CN103630696A - Reagent container - Google Patents
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- CN103630696A CN103630696A CN201310363406.1A CN201310363406A CN103630696A CN 103630696 A CN103630696 A CN 103630696A CN 201310363406 A CN201310363406 A CN 201310363406A CN 103630696 A CN103630696 A CN 103630696A
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Abstract
The present invention provides a reagent container used to store an automatic analysis device, which includes a neck with an opening that located at an upper portion of the reagent container; a reagent storage portion for storing the reagent; a middle part of the reagent storage section that is connected with the neck. The reagent storage portion comprises a width between the inner surfaces gradually upward from the bottom of a first enlarged portion becomes large, and the width between the inner surface of the first expanded portion of the upwardly tapered portion becomes smaller. Moreover, the middle part comprises a narrow intermediate portion upwardly from said second enlarged progressively larger portion including an upper end portion of the width between the inner surfaces. The narrow portion at a boundary portion and the second enlarged portion in the circumferential inner surface of the container out direction.
Description
Technical field
The present invention relates to a kind of for holding the reagent container for the reagent of automatic analysing apparatus, particularly relate to a kind of reagent container for following automatic analysing apparatus: this automatic analysing apparatus has the reagent assembled portion of assembling reagent container and inhales from the reagent container being placed on reagent assembled portion the transfer pipet that moves reagent, and this automatic analysing apparatus assigns to stir the reagent in reagent container by mobile reagent department of assembly, with transfer pipet, inhale and move the reagent after stirring and use it for analysis.
Background technology
Reagent container for automatic analysing apparatus is widely known by the people.
On TOHKEMY (patent is open) 2007-147658 communique, a kind of reagent container using for analyzing the automatic analysing apparatus of clinical sample that is arranged on is disclosed.Reagent container is the cylindric vial of bottom flat, and upper end is provided with opening.In reagent container, hold the aqueous reagent containing fine particle.Therefore, a minute installed reagents need to stir reagent to fine particle is broken up while analyzing, and makes concentration even.In the device of describing at JP (Japanese Patent Publication) 2007-147658, reagent container is placed on to turntable (reagent assembled portion) upper, revolving-turret stirs the fine particle in reagent container.In using the automatic analysing apparatus of this reagent, widely used structure is to use transfer pipet (volumetric pipette) suction with liquid level detection function move the reagent in reagent container and carry out packing.
Yet, in JP (Japanese Patent Publication) 2007-147658, there is following problems: device stirs after the reagent in reagent container, stirring can make reagent solution rise along container inner face, and reagent arrives after vessel port, and liquid forms a film at opening part.Opening part forms a film, inserts while thering is the transfer pipet (volumetric pipette) of liquid level detection function, and by film flase drop, be likely liquid level.The flase drop of liquid level can cause reagent packing failure or dispensed loading amount deficiency, hinders automatic analysis, so people need to prevent that reagent solution from arriving vessel port place.
The present invention is just in order to solve above-mentioned problem, and one of object of the present invention is to provide a kind of reagent container, and this reagent container can prevent when stirring reagent that reagent from arriving vessel port.
Summary of the invention
For achieving the above object, the reagent container of the first level of the present invention is a kind of reagent container of taking in for the reagent of automatic analysing apparatus, it has: be positioned at reagent container top and have the neck of opening, take in the reagent containing section of reagent, the center section that connects neck and reagent containing section, reagent containing section comprises that the width between inner face upwards becomes the first large enlarged gradually from inner bottom part, and the width between inner face from the first enlarged, upwards diminish gradually dwindle part, center section comprises that the width between inner face upwards becomes the second large enlarged gradually from dwindling the upper end of part, be positioned to dwindle partly and along the circumferential direction extend at container inner face with the narrow of the second enlarged boundary.In the present invention, so-called " along the circumferential direction extending " is not limited only to narrow and at container inner face, along its whole circumference, extends into the situation of ring-type, the two ends of the ring-type that narrow forms can be also (such as being also that the two ends of narrow are non-intersect, the staggering up and down) disconnecting.The invention is not restricted to comprise that the narrow along the circumferential direction extending is this continuous situation, also comprise the structure that narrow extends by spells in the form of a ring.
In the reagent container of the first level of the present invention, as mentioned above, be positioned at and dwindle part and the narrow of the second enlarged boundary by along the circumferential direction extending and form at container inner face, so just can make moving direction along the reagent of container inner face rising at narrow towards container center.In addition, from narrow, be upwards provided with the second enlarged, the moving direction of reagent is at narrow towards center, and on the other hand, container inner face can be expanded to outside of containers.Therefore, the reagent of attempting to cross along container inner face narrow still keeps moving direction towards the state of container center at narrow, and under this state, departs from container inner face, returns to reagent containing section.With this, even if reagent rises along container inner face along with stirring operation, reagent also can not be crossed narrow and rise, thereby in the time of can preventing from stirring reagent, reagent arrives neck (vessel port).With this, just can avoid the liquid that arrives vessel port to form a film at opening part.In said structure, liquid is difficult to move up from reagent containing section, and the drop producing while falling again after therefore can confined liquid moving up, can prevent that with this reagent containing section internal cause from stirring and producing bubble.
In addition, in the past, in order to prevent that liquid from arriving opening part, people take is the amount that reduces the reagent being equipped with in reagent containing section, reduce the countermeasure of liquid level etc., and in the present invention, even if also can effectively prevent that when liquid level is higher liquid from arriving opening part, compared with the pastly can increase the amount of reagent that reagent containing section is taken in.Therefore, the replacement frequency of reagent container can be reduced, by reducing the discarded amount of container, just the burden causing to environment can be alleviated.
