CN217793318U - Temperature measurable treatment optical fiber and laser thermotherapy system - Google Patents

Abstract

The present application provides a therapeutic optical fiber and a laser hyperthermia system comprising such a therapeutic optical fiber, the therapeutic optical fiber comprising: a double-clad fiber and a treatment tip, the proximal end of the treatment tip abutting the distal end of the double-clad fiber; the double-cladding optical fiber comprises a fiber core, a first cladding and a second cladding, wherein the far end of the fiber core is provided with a temperature measurement grating, the refractive index of the first cladding is smaller than that of the fiber core, the refractive index of the second cladding is smaller than that of the first cladding, the fiber core can transmit temperature measurement light, the first cladding can transmit treatment light, and the treatment end can change the direction of at least one part of the treatment light.

Description

Temperature measurable treatment optical fiber and laser thermotherapy system

Technical Field

The application relates to the technical field of medical equipment, in particular to a temperature-measurable treatment optical fiber and a laser thermotherapy system comprising the same.

Background

The laser thermotherapy is a new therapeutic technology which can introduce the light into the interior of human body by means of optical fibre to make local biological tissue produce coagulation and necrosis after absorbing energy, and can remove in-situ tumor or focus by means of small invasion. Compared with the traditional surgical excision operation, the method has the characteristics of short operation time, small operation wound surface, less occurrence of massive hemorrhage, less pain to patients, good postoperative recovery effect and certain anti-inflammatory and bactericidal effects. Has good prospect in disease treatment, especially in the treatment research of tumors, and is currently used for treating many types of tumors, such as tumors in the liver, brain, mammary gland, retina and other parts.

In laser hyperthermia, laser light is typically introduced into tissue through an optical fiber. The distal end of the fiber is generally centered in the tissue being thermally treated, and is also typically the highest temperature. In addition, the fiber ends typically have a treatment tip such as a scattering treatment tip that produces a spherical or ellipsoidal spot, and a reflective treatment tip that deflects the exiting beam. The temperature detection of the treatment end is the key of the safe treatment of the laser thermotherapy. The tissue temperature is kept too low to achieve the treatment effect, the tissue can be carbonized or gasified quickly when the temperature is too high, the normal tissue is damaged, and the condition that the optical fiber tip is burnt or broken in the tissue of a human body can be caused most seriously. Moreover, the laser dose is also the core of the whole treatment process, and directly determines the range and safety of the treatment area, for example, in brain surgery, when the tumor to be treated is very close to the vital tissue, the damage to the adjacent monitored tissue and sensitive structures must be strictly controlled. Therefore, in order to ensure that the tumor tissue or focus is completely inactivated and simultaneously avoid the damage to normal tissues around the tumor, the accurate heating and temperature control of the treatment part and the end of the treatment optical fiber are the key for realizing the laser thermotherapy technology, and a reliable temperature measurement mode is needed for monitoring and effective evaluation.

At present, the common practice is to utilize Magnetic Resonance Imaging (MRI) to measure temperature, but MRI imaging measurement time is long, minimum time interval causes delay between measured images and an actual damage process, equipment is complex, and cost is high. In addition, the temperature monitoring is carried out by MRI imaging, only the relative temperature change can be calculated, and then the superposition is carried out by combining the actual temperature measured by the reference point. There is also a measurement using an ultrasonic method, but it is necessary to measure acoustic characteristics as well as temperature characteristics of various tissues in advance. In practice, because characteristic parameters are different among individuals, the measurement process is complex, time-consuming and low in accuracy.

Another common method is to measure by means of thermistor and thermocouple. Because the probes and wires of the thermistor and the thermocouple are generally made of metal, laser is absorbed, certain background noise is generated, the measured temperature is higher than the actual temperature, the resistor generates heat under the influence of electromagnetism, the resistance influences the electromagnetism to generate artifacts and the like, the interference is caused, and the probe and the wire are not suitable for being used together with the MRI imaging technology and the like.

It is proposed to use single mode fiber with 6-20 micron fiber core for energy transmission and temperature measurement, but the semiconductor laser used for ablation therapy is generally output by fiber with 100-600 um core diameter, which results in extremely low fiber coupling efficiency between the therapeutic fiber and the therapeutic host, and thus insufficient therapeutic energy; in addition, the fiber core of the single-mode fiber is only 6-20 microns, so that the optical power density on the end face of the fiber is extremely high, the fiber is very easy to burn, and potential safety hazards are brought.

In addition, the individually-placed temperature measuring optical fiber cannot reach the optimal temperature detection position, and the potential high-temperature risk near the ablation tip cannot be warned in time; if the two optical fibers are integrated, the diameter of the optical fibers and the complexity of packaging are increased, and certain problems are caused in the aspects of processing difficulty, cost control and wound increase;

in order to solve some or all of the above problems, the present application proposes a treatment optical fiber and a laser thermotherapy system including the treatment optical fiber.

