CN217910519U

CN217910519U - Kit and micro-fluidic medical analyzer

Info

Publication number: CN217910519U
Application number: CN202221287468.XU
Authority: CN
Inventors: 孟杰; 余波; 罗伟; 章铖皓; 魏峰
Original assignee: Zhejiang Pushkang Biotechnology Co ltd
Current assignee: Zhejiang Pushkang Biotechnology Co ltd
Priority date: 2022-05-23
Filing date: 2022-05-23
Publication date: 2022-11-29
Anticipated expiration: 2032-05-23

Abstract

The application discloses kit and medical micro-fluidic analyzer. The kit comprises a kit body, a first reagent bottle and a second reagent bottle. The box body is provided with at least one first positioning part and a plurality of second positioning parts, and the first positioning parts and the second positioning parts are arranged at intervals along the same circumference; at least one first reagent bottle is arranged, and the first reagent bottles are arranged on the first positioning part in a one-to-one correspondence manner; the second reagent bottle is a plurality of, the second reagent bottle set up in one-to-one correspondence in second location portion. The reagent needle can solve the problem that the difficulty of controlling the reagent needle for microfluidic medical analysis in the related technology is high when the reagent needle sucks the reagent.

Description

Kit and micro-fluidic medical analyzer

Technical Field

The application relates to the technical field of medical instruments, in particular to a kit and a micro-fluidic medical analyzer.

Background

In a microfluidic medical analyzer, such as a luminescence immunoassay analyzer, a reagent such as a magnetic bead or an enzyme label is loaded on a cartridge loading tray via a cartridge. At present, the reagent bottles used for loading magnetic beads and loading enzyme labels on the reagent kit are all arranged along the same straight line, in the process of practical use, after the reagent kit loading disc rotates to a certain position each time, the position of a reagent needle is required to be continuously controlled to align the reagent bottles, the positions of the reagent needles when the reagent needles absorb different reagents are different, the control difficulty of a controller of the micro-fluidic medical analyzer on the reagent needles is high, and the control logic is complex.

Disclosure of Invention

The main purpose of this application is to provide a kit and micro-fluidic medical analysis appearance to control the problem that the degree of difficulty is great when solving the medical analytic reagent needle aspiration reagent of micro-fluidic among the correlation technique.

According to an aspect of embodiments herein, there is provided a kit comprising:

the positioning device comprises a box body, a positioning device and a positioning device, wherein at least one first positioning part and a plurality of second positioning parts are arranged on the box body, and the first positioning parts and the second positioning parts are arranged at intervals along the same circumference; and

at least one first reagent bottle is arranged on the first positioning part in a one-to-one correspondence manner; and

the second reagent bottle, the second reagent bottle is a plurality of, the second reagent bottle one-to-one set up in second location portion.

Further, the cross section of the box body is an arc surface, and the first positioning portion and the second positioning portion are arranged at intervals along the circumferential direction of the arc surface.

Furthermore, the first positioning portion and the second positioning portion are positioning holes, and the positioning holes extend along the height direction of the box body and penetrate through the box body.

Further, the first reagent bottle includes:

the bottle body penetrates through the first positioning part from the bottom of the first positioning part and is limited by the limiting part; and

the bottle cap is buckled on the bottle body and cooperates with the limiting part to limit the bottle body on the box body.

Furthermore, one side of the bottle cap close to the bottle body is provided with an annular convex part, the end part of the annular convex part is provided with a conical surface, and when the bottle cap is arranged on the bottle body, the annular convex part is inserted into the bottle opening of the bottle body and seals the bottle opening of the bottle body through the conical surface.

Furthermore, the bottom of the bottle body is provided with a connecting portion, the connecting portion is used for being connected with a driving piece to drive the bottle body to rotate in the first positioning portion, and the bottom of the box body is provided with an avoiding portion for avoiding the driving piece.

Furthermore, the inside wall face of body is provided with vortex portion.

Further, the second location portion is a location hole, and the second reagent bottle includes:

a bottle body detachably disposed at the second positioning portion; and

the cover body covers the bottle body, and the outer diameter of the cover body is not smaller than the aperture of the positioning hole.

Further, the periphery of box body is provided with spacing outward flange.

On the other hand, the application also discloses a microfluidic medical analyzer, which comprises a kit, wherein the kit is the kit.

