gain the better performance of more poles.
Description
Technical Field
The utility model relates to a mass spectrograph technical field, in particular to collision reaction pond based on ion funnel.
Background
Mass spectrometers, electron microscopes, nuclear magnetic instruments and the like belong to high-end scientific instruments. At present, ten thousands of mass spectrometers are imported in China every year, and the triple quadrupole mass spectrometer for liquid chromatography and mass spectrometry has qualitative and quantitative functions, so that the triple quadrupole mass spectrometer is widely applied to the industries of pharmacy, food safety, inspection and quarantine, clinical detection and the like. However, the triple quadrupole mass spectrometer is also one of the mass spectrometers with higher research and development difficulty. The triple quadrupole mass spectrometer is different from the single quadrupole mass spectrometer in that it is provided with a key component, namely a collision reaction cell. The collision reaction pool is a place where the parent ions are subjected to collision dissociation and chemical reaction to produce product ions. The collision reaction pool relates to collision, focusing, dissociation, transmission and other functions. The adoption of the collision reaction pool can enable the instrument to form parent-child ion two-stage mass spectrum information, thereby having stronger substance identification capability. The current collision reaction tank structure mainly comprises a multipole rod, a quadrupole rod, a hexapole rod, an octapole rod and the like. However, the multipole rod technique commonly used in the current collision reaction cell cannot control ions under higher gas pressure, and the kinetic energy of the ions for collision and dissociation is limited.
Ion funnels are a technology of last century utility model with high focusing and transmission efficiency. Ion funnels are currently widely used for ion transport of ions at the atmospheric-vacuum interface. Ion funnels can manipulate ions at higher gas pressures than multipole rods, allowing ions to undergo collision dissociation with greater kinetic energy, theoretically achieving better performance with more rods for a collision cell.
SUMMERY OF THE UTILITY MODEL
In order to realize the above objects and other advantages according to the present invention, the present invention provides a collision reaction tank based on an ion funnel, including: cavity, ion funnel, power supply board, entry lens, export lens, the cavity entry lens export lens enclose into airtight space, the ion funnel the power supply board is arranged in the airtight space, the power supply board with ion funnel connects, be equipped with the hole that is used for the ion to get into on the entry lens, be equipped with the hole that is used for the ion departure on the export lens, the cavity bottom is equipped with the hole of feed-in collision gas, be equipped with the hole as ion channel on the ion funnel.
Further, the ion funnel includes a plurality of metal pole pieces and insulating piece, the insulating piece is arranged in adjacently between the metal pole piece, the metal pole piece with be equipped with the hole as ion channel on the insulating piece.
Further, from the entrance lens side to the exit lens side, the direct voltage output by the power supply plate is linearly distributed among all the metal pole pieces to form an axial electric field to drive ions to move from the entrance to the exit;
the amplitude of the radio frequency voltage output to all the metal pole pieces by the power supply board is the same, and the phase of the radio frequency voltage output to the adjacent metal pole pieces by the power supply board is opposite.
Further, the inner diameter of the aperture of the ion funnel on the side close to the entrance lens is larger than the inner diameter of the aperture of the ion funnel on the side close to the exit lens.
Further, the ion funnel comprises a channel section and a focusing section, wherein the channel section is close to the inlet lens side, the inner diameters of the holes of the channel section are equal, the focusing section is close to the outlet lens side, and the inner diameter of the hole of the focusing section is gradually reduced along the direction from the inlet lens to the outlet lens.
Further, the metal pole pieces of the ion funnel are arranged in an off-axis mode.
Further, the ion channel of the ion funnel comprises a circular arc-shaped ion channel.
Further, the inlet lens is coaxial with an inlet of the ion funnel, and the outlet lens is coaxial with an outlet of the ion funnel.