SUMMERY OF THE UTILITY MODEL

In view of the above, in a first aspect, the present application provides a therapeutic optical fiber, comprising: the near end of the treatment tip is adjacent to the far end of the double-cladding optical fiber; the double-clad optical fiber comprises a fiber core, a first cladding and a second cladding, wherein the far end of the fiber core is provided with a temperature measuring grating (such as a Bragg grating), the refractive index of the first cladding is smaller than that of the fiber core, and the refractive index of the second cladding is smaller than that of the first cladding; the core can transmit temperature measuring light (light for temperature monitoring), the first cladding can transmit therapeutic light (light for treatment), and the treatment tip can change the emitting direction of at least one part of the therapeutic light.

Optionally, the first cladding layer can also transmit indicating light for emitting visible light before treatment, so that a user can conveniently and quickly confirm the availability of the treatment optical fiber.

Optionally, the treatment end still is provided with the beam splitting membrane, and the beam splitting membrane has high reflectivity to monitoring cracked monitoring light, has high transmissivity to other light, can be used for monitoring cracked monitoring light through the transmission of first covering to whether the monitoring takes place optic fibre fracture in the use.

The reference to the high transmittance of the light-splitting film for light in the present application means that the light passes through the light-splitting film at a rate of not less than 90%, preferably not less than 95%, more preferably not less than 98%, etc.

The monitoring light reflected by the light splitting film has a high reflectivity, and the monitoring light is obviously different from the monitoring light returned by other reflecting surfaces when reaching the monitoring light detector and can be identified by the detector; for example, the intensity of the monitoring light reflected by the spectroscopic film upon reaching the monitoring light detector is at least 50% higher, preferably 1 times higher, than the intensity of the monitoring light returned to the detector by the other reflecting surface.

In the application, the treatment tip is used for transmitting light to a target position, and the emergent direction of the light or at least a part of the light can be changed; the treatment tip can be selected in various ways, and in some embodiments, the treatment tip comprises a reflecting end surface so that light rays are emitted directionally according to a preset direction; in other embodiments, the treatment tip comprises scattering particles that cause light to exit in a direction perpendicular to the long axis of the light delivery structure; in still other embodiments, the treatment tip can have both scattering particles and a reflective surface; in some embodiments, the treatment tip has scattering particles and a diffusive reflective surface. The light rays which can be emitted by the treatment end head not only comprise treatment light, but also comprise indicating light rays and the like. The therapeutic light may include laser light for ablation, but also light for other methods such as photodynamic therapy. Therefore, the treatment optical fiber can be used for laser thermotherapy and photodynamic therapy.

Furthermore, the treatment optical fiber transmits the temperature measuring light through the fiber core, after the temperature measuring light reaches the temperature measuring grating through the fiber core, at least one part of the temperature measuring light returns, the returned temperature measuring light is measured, and the temperature reaching the temperature measuring grating (namely the near end of the treatment end) can be obtained. Further, through measuring the temperature measurement light that returns, can also obtain from the near-end of treatment optic fibre to the structural aspect between the temperature measurement grating (whether damage such as fracture has taken place promptly), when breaking, the signal that obtains from the temperature measurement grating can take place abrupt change to can let the user in time know.

In a second aspect, the present application provides a laser hyperthermia system comprising: control center, treatment light source module, temperature sensing module, beam combiner, the treatment optic fibre of at least one this application. The therapeutic light source module can generate light of one or more wavelengths, for example, several laser generators and corresponding controllers can be included, and therapeutic (ablative) laser light of various common wavelengths, such as 980nm and 1064nm, can be generated.

The temperature sensing module comprises a temperature measurement light source and a demodulation module. The temperature measurement light source and the demodulation module can adopt appropriate combination equipment, for example, in some embodiments, the temperature measurement light source is a C-band tunable laser, and the demodulation module is a photoelectric detector; in other embodiments, the thermometric light source is a C-band ASE (spontaneous emission) light source and the demodulation module is a spectral demodulation module. The temperature measuring light source emits temperature measuring light which is transmitted to the temperature measuring grating through the fiber core. The temperature measurement grating can selectively reflect light with certain wavelength according to the grating characteristics, and the grating characteristics change along with the temperature change, so that the grating can reflect light with different wavelengths at different temperatures. The demodulation module measures the returned temperature measurement light, demodulates the wavelength of the returned temperature measurement light, and then calculates the temperature of the temperature measurement grating.

The beam combiner integrates the light rays generated by the treatment light source module and the temperature sensing module, the light rays are output through the transmission optical fiber, the transmission optical fiber is connected with the treatment optical fiber through the coupler, and finally the light rays generated by the treatment light source module and the temperature sensing module reach the target position.