Compared with the prior art, the technical scheme of the application has at least the following technical effects:

when the reagent box loading disc is actually used, the reagent box is installed on the reagent box loading disc, and after the reagent box loading disc is installed, the circumference formed by the first positioning part and the second positioning part is consistent with the circumference of the reagent box loading disc. In this way, when the reagent cartridge loading tray is rotated, the first reagent bottle and the second reagent bottle mounted on the first positioning portion and the second positioning portion may be driven to rotate, so that one of the first reagent bottle or the second reagent bottle is rotated to a predetermined position, and then the reagent needle assembly is controlled to move, so that the reagent in the first reagent bottle or the second reagent bottle may be sucked.

Because first location portion and second location portion in this application are along same circumference arrangement, when needs add different reagent, only need control kit load dish and rotate preset position, move reagent needle subassembly to this preset position directly over simultaneously, can absorb the reagent, control mode is simple, can reduce the control cost of micro-fluidic medical analysis appearance.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:

fig. 1 is a schematic structural diagram of a microfluidic medical analyzer disclosed in an embodiment of the present application;

FIG. 2 is a schematic perspective view of a kit disclosed in an embodiment of the present application;

FIG. 3 is a front view of a kit disclosed in embodiments of the present application;

FIG. 4 is a bottom view of a kit disclosed in embodiments herein;

FIG. 5 is a top view of a kit disclosed in embodiments herein;

FIG. 6 is a schematic structural diagram of a cartridge body of the kit disclosed in the embodiments of the present application;

fig. 7 is a schematic perspective view of a bottle cap according to an embodiment of the present disclosure;

FIG. 8 is a cross-sectional view of FIG. 7;

FIG. 9 is a schematic structural diagram of a bottle body disclosed in an embodiment of the present application;

FIG. 10 is a cross-sectional view of the body of FIG. 9;

FIG. 11 is a side view of a body disclosed in an embodiment of the present application;

FIG. 12 is a schematic view of a bottle disclosed in the examples of the present application;

fig. 13 is a cross-sectional view of fig. 12.

Wherein the figures include the following reference numerals:

10. a box body; 11. a first positioning portion; 12. a second positioning portion; 13. a limiting outer flange; 14. an avoidance part; 20. a first reagent bottle; 21. a bottle body; 211. a connecting portion; 212. a spoiler portion; 213. a limiting part; 22. a bottle cap; 221. an annular protrusion; 222. a conical surface; 30. a second reagent bottle; 31. a bottle body; 32. a cover body; 40. a reagent cartridge loading tray; 50. a detection module; 60. a reagent needle module; 61. a slide rail assembly; 62. a drive assembly; 63. a reagent needle assembly; 70. and a frame.

Detailed Description

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The relative arrangement of the components and steps, the numerical expressions, and numerical values set forth in these embodiments do not limit the scope of the present application unless specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective portions shown in the drawings are not drawn in an actual proportional relationship for the convenience of description. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be discussed further in subsequent figures.

Referring to fig. 1, according to an embodiment of the present application, there is provided a microfluidic medical analyzer including a rack 70, a cartridge loading tray 40, a detection module 50, and a reagent needle module 60.

Wherein the reagent cartridge loading tray 40 and the detecting module 50 are disposed side by side on the rack 70, and the reagent needle module 60 is disposed on the rack 70 above the reagent cartridge loading tray 40 and the detecting module 50. Specifically, the reagent cartridge loading tray 40 is driven by a motor or the like and is rotatable on the rack 70, and the reagent cartridges are detachably set on the reagent cartridge loading tray 40. The detection module 50 is provided with a rotatable tray for placing the microfluidic disc, and a detection assembly, and the like, and when the tray rotates, the tray can drive the microfluidic disc to rotate so as to separate and react samples such as blood filled in the microfluidic disc. The reagent needle module 60 comprises a slide rail assembly 61, a driving assembly 62 and a reagent needle assembly 63, wherein the slide rail assembly 61 is arranged on the rack 70, the driving assembly 62 is in driving connection with the reagent needle assembly 63 to drive the reagent needle assembly 63 to move along the slide rail assembly 61, and when the reagent needle assembly 63 moves along the slide rail assembly 61, the reagent needle assembly 63 moves two-dimensionally along the slide rail assembly 61, that is, the reagent needle assembly 63 can move along the horizontal direction and the vertical direction of the rack 70.

