CN217878856U - Sample reaction tank and sample analyzer - Google Patents

Abstract

The application provides a sample reaction pond and sample analysis appearance. The sample reaction cell includes: the reaction chamber is formed by connecting the side wall and the bottom wall, and further a liquid discharge port is arranged on one side of the side wall close to the bottom wall and used for discharging waste liquid in the reaction chamber. In the sample reaction pond of this application, the leakage fluid dram sets up on the lateral wall, through this kind of mode, can reduce the bubble that the leakage fluid dram produced in the reaction time of sample to improve sample detection's accuracy.

Description

Sample reaction tank and sample analyzer

Technical Field

The application relates to the field of medical equipment, in particular to a sample reaction tank and a sample analyzer.

Background

After the cell analyzer collects a sample, the sample is added into the reaction tank and is mixed and reacted with the reagent in the reaction tank, so that the sample is detected.

The flowing back structure in current reaction tank sets up unreasonablely, leads to having more bubbles in the reaction tank to produce, and produced more bubbles in the reaction tank can produce the interference to detecting signal, and then influences the accuracy that the sample detected.

SUMMERY OF THE UTILITY MODEL

The application provides a sample reaction tank and sample analyzer to the flowing back structure who solves sample reaction tank among the prior art sets up unreasonablely, thereby influences the technical problem of sample detection's accuracy.

In order to solve the technical problem, the application adopts a technical scheme that: providing a sample reaction cell, the sample reaction cell comprising: the lateral wall is connected with the bottom wall to form a reaction cavity, wherein one side of the lateral wall, which is close to the bottom wall, is provided with a liquid discharge port, and the liquid discharge port is used for discharging waste liquid in the reaction cavity.

Further, the inner surface of the bottom wall is a planar structure, or at least a part of the inner surface of the bottom wall is recessed toward a side close to the opening of the sample reaction cell.

Further, at least part of the inner surface is arranged in an arc surface.

Furthermore, a cleaning liquid inlet is formed in the side wall and used for injecting cleaning liquid into the reaction cavity, and the cleaning liquid inlet is overlapped with the liquid outlet.

Furthermore, a reagent inlet is arranged on the side wall and used for injecting a reagent into the reaction cavity, and the reagent inlet is superposed with the liquid outlet.

Further, a reagent inlet is further arranged on the side wall and is positioned on one side, far away from the bottom wall, of the liquid outlet.

Furthermore, a sample inlet, a reagent inlet and a cleaning solution inlet are also arranged on the side wall.

Furthermore, an optical detection window is arranged on the side wall and used for optical detection.

Further, the liquid discharge port is disposed adjacent to the bottom wall.

In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a sample analyser comprising a sample reaction cell according to any one of the embodiments above.

The beneficial effect of this application is: the utility model provides a sample reaction pond includes lateral wall and diapire, and wherein, the lateral wall is connected in order to form the reaction chamber with the diapire, and sample and reagent are at reaction intracavity mixing and reaction, and one side that the lateral wall is close to the diapire is provided with the leakage fluid dram, and the leakage fluid dram is used for the waste liquid of discharge reaction intracavity. The utility model provides a leakage fluid dram sets up in the lower part of lateral wall, through this kind of mode, can reduce the bubble that the leakage fluid dram produced in the reaction time of sample to improve sample detection's accuracy.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:

FIG. 1 is a schematic diagram of a prior art sample reaction cell;

fig. 2 is a schematic structural diagram of an embodiment of a sample reaction cell provided in the present application.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It should be noted that if directional indications (such as up, down, left, right, front, back, 8230; \8230;) are referred to in the embodiments of the present application, the directional indications are only used to explain the relative positional relationship between the components, the motion situation, etc. in a specific posture (as shown in the attached drawings), and if the specific posture is changed, the directional indications are correspondingly changed.

In addition, if there is a description of "first", "second", etc. in the embodiments of the present application, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between the embodiments may be combined with each other, but must be based on the realization of the technical solutions by a person skilled in the art, and when the technical solutions are contradictory to each other or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope claimed in the present application.

The existing sample reaction pool, such as a C-reactive protein reaction pool, generally comprises a sample port, an emptying port, a hemolytic agent port and a cleaning solution port, and because a sample needle for sample addition greatly influences the speed of the whole machine, the hemolytic agent port and the cleaning solution port do not share the same port with the sample port, and the hemolytic agent port and the cleaning solution port are generally arranged on the side surface of the lower part of the pool; the sample port is generally arranged right above the pool, so that the sample can be conveniently added to different pools by the movable sample needle. As shown in fig. 1, the evacuation port 21 of the sample reaction cell 20 in the prior art is generally disposed right below the cell, so as to facilitate the timely evacuation of waste liquid. However, the original emptying port 21 at the bottom of the reaction tank is generally in a tapered shape with a gradually reduced cross section when viewed from the side, and before emptying, the cross section of liquid in the reaction tank is increased from bottom to top, so that the gas dissolved in the mixed liquid is easily amplified to form bubbles, and the inspection effect is further influenced. Especially, the evacuation port 21 extends downward to a section of pipeline at the relevant valve, because the pipe diameter is narrow, under the amplification effect of gas-liquid mixing, a section of gas or large bubbles is easily sealed in the pipeline, and after standing for a period of time, the section of gas or large bubbles escapes upwards, thereby affecting the detection light path and the final detection result.