In the reagent container of above-mentioned the first level, preferably arrange as follows: narrow is substantially and is horizontally disposed with.In structure like this, for example, when narrow is oblique to oblique inclination, reagent is likely along the oblique rising in its inclined-plane, and substantially for the narrow of level can make moving direction along the reagent of container inner face rising conscientiously towards container center.With this, can more effectively prevent that reagent from crossing narrow and rising.
In the reagent container of above-mentioned the first level, preferably arrange as follows: the inner face from the inner bottom part of reagent containing section to the narrow of coupling part consists of the curved surface of smooth connection.In structure like this, in reagent containing section, can not be formed with the jump of corner angle and angle etc., such as when reagent contains fine particle, particle can not concentrate on part (jump and Jiao Chu) accumulation in reagent containing section.While stirring with this, just can stir more equably the reagent in reagent containing section.
Preferably arrange as follows in the case: the interior shape of reagent containing section is the shape that is substantially sphere that comprises the first enlarged and dwindle part.In structure like this, reagent containing section inside can not form jump and angle etc., therefore can prevent particle set in local (jump and Jiao Chu) and pile up.Therefore in addition, when reagent reduces along with use, reagent also can concentrate on the inner bottom surface of the reagent containing section of dome shape, can reduce transfer pipet etc. and can not inhale the amount of reagent (so-called dead volume, dead space volume) of moving.
In the reagent container of above-mentioned the first level, preferably arrange as follows: the horizontal section area of center section is dwindled to neck gradually from the position of the second enlarged top.In structure like this, in the structure that is provided with the second enlarged, also can prevent that container from maximizing.
Preferably arrange as follows in the case: at least a portion of center section has the inner face that is substantially polygon shape on horizontal section.In structure like this, if reagent is along rising on rotation limit, container inner face limit when stirring, even when a part of reagent is crossed narrow and arrived center section, the inner face of polygon shape that also can be by center section stops reagent to rotate along container inner face.With this, even if having crossed narrow, part reagent also can prevent that reagent from arriving neck.
Inner face at above-mentioned center section has preferably setting as follows in the structure that is substantially polygon shape in horizontal section: the shape that the inner face that is substantially polygon shape of center section has ，Gai angle part, angle part is fillet.In structure like this, although center section has the inner face that is substantially polygon shape, angle part is not acute angle, such as when reagent contains fine particle, can prevent that particle is in the accumulation of the angle part of center section.
At the inner face of above-mentioned center section, in being the structure of polygon shape substantially, horizontal section preferably arranges as follows: polygon is shaped as triangular shaped.In structure like this, polygonal angle (summit) of the inner face on horizontal section is fewer, and reagent moving direction when reagent spirals along container inner face changes will be greatly, and therefore, leg-of-mutton inner face can prevent that reagent from rotating along container inner face effectively.
In the reagent container of above-mentioned the first level, preferably arrange as follows: the horizontal section of narrow is larger than the sectional area of the horizontal section of neck.In structure like this, if the horizontal section area of narrow is too little, just likely equally with neck (opening) at narrow, form reagent membrane, so allow the sectional area of horizontal section of narrow be greater than the horizontal section of neck, so just can prevent that reagent from forming film at narrow.
In the reagent container of above-mentioned the first level, preferably arrange as follows: reagent containing section and narrow have circular horizontal section, in the first enlarged, the first radius r 1 of the upper end of horizontal section maximum and the second radius r 2 of narrow meet r2/r1 and equal more than 0.50 below 0.95.At this, r2/r1 is less, is more conducive to the moving direction of the reagent that rises at narrow towards container center, more be conducive to prevent that reagent from arriving neck (opening), but if r2/r1 is too small, the internal diameter of narrow can be too small, and reagent may form film at narrow.Therefore, as shown in the present, r2/r1 equals more than 0.50, below 0.95, so neither can to form reagent membrane at narrow, can obtain again suitable container shapes and effectively prevent that reagent from arriving neck (opening).
In the reagent container of above-mentioned the first level, preferably arrange as follows: also have and comprise the container body of neck, reagent containing section and center section and make container body be supported for the brace table of erectility.At this, while being dome shape such as the inner face when reagent containing section, if container inner wall thickness is certain, the outside of reagent containing section is also dome shape, and therefore, container body is difficult to the state of being kept upright separately.Now, brace table is set container body is supported for to erectility, so just can make container body stably be supported for erectility, therefore can carry out like a cork the automated reagent packing of analytical equipment.
In the reagent container of above-mentioned the first level, preferably arrange as follows: pack is containing solvent and insoluble composition.The reagent that comprises solvent and insoluble composition must be distributed to insoluble composition equably in solvent when packing, therefore, needs to stir during use.In the present invention, while stirring reagent, can prevent that reagent from arriving neck (vessel port), therefore can provide a kind of reagent container that is applicable to holding the reagent that contains solvent and insoluble composition.
Now also can arrange as follows: insoluble composition is magnetic particle.
In the reagent container of above-mentioned the first level, preferably arrange as follows: reagent container is assemblied in the reagent assembled portion that can move and uses, the mobile operating by reagent assembled portion stirs the reagent in reagent container.In structure like this, even when reagent assembled portion is moved and is stirred together with reagent container, also in the time of preventing from stirring reagent, reagent arrives neck (vessel port), and therefore reagent container of the present invention is applicable to have the automatic analysing apparatus of this reagent assembled portion.
Now preferably arrange as follows: reagent container stirs reagent by the mobile operating of the circumferencial direction centered by the axle by reagent assembled portion, and wherein said reagent assembled portion can be assembled along the circumference centered by axle a plurality of reagent containers.In structure like this, even if being assembled to, concentrates in the reagent assembled portion that stirs a plurality of reagent containers reagent container, in the time of also preventing from stirring reagent, reagent arrives neck (vessel port).