During actual work, a reagent box is placed on the reagent box loading disc 40, the microfluidic disc is placed on the tray, then the reagent box loading disc 40 is rotated to enable the reagent box to rotate to a certain position, the reagent needle assembly 63 is controlled to move to the position above the reagent box loading disc 40 to suck reagents and samples, the reagents and the samples are filled into the microfluidic disc, the tray rotates to enable the samples such as blood and the like filled in the microfluidic disc to be separated and reacted, and then the samples are detected through the detection assembly on the detection module 50.

In the present application, the reagent kit comprises a kit body 10, a first reagent bottle 20 and a second reagent bottle 30, wherein at least one first positioning portion 11 and a plurality of second positioning portions 12 are arranged on the kit body 10, and the first positioning portion 11 and the second positioning portions 12 are arranged at intervals along the same circumference; at least one first reagent bottle 20 is provided, and the first reagent bottles 20 are arranged on the first positioning parts 11 in a one-to-one correspondence manner; the second reagent bottles 30 are provided in a plurality, and the second reagent bottles 30 are provided in the second positioning portion 12 in one-to-one correspondence.

In actual use, the reagent cartridge is mounted on the reagent cartridge loading tray 40, and after mounting, the circumference formed by the first positioning portion 11 and the second positioning portion 12 coincides with the circumference of the reagent cartridge loading tray 40. In this way, when the reagent cassette loading tray 40 is rotated, the first reagent bottle 20 and the second reagent bottle 30 mounted on the first positioning portion 11 and the second positioning portion 12 are rotated, so that one of the first reagent bottle 20 or the second reagent bottle 30 is rotated to a predetermined position, and then the reagent needle assembly 63 is controlled to move, so that the reagent in the first reagent bottle 20 or the second reagent bottle 30 can be sucked.

Because the first positioning portion 11 and the second positioning portion 12 in this embodiment are arranged along the same circumference, when different reagents need to be added, the reagent can be sucked only by controlling the reagent cartridge loading tray 40 to rotate to a predetermined position and moving the reagent needle assembly 63 to a position right above the predetermined position, and the control method is simple and can reduce the control cost of the microfluidic medical analyzer.

Referring to fig. 1 to 6, the cross section of the box 10 in this embodiment is an arc surface, that is, the box 10 is an arc-shaped box structure, and when the box is processed, the first positioning portion 11 and the second positioning portion 12 are arranged along the circumferential direction of the arc surface, so that the structure is stable and reliable. Of course, in other embodiments of the present application, the case 10 may also be provided in a cylindrical or prismatic shape as long as it is ensured that the first positioning portions 11 and the second positioning portions 12 are arranged in the same circumferential direction.

Specifically, the first positioning portion 11 and the second positioning portion 12 in this embodiment are positioning holes, which extend along the height direction of the cassette 10 and penetrate through the cassette 10, so as to facilitate mounting and supporting the first reagent bottle 20 and the second reagent bottle 30. In a specific embodiment of the present application, the first positioning portion 11 is provided as one, the second positioning portion 12 is provided as two, and correspondingly, the first reagent bottle 20 is provided as one, the first reagent bottle 20 is a magnetic bead bottle, the second reagent bottle 30 is provided as two, and the second reagent bottle 30 is an elisa bottle, and when the reagent bottle is mounted, the first reagent bottle 20 is detachably mounted at the first positioning portion 11, and the second reagent bottle 30 is detachably mounted at the second positioning portion 12. The outer periphery of the cassette body 10 is provided with a limit outer flange 13, and the reagent cartridge can be mounted on the reagent cartridge loading tray 40 by the operation of the limit outer flange 13. Specifically, the reagent box loading tray 40 is provided with an installation groove, when the reagent box is installed, the reagent box is placed in the installation groove, when the reagent box is installed in place, the limiting outer flange 13 is erected on the upper surface of the reagent box loading tray 40, the bottom of the reagent box and the bottom of the installation groove are separated by a certain distance, and the first reagent bottle 20 and the second reagent bottle 30 are prevented from being damaged due to the fact that the bottom of the first reagent bottle 20 or the second reagent bottle 30 touches the bottom of the installation groove.