Optionally, the laser thermotherapy system of the present application further comprises an indication light source, the indication light source comprises a visible light laser, generates visible light for indication, and can be separately arranged or arranged in the therapy light source module, i.e. the therapy light source module not only comprises a laser for emitting therapy light, but also comprises a laser for emitting indication light.

In some embodiments, the laser thermotherapy system further includes a splitter, the splitter can divide received light into multiple paths for output, the therapeutic light source module and the temperature sensing module can be respectively connected with n splitters (n is a natural number greater than or equal to 2), n therapeutic lights output after passing through the n splitters and n corresponding temperature measuring lights are paired pairwise, and the n therapeutic lights enter the n therapeutic optical fibers after passing through the n combiners. Further, there may be two or more therapy modules, each therapy module being used with one of the therapy fibers of the present application.

The laser thermotherapy system can also comprise a cooling module matched with the therapeutic optical fiber; the cooling module includes: when the peristaltic pump is used, the treatment optical fiber is placed in the cooling sleeve, the peristaltic pump pumps the cooling interstitial substance into the cooling sleeve, and the treatment optical fiber absorbs heat of the treatment optical fiber and then flows out of the cooling sleeve, so that the temperature of the treatment optical fiber and nearby tissues is reduced.

A magnetic resonance interstitial based laser hyperthermia system comprising a treatment fiber according to the present application, or a laser hyperthermia system.

In some embodiments, the magnetic resonance interstitial based laser hyperthermia system of the present application comprises a workstation comprising a host and a human machine interaction module; further, the system may further include a Magnetic Resonance (MRI) device; in the use state, the host computer is in communication connection with the magnetic resonance device, receives the information of the magnetic resonance module, and completes at least one of the following according to the digital image information of the patient: the patient is documented, 3D modeling is carried out according to preoperative medical image information, and an operation scheme is generated; the MRI temperature imaging technology generates a real-time temperature image according to magnetic resonance information, the temperature image and the 3D model are fused and displayed in a man-machine interaction module, the digital image information comprises but is not limited to a CT image and a magnetic resonance image, and the temperature calculation and ablation evaluation based on the magnetic resonance are verified and corrected through the temperature measured by the treatment optical fiber.

The host computer is loaded with a temperature measurement program which can execute temperature correction, and the temperature measurement program can execute the following method:

the temperature of the proximal end of the treatment tip is continuously obtained by using the temperature sensing module as a reference temperature,

the temperature of the near end of the therapeutic end head obtained by the magnetic resonance temperature measurement method is used as the calculated temperature,

after the primary calculated temperature is obtained, comparing the reference temperature with the calculated temperature;

when the absolute value of the difference value between the reference temperature and the calculated temperature exceeds a threshold value, correcting the calculated temperature;

extracting the highest temperature in the corrected calculated temperature, comparing the highest temperature with the warning temperature, and if the highest temperature exceeds the warning temperature, sending an instruction for closing the treatment laser; if the warning temperature is not exceeded, the next round of magnetic resonance temperature measurement is continuously compared with the temperature until the execution of the preset program is finished.

In some embodiments, the threshold may be set as desired, e.g., 1 ℃, 1.2 ℃, 1.5 ℃, 2 ℃,3 ℃, etc.

In some embodiments, the warning temperature may be set as desired, such as 85 ℃, 88 ℃, 90 ℃, etc.

The application has at least the following advantages:

1. the treatment optical fiber has a built-in temperature measurement structure (temperature measurement grating), realizes simultaneous treatment and temperature measurement under the condition of not increasing the outer diameter, and can carry out continuous real-time temperature measurement.

2. The built-in temperature measurement structure of treatment optic fibre of this application can also be used for structural damage to detect, can't receive the temperature measurement light signal that the temperature measurement structure returned when unable detector, explains and takes place structural damage from near-end to temperature measurement structure in the treatment optic fibre between, and temperature measurement light can't pass through.

3. According to the laser thermotherapy system, in some using processes, the highest temperature in the laser thermotherapy can be detected in real time through the built-in temperature measurement structure of the treatment optical fiber, so that the judgment time that the actual temperature exceeds the warning temperature is shortened, and the safety of the laser thermotherapy is improved.

4. According to the laser thermotherapy system based on the magnetic resonance interstitium, the temperature of the near end of the treatment end can be detected in real time through the temperature measuring structure arranged in the treatment optical fiber, the temperature at the near end is used as the reference temperature, and the reference temperature is compared with the calculated temperature obtained according to the magnetic resonance scanning method, so that the error of the temperature measurement of the magnetic resonance scanning method is corrected, and further the auxiliary correction is carried out on the ablation calculation.

In order to make the aforementioned objects, features and advantages of the present application more comprehensible, preferred embodiments accompanied with figures are described in detail below.