The ion source comprises an ion channel inlet section and an ion channel outlet section, wherein the ion channel inlet section and the ion channel outlet section comprise a plurality of metal pole pieces, the inner diameter of the ion channel inlet section is equal to that of the ion channel inlet, and the inner diameter of the ion channel outlet section is equal to that of the ion channel outlet.
Further, the arc-shaped ion channel is a 90-degree arc-shaped ion channel or a 180-degree arc-shaped ion channel.
Compared with the prior art, the beneficial effects of the utility model are that:
the utility model provides a collision reaction pond is based on ion funnel, compares in the common multipole pole technique of collision reaction pond at present, can control the ion under higher gas pressure, allows the ion to collide with bigger kinetic energy and dissociate, can gain the better performance of more polars.
The above description is only an overview of the technical solution of the present invention, and in order to make the technical means of the present invention clearer and can be implemented according to the content of the description, the following detailed description is made with reference to the preferred embodiments of the present invention and accompanying drawings. The detailed description of the present invention is given by the following examples and the accompanying drawings.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention without undue limitation to the invention. In the drawings:
FIG. 1 is a schematic diagram of an ion funnel-based collision cell of example 1;
FIG. 2 is a schematic diagram of the application of DC voltage and RF voltage to the ion funnel;
FIG. 3 is a schematic view of a 90 ° ion channel;
figure 4 is a schematic diagram of a 180 ° ion channel.
In the figure: 1. a cavity; 2. an ion funnel; 21. a metal pole piece; 22. an inlet ion channel section; 23. an outlet ion channel section; 3. a power supply board; 4. an entrance lens; 5. an exit lens.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that the embodiments or technical features described below can be arbitrarily combined to form a new embodiment without conflict.
In the following description, suffixes such as "module", "part", or "unit" used to indicate elements are used only for facilitating the explanation of the present invention, and have no specific meaning in itself. Thus, "module", "component" or "unit" may be used mixedly.
Example 1
An ion funnel 2-based collision reaction cell, as shown in fig. 1, comprises: the collision cell comprises a cavity 1, an ion funnel 2, a power supply plate 3, an inlet lens 4 and an outlet lens 5, wherein the cavity 1, the inlet lens 4 and the outlet lens 5 are enclosed to form a closed space, and the inlet lens 4 and the outlet lens 5 can be well sealed with the cavity 1 in a bonding mode, a screw with a sealing ring is used for compressing and the like so as to ensure that the collision cell can maintain the pressure in the cell different from the vacuum degree of the vacuum environment in which the collision cell is located.
In airtight space was arranged in to ion funnel 2, power supply board 3 was connected with ion funnel 2, was equipped with the hole that is used for the ion to get into on the entry lens 4, was equipped with the hole that is used for the ion departure on the exit lens 5, was equipped with the hole as ion channel on the ion funnel 2. Ions can only enter from the aperture on the entrance lens 4, from Kong Feichu on the exit lens 5. One side of the bottom of the cavity 1, which is close to the inlet lens 4, is provided with a hole for feeding collision gas, and the hole is used for introducing the collision gas to perform collision dissociation reaction on ions and the like.
The inner diameter of the aperture of the ion funnel 2 on the side close to the entrance lens 4 is larger than the inner diameter of the aperture of the ion funnel 2 on the side close to the exit lens 5. Preferably, the ion funnel 2 includes a channel section and a focusing section, the channel section is close to the inlet lens 4 side, the aperture diameters of the channel section are equal, the focusing section is close to the outlet lens 5 side, and the aperture diameter of the focusing section is gradually reduced along the direction from the inlet lens 4 to the outlet lens 5, so as to facilitate ion focusing.
The power supply board 3 is specifically a power supply PCB board, and the power supply PCB board supplies a direct current voltage and a radio frequency voltage to the metal pole piece 21. The dc voltage and rf voltage application principle is shown in fig. 2. The direct current voltage is linearly distributed among all the metal pole pieces 21 from the side of the inlet lens 4 to the side of the outlet lens 5 to form an axial electric field to drive ions to move from an inlet to an outlet; the rf voltage is set according to the rule that the amplitudes are the same and the phases of the adjacent metal pole pieces 21 are opposite.