In the reagent container of above-mentioned the first level, preferably arrange as follows: the transfer pipet that reagent container can detect the automatic analysing apparatus of liquid level according to the variation of the electric capacity of the transfer pipet consisting of conductive material inserts from opening.In structure like this, in the time of can preventing from stirring reagent, reagent arrives neck (vessel port), can also avoid the reagent that arrives vessel port to form film at opening part, therefore, even when the transfer pipet (volumetric pipette) with liquid level detection function is inserted to reagent container, also can prevent that the reagent that arrives opening from forming film and causing the error-detecting to liquid level.
The reagent container of the present invention's the second aspect is a kind of reagent container of taking in for the reagent of automatic analysing apparatus, it has: at the neck that has opening on reagent container top, for taking in the reagent containing section of reagent and the center section that connects neck and reagent containing section, at the inwall that is shaped as the left and right sides of vertical cross-section, the bound fraction towards reagent containing section and center section shrinks reagent containing section to the inside, and center section has the sectional area of the horizontal section of a part to be greater than the part of contraction.
In the reagent container of the present invention's the second aspect, as mentioned above, reagent containing section is set on reagent container, the inwall that be shaped as the left and right sides of this reagent containing section on vertical cross-section shrinks to the inside towards the bound fraction of reagent containing section and center section, the moving direction that so just can make the reagent that rises along container inner face in constriction towards container center.Center section is set on reagent container, and some sectional area in horizontal section of this center section is greater than constriction, with this, makes container inner face to outside of containers, expand (horizontal section increase) at center section.Thus, the reagent rising to center section along container inner face from constriction still keeps moving direction towards container center at bound fraction, and under this state, departs from container inner face, returns to reagent containing section.With this, even if reagent along with stirring while rising along container inner face, also can prevent reagent, cross bound fraction and rise, reagent arrival neck (vessel port) in the time of therefore can preventing from stirring reagent.With this, just can avoid the liquid that arrives vessel port to form film at opening.In addition, in said structure, liquid is difficult to move on to the upside of reagent containing section, and the drop therefore can confined liquid moving up while falling again also can prevent that reagent containing section inside from producing bubble because of stirring.
The reagent container of the present invention's the 3rd aspect is a kind of reagent container of taking in for the reagent of automatic analysing apparatus, and described reagent container comprises the following part (a) to (c) that starts from top to be connected successively and arrange: the neck that (a) comprises the opening of described reagent container; (b) the first trunk; (c) the second trunk of the bottom of taking in reagent and comprising reagent container; Wherein the boundary of the first trunk and the second trunk is provided with and tightens up part, and the more approaching part of tightening up of the inwall of the second trunk is more crooked, so that the mobile deflection internal diameter direction of the liquid rising along internal face while rocking reagent container.
The reagent container of the present invention's the 4th aspect is a kind of reagent container of taking in for the reagent of automatic analysing apparatus, it has: the box of taking in the container body of reagent and surrounding container body, and described container body comprises and from top, starts the following part (a) to (c) that is connected successively and arranges: the neck that (a) comprises the opening of described container body; (b) the first trunk; (c) the second trunk of the bottom of taking in reagent and comprising reagent container; Wherein the boundary of the first trunk and the second trunk is provided with and tightens up part, and the more approaching part of tightening up of the inwall of the second trunk is more crooked, so that the mobile deflection internal diameter direction of the liquid rising along internal face while rocking reagent container.
The reagent container of layer 5 face of the present invention is a kind of reagent container of taking in for the reagent of automatic analysing apparatus, it has the trunk that there is the neck of opening on top and is located at neck below, trunk is tightened up part and is divided into upper portion and lower portion, lower portion is taken in reagent, from bottom, near tightening up the process of part, then the horizontal sectional area of lower portion first dwindles to lateral spread.
Accompanying drawing explanation
Fig. 1 is the oblique view of the reagent container outward appearance of an embodiment of the present invention;
Fig. 2 is the oblique view of the container body of the reagent container of an embodiment shown in Fig. 1;
Fig. 3 is the longitudinal section key diagram of container body structure shown in Fig. 2;
Fig. 4 is the schematic top plan view of container body structure shown in Fig. 2;
Fig. 5 is the longitudinal section schematic diagram of the use form during for analytical equipment by the reagent container of an embodiment of the present invention;
Fig. 6 is the floor map of an example of the analytical equipment of the reagent container of use an embodiment of the present invention;
Fig. 7 is the oblique view of an example of the reagent placement part of analytical equipment shown in Fig. 6;
Fig. 8 is the key diagram of the stirring operation of the R2 reagent in reagent placement part shown in Fig. 7;
Fig. 9 be in the stirring operation of R2 reagent reagent at the explanation schematic diagram of narrow motion;
Figure 10 is that R2 reagent stirs in operation reagent at the explanation schematic diagram of the motion in tapering;
Figure 11 is the longitudinal section schematic diagram of variation of the reagent container of an embodiment of the present invention;
Figure 12 is the horizontal section schematic diagram of narrow of variation of the reagent container of an embodiment of the present invention.
Embodiment
The specific embodiment of the present invention is described below with reference to the accompanying drawings.
First with reference to Fig. 1 ~ Fig. 5, with regard to the one-piece construction of the reagent container 1 of an embodiment of the present invention, describe.In the present embodiment, by the present invention, for a kind of reagent container 1 of installed reagents, wherein said reagent is the reagent that automatic analysing apparatus that antigen contained in blood equal samples to determination object blood samples such as () serum and antibody etc. are measured is used.
The reagent container 1 of present embodiment as depicted in figs. 1 and 2, has container body 2(with reference to Fig. 2), cover 3 and the brace table 4 of accommodating container main body 2.Supported 4 of the container body 2 of reagent container 1 supports, and is accommodated in cover 3 inside, and under state shown in this Fig. 1, reagent container 1 can be arranged in analytical equipment as boxlike (cartridge) reagent container.