Drawings

In order to more clearly illustrate the detailed description of the present application or the technical solutions in the prior art, the drawings needed to be used in the detailed description of the present application or the prior art description will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic view of a treatment fiber according to one embodiment of the present application;

FIG. 2 is a schematic structural view of a treatment fiber showing a light splitting membrane according to some embodiments of the present application;

FIG. 3 is a schematic view of a laser hyperthermia system according to an embodiment of the present application;

figure 4 is a schematic view of a laser hyperthermia system according to a further embodiment of the present application;

FIG. 5 is a schematic view of a laser hyperthermia system according to another embodiment of the present application;

figure 6 is a schematic view of a laser hyperthermia system according to a further embodiment of the present application;

FIG. 7 is a schematic view of a laser hyperthermia system according to a further embodiment of the present application;

icon:

0-control center, 1-therapeutic light source module; 2-a temperature sensing module; 3-a combiner; 4-double clad passive fiber; 5-coupler or fiber flange; 6-treatment optical fiber; 61-a core; 62-a first cladding; 63-a second cladding layer; 64-coating, 65-cannula, 66-treatment tip; 67-temperature measurement grating; 68-a light splitting film; 681-refracting surfaces.

Detailed Description

To make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the present application will be clearly and completely described below with reference to the accompanying drawings, and it is obvious that the described embodiments are some, but not all embodiments of the present application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Reference in this application to the use of proximal and distal end-described assemblies means that the proximal end of the assembly is the end that is farther from the tissue to be treated during use and the distal end of the assembly is the end that is closer to the tissue to be treated during use.

Example 1

Referring to fig. 1-2, there is shown a schematic view of a treatment fiber of the present application, the treatment fiber 6 comprising: a double-clad optical fiber 60 and a treatment tip 66, wherein: the double-clad optical fiber 60 includes a core 61, a first cladding 62, a second cladding 63; the treatment tip 66 can be a treatment tip for laser thermotherapy or a treatment tip for photodynamic therapy; the fiber core 61 of the double-clad fiber is provided with a temperature measuring grating 67 at the far end, the far end of the double-clad fiber is adjacent to the near end of the treatment tip, and the temperature at the far end can be continuously measured through the temperature measuring grating. The structure is only exemplary, the axial length of the double-clad fiber is far longer than that of the treatment tip, and most of the homogeneous structure of the proximal end is omitted;

one example of a temperature grating is a bragg grating;

the core 61 of the double-clad fiber is a single-mode core, preferably a single-mode core with a diameter of 9 to 25 microns;

the refractive index of the first cladding 62 of the double-clad optical fiber is smaller than that of the fiber core 61, so that temperature measuring laser can be transmitted in the fiber core 61;

the refractive index of the second cladding 63 of the double-clad fiber is smaller than that of the first cladding 62, so that the therapeutic laser can be transmitted in the first cladding 62;

it will be appreciated by those skilled in the art that the second cladding outer side may also be provided with different coating layers 64 as generally desired;

the treatment tip 66 can redirect at least a portion of the light, using a variety of different configurations as desired, for example, in some instances the treatment tip 66 can be a scattering tip that scatters light to direct light in a direction perpendicular to the long axis of the light-transmitting structure; in other embodiments, the treatment tip 66 is based on the scattering tip, and a portion of the area along the long axis is covered by a reflective material to achieve directional light extraction; further details of the treatment tip 66 can be found in the company's prior patent applications: 201810633280.8, a device for laser ablation; 201911409241.0, a device for laser interstitial hyperthermia system, the entire contents of which are incorporated herein by reference; in still other examples, the treatment tip 66 may have a refractive surface 661 to allow light to exit in a particular direction, see fig. 2C.

In some examples, the treatment tip 66 may be directly connected to the double-clad fiber 60, such as by fusion splicing or the like.

In the case where the treatment tip 66 is not directly connected to the double-clad fiber 60, the treatment tip 66 further comprises a sleeve 65 for connecting the double-clad fiber, the sleeve 65 is made of a material that can transmit the treatment laser light, such as quartz, sapphire, PC, PTFE, etc., and the treatment tip 66 can be processed by injecting a plastic fluid containing scattering particles into the sleeve 65.

Examples 2 to 4

Further, on the basis of embodiment 1, the treatment tip 66 may further include a light splitting film 68. Referring to fig. 2A-2C, there is shown the double-clad optical fiber 60, the treatment tip 66, and the spectroscopic membrane 68, with embodiment 2 shown in fig. 2A with the spectroscopic membrane 68 disposed at the proximal end of the treatment tip 66, and embodiment 3 shown in fig. 2B with the spectroscopic membrane 68 disposed at the distal end of the treatment tip 66; embodiment 4 in fig. 2C, the treatment tip 66 further has a refractive surface 661, the light splitting film 68 is disposed on the light outgoing path, and the unidirectional arrows indicate the outgoing directions of the treatment light and the indication light; the double-headed arrow indicates the optical path of the monitor light entering and returning for monitoring whether or not the structural breakage occurs in the optical path.