In order to avoid noise interference such as neutral particles in the process, the metal pole piece 21 of the ion funnel 2 can be arranged in an off-axis manner. Preferably, the ion channel of ion funnel 2 comprises a circular arc ion channel. Such as a 90 arc ion channel as shown in fig. 3, or a 180 arc ion channel as shown in fig. 4. It should be understood that other arc ion channels can be designed according to actual requirements.
When the ion channel is configured as an arc-shaped ion channel, it is necessary to ensure that the design and layout of the cavity 1, the inlet lens 4 and the outlet lens 5 change along with the shape change of the ion funnel 2, the inlet lens 4 is coaxial with the inlet of the ion funnel 2, and the outlet lens 5 is coaxial with the outlet of the ion funnel 2.
It should be noted that, when the ion channel is configured as an arc-shaped ion channel, generally, an inlet ion channel section 22 is disposed at an inlet of the ion channel, an outlet ion channel section 23 is disposed at an outlet of the ion channel, the inlet ion channel section 22 and the outlet ion channel section 23 include a plurality of metal pole pieces 21, an inner diameter of a hole of the inlet ion channel section 22 is equal to an inner diameter of a hole at the inlet of the ion channel, and an inner diameter of a hole of the outlet ion channel section 23 is equal to an inner diameter of a hole at the outlet of the ion channel. The inlet ion channel section 22 is mainly used to generate good collisional cooling, which is convenient to reduce the noise of ions entering the arc channel of the next stage and improve the signal-to-noise ratio. The exit ion channel is mainly used to form a good ion focus for the ion beam to fly out of the exit lens 5.
The commonly used multipole rod structure and the ion funnel 2 adopt a radio frequency electric field to form a pseudo potential field, thereby realizing the ion focusing effect. The magnitude of the voltage of the pseudopotential field directly determines the structure's ability to bind charged ions. The commonly used multipole rod structure at present is 5-10mm pole rod diameter, and the multipole rod pseudopotential field maximum value is:
wherein n is the electrode logarithm of the multipole rod; q and m are respectively the charge quantity and the ion mass of the ions; v rf Is the radio frequency voltage amplitude; r is a radical of hydrogen 0 And r is the field circle radius and pole radius of the multipole, respectively.
For example, for a typical 9.4mm quadrupole crash bar set configuration, the inscribed circle r thereof 0 The voltage is about 0.7-1.2MHz, which is generally 8.32 mm.
And for the common ion funnel 2, the maximum value of the pseudopotential field is as follows:
d is the annular electrode pole piece spacing; δ = d/π.
For example, for a common ion funnel 2 model, typically d =1mm, then
From the above calculations, it can be seen that for the same mass-to-charge ratio (q/m, or z/m) ion, the ion funnel 2 generates a pseudo-potential field with a maximum value of several tens of times larger than that of the conventional multipole rod design when the rf power source with the same amplitude and frequency is applied, thereby generating a stronger ion-binding capability. The stronger confining ability means that higher collision cell gas pressure can be used, resulting in more efficient ion-molecule collisions, and also means more efficient parent and daughter ion focusing transport efficiency, less ion loss. It is expected that the performance of the collision reaction cell can be significantly improved.
The utility model provides a collision reaction pond based on ion funnel compares in the collision reaction pond based on multipole pole technique commonly used, can control the ion under higher gas pressure, allows the ion to collide with bigger kinetic energy and dissociate, is used for collision reaction pond in theory to gain the better performance of more poles.
The foregoing is merely an example of the present specification and is not intended to limit one or more embodiments of the present specification. Various modifications and alterations to one or more embodiments described herein will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of one or more embodiments of the present specification should be included in the scope of claims of one or more embodiments of the present specification. One or more embodiments of this specification.
