CN217828158U - In-vitro heart valve test system - Google Patents

Abstract

The utility model discloses an external heart valve test system, it can be including the ventricle simulation chamber that can communicate each other, atrium simulation chamber, first valve test chamber, second valve simulation chamber, sealed second valve compliance chamber and the chamber is complied with to sealed first valve, just atrium simulation chamber first valve test chamber ventricle simulation chamber second valve test chamber and second valve simulation chamber connect gradually and form the return circuit that is suitable for circulating fluid to flow. The in vitro heart valve test system can accurately simulate the heart structure, the heart pulsation and the blood flow condition, and can provide reliable performance test for the aortic valve and the mitral valve. In addition, during the test process, the water bath heater can realize automatic water replenishing, and the reliable operation of the system is ensured.

Description

In-vitro heart valve test system

Technical Field

The utility model relates to the technical field of medical treatment, specifically be an external heart valve test system.

Background

The human heart typically includes the aorta, pulmonary artery, left ventricle, left atrium, right ventricle, and right atrium. The left atrium is above the left ventricle, and there is a mitral valve between the left atrium and the left ventricle. The right atrium is above the right ventricle, and there is a tricuspid valve between the right ventricle and the right atrium. The aortic valve is located between the left ventricle and the aorta, and the pulmonary valve is located in the pulmonary trunk.

The flow of blood in the heart is generally as follows: venous blood collected from various parts of the body is taken into the right atrium of the body, and the right atrium blood of the heart flows through the tricuspid valve into the right ventricle, and the blood is injected into the large pulmonary artery by contraction of the right ventricle. The pulmonary artery blood is filtered through the circulation of the lung, venous blood with lower oxygen content is filtered into arterial blood with higher oxygen content and lower carbon dioxide content, and the arterial blood flows back to the left atrium through the pulmonary vein. Blood in the left atrium is transferred into the left ventricle through the mitral valve, the left ventricle contracts, and arterial blood with sufficient oxygen content is ejected out of the body after contraction and is ejected into the aorta of a human body.

With the pressure of work and life increasing, many patients are afflicted with cardiovascular and cerebrovascular diseases, and once the heart has a problem, if the heart cannot be rescued in time, the consequences are always fatal. The advent of prosthetic heart valves and stents has become a boon to patients with heart disease, requiring rigorous and comprehensive performance testing of prosthetic heart valves prior to surgical implantation into the body. However, the existing in vitro heart valve testing system is difficult to accurately simulate the heart beat.

To this end, there is a need in the art to develop an in vitro heart valve testing system that accurately simulates the beating of the heart.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide an external heart valve test system which can accurately simulate the heart beat.

In order to achieve the above purpose, the utility model provides the following technical scheme.

In a first aspect, the present application provides an extracorporeal heart valve testing system comprising a ventricular simulation chamber, an atrial simulation chamber, a first valve testing chamber, a second valve simulation chamber, a sealed second valve compliance chamber, and a sealed first valve compliance chamber, all of which are capable of communicating with each other;

the second valve compliance lumen is in fluid communication with the second valve testing lumen;

the first valve compliance lumen is in fluid communication with the first valve testing lumen;

the atrium simulates the chamber and sets up first valve test chamber top, first valve test chamber sets up ventricle simulation chamber top, second valve simulation chamber sets up second valve test chamber top, second valve test chamber sets up ventricle simulation chamber top, just atrium simulates the chamber first valve test chamber ventricle simulation chamber second valve test chamber with second valve simulation chamber connects gradually and forms the return circuit that is suitable for circulating fluid to flow.

In another embodiment, the extracorporeal heart valve testing system further comprises a peristaltic pump, the ventricular simulation chamber is an elastic structure, the outside and the inside of the ventricular simulation chamber are both liquid environments, the peristaltic pump provides intermittent peristaltic motion for liquid in the ventricular simulation chamber, and the outside liquid provides periodic squeezing and pulling for the ventricular simulation chamber, so that the ventricular simulation chamber contracts and expands.

In one embodiment of the first aspect, the atrium simulation chamber, the first valve testing chamber, the ventricle simulation chamber, the second valve testing chamber and the second valve simulation chamber are transparent.

In one embodiment of the first aspect, the second valve compliance lumen has a volume greater than a volume of the first valve compliance lumen.