Example 5

Referring to fig. 3, there is shown a schematic diagram of a laser hyperthermia system of the present application, the system comprising: the control center 0, the therapeutic light source module 1; a temperature sensing module 2; a beam combiner 3; a double-clad passive optical fiber 4; a coupler (or fiber flange) 5; the treatment optical fiber 6 of the present application; and the control center 0 comprises a host and a human-computer interaction device (such as a touch screen).

The therapeutic light source module 1 comprises one or more sets of therapeutic lasers and corresponding controllers, the lasers being capable of generating laser light of any wavelength suitable for therapy, the lasers preferably being semiconductor lasers or solid state lasers of any wavelength in the 700-1100 nm band.

Under the condition that the treatment light source module 1 comprises two or more groups of lasers and corresponding controllers, the treatment lasers in each group can be the same or different, and the lasers generated by the two or more groups of lasers can be integrated in the beam combiner; in some examples, two lasers producing laser light of the same wavelength are included, and in other examples, two lasers producing laser light of different wavelengths are included, for example, one of the lasers can produce laser light of 980nm wavelength and the other laser can produce laser light of 1064nm wavelength; during the use process, the laser devices can be controlled according to the requirements, for example, the optical power, the light emitting time and the light emitting mode of each laser device can be controlled simultaneously and respectively; the combined use mode of the two lasers can be various, and can be synchronous or asynchronous, alternate and the like; for example, a first laser generating 980nm laser light is controlled to work in a first time period, and then a second laser generating 1064nm laser light is controlled to work in a second subsequent time period; or a first laser generating 980nm wavelength laser and a second laser generating 1064nm wavelength laser may be controlled to operate at the same time in the first period, and then the first laser is turned off and only the second laser continues to operate in the second period. It is understood that the therapeutic light source module 1 may contain different number groups of 1, 2, 3, 4, 5, 6, etc. lasers and corresponding controllers.

The temperature sensing module, preferably a fiber grating demodulator, comprises a light source module and a demodulation module; the light source module generates temperature measuring light which is transmitted to the Bragg grating 67 through the fiber core 61, the temperature measuring light returns after reaching the Bragg grating 67, and the temperature measuring light is received by the demodulation module and calculates the wavelength change and the temperature of the Bragg grating 67; the light source module and the corresponding demodulation module can be selected from various options, such as a C-band tunable laser and a photoelectric detector; or a C-band ASE light source and a spectrum demodulation module.

The combiner can be a module for combining the therapeutic optical signal and the monitoring optical signal, and is preferably a pump/signal combiner, and can also be a wavelength division multiplexer.

This embodiment may also include a cooling circulation device comprising a peristaltic pump, a cooling fluid and a cooling cannula, the cooling cannula being used in combination with the therapeutic optical fiber, the cooling fluid being any fluid suitable for cooling, preferably including double distilled water, medical saline, and the like; the cooling cycle device may also be provided with one or more monitoring sensors for measuring the pressure in the cooling jacket, the flow rate of the cooling fluid, etc., detecting whether a blockage has occurred, a cooling jacket rupture, etc.

The embodiment can be further provided with an indication optical module, the indication optical module is fused in the therapeutic light source module, and can also be independently arranged, and when the indication optical module is independently arranged, the indication optical module is transmitted through the first cladding of the therapeutic optical fiber through the beam combiner.

Example 6

Referring to fig. 4, there is shown a schematic view of a laser hyperthermia system of the present application, comprising: the control center 0,3 treatment light source modules 1, each treatment module 1 comprises 3 groups of lasers, the first group of lasers can generate first treatment light (for example 980nm laser), the second group of lasers can generate second treatment light (for example 1064nm laser), the third group of lasers can generate indication light, the 3 temperature sensing modules 2 comprise temperature measurement light sources and demodulation modules, 1550 tunable lasers and photodetectors can be used, or C-band ASE light sources and spectrum demodulation modules; 3 beam combiners 3;3 double-clad passive optical fibers 4;3 couplers 5;3 treatment optical fibers 6;

this embodiment may also include a corresponding 3 cooling circulations, i.e. each subsystem includes one cooling circulation, which includes a peristaltic pump, a cooling fluid and a cooling cannula, which is used in combination with the treatment fibers, each of which may be used with a corresponding cooling cannula, the cooling fluid may be any fluid suitable for cooling, preferably including double distilled water, medical saline, etc.; the cooling cycle device may also be provided with one or more monitoring sensors for measuring the pressure in the cooling jacket, the flow rate of the cooling fluid, etc., detecting whether a blockage has occurred, a cooling jacket rupture, etc.