As shown in Figure 3, reagent containing section 20 is integrally provided with following part: the first enlarged 21 that the width between inner face upwards expands gradually from inner bottom surface and the width between inner face upwards diminish gradually from the first enlarged 21 dwindles part 22.So, reagent containing section 20 being shaped as on vertical cross-section: the inwall of the left and right sides shrinks to the bound fraction of reagent containing section 20 and center section 30.Reagent containing section 20 interior shapes are by the first enlarged 21 and dwindle the shape that is substantially sphere that part 22 forms, and from inner bottom surface to the boundary with center section 30, the whole inner face of (aftermentioned narrow 40) is by not having the curved surface of the smooth connection of angle and jump to form.Therefore, the horizontal section of reagent containing section 20 is circular, the first enlarged 21 and dwindle the inside diameter of vessel that width between the inner face of part 22 is equivalent to each position in present embodiment.
In the semisphere that the first enlarged 21 is R3 by radius, face portion forms.On horizontal section, in the upper end of the first enlarged 21 (dwindling part 22 lower ends), i.e. the position of the height H from inner bottom surface 1, the internal diameter of the first enlarged 21 is maximum radius R3.The radius R 3 of this height H 1 position is the radius of the horizontal section area maximum of reagent containing section 20.Radius R 3 is equivalent to claim " the first radius r 1 ".
Dwindle part 22 and be dome shape the face portion more than position that is positioned at height H 1 in reagent containing section 20.On horizontal section, height H 2 positions that dwindle part 22 upper ends have least radius R4.Radius R 4 in these height H 2 positions is the radiuses that dwindle the minimum place of horizontal section area of part 22.Radius R 4 is equivalent to claim " the second radius r 2 ".
The second enlarged 31 has round section, and more upwards radius is larger, so the width between inner face increases upward gradually.On longitudinal section shown in Fig. 3, the second enlarged 31 has level and smooth curved inner face, and is connected with the part 22 of dwindling with dome shape inner face.On horizontal section, there is maximum radius R5 height H 3 positions of the upper end of the second enlarged 31.
At this, in the present embodiment, by the narrow 40 that dwindles the upper end of part 22 and the lower end of the second enlarged 31 and formed inside diameter of vessel local contraction.Narrow 40 is positioned at and dwindles part 22(reagent containing section 20) and the second enlarged 31(center section 30) boundary (height H 2 positions) locate.As shown in Figure 4, narrow 40 along the circumferential direction extends at container inner face.In the present embodiment, above-mentionedly dwindle part 22 and the second enlarged 31 has circular horizontal section, so narrow 40 is annular, and at the container inner face whole circle that is continuous continuously.
As shown in Figure 3, narrow 40 is at container inner face horizontal-extending.Narrow 40 is arranged at the upper part (dwindling the upper end of part 22) of reagent containing section 20, is positioned at the top position of the liquid level of reagent RS.This narrow 40 has limitation function as described later, when the stirring operation of reagent RS makes reagent RS rise along the inner face of container body 2, when reagent RS passes through narrow 40, its moving direction meeting turning containers center, limits reagent RS with this and crosses center section 30 arrival necks 10.
At this, maximum radius about radius R 3(first enlarged 21 of the horizontal section area maximum of reagent containing section 20) and the radius R 4(of narrow 40 dwindle the least radius of part 22), set R3 and R4 and make R4/R3 in more than 0.50 scope below 0.95.In addition, the sectional area of the horizontal section of narrow 40 is greater than the horizontal section of neck 10.In the present embodiment, the cross section of narrow 40 and neck 10 is circle, and therefore, horizontal section area depends on the size of radius, the radius R 4(horizontal section area=π * R4 of narrow 40
2) the radius R 2(horizontal section area=π * R2 of > neck 10
2).These size relationships for example can be as follows: take that to fill 200 tests be example with the container body 2 of reagent, and the about 13mm of R3=, the about 11.5mm of R4=, R4/R3=approximately 0.89.The about 5mm of R2=.
Narrow 40(dwindles the upper end of part 22) radius R 4 and the maximum radius R5 of the second enlarged 31 meet R4 < R5.Therefore, the sectional area of the second enlarged 31 horizontal sections of center section 30 is greater than and dwindles part 22.
Tapering 33 is connecting the upper end of cylindrical shape part 32 and the lower end of neck 10.From Kan， tapering, horizontal section 33 end portions (with the intersection of cylindrical shape part 32), have circular inner face, upper part (with neck 10 intersections) has polygonal inner face 33a as shown in Figure 4.In the present embodiment, the horizontal section of the inner face 33a of 33 upper parts, tapering is triangle.Therefore tapering 33 is formed by circular end portion and the smooth connection of leg-of-mutton upper part.It is fillet that the triangular-section part in tapering 33 has the shape of ，Qie Gai angle part, angle part.As shown in Figure 3, tapering 33 end portion radiuses are that the width (triangle length on one side) of R5, upper part is that L1(is with reference to Fig. 4), the diameter (R5 * 2) of L1 < end portion.That is, the horizontal section area in tapering 33 is dwindled to upper part gradually from end portion.
As shown in Figure 1 and Figure 5, covering 3 is casing shapes that open bottom surface, covers brace table 4 and container body 2.Cover 3 be provided with above the barrel 3a(of opening 11 for inserting reagent container 1 with reference to Fig. 5) and for the slipping switch lid 3b of switch barrel 3a, along with the switch (switch of barrel 3a) of switch cover 3b, can open or close the opening 11 of reagent container 1.