As shown in fig. 2, 3, 6 to 9, the first reagent bottle 20 in the present embodiment includes a bottle body 21 and a bottle cap 22, a limiting portion 213 is disposed on an outer periphery of the bottle body 21, and the bottle body 21 passes through the first positioning portion 11 from a bottom of the first positioning portion 11 and is limited by the limiting portion 213; the bottle cap 22 is fastened to the bottle body 21 and cooperates with the limiting portion 213 to limit the bottle body 21 to the box 10. That is, during assembly, the bottle body 21 passes through the positioning hole from the bottom of the first positioning portion 11, that is, the positioning hole, and then the bottle cap 22 covers the bottle body 21 from the top of the positioning hole, and the bottle body 21 is limited on the box body 10 by the bottle cap 22 and the limiting portion 213, so that the structure is stable and reliable.

Alternatively, the limiting portion 213 in this embodiment may be an external annular flange disposed along the outer periphery of the body 21, or may be a limiting block, and any other modifications under the concept of this application are within the scope of this application. The outer diameter of the bottle cap 22 is larger than the diameter of the positioning hole, and can cooperate with the limiting portion 213 to limit the bottle body 21 on the box body 10.

Further, in the present embodiment, the side of the bottle cap 22 close to the bottle body 21 is provided with an annular convex portion 221, an end of the annular convex portion 221 is provided with a conical surface 222, and when the bottle cap 22 is covered on the bottle body 21, the annular convex portion 221 is inserted into the mouth of the bottle body 21 and seals the mouth of the bottle body 21 through the conical surface 222. In actual processing, the annular protrusion 221 and the bottle cap 22 are integrally formed, and the mouth of the bottle body 21 is sealed by the conical surface 222 of the annular protrusion 221, compared with a mode of sealing the mouth by using a sealing ring or the like, the sealing performance of the mode of sealing the mouth by the conical surface 222 on the annular protrusion 221 in the present application is better, and the sealing ring is usually a plastic ring, and is easy to chemically react with the reagent in the first reagent bottle 20, that is, the mode of sealing the mouth by using the conical surface 222 on the annular protrusion 221 in the present application can also play a role of preventing the reagent in the first reagent bottle 20 from deteriorating.

Referring to fig. 7 to 11, the bottle cap 22 and the bottle body 21 may be connected by a thread, a snap assembly, or the like, and the structure is stable and reliable.

Because the first reagent bottle 20 is a magnetic bead bottle, during use, it is necessary to mix magnetic beads in the magnetic bead bottle, therefore, the bottom of the bottle body 21 in this embodiment is provided with the connecting portion 211, and this connecting portion 211 is used for being connected with a driving member (for example, a driving motor, a driving gear, and other structures) to drive the bottle body 21 to rotate in the first positioning portion 11, so as to mix the magnetic beads in the magnetic bead bottle. Optionally, connecting portion 211 can be protruding muscle encloses the groove structure who establishes the formation, during actual design, is the motor of setting in frame 70 with the driving piece, this motor and connecting portion 211 between through the gear assembly with set up the spliced pole on the gear assembly and be connected, when the motor rotates, can drive gear assembly and body 21 and rotate, and then can carry out the mixing to the magnetic bead in the first reagent bottle 20. Optionally, the bottom of the box 10 is provided with an avoiding portion 14 for avoiding the driving member, and the avoiding portion 14 may be an avoiding notch or the like.

Optionally, the inner side wall surface of the bottle body 21 in this embodiment is provided with the spoiler 212, so that when the bottle body 21 rotates, the magnetic beads in the bottle body 21 can be effectively mixed. Illustratively, the spoiler 212 may be a spoiler rib or a spoiler protrusion.

Referring to fig. 2 to 6, 12 and 13, the second reagent bottle 30 of the present embodiment includes a bottle body 31 and a cover 32, wherein the bottle body 31 is detachably disposed on the second positioning portion 12; the lid 32 covers the bottle 31, and the outer diameter of the lid 32 is not smaller than the diameter of the positioning hole at the second positioning portion 12, so that the second reagent bottle 30 can be limited at the second positioning portion 12 by the lid 32. In order to seal the mouth of the bottle body 31, the cap 32 in this embodiment may also be provided with an annular protrusion, and a conical surface is provided at the end of the annular protrusion, so that when the cap 32 is covered on the bottle body 31, the annular protrusion is inserted into the mouth of the bottle body 31 and seals the mouth of the bottle body 31 via the conical surface.