The application provides a sample reaction pond and sample analysis appearance, the sample reaction pond of this application has cancelled the evacuation port of bottom, simple structure, and convenient the manufacturing, and can improve the accuracy that the sample detected. The sample reaction tank can be a CRP reaction tank, namely a reaction tank for detecting C-reactive protein, and can also be various reaction tanks applied to other colorimetric or turbidimetric reactions.

Referring to fig. 2, fig. 2 is a schematic structural diagram of an embodiment of a sample reaction cell provided in the present application, in which the sample reaction cell 10 includes a side wall 11 and a bottom wall 12. The side wall 11 is connected with the bottom wall 12, and the side wall 11 and the bottom wall 12 form a reaction chamber (not labeled in the figure) for placing a sample and a reagent, and the sample and the reagent are uniformly mixed and reacted in the reaction chamber.

The side wall 11 is provided with a liquid outlet 111, and the liquid outlet 111 is used for discharging waste liquid in the reaction chamber. Further, a drain 111 is disposed on a side of the sidewall 11 near the bottom wall 12 to facilitate the waste liquid to drain out of the reaction chamber under the action of gravity and/or external pressure. Preferably, the drain port 111 is disposed adjacent to the bottom wall 12, i.e., the drain port 111 is located at the junction of the side wall 11 and the bottom wall 12. By the mode, the waste liquid is discharged conveniently, and the influence of the liquid discharge port 111 on the inlet of other liquid is reduced to a great extent.

The shape of the drain port 111 may be circular to facilitate connection of the drain port 111 with external piping. In other embodiments, the shape of the liquid discharge port 111 may also be oval, square, rectangular, triangular, diamond, irregular, or the like. The shape of the liquid discharge port 111 may be selected and provided according to the specific situation, and is not limited herein.

In the above embodiment, the liquid discharge port 111 is disposed on the side wall 11 of the sample reaction well 10 and arranged laterally, so that bubbles generated by the liquid discharge port 111 during the sample reaction time can be reduced, thereby improving the accuracy of sample detection.

Further, the bottom wall 12 may have a planar structure to simplify the structure of the sample reaction cell 10. In other embodiments, at least a portion of the inner surface of the bottom wall 12 is recessed to a side adjacent to the opening of the sample well 10. That is, bottom wall 12 includes a concave bottom surface. In this way, after the reaction chamber is emptied, the liquid remaining on the inner wall of the tank slowly flows to the depressions at the bottom of the reaction tank 10 due to gravity. When the next evacuation is performed, the sample is conveniently pumped away by negative pressure, so that the evacuation effect of the sample reaction cell 10 is improved. That is to say, after sample reaction cell 10 evacuation, before the liquid feeding next time, carry out evacuation action again, can carry out more effective washing to sample reaction cell 10, reduce the influence of portable pollution to improve the accuracy that the sample detected.

Wherein, at least part of the inner surface of the inner recess of the bottom wall 12 is arranged in a cambered surface. So, can carry out the drainage to liquid, reduce the hanging liquid phenomenon.

Further, the sidewall 11 may be provided with a sample inlet 112, a reagent inlet 113, a cleaning solution inlet 114, and the like as needed. The sample inlet 112 is used for injecting a sample into the reaction chamber, the reagent inlet 113 is used for injecting a reagent into the reaction chamber, and the cleaning solution inlet 114 is used for injecting a cleaning solution into the reaction chamber. In other embodiments, an opening (not shown) of the sample reaction cell 10 may be used as the sample inlet 112 to facilitate the sample needle to add the sample to the reaction chamber.

Alternatively, the cleaning solution inlet 114 may merge with the liquid discharge port 111, that is, the cleaning solution inlet 114 may coincide with the liquid discharge port 111. Alternatively, the reagent inlet 113 may be integrated with the liquid discharge port 111, that is, the reagent inlet 113 may overlap with the liquid discharge port 111, thereby simplifying the structure of the sample well 10.

Preferably, the cleaning fluid inlet 114 is incorporated into the drain port 111, since in this way, multiple alternating steps of evacuation at high negative pressure and replenishment at low positive pressure may be used to enhance cleaning of the lines connected to the drain port 111. Wherein, the cleaning agent can be acid, alkaline or neutral cleaning agent to further enhance the cleaning effect.