As shown in Figure 5, brace table 4 is supports that comprise support section 4a and bottom 4c, and wherein support section 4a has the engaged claw 4b of mate 12 engagements on the neck 10 with container body 2.Support section 4a is supporting the neck 10 of container body 2, with this, makes supported 4 of the container body 2 that has dome shape outer bottom be supported for erectility.The bottom surface when shape of bottom 4c is opened with cover 3 is corresponding, at cover 3 and brace table 4, is covered with accommodating container main body 2 under container body 2 state around.
With regard to the reagent container 1 of present embodiment, the example in analytical equipment describes below.
First just use an example of the analytical equipment of reagent container 1 to carry out brief description.Analytical equipment shown in Fig. 6 100 is a kind of automatic analysing apparatus, for the contained antigen of determination object sample (blood samples of serum etc.) and antibody etc.Analytical equipment 100 is scattered in sample (serum) in damping fluid (R1 reagent), by antigen-antibody reaction, allows magnetic particle (R2 reagent) contained antigen in the sample disperseing be combined.Then by magnetic, catch the compound of antigen, seizure antibody and the magnetic particle of combine (Bound), remove the antibody (being that BF is separated) of unreacted (Free) simultaneously.Then, analytical equipment 100 by compound and labelled antibody (R3 reagent) in conjunction with after, by magnetic, catch the compound of magnetic particle, antigen and the labelled antibody of combine (Bound), remove the R3 reagent (being that BF is separated) containing unreacted (Free) labelled antibody simultaneously.After this, analytical equipment 100 add dispersion liquids (R4 reagent) and with labelled antibody course of reaction in luminous luminous substrate (R5 reagent), then measure labelled antibody reacts generation luminous quantity with luminous substrate.Contained antigen in the sample that analytical equipment 100 is combined with labelled antibody by above-mentioned steps quantitative measurement, can carry out plural number to sample and plant different analysis item goal analysis.
This analytical equipment 100 as shown in Figure 6, have measure member part 101, sample transport part (sampler) 102 and with measure that member part 101 circuit are connected by PC(computer) control device 103 of formation.Control device 103 has without illustrated main frame and display unit 103a and input block (keyboard) 103b etc., can be according to analyzing with programmed control analytical equipment 100 and analyzing the determination data recording.
Measuring member part 101 mainly consists of following part: sample packing arm 111, R1 reagent packing arm 112, R2 reagent packing arm 113, R3 reagent packing arm 114, reactive moieties 115, reaction cup supply section 116, BF separating part 117, quadratic B F separating part 118, test section 119, R4/R5 agent delivery part 120, reagent placement part 121.
Reaction cup supply section 116 is to sample drain position 100b supply reaction cup.R1 reagent packing arm 112 has the transfer pipet 112a that moves and discharge R1 reagent for inhaling, and inhales and moves the R1 reagent that is placed on reagent placement part 121, and R1 reagent is divided and installed in reaction cup with this transfer pipet 112a.Sample packing arm 111 inhale the sample that moves in sample drain position 100b packing (discharge) in reaction cup, and with R1 reagent mix.In addition, R1 reagent packing arm 112 is also with without illustrated clamp, the reaction cup that is positioned at sample drain position 100b being transplanted on to reactive moieties 115.
R2 reagent packing arm 113 has the transfer pipet 113a that moves and discharge R2 reagent for inhaling, inhale to move the R2 reagent in reagent placement part 121, and by R2 reagent packing (discharge) to being equipped with in the reaction cup of R1 reagent and sample.
One time BF separating part 117 use are taken into the reaction cup that sample, R1 reagent and R2 reagent are housed without illustrated clamp, sample separated (B/F is separated) unreacted R1 reagent (unwanted composition) and magnetic particle in reaction cup.
R3 reagent packing arm 114 has the transfer pipet 114a that moves and discharge R3 reagent for inhaling.R3 reagent packing arm 114 is inhaled and is moved the R3 reagent in reagent placement part 121, and by R3 reagent packing (discharge) in reaction cup, sample from BF separating part 117 is got back to the B/F separation of reactive moieties 115 is housed in this reaction cup.
Each transfer pipet 112a, 113a and the 114a of above-mentioned R1 reagent packing arm 112, R2 reagent packing arm 113 and R3 reagent packing arm 114 are made by the stainless steel of electric conductivity, with level detection with testing circuit 130(with reference to Fig. 5) circuit is connected.With this, mentioned reagent packing arm 112,113 and 114 detects the variation of the electric capacity of following while contacting with reagent liquid level.Control device 103 has liquid level detection function, namely can when transfer pipet declines, automatically detect according to the testing result of testing circuit 130 liquid level.
Quadratic B F separating part 118 use are taken into the reaction cup that BF separating part 117 has carried out sample and the R3 reagent of B/F separation are housed from reactive moieties 115 without illustrated clamp, from the separated unreacted R3 reagent (unwanted composition) of sample and the magnetic particle in reaction cup.
R4/R5 agent delivery part 120 use without illustrated pipe to quadratic B F separating part 118 is housed has carried out in the reaction cup of sample of B/F separation packing R4 reagent and R5 reagent successively.
Fig. 7 has shown an example of the apparatus structure of reagent placement part 121.Reagent placement part 121 as shown in Figure 7, comprises following part: central shaft 131a, can centered by central shaft 131a, rotate and can with circular reagent seating part 131 of laying reagent container 1 and cover reagent seating part 131 above also can switch cap 132.Cap 132 is provided with transfer pipet jack 132b and reagent jack 132c, wherein in transfer pipet jack 132b, be provided with the switching member 132a of the switch cover 3b of cover 3 that can switch reagent container 1, reagent jack 132c is for being placed on reagent seating part 131 by reagent container 1.