In one embodiment of the first aspect, the atrial simulation chamber is open.

In one embodiment of the first aspect, the in vitro heart valve testing system further comprises a water bath heater and a flow regulating pump. The atrium simulation chamber comprises an atrium simulation chamber water filling port and an atrium simulation chamber circulating fluid inlet, and the atrium simulation chamber water filling port is communicated with the atmosphere. The second valve simulation chamber comprises a second valve simulation chamber circulating fluid outlet. The water bath heater comprises a water bath heater circulating fluid inlet, a water bath heater circulating outlet, a hot water inlet and a hot water outlet, wherein the hot water inlet is used for inputting hot water, the hot water outlet is used for outputting hot water, and the hot water is used for exchanging heat with circulating fluid. The flow regulating pump includes a flow regulating pump circulating fluid inlet and a flow regulating pump circulating fluid outlet. The water bath heater circulating fluid outlet is in fluid communication with the flow regulating pump circulating fluid inlet, the flow regulating pump circulating fluid outlet is in fluid communication with the atrium simulation lumen circulating fluid inlet, and the second valve simulation lumen circulating fluid outlet is in fluid communication with the water bath heater circulating fluid inlet.

In one embodiment of the first aspect, the second valve simulation chamber further comprises a second valve simulation chamber exit port for fluid communication with the second valve compliance chamber, the second valve simulation chamber exit port being located higher than the second valve simulation chamber exit port.

In one embodiment of the first aspect, the water bath heater comprises a hollow water bath heater body and a hollow water bath heater jacket disposed around the water bath heater, the water bath heater circulating fluid inlet is disposed on a lower surface of the hollow water bath heater body, the water bath heater circulating fluid outlet is disposed on an upper surface of the hollow water bath heater body, the hot water inlet is disposed closer to a lower surface of the hollow water bath heater jacket than the hot water outlet, and the hot water outlet is disposed closer to an upper surface of the hollow water bath heater jacket than the hot water inlet.

In one embodiment of the first aspect, the system further comprises a water replenishment tank in fluid communication with the water bath heater circulating fluid inlet via a water replenishment pipeline, a controller, a level sensor and a water replenishment regulating valve, the water replenishment regulating valve being disposed on the water replenishment pipeline, the level sensor being configured to detect a level of circulating fluid in the water bath heater, the controller being in communication with the level sensor and the water replenishment regulating valve and being configured to open the water replenishment regulating valve when the level of circulating fluid is below a threshold value.

In one embodiment of the first aspect, the water replenishment regulating valve is an electromagnetic valve.

Compared with the prior art, the in-vitro heart valve test system has the advantages that the in-vitro heart valve test system can accurately simulate the heart structure, the heart pulsation and the blood flow condition, and can provide reliable performance tests for the aortic valve and the mitral valve. In addition, during the test process, the water bath heater can realize automatic water replenishing, and the reliable operation of the system is ensured.

Drawings

The present application may be better understood by describing embodiments thereof in conjunction with the following drawings, in which:

fig. 1 is a schematic perspective view of an extracorporeal heart valve testing system in accordance with an embodiment of the present invention;

fig. 2 is a schematic end view of an in vitro heart valve testing system according to an embodiment of the present invention;

fig. 3 is a schematic perspective view of another angle of an extracorporeal heart valve testing system in an embodiment of the present invention;

fig. 4 is a schematic perspective view of another angle of an extracorporeal heart valve testing system in an embodiment of the present invention;

fig. 5 is a bottom view of an in vitro heart valve testing system in an embodiment of the present invention;

fig. 6 is a schematic view of a water bath heater in an embodiment of the invention;

fig. 7 is a schematic structural view of an extracorporeal heart valve testing system according to another embodiment of the present invention;

fig. 8 is a schematic end view of an in vitro heart valve testing system according to another embodiment of the present invention;

the reference numerals and names in the figures are as follows:

1. an atrial simulation chamber; 11. an atrium simulating a luminal circulating fluid inlet; 12. an atrium simulating chamber water filling port; 13. adding a water buffer piece; 2. a first valve testing chamber; 3. a ventricular simulation chamber; 31. an elastic structure; 4. a second valve testing chamber; 5. an active flap simulation cavity; 51. the active flap simulates a cavity water outlet; 52. the active valve simulates a cavity air outlet; 6. a water bath heater; 61. A water bath heater circulating fluid inlet; 62. a water bath heater circulating fluid outlet; 63. a hot water inlet; 64. a hot water outlet; 601. a water bath heater body; 602. a water bath heater jacket; 603. a water replenishing tank; 604. a controller; 605. a liquid level sensor; 606. a water replenishing regulating valve; 7. a flow regulating pump; 8. a second valve compliance lumen; 9. a first valve compliance lumen; 10. a peristaltic pump.