From the above description, it can be seen that the above-described embodiments of the present application achieve the following technical effects: when the reagent box loading disc is actually used, the reagent box is installed on the reagent box loading disc, and after the reagent box loading disc is installed, the circumference formed by the first positioning part and the second positioning part is consistent with the circumference of the reagent box loading disc. In this way, when the reagent cartridge loading tray is rotated, the first reagent bottle and the second reagent bottle mounted on the first positioning portion and the second positioning portion may be driven to rotate, so that one of the first reagent bottle or the second reagent bottle is rotated to a predetermined position, and then the reagent needle assembly is controlled to move, so that the reagent in the first reagent bottle or the second reagent bottle may be sucked.

Because the first positioning part and the second positioning part in the embodiment are arranged along the same circumference, when different reagents need to be added, the reagent can be sucked only by controlling the reagent box loading disc to rotate to a preset position and moving the reagent needle assembly right above the preset position, the control mode is simple, and the control cost of the microfluidic medical analyzer can be reduced.

For ease of description, spatially relative terms such as "over 8230 \ 8230;,"' over 8230;, \8230; upper surface "," above ", etc. may be used herein to describe the spatial relationship of one device or feature to another device or feature as shown in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary terms "at 8230; \8230; 'above" may include both orientations "at 8230; \8230;' above 8230; 'at 8230;' below 8230;" above ". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

It should be noted that the terms "first", "second", and the like are used to define the components, and are only used for convenience of distinguishing the corresponding components, and the terms have no special meanings unless otherwise stated, and therefore, the scope of protection of the present application is not to be construed as being limited.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A kit, comprising:

the box body (10) is provided with at least one first positioning part (11) and a plurality of second positioning parts (12), and the first positioning part (11) and the second positioning parts (12) are arranged at intervals along the same circumference; and

at least one first reagent bottle (20), wherein the first reagent bottles (20) are arranged on the first positioning parts (11) in a one-to-one correspondence manner; and

a plurality of second reagent bottles (30), wherein the second reagent bottles (30) are arranged in the second positioning portion (12) in a one-to-one correspondence manner.

2. The reagent kit according to claim 1, wherein the cross section of the box body (10) is a circular arc surface, and the first positioning portion (11) and the second positioning portion (12) are arranged at intervals along the circumferential direction of the circular arc surface.

3. The reagent cartridge according to claim 1, wherein the first positioning portion (11) and the second positioning portion (12) are each a positioning hole extending in the height direction of the cartridge body (10) and penetrating the cartridge body (10).

4. The kit according to claim 1, characterized in that the first reagent bottle (20) comprises:

the bottle comprises a bottle body (21), wherein a limiting part (213) is arranged on the periphery of the bottle body (21), and the bottle body (21) penetrates through the first positioning part (11) from the bottom of the first positioning part (11) and is limited by the limiting part (213); and

the bottle cap (22) is buckled on the bottle body (21) and cooperates with the limiting part (213) to limit the bottle body (21) on the box body (10).

5. The kit according to claim 4, characterized in that an annular convex part (221) is arranged on one side of the bottle cap (22) close to the bottle body (21), a conical surface (222) is arranged at the end part of the annular convex part (221), and when the bottle cap (22) is covered on the bottle body (21), the annular convex part (221) is inserted into the bottle opening of the bottle body (21) and seals the bottle opening of the bottle body (21) through the conical surface (222).

6. The reagent kit according to claim 4, characterized in that the bottom of the bottle body (21) is provided with a connecting part (211), the connecting part (211) is used for connecting with a driving part to drive the bottle body (21) to rotate in the first positioning part (11), and the bottom of the box body (10) is provided with an avoiding part (14) for avoiding the driving part.

7. The reagent kit according to claim 4, characterized in that the inner side wall surface of the bottle body (21) is provided with a flow disturbing part (212).

8. The reagent cartridge according to claim 1, wherein the second positioning portion (12) is a positioning hole, and the second reagent bottle (30) includes:

a bottle body (31), wherein the bottle body (31) is detachably arranged on the second positioning part (12); and

the bottle body (31) is covered by the cover body (32), and the outer diameter of the cover body (32) is not smaller than the diameter of the positioning hole.

9. Kit according to any of claims 1 to 8, characterized in that the outer periphery of the box (10) is provided with a limiting outer flange (13).

10. A microfluidic medical analyser comprising a kit, characterised in that the kit is as claimed in any one of claims 1 to 9.