As shown in Figure 5, during minute installed reagents (such as R2 reagent), 131 rotations of reagent seating part, with this, packing subject assay container 1 be placed in cap 132 switching member 132a under, cover 3 switch cover 3b and be opened.Then, the transfer pipet 113a of R2 reagent packing arm 113 declines by the transfer pipet jack 132b of cap 132, through opening 11 and the neck 10 arrival reagent containing sections 20 of container body 2.When the front end of transfer pipet 113a touches the liquid level of reagent, testing circuit 130 detects the variation of the electric capacity of transfer pipet 113a, and to control device 103 transmitted signals, control device 103 detects liquid level.It is a certain amount of that control device 103 allows the transfer pipet position of transfer pipet 113a when receiving signal decline, and then implements reagent aspirating operation.
At this, the R2 reagent that contains magnetic particle needs to stir, to the magnetic particle in reagent is uniformly dispersed.For this reason, reagent seating part 131 can stir the R2 reagent limit rotation of being equipped with in reagent container 1 in limit.
An example that stirs the stirring operation of R2 reagent with regard to reagent placement part 121 below with reference to Fig. 8 ~ Figure 10 describes.
As shown in Figure 8, reagent container 1(container body 2) Yi Bian intermittently rotate reagent seating part 131 to a direction (arrow A 1 direction) Yi Bian the stirring operation of interior R2 reagent RS refers to periodically to switch acceleration and slow down.Before suction moves reagent and suction move reagent and suction and move between reagent (automatic analysing apparatus 100 do not inhale and move reagent in) and carry out this stirring operation.First, in original state, reagent seating part 131 is in halted state, and the liquid level of the reagent RS in container body 2 is also basic horizontal state.Reagent seating part 131 thus state starts intermittently to drive to arrow A direction, with this, stirs operation.
Along with the acceleration of reagent seating part 131, container body 2 also moves to arrow A 1 direction, and R2 reagent RS in container body 2 is parked in the trend in original place because inertia has.Therefore,, when accelerating to arrow A 1 direction, the R2 reagent RS in container body 2, to opposite direction (arrow A 2 directions) mobile (flowing), during deceleration, moves (flowing) to arrow A 1 direction with container body 2 conversely on the contrary.Therefore, because periodic acceleration and the deceleration of reagent seating part 131, the R2 reagent RS in container body 2 rocks to arrow A 1 direction and arrow A 2 directions container body 2 is interior.Constantly repeat the periodicity of circumferencial direction (A1 direction) and accelerate and slow down, therefore, the inner face of the R2 reagent RS edge container body 2 in container body 2 flows on circumferencial direction rotation (spiraling) limit.Therefore, in the R2 reagent RS in container body 2, contained magnetic particle is stirred, dispersed.
While carrying out above-mentioned stirring operation, as shown in Figure 9, in a part of the R2 reagent RS of container body 2 interior rotations, can rise along the inner face of container body 2, sometimes almost from reagent containing section 20, fly out.In the present embodiment, there is narrow 40 upper end (with the boundary of the second enlarged 31) that dwindles part 22, therefore, the radial direction center of the moving direction turning containers main body 2 of the reagent RS rising along container inner face, and the amplitude turning to is equivalent to the radius R 3 of the first enlarged 21 and poor (difference) dr of the radius R 4 of narrow 40.In addition, the top of narrow 40 is provided with the second enlarged 31 that container inner face is expanded to outside of containers again.Therefore the reagent RS, rising along container inner face just in time moves to the contrary radial direction central side of the container inner face dimension with the second enlarged 31 (radial direction outside) in the position of narrow 40.Therefore, reagent RS departs from and turns back to reagent containing section 20 from container inner face at narrow 40.
In addition, when a part of reagent RS crosses narrow 40 arrival center section 30, as shown in figure 10, the horizontal cross sectional geometry of tapering 33 inner faces of center section 30 becomes triangle from circle from bottom to top.Therefore, the reagent RS that carries out circle-shaped rotation along the circular inner face of container body 2 is changed moving direction by the triangle inner face 33a on 33 tops, tapering with sharp angle, because rotation is stopped and slow down.With this, even when a part of reagent RS crosses narrow 40 arrival center section 30, the further rising of reagent RS also can be stopped by the tapering 33 of center section 30.Therefore, the vertical motion that reagent RS occurs along with stirring operation is inhibited, and prevents that reagent RS from forming film at neck 10.
In the present embodiment, as mentioned above, being positioned at the narrow 40 that dwindles part 22 and the second enlarged 31 boundarys along the circumferential direction extends at container inner face, like this, narrow 40 is crossed in attempt reagent RS along container inner face can leave container inner face at narrow 40 places under the state of container center at moving direction, return to reagent containing section 20.With this, even when reagent RS rises along container inner face along with stirring operation, also can stop reagent cross narrow 40 and rise, therefore, in the time of can preventing from stirring reagent RS, reagent arrives neck 10(opening 11).
In the present embodiment, as mentioned above, reagent containing section 20(the first enlarged 21 and dwindle part 22) interior shape be dome shape substantially.With this, just can prevent particle set and be piled up in part (jump or corner), can also reduce dead volume simultaneously.
In the present embodiment, as mentioned above, on horizontal section, there is leg-of-mutton inner face 33a in the tapering 33 of center section 30, and the angle part of this leg-of-mutton inner face 33a is fillet.With this, just can hinder reagent RS to rotate along container inner face by inner face 33a, can stop reagent RS to arrive neck 10, can also prevent that magnetic particle is deposited in angle part simultaneously.
In the present embodiment, as mentioned above, make the horizontal section area of narrow 40 be greater than the horizontal section area of neck 10, R4/R3 is equaled more than 0.50 below 0.95, therefore, reagent RS can not form film at narrow 40, can effectively stop reagent RS to arrive neck 10(opening 11).
This time disclosed embodiment and each embodiment are illustration in all respects, do not have restricted.Scope of the present invention is not limit by the explanation of above-mentioned embodiment and each embodiment, and scope of the present invention is only by claim defined, and comprises all distortion with the equal scope of claim, equivalence.