The subsystem of this embodiment may further be provided with an indication light module, which is fused in the therapeutic light source module as described above, or may be separately provided, and when separately provided, the indication light module is also transmitted through the first cladding of the therapeutic optical fiber by the beam combiner. The control center simultaneously and respectively controls 3 laser thermotherapy subsystems formed by a therapeutic light source module 1, a temperature sensing module 2, a beam combiner 3, a double-cladding passive optical fiber 4, a coupler 5 and a therapeutic optical fiber 6.

The control center may control each subsystem to use the same or different treatment protocols, e.g., 980nm wavelength in the first subsystem, 1064nm wavelength in the second subsystem, and 980nm and 1064nm wavelength in the third subsystem; for example, the three subsystems each use therapeutic light wavelengths that are 980nm in combination with 1064nm, but the ablation times and intervals are different; the treatment scheme comprises the wavelength, the laser output power, the light emitting time, the light emitting mode, the laser emitting angle, the cooling fluid flow and other parameters.

It is understood that the first therapeutic light and the second therapeutic light may also use other wavelengths of laser light suitable for laser hyperthermia, and that such wavelength schemes are included within the scope of the present application; the indicator light is typically selected to be visible light.

It is understood that based on the present embodiment, the laser hyperthermia system of the present application may comprise other number of subsystems, for example, including 2, 4, 5, 6, etc., which are also included in the scope of the present application.

Example 7

Referring to fig. 5, there is shown a schematic view of another laser hyperthermia system of the present application, comprising: a control center (not shown), a therapeutic light source module, which includes 3 sets of lasers; a first group of lasers can generate first treatment light (for example 980nm laser), a second group of lasers can generate second treatment light (for example 1064nm laser), a third group of lasers can generate indication light, a temperature sensing module comprises a temperature measurement light source and a demodulation module, a 1550 tunable laser and a photoelectric detector can be used, or a C-band ASE light source and a spectrum demodulation module; 2 beam splitters and 3 beam combiners; 3 couplers; 3 treatment optical fibers; the control center is in communication connection with the therapeutic light source module, the temperature sensing module and the like;

the therapeutic light generated by the therapeutic light source module is divided into 3 parts by the beam splitter, and the therapeutic light output by the therapeutic light source module can comprise one or more types of therapeutic light, such as therapeutic light with the output of 980nm and 1064nm at the same time; temperature measurement light generated by the temperature sensing module is divided into 3 parts through the beam splitter, then is paired with treatment light one by one, and is combined through the first beam combiner, the second beam combiner and the third beam combiner respectively and then is output to the corresponding first treatment optical fiber, the second treatment optical fiber and the third treatment optical fiber, wherein the temperature measurement light enters a fiber core of the treatment optical fiber for transmission, and the treatment light and other light enter a first cladding for transmission.

The embodiment can also be further provided with an indication light module separately, and the indication light module is fused in the therapeutic light source module, namely one group of laser generators generates indication light; when the device is independently arranged, the indicating light passes through the beam combiner and is transmitted through the first cladding layer of the treatment optical fiber, and the indicating light module is in communication connection with the control center.

This embodiment may also include 3 corresponding cooling circulations, i.e. one cooling circulation is matched for each treatment fiber, the cooling circulations include a peristaltic pump, a cooling fluid and a cooling cannula, the cooling cannula is used in combination with the treatment fibers, each treatment fiber can be used with the corresponding cooling cannula, the cooling fluid can be any fluid suitable for cooling, preferably including double distilled water, medical saline, etc.; the cooling cycle device may also be provided with one or more monitoring sensors for measuring the pressure in the cooling jacket, the flow rate of the cooling fluid, etc., detecting whether a blockage has occurred, a cooling jacket rupture, etc.

Under the condition that the laser thermotherapy system does not comprise the cooling circulation device, the temperature measurement structure arranged in the treatment optical fiber can detect the highest temperature in the laser thermotherapy in real time, so that the judgment time that the actual temperature exceeds the warning temperature is reduced, and the safety of the laser thermotherapy is improved.

It is understood that the first therapeutic light and the second therapeutic light may also use other wavelengths of laser light suitable for laser hyperthermia, and that such wavelength schemes are included within the scope of the present application; the indicator light is typically selected to be visible light.

It is understood that, based on the present embodiment, other numbers of beam combiners and corresponding therapy fibers may be included in the laser hyperthermia system of the present application, for example, 2, 4, 5, 6, etc.; the therapeutic light generated by the therapeutic light source module and the temperature measuring light generated by the temperature sensing module can be divided into corresponding parts, such as 2 parts, 4 parts, 5 parts, 6 parts and the like, by the beam splitter, and the schemes are also within the scope of the application.