Claims (10)
1. An ion funnel-based collision reaction cell, comprising: cavity, ion funnel, power supply board, entry lens, export lens, the cavity entry lens export lens enclose into airtight space, the ion funnel the power supply board is arranged in the airtight space, the power supply board with ion funnel connects, be equipped with the hole that is used for the ion to get into on the entry lens, be equipped with the hole that is used for the ion departure on the export lens, the cavity bottom is equipped with the hole of feed-in collision gas, be equipped with the hole as ion channel on the ion funnel.
2. The ion funnel-based collision reaction cell of claim 1, wherein: the ion funnel comprises a plurality of metal pole pieces and an insulating piece, the insulating piece is arranged between the metal pole pieces and is adjacent to the metal pole pieces, and the metal pole pieces and the insulating piece are provided with holes serving as ion channels.
3. The ion funnel-based collision reaction cell of claim 1, wherein:
from one side of the inlet lens to one side of the outlet lens, the direct-current voltage output by the power supply plate is linearly distributed among all the metal pole pieces to form an axial electric field to drive ions to move from an inlet to an outlet;
the amplitude of the radio frequency voltage output by the power supply board to all the metal pole pieces is the same, and the phase of the radio frequency voltage output by the power supply board to the adjacent metal pole pieces is opposite.
4. The ion funnel-based collision reaction cell of claim 1, wherein: the inner diameter of the hole of the ion funnel close to the inlet lens side is larger than that of the hole of the ion funnel close to the outlet lens side.
5. The ion funnel-based collision reaction cell of claim 4, wherein: the ion funnel comprises a channel section and a focusing section, wherein the channel section is close to the inlet lens side, the inner diameters of holes of the channel section are equal, the focusing section is close to the outlet lens side, and the inner diameter of the hole of the focusing section is gradually reduced along the direction from the inlet lens to the outlet lens.
6. The ion funnel-based collision reaction cell of claim 1, wherein: the metal pole pieces of the ion funnel are arranged in an off-axis mode.
7. The ion funnel based collision reaction cell of claim 6, wherein: the ion channel of the ion funnel comprises a circular arc-shaped ion channel.
8. The ion funnel-based collision reaction cell of claim 7, wherein: the inlet lens is coaxial with the inlet of the ion funnel, and the outlet lens is coaxial with the outlet of the ion funnel.
9. The ion funnel-based collision reaction cell of claim 7, wherein: the ion source comprises an ion channel inlet, an ion channel outlet and an ion channel inlet, and is characterized by further comprising an inlet ion channel section and an outlet ion channel section, wherein the inlet ion channel section and the outlet ion channel section comprise a plurality of metal pole pieces, the inner hole diameter of the inlet ion channel section is equal to the inner hole diameter of the ion channel inlet, and the inner hole diameter of the outlet ion channel section is equal to the inner hole diameter of the ion channel outlet.
10. The ion funnel-based collision reaction cell according to claim 7, wherein the arc-shaped ion channel is a 90 ° arc-shaped ion channel or a 180 ° arc-shaped ion channel.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222180576.3U CN218039096U (en) | 2022-08-18 | 2022-08-18 | Collision reaction tank based on ion funnel |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202222180576.3U CN218039096U (en) | 2022-08-18 | 2022-08-18 | Collision reaction tank based on ion funnel |
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| CN218039096U true CN218039096U (en) | 2022-12-13 |
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| CN202222180576.3U Active CN218039096U (en) | 2022-08-18 | 2022-08-18 | Collision reaction tank based on ion funnel |
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Effective date of registration: 20240328 Address after: Building 4, No.16 Wujing Road, development zone, Dongli District, Tianjin Patentee after: Tianjin Guoke Medical Technology Development Co.,Ltd. Country or region after: China Patentee after: Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Address before: Building 4, No.16 Wujing Road, development zone, Dongli District, Tianjin Patentee before: Tianjin Guoke Medical Technology Development Co.,Ltd. Country or region before: China |
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