Such as in the illustration of above-mentioned embodiment, reagent container is the container of taking in the reagent (R2 reagent) that the analytical equipment of blood sample uses, but the invention is not restricted to this.The present invention also can be for taking in the reagent container of any reagent.
In the example of above-mentioned embodiment, reagent container is taken in magnetic particle (insoluble composition) is scattered in to the reagent in damping fluid (solvent), but the invention is not restricted to this.In the present invention, the reagent being contained in reagent container can be also the mix reagent of plurality of liquid composition.Such as, the reagent stirring when needs with when the reagent that does not need to stir is placed on same reagent placement part, while implementing to stir operation, do not need the reagent of stirring may form film in vessel port yet.Therefore, the present invention also can be for filling the reagent container of the reagent that does not need stirring.
In the illustration of above-mentioned embodiment, by container body, cover and brace table, formed boxlike reagent container, but the invention is not restricted to this.The present invention also can only form reagent container by container body.Now, also can arrange as follows: during to analytical equipment assembling container main body, cover and brace table are used as adapter, take off and use container body, and be replaced by new container body (reagent container) from this adapter.Can also make container body (reagent container) can directly be installed on the reagent placement part of analytical equipment.
In the example of above-mentioned embodiment, at center section, configure the second enlarged, but the invention is not restricted to this.The present invention also can be arranged on reagent containing section by the second enlarged.; in the above-described embodiment; dwindle part be provided with narrow with the boundary of the second enlarged; with this, narrow is disposed between reagent containing section and center section; but also the second enlarged can be arranged on to reagent containing section, with this, narrow be disposed in reagent containing section.
In the illustration of above-mentioned embodiment, the thickness t of the reagent containing section of container body is substantially certain, the shape (with reference to Fig. 3) of container body outside surface reflection inner face, but the invention is not restricted to this.The external surface shape of container body is not particularly limited in the present invention.Particularly, as shown in Figure 11 (a) variation, can form narrow 240(by the thickness of change container body and dwindle part 222 and the second enlarged 231).Equally, also can form by changing the thickness of container body the interior shape in the first enlarged of reagent containing section and the tapering of center section.
In the illustration of above-mentioned embodiment, by thering is dwindling part and having formed with second enlarged of dwindling part smooth connection the level and smooth curved narrow that there is no angle of dome shape interior shape, but the invention is not restricted to this.In the present invention, also can be as shown in Figure 11 (b) variation, by dwindling part 322 and the second enlarged 331 and be set to the straight line class shape at angle, with the angle part that dwindles part 322 and the second enlarged 331 boundarys, form narrow 340.
In the illustration of above-mentioned embodiment, the internal diameter that dwindles part of dome shape upwards diminishes gradually, and the internal diameter of the second enlarged upwards increases gradually, but the invention is not restricted to this.The present invention also comprises and dwindles part and the internal diameter (width between inner face) of the second enlarged in the structure of the stepped variation of certain position.Particularly, as shown in the variation of Figure 11 (c), form stair-stepping part 422 and stair-stepping the second enlarged 431 of dwindling, by this, dwindle part 422 and the second enlarged 431 forms with flange shape to the outstanding narrow 440 of container inside.
In the illustration of above-mentioned embodiment, dwindle part 22 and the second enlarged 31 has circular horizontal section, with this, formed the dot-and-dash line with reference to Fig. 4 at the container inner face annular narrow 40(of continuous a week), but the invention is not restricted to this.Narrow can be not yet around container inner face one week.Such as, as shown in the variation of Figure 12 (a), also can make narrow 540 along the circumferential direction extend 2/3rds of circumference.
Above-mentioned embodiment is illustrative is continuous annular stricture part, but the invention is not restricted to this.The present invention also can be as shown in the variation of Figure 12 (b), allows narrow 640 is discontinuous along the circumferential direction to be extended.
In the illustration of above-mentioned embodiment, the part of dwindling of dome shape keeps necessarily internal diameter (radius) R4 of narrow on whole circumference, but the invention is not restricted to this.The internal diameter of the narrow in the present invention (width between inner face) also can along the circumferential direction change.
In an example of the internal diameter of the narrow of enumerating at above-mentioned embodiment (radius) R4, the about 11.5mm of R4=, but the invention is not restricted to this.From the viewpoint that stops reagent to form film at narrow, consider, more than the internal diameter of narrow (radius) R4 is preferably about 10mm.Even if narrow does not have round section, if while being converted into sectional area more than equal extent.
In the illustration of above-mentioned embodiment, reagent containing section (the first enlarged and dwindle part) has the interior shape of dome shape, but the invention is not restricted to this.In the present invention, reagent containing section also can have other interior shapes beyond dome shape.Such as also making the horizontal section of the inner face of reagent containing section, it is polygon.
The inner face in the illustrative tapering of above-mentioned embodiment has triangle horizontal section, but the invention is not restricted to this.Also the horizontal section in tapering can be made as beyond triangle as quadrangle or hexagonal polygon.
Claims (20)
1. take in the reagent container for the reagent of automatic analysing apparatus, comprising:
Be positioned at the top of described reagent container and have the neck of opening;
Take in the reagent containing section of described reagent;
The center section that connects described neck and described reagent containing section;
Described reagent containing section comprises that width between inner face upwards becomes from inner bottom part the part of dwindling that large the first enlarged and the width between inner face upwards diminish gradually from the first enlarged gradually;
Described center section comprises that the width between inner face upwards becomes the second large enlarged gradually from the described upper end that dwindles part;
Described in being positioned at, dwindling part along the circumferential direction extends at container inner face with the narrow of the boundary of described the second enlarged.
2. reagent container according to claim 1, is characterized in that:
Described narrow is substantially and is horizontally disposed with.