Example 8

Referring to fig. 6, there is shown a schematic view of yet another laser hyperthermia system of the present application, comprising: a control center (not shown), 3 therapeutic light source modules, each therapeutic light source module comprising 3 sets of lasers; the first group of lasers can generate first treatment light (for example 980nm laser), the second group of lasers can generate second treatment light (for example 1064nm laser), the third group of lasers can generate indication light, the temperature sensing module comprises a temperature measurement light source and a demodulation module, a 1550 tunable laser and a photoelectric detector can be used, or a C-band ASE light source and a spectrum demodulation module can be used; 1 beam splitter and 3 beam combiners; 3 couplers; 3 treatment optical fibers; the control center is in communication connection with the therapeutic light source module and the temperature sensing module;

the therapeutic light output by the therapeutic light source module may include one or more therapeutic lights, for example, therapeutic lights of 980nm and 1064nm output simultaneously; the temperature measuring light generated by the temperature sensing module is divided into 3 parts by the beam splitter, then is paired with the treatment light output by the 3 treatment light source modules one by one, and is combined by the first beam combiner, the second beam combiner and the third beam combiner respectively and then is output to the corresponding first treatment optical fiber, the second treatment optical fiber and the third treatment optical fiber, wherein the temperature measuring light enters the fiber core of the treatment optical fiber for transmission, and the treatment light and other light enter the first cladding for transmission.

The embodiment can also be further provided with an indication light module separately, and the indication light module is fused in the therapeutic light source module, namely one group of laser generators generates indication light; when the device is independently arranged, the indicating light passes through the beam combiner and is transmitted through the first cladding layer of the treatment optical fiber, and the indicating light module is in communication connection with the control center.

This embodiment may also include a corresponding 3 cooling circulations, i.e., each subsystem includes one cooling circulation, which includes a peristaltic pump, a cooling fluid and a cooling cannula, which is used in combination with the therapeutic fibers, each of which may be used with a corresponding cooling cannula, the cooling fluid may be any fluid suitable for cooling, preferably including double distilled water, medical saline, etc.; the cooling cycle device may also be provided with one or more monitoring sensors for measuring the pressure in the cooling jacket, the flow rate of the cooling fluid, etc., detecting whether a blockage has occurred, a cooling jacket rupture, etc.

It is understood that the first therapeutic light and the second therapeutic light may also use other wavelengths of laser light suitable for laser hyperthermia, and that such wavelength schemes are included within the scope of the present application; the indicator light is typically selected to be visible light.

It is understood that, based on the present embodiment, the laser thermal therapy system of the present application may include other numbers of beam combiners and corresponding therapy optical fibers, for example, 2, 4, 5, 6, etc., and the therapy light source module may generate the temperature measuring light, which is divided into several parts corresponding to the number of the therapy light source modules by the beam splitter, for example, 2 parts, 4 parts, 5 parts, 6 parts, etc., and these solutions are also within the scope of the present application.

Example 9

Referring to fig. 7, the embodiment 9 is different from the embodiment 8 in that the internal structures of the 3 therapeutic light source modules are different, the first therapeutic light source module further includes a laser and a corresponding controller, the second therapeutic light source module includes two lasers and a corresponding controller, and the third therapeutic light source module includes three lasers and a corresponding controller.

It is understood that based on this embodiment, the internal structure of the therapeutic light source module in the laser thermotherapy system of the present application can be the same or different, and these solutions are also within the scope of the present application.

In the aforementioned embodiments 5 to 8, in the case that the laser hyperthermia system uses the cooling circulation device, the control center can also be connected to the cooling circulation device in communication, and can perform feedback control based on temperature and ablation estimation, that is, when the highest temperature is detected to be close to the alarm temperature, the output power of the laser is reduced, and the output quantity of the cooling liquid of the cooling module is increased, so as to prevent the highest temperature from exceeding the alarm temperature, for example, the highest temperature is not increased or decreased any more; thereby maintaining the whole system to operate in a controllable interval.

Example 10

The magnetic resonance-based laser hyperthermia system of the present application, the structural composition of the magnetic resonance-based laser hyperthermia system can be referred to the 'magnetic resonance guidance-based laser hyperthermia device and system' 201810459539.1, a prior application of the present company, the entire contents of which are incorporated herein by reference; the system of the present application includes:

a magnetic resonance apparatus, a workstation and a laser hyperthermia system as described herein before;

the magnetic resonance equipment can acquire images before and during operation;