Detailed Description

Unless otherwise defined, technical or scientific terms used herein shall have the ordinary meaning as is understood by those of ordinary skill in the art to which the invention belongs.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts all belong to the protection scope of the present invention.

Referring first to fig. 1-5, the present application provides an extracorporeal heart valve testing system that may include an atrial simulation chamber 1, a first valve testing chamber 2, a ventricular simulation chamber 3, a second valve testing chamber 4, a second valve simulation chamber 5, a water bath heater 6, a flow regulating pump 7, a sealed second valve compliance chamber 8, a sealed first valve compliance chamber 9, and a peristaltic pump 10.

In one embodiment, the atrial simulation chamber may be a left atrial simulation chamber, the ventricular simulation chamber may be a left ventricular simulation chamber, the first valve may be a mitral valve, and the second valve may be an aortic valve.

In one embodiment, the ventricular mimic chamber 3 may be an elastic structure 31. Referring to fig. 7 and 8, the elastic structure 31 may be made of a flexible transparent material, and the outer shape may be an elliptic curved surface, similar to a human left ventricle structure. Furthermore, the resilient structure 31 may be in fluid communication with the second valve test chamber 4 and the first valve test chamber 2. The elastic structure 31 fills only a part of the space of the ventricular mimic chamber 3 and is spaced apart from the rest of the ventricular mimic chamber 3. The space in the ventricular simulation chamber 3 not filled by the elastic structure 3 may also be filled with a fluid to simulate the environment of blood.

The peristaltic pump 10 is used to provide intermittent peristaltic motion to the elastic structure 31, simulating cardiac contraction. For example, the peristaltic pump 10 may cyclically vary its internal volume by intermittently squeezing the resilient structure 31 by a piston or motor. In particular, when the elastic structure 31 is compressed, the hollow internal volume decreases, giving a pressure to the circulating fluid therein and compressing it to the second valve testing chamber 4. When the external pressure disappears, the elastic structure 31 is restored to its original shape and the internal volume is increased.

Referring to fig. 1, in this embodiment, a second valve compliance lumen 8 may be in fluid communication with the second valve testing lumen 5 for improving compliance of the latter. Similarly, the first valve compliance lumen 9 may be in fluid communication with the first valve testing lumen 2 for improving compliance of the latter.

In the in vitro heart valve testing system described herein, the in vitro heart valve testing system described herein has a particular structure and circulating fluid flow circuit in order to simulate the pulsatile and blood flow environment of a human heart. Specifically, the atrium simulation chamber 1 is disposed above the first valve testing chamber 2, the first valve testing chamber 2 is disposed above the ventricle simulation chamber 3, the second valve simulation chamber 4 is disposed above the second valve testing chamber 5, and the second valve testing chamber 5 is disposed above the ventricle simulation chamber 3. The atrium simulation cavity 1, the first valve test cavity 2, the ventricle simulation cavity 3, the second valve test cavity 4, the second valve simulation cavity 5, the water bath heater 6 and the flow regulating pump 7 are connected in sequence to form a loop suitable for circulating fluid to flow. In one embodiment, the circulating fluid is warm water, which may be at the same or similar temperature as the human body.

In one embodiment, the atrium simulation chamber 1, the first valve testing chamber 2, the ventricle simulation chamber 3, the second valve testing chamber 4 and the second valve simulation chamber 5 are transparent for easy observation. In one embodiment, the volume of the second valve compliance chamber 8 is greater than the volume of the first valve compliance chamber 9.