3. reagent container according to claim 1 and 2, is characterized in that:
Inner face from the inner bottom part of described reagent containing section to the narrow of described center section consists of the curved surface of smooth connection.
4. reagent container according to claim 3, is characterized in that:
The interior shape of described reagent containing section be comprise described the first enlarged and described in dwindle part the shape that is substantially sphere.
5. reagent container according to claim 1, is characterized in that:
The horizontal section area of described center section is dwindled to described neck gradually from the position of described the second enlarged top.
6. reagent container according to claim 5, is characterized in that:
At least a portion of described center section has the inner face that is substantially polygon shape on horizontal section.
7. reagent container according to claim 6, is characterized in that:
Substantially the shape that the inner face that is polygon shape of described center section has ，Gai angle part, angle part is fillet.
8. reagent container according to claim 6, is characterized in that:
Described polygon is shaped as triangular shaped.
9. reagent container according to claim 1, is characterized in that:
The horizontal section of described narrow is larger than the sectional area of the horizontal section of described neck.
10. reagent container according to claim 1, is characterized in that:
Described reagent containing section and described narrow have circular horizontal section,
In described the first enlarged, the second radius r 2 of the first radius r 1 of the upper end of horizontal section maximum and described narrow meets:
R2/r1 equals more than 0.50 below 0.95.
11. reagent containers according to claim 1, is characterized in that also having:
The container body that comprises described neck, described reagent containing section and described center section; And
Make described container body be supported for the brace table of erectility.
12. reagent containers according to claim 1, is characterized in that:
Described pack is containing solvent and insoluble composition.
13. reagent containers according to claim 12, is characterized in that:
Described insoluble composition is magnetic particle.
14. reagent containers according to claim 1, is characterized in that:
Described reagent container is assemblied in the reagent assembled portion that can move of described automatic analysing apparatus and uses, and the mobile operating by described reagent assembled portion stirs the reagent in described reagent container.
15. reagent containers according to claim 14, is characterized in that:
Described reagent container stirs described reagent by the mobile operating of the circumferencial direction centered by the axle by described reagent assembled portion, and wherein said reagent assembled portion can be assembled along the circumference centered by axle a plurality of reagent containers.
16. reagent containers according to claim 1, is characterized in that:
Described reagent container can insert the described transfer pipet that can detect the described automatic analysing apparatus of liquid level according to the variation of the electric capacity of the transfer pipet consisting of conductive material from described opening.
17. 1 kinds of reagent containers of taking in for the reagent of automatic analysing apparatus, comprising:
The neck that has opening on described reagent container top,
For taking in the reagent containing section of described reagent,
And the center section that connects described neck and described reagent containing section,
At the inwall that is shaped as the left and right sides of vertical cross-section, the bound fraction towards described reagent containing section and described center section shrinks described reagent containing section to the inside,
Described center section has the sectional area of the horizontal section of a part to be greater than the part of contraction.
18. 1 kinds of reagent containers of taking in for the reagent of automatic analysing apparatus, comprise the following part (a) to (c) that starts from top to be connected successively and arrange:
(a) comprise the neck of opening of the top of described reagent container;
(b) the first trunk;
(c) the second trunk of the bottom of taking in reagent and comprising reagent container;
Wherein, the boundary of the first trunk and the second trunk is provided with and tightens up part,
The more approaching part of tightening up of the inwall of the second trunk is more crooked, so that the mobile deflection internal diameter direction of the liquid rising along internal face while rocking reagent container.
19. 1 kinds of reagent containers of taking in for the reagent of automatic analysing apparatus, comprising:
Take in the container body of reagent
And the box that surrounds container body;
Described container body comprises the following part (a) to (c) that starts from top to be connected successively and arrange:
(a) comprise the neck of the opening of described container body;
(b) the first trunk;
(c) the second trunk of the bottom of taking in reagent and comprising reagent container;
Wherein the boundary of the first trunk and the second trunk is provided with and tightens up part,
The more approaching part of tightening up of the inwall of the second trunk is more crooked, so that the mobile deflection internal diameter direction of the liquid rising along internal face while rocking reagent container.
20. 1 kinds of reagent containers of taking in for the reagent of automatic analysing apparatus, comprising: the trunk that there is the neck of opening on top and is located at neck below;
Wherein, trunk is tightened up part and is divided into upper portion and lower portion, and lower portion is taken in reagent;
From bottom, near tightening up the process of part, then the horizontal sectional area of lower portion first dwindles to lateral spread.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012183170A JP5995605B2 (en) | 2012-08-22 | 2012-08-22 | Reagent container |
| JP2012-183170 | 2012-08-22 |
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| Publication Number | Publication Date |
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| CN103630696A true CN103630696A (en) | 2014-03-12 |
| CN103630696B CN103630696B (en) | 2017-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310363406.1A Active CN103630696B (en) | 2012-08-22 | 2013-08-20 | Reagent container |
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| JP (1) | JP5995605B2 (en) |
| CN (1) | CN103630696B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110082551A (en) * | 2018-01-25 | 2019-08-02 | 希森美康株式会社 | Reagent container, the aspirating method of reagent and sample measures device |
| CN111101428A (en) * | 2019-03-26 | 2020-05-05 | 广州振中建设有限公司 | Pin-connected panel precast concrete template structure for road construction |
| CN113391081A (en) * | 2015-12-17 | 2021-09-14 | 希森美康株式会社 | Sample analyzer, sample analyzing method, and reagent container holder |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6274081B2 (en) * | 2013-12-16 | 2018-02-07 | 株式会社島津製作所 | Liquid collection device and automatic analyzer equipped with the liquid collection device |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2014041045A (en) | 2014-03-06 |
| CN103630696B (en) | 2017-03-01 |
| JP5995605B2 (en) | 2016-09-21 |
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