the workstation comprises a host and a human-computer interaction module (such as a touch screen), wherein the host is in communication connection with the magnetic resonance device and can receive preoperative and intraoperative medical image information of the magnetic resonance device and other imaging devices (such as CT), receive the filing of a patient, perform 3D modeling according to the preoperative medical image information and generate an operation scheme; generating a real-time temperature image according to the magnetic resonance information, planning a treatment area, displaying intraoperative information, sending control information to a laser thermal therapy instrument, calculating temperature and estimating ablation, fusing and displaying the temperature image and the 3D model in a human-computer interaction module, and the like;

the host computer is loaded with a temperature measurement program which can execute temperature correction, and the temperature measurement program can execute the following method:

the temperature of the proximal end of the treatment tip is continuously obtained by using the temperature sensing module as a reference temperature,

the temperature of the near end of the therapeutic end head obtained by the magnetic resonance temperature measurement method is used as the calculated temperature,

after the primary calculated temperature is obtained, comparing the reference temperature with the calculated temperature;

when the absolute value of the difference between the reference temperature and the calculated temperature exceeds a threshold value, the calculated temperature is corrected.

Further, an alert step may also be performed:

extracting the highest temperature in the corrected calculated temperature, comparing the highest temperature with the warning temperature, and if the highest temperature exceeds the warning temperature, sending an instruction for closing the treatment laser; if the warning temperature is not exceeded, the next round of magnetic resonance temperature measurement is continuously compared with the temperature until the execution of the preset program is finished.

The magnetic resonance-based laser thermotherapy system can also perform feedback control based on temperature and ablation conditions, namely when the highest temperature is detected to be close to the alarm temperature, the output power of the laser is reduced, and the output quantity of cooling liquid of the cooling module is increased, so that the highest temperature is prevented from exceeding the alarm temperature, for example, the highest temperature does not rise or fall any more; thereby maintaining the whole system to operate in a controllable interval.

The relative temperature is calculated according to the magnetic resonance image, then the absolute temperature is obtained according to the temperature reference point, the ablation condition is calculated by combining the time, the temperature cannot be continuously obtained due to the limitation of the magnetic resonance scanning speed, the current minimum interval of each round of magnetic resonance scanning is 3 seconds or more, so the temperature at the position can be accurately obtained in real time by using the temperature measurement grating in the treatment optical fiber, and the easily determined spatial position can be used as the reference temperature to be compared with the temperature calculated by the magnetic resonance image.

It is clear to those skilled in the art that, for convenience and brevity of description, the specific working processes of the system and the apparatus described above may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.

In addition, in the description of the embodiments of the present application, unless otherwise explicitly specified or limited, the term "connected" is to be interpreted broadly, e.g., as being fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in this application will be understood to be a specific case for those of ordinary skill in the art.

Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present application, and are used for illustrating the technical solutions of the present application, but not limiting the same, and the scope of the present application is not limited thereto, and although the present application is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope disclosed in the present application; such modifications, changes or substitutions do not depart from the spirit and scope of the exemplary embodiments of the present application, and are intended to be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims (11)

1. A therapeutic optical fiber, comprising: a double-clad optical fiber and a treatment tip, a proximal end of the treatment tip abutting a distal end of the double-clad optical fiber; the double-clad optical fiber comprises a fiber core, a first clad and a second clad, wherein a temperature measurement grating is arranged at the far end of the fiber core, the refractive index of the first clad is smaller than that of the fiber core, the refractive index of the second clad is smaller than that of the first clad, the fiber core can transmit temperature measurement light, the first clad can transmit treatment light, and the treatment end can change at least one part of the emergent direction of the treatment light.

2. A treatment fibre according to claim 1 wherein the first cladding is also transmissive of light for indication.

3. A therapeutic optical fiber according to claim 1, wherein the temperature of the temperature sensing grating is obtained by analyzing temperature sensing light returned from the temperature sensing grating.

4. The treatment fiber of claim 3, wherein structural information of the treatment fiber is further obtained by analyzing the thermometric light returned from the thermometric grating.

5. A laser hyperthermia system, comprising: a control center, a therapeutic light source module, a temperature sensing module, a beam combiner, and at least one therapeutic optical fiber of any of claims 1-4.

6. A laser hyperthermia system according to claim 5, wherein the treatment light source module comprises two or more laser generators.

7. A laser hyperthermia system according to claim 5, further comprising a beam splitter.

8. A laser hyperthermia system according to claim 5, wherein the temperature sensing module comprises a thermometric light source and a demodulation module.

9. A laser hyperthermia system according to claim 5, further comprising an indicator light source, wherein the indicator light source can emit an indicator light.

10. A laser hyperthermia system based on magnetic resonance guidance, comprising the therapeutic optical fiber of any one of claims 1 to 4, or the laser hyperthermia system of any one of claims 5 to 9.

11. A magnetic resonance guidance-based laser hyperthermia system according to claim 10, further comprising a host computer, a display, the host computer being loaded with a thermometry program that can perform temperature correction.

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