In one embodiment, referring to FIG. 1, the atrial simulator chamber 1 is open. Specifically, the atrial simulation chamber 1 may include an atrial simulation chamber fill port 12 that is in communication with the atmosphere and an atrial simulation chamber circulating fluid inlet port 12. Referring to fig. 7 to 8, the atrial simulation chamber filler may further include a buffer member 13 having a cylindrical shape, and in other preferred embodiments, the height of the buffer member 13 on the side facing the atrial simulation chamber circulation fluid inlet 11 is greater than the height of other portions. Extending a predetermined distance up from the bottom of the atrium simulation chamber 1 and the wall of the cylinder comprises at least one slit for slowing down the flow of the circulating fluid into the first valve testing chamber 2. The cylinder bottom may also include a circular ring, with the circulating fluid flowing into the first valve testing chamber through an opening of the circular ring.

In one embodiment, the second valve simulation chamber 5 comprises a second valve simulation chamber circulation fluid outlet 51. The water bath heater 6 includes a water bath heater circulation fluid inlet 61, a water bath heater circulation outlet 62, a hot water inlet 63 and a hot water outlet 64. The hot water inlet is used for inputting hot water, the hot water outlet is used for outputting hot water, and the hot water is used for exchanging heat with circulating fluid. It will be appreciated by those skilled in the art that the hot water is separate from the circulating fluid. The flow regulating pump 7 includes a flow regulating pump circulating fluid inlet 71 and a flow regulating pump circulating fluid outlet 72.

In one embodiment, the water bath heater circulation fluid outlet 62 is in fluid communication with a flow regulating pump circulation fluid inlet 71, the flow regulating pump circulation fluid outlet 72 is in fluid communication with the atrium simulation lumen circulation fluid inlet 51, and the second valve simulation lumen circulation fluid outlet 51 is in fluid communication with the water bath heater circulation fluid inlet 61.

In one embodiment, the second valve simulation chamber 5 further comprises a second valve simulation chamber outlet port 52 for fluid communication with the second valve compliance chamber 8, the second valve simulation chamber outlet port 52 being located at a higher level than the second valve simulation chamber outlet port 51.

Since the atrium simulation chamber 1 is open, the thermostatically circulating fluid may evaporate after a number of cycles resulting in an insufficient volume of circulating fluid. For this reason, this application has still improved water bath heater 6 to realize carrying out automatic water supply to water bath heater in the circulation process.

Specifically, referring to fig. 6, the water bath heater 6 comprises a hollow water bath heater body 601 and a hollow water bath heater jacket 602 disposed at the outer periphery of the water bath heater. A water bath heater circulating fluid inlet 61 is provided on the lower surface of the hollow water bath heater body 601 and a water bath heater circulating fluid outlet 62 is provided on the upper surface of the hollow water bath heater body 601. The hot water inlet 63 is located closer to the lower surface of the hollow water bath heater jacket 602 than the hot water outlet 64, and the hot water outlet 64 is located closer to the upper surface of the hollow water bath heater jacket 602 than the hot water inlet 63.

In the embodiment shown in fig. 6, the extracorporeal heart valve testing system further comprises a refill tank 603, a controller 604, a level sensor 605, and a refill regulator valve 606. The water replenishing tank 603 is in fluid communication with the water bath heater circulating fluid inlet 61 through a water replenishing pipeline, and the water replenishing regulating valve 606 is arranged on the water replenishing pipeline. The level sensor 605 is used to detect the level of the circulating fluid in the water bath heater 6, and the controller 604 is in communication with the level sensor 605 and the refill regulating valve 606 and is configured to open the refill regulating valve 606 when the level of the circulating fluid is below a threshold, thereby enabling automatic refill of the water bath heater 6. In a preferred embodiment, the refill regulating valve 606 may be a solenoid valve.

The operation of the in vitro heart valve testing system described herein will be briefly described, as it requires an external data acquisition system to record the temperature and pressure of the various components during testing. These are well known in the art and will not be described further herein.