In the above steps, the evacuation with strong negative pressure is understood to be the rapid evacuation of the liquid in the place to be cleaned (such as the reaction tank 10) with negative pressure, and the replenishment with weak positive pressure is understood to be the slow filling of the liquid in the place to be cleaned (such as the reaction tank 10) with positive pressure. In other words, when the cleaning time constraint is considered, the larger gear of the negative pressure driving component is used during the pumping, and when the cleaning time constraint is considered, the smaller gear of the positive pressure driving component is used during the weak positive pressure fluid infusion. And the positive pressure driving part and the corresponding valve are started at the slowest speed as far as possible when being started, so that the liquid is prevented from being stirred violently at the moment of starting, new bubbles are brought in the liquid adding process, and after the positive pressure driving part and the corresponding valve are started for a period of time, the positive pressure driving part and the corresponding valve are started at the constant speed or the slow speed to the maximum opening degree. This is because the positive pressure does not cause dissolved bubbles in the liquid to come free and then adhere to the walls of the chamber, thereby adversely affecting subsequent operations.

The negative pressure drive member can be initially opened at a maximum speed to increase the agitation of the liquid and maximize the turbulence created by the evacuation. This is because the negative pressure will make the bubble that dissolves in the liquid and the bubble that attaches on the liquid path chamber wall enlarge, and because volume change, the bubble that attaches on the chamber wall drops easily, and by the way dissociates and takes away the bloodiness on the chamber wall, and the cleaning performance is best.

Further, liquid discharge port 111 is located below reagent inlet 113, that is, liquid discharge port 111 is located closer to bottom wall 12, and the distance between liquid discharge port 111 and the plane of the planar structure of bottom wall 12 is smaller than the distance between reagent inlet 113 and the plane of the planar structure of bottom wall 12. In this way, it is possible to reduce the influence of the cleaning liquid injected through the liquid discharge port 111 or the waste liquid drawn out on the reagent inlet 113 and the connection line to the reagent inlet 113.

Further, an optical detection window (not shown) is disposed on the sidewall 11, and the optical detection window is used for performing optical detection on the sample in the reaction chamber. For example, the sample may be optically detected by transmitted light or by scattered light.

The sample reaction pond 10 that this application provided's simple structure, drain port 111's position sets up rationally, can reduce the bubble that drain port 111 produced in sample reaction time to improve the accuracy that the sample detected.

The application also provides a sample analyzer, which comprises the sample reaction cell 10 of any one of the embodiments, wherein the sample and the reagent are uniformly mixed and reacted in the reaction cavity of the sample reaction cell 10, and the sample analyzer detects the uniformly mixed sample to obtain the detection result of the sample.

In the sample analyzer of the present application, the structure of the sample reaction tank 10 is simple, and the bubbles generated by the liquid discharge port 111 in the reaction time can be reduced, thereby improving the accuracy of the detection of the sample analyzer.

The above embodiments are merely examples and are not intended to limit the scope of the present disclosure, and all modifications, equivalents, and flow charts using the contents of the specification and drawings of the present disclosure, which are directly or indirectly applied to other related technical fields, are included in the scope of the present disclosure.

Claims (10)

1. A sample reaction cell, comprising:

the side wall is connected with the bottom wall to form a reaction cavity, wherein a liquid discharge port is formed in one side, close to the bottom wall, of the side wall, and the liquid discharge port is used for discharging waste liquid in the reaction cavity.

2. The sample reaction cell according to claim 1, wherein the inner surface of the bottom wall is a planar structure, or at least a part of the inner surface of the bottom wall is recessed to a side near the opening of the sample reaction cell.

3. The sample reaction cell according to claim 2, wherein the at least part of the inner surface is provided in a curved surface.

4. The sample reaction cell according to claim 1, wherein a cleaning solution inlet is further disposed on the sidewall for injecting a cleaning solution into the reaction chamber, and the cleaning solution inlet coincides with the liquid outlet.

5. The sample reaction cell according to claim 1, wherein a reagent inlet is further disposed on the side wall for injecting a reagent into the reaction chamber, and the reagent inlet coincides with the liquid outlet.

6. The sample reaction cell according to claim 1, wherein a reagent inlet is further disposed on the side wall, and the reagent inlet is located on a side of the liquid discharge port away from the bottom wall.

7. The sample reaction cell according to claim 1, wherein the sidewall is further provided with a sample inlet, a reagent inlet and a cleaning solution inlet.

8. The sample reaction cell according to claim 1, wherein an optical detection window is disposed on the sidewall, and the optical detection window is used for optical detection.

9. The sample reaction cell according to claim 1, wherein the liquid discharge port is provided adjacent to the bottom wall.

10. A sample analyzer, characterized in that it comprises a sample reaction cell according to any one of claims 1 to 9.

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