The mitral valve or aortic valve to be tested is placed in the corresponding test chamber and the temperature and pressure of the circulating fluid are adjusted to the desired values. The cycle is then started by adding water to the filler port 52 of the atrium simulation chamber 1. And after the in-vitro heart valve test system operates stably, acquiring corresponding data. It should be noted that when testing the performance of the mitral valve, a standard aortic valve needs to be placed in the second valve testing chamber, and when testing the performance of the aortic valve, a standard mitral valve needs to be placed in the first valve testing chamber.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims (10)

1. An in vitro heart valve test system is characterized by comprising a ventricle simulation cavity, an atrium simulation cavity, a first valve test cavity, a second valve simulation cavity, a sealed second valve compliance cavity and a sealed first valve compliance cavity which can be mutually communicated;

the second valve compliance lumen is in fluid communication with the second valve testing lumen;

the first valve compliance lumen is in fluid communication with the first valve testing lumen;

the atrium simulates the chamber and sets up first valve test chamber top, first valve test chamber sets up ventricle simulation chamber top, second valve simulation chamber sets up second valve test chamber top, second valve test chamber sets up ventricle simulation chamber top, just atrium simulation chamber first valve test chamber ventricle simulation chamber second valve test chamber with second valve simulation chamber connects gradually and forms the return circuit that is suitable for circulating fluid to flow.

2. The in vitro heart valve testing system of claim 1, further comprising a peristaltic pump, wherein the ventricular analog chambers are elastic structures, and wherein the peristaltic pump provides intermittent peristaltic motion to the fluid in the ventricular analog chambers, and wherein the external fluid provides periodic squeezing and retraction to the ventricular analog chambers to cause contraction and expansion of the ventricular analog chambers.

3. The extracorporeal heart valve test system of claim 1, wherein the atrial simulation chamber, the first valve test chamber, the ventricular simulation chamber, the second valve test chamber, and the second valve simulation chamber are transparent.

4. The extracorporeal heart valve testing system of claim 1, wherein the volume of the second valve compliance chamber is greater than the volume of the first valve compliance chamber.

5. The extracorporeal heart valve testing system of claim 1, wherein the atrial mimic is open.

6. The in vitro heart valve testing system of claim 1, further comprising a water bath heater and a flow regulating pump;

the atrium simulation cavity comprises an atrium simulation cavity water filling port and an atrium simulation cavity circulating fluid inlet, and the atrium simulation cavity water filling port is communicated with the atmosphere;

the second valve simulation cavity comprises a second valve simulation cavity circulating fluid outlet;

the water bath heater comprises a water bath heater circulating fluid inlet, a water bath heater circulating outlet, a hot water inlet and a hot water outlet, the hot water inlet is used for inputting hot water, the hot water outlet is used for outputting hot water, and the hot water is used for exchanging heat with the circulating fluid;

the flow regulating pump comprises a flow regulating pump circulating fluid inlet and a flow regulating pump circulating fluid outlet;

the water bath heater circulating fluid outlet is in fluid communication with the flow regulating pump circulating fluid inlet, the flow regulating pump circulating fluid outlet is in fluid communication with the atrium simulation lumen circulating fluid inlet, and the second valve simulation lumen circulating fluid outlet is in fluid communication with the water bath heater circulating fluid inlet.

7. The in-vitro heart valve testing system of claim 6, wherein the second valve simulation chamber further comprises a second valve simulation chamber outlet port for fluid communication with the second valve compliance chamber, the second valve simulation chamber outlet port being positioned higher than the second valve simulation chamber outlet port.

8. The extracorporeal heart valve test system of claim 6, wherein the water bath heater comprises a hollow water bath heater body and a hollow water bath heater jacket disposed around the water bath heater, the water bath heater circulation fluid inlet is disposed on a lower surface of the hollow water bath heater body, the water bath heater circulation fluid outlet is disposed on an upper surface of the hollow water bath heater body, the hot water inlet is disposed closer to the lower surface of the hollow water bath heater jacket than the hot water outlet, and the hot water outlet is disposed closer to the upper surface of the hollow water bath heater jacket than the hot water inlet.

9. The extracorporeal heart valve testing system of claim 8, further comprising a refill tank in fluid communication with the water bath heater circulating fluid inlet via a refill line, a controller, a fluid level sensor disposed on the refill line, and a refill regulator valve for sensing the level of circulating fluid in the water bath heater, the controller being in communication with the fluid level sensor and the refill regulator valve and configured to open the refill regulator valve when the level of circulating fluid is below a threshold.

10. The in vitro heart valve testing system of claim 9, wherein the water replenishment regulating valve is a solenoid valve.

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