CN116407270A

CN116407270A - Optical fiber with optical fiber fracture monitoring function and laser treatment system

Info

Publication number: CN116407270A
Application number: CN202111670146.3A
Authority: CN
Inventors: 黄祖炎; 刘文博; 韩萌
Original assignee: Sinovation Beijing Medical Technology Co ltd
Current assignee: Sinovation Beijing Medical Technology Co ltd
Priority date: 2021-12-31
Filing date: 2021-12-31
Publication date: 2023-07-11

Abstract

The invention provides a therapeutic optical fiber with an optical fiber breakage monitoring function and a laser therapeutic system using the therapeutic optical fiber, wherein the therapeutic optical fiber comprises: a light guide fiber and a treatment tip comprising a light splitting film; the treatment fiber may transmit at least two different wavelengths of laser light, at least one of which is treatment light for treatment and at least one of which is monitoring light for monitoring breakage; the spectroscopic film has high permeability to therapeutic light, and the spectroscopic film has high reflectivity to monitoring light.

Description

Optical fiber with optical fiber fracture monitoring function and laser treatment system

Technical Field

The invention relates to the technical field of medical equipment, in particular to an optical fiber with an optical fiber fracture detection function and a laser treatment system.

Background

The laser ablation is a treatment means for leading light into the human body through optical fibers to enable local biological tissues to coagulate and necrotize after absorbing energy, and compared with the traditional surgical excision operation, the method has the characteristics of short operation time, small operation wound surface, less occurrence of massive hemorrhage, less pain to patients, good postoperative recovery effect and certain anti-inflammatory and bactericidal effects. Has good prospect in the treatment of various diseases, especially in the treatment research of tumors, and is currently used for treating tumors of many types, such as tumors of liver, brain, breast, retina and the like.

However, ablation fibers generally require a higher output power, have a larger diameter, and penetrate deep into the tissue. If the optical fiber or the treatment end is broken in the using process, the laser is likely to direct forward along the direction of the optical fiber, so that healthy tissues are injured; or under the condition that the transmission optical fiber is accidentally broken, the treatment laser can be irradiated to a non-target position, so that accidental injury is caused to a patient or a user, and the injury can be generated instantaneously due to high treatment laser power, so that the generation of wounds can not be prevented in time by manually closing the laser. Therefore, the problems of whether the laser transmission optical fiber and the treatment end are broken, whether the treatment end is dropped or burnt and the like in laser ablation need to be continuously detected and monitored, and are not solved.

Disclosure of Invention

Accordingly, the present invention is directed to a therapeutic optical fiber and a laser ablation system with fracture detection.

In a first aspect, the present application provides a therapeutic optical fiber comprising: a light guide fiber and a treatment tip comprising a light splitting film; in a use state, at least two different wavelengths of light can be input into the treatment optical fiber, wherein at least one of the light is treatment light for treatment, and at least one of the light is monitoring light for fracture monitoring; the light splitting film has high permeability to the therapeutic light such that the therapeutic light passes through the therapeutic tip to a desired location, and the light splitting film has high reflectivity to the monitoring light.

The treatment tip may be of any suitable configuration that may achieve various modes of exit of the treatment light, such as axial exit along the long axis of the treatment fiber, annular radial exit at defined angles, directional exit, etc., as the present description is not limited in this respect.

Alternatively, the therapeutic optical fiber of the present invention may transmit therapeutic light of two or more different wavelengths.

Alternatively, the therapeutic optical fiber of the present invention may transmit two or more different wavelengths of the monitoring light, further, the wavelength of the monitoring light is significantly different from that of the therapeutic light, and is easily distinguished.

In the present invention, the reference to the spectroscopic film having high permeability to the therapeutic light means that the therapeutic light passes through the spectroscopic film at a ratio of not less than 90%, preferably not less than 95%, more preferably not less than 98%, or the like.

The light splitting film has high reflectivity to the monitoring light, namely the monitoring light reflected by the light splitting film has obvious difference compared with the monitoring light returned by other reflecting surfaces when reaching the light detector, and can be identified by the photoelectric detector; for example, the intensity of the monitoring light reflected by the spectroscopic film when reaching the monitoring light detector is at least 50% higher, preferably more than 1 time higher, than the monitoring light returned by the other reflecting surface to the detector.

The position of the light-splitting film in the treatment end can be in various conditions, as long as the light-splitting film is arranged on the light path of the treatment laser after exiting from the light-guiding optical fiber. In some embodiments, the light splitting film is disposed proximal to the treatment tip, i.e., adjacent to the light guide fiber; in other embodiments, the light splitting membrane is disposed at the distal end of the treatment tip; in other embodiments, the light splitting films are disposed in the light exit portion of the treatment tip, i.e., where the treatment light exits the treatment tip.

The structure of the treatment end of the invention except the light-splitting film can be any existing structure, and can be used for laser ablation (laser thermotherapy) and photodynamic therapy.

Optionally, the treatment optical fiber is further provided with a temperature measuring structure and has a temperature measuring function, in this case, the light guide optical fiber of the treatment optical fiber is a double-clad optical fiber, the double-clad optical fiber comprises a fiber core, a first cladding and a second cladding, the far end of the light guide optical fiber is provided with the temperature measuring structure, after the temperature measuring light passes through the fiber core to the temperature measuring structure, at least a part of the temperature measuring light is modulated by the temperature measuring structure and returns, and a photoelectric detector or a spectrum analysis device is used for measuring the returned temperature measuring light, so that the temperature of the temperature measuring structure can be obtained; therapeutic light and monitoring light are transmitted through the first cladding layer.

Further, the temperature measuring structure can be a temperature measuring grating or a temperature measuring sensor; preferably, the thermometric structure is a Bragg grating disposed at the distal end of the core.

In a second aspect, the present invention provides a laser treatment system comprising: the device comprises a control center, at least one therapeutic light generator, at least one monitoring light generator, a wavelength beam combining module, a receiving and transmitting branching device, at least one photoelectric detector and at least one therapeutic optical fiber; the therapeutic light generated by the therapeutic light generator and the monitoring light generated by the monitoring light generator can enter the transmission optical fiber after being processed by the wavelength beam combining module.

In the use process of the laser treatment system, the monitoring light is generated by the monitoring light generator, the monitoring light passes through the receiving and transmitting branching device and then is combined with the treatment light in the wavelength beam combining module, then the treatment light enters the treatment optical fiber, part of the monitoring light is reflected at the beam splitting film and returns, finally reaches the photoelectric detector after reentering the receiving and transmitting branching device, the photoelectric detector can ensure that the optical fiber breakage and other problems do not occur in the optical path through continuously monitoring the returned monitoring light, and whether the structure of the treatment optical fiber is good is judged.

Optionally, the laser treatment system of the present invention may further include a beam splitter, wherein the beam splitter connects the transmission optical fiber and the treatment optical fiber, and the beam splitter receives the light transmitted by the transmission optical fiber and distributes the light to two or more treatment optical fibers, in which case the wavelength of the monitoring light returned by the splitting film corresponding to each treatment optical fiber is different.

Further, at least a portion of the monitoring light may be detected by a photodetector by reflection from a light splitting film, which may employ a variety of techniques, such as a Photodiode (PD), an Avalanche Photodiode (APD), a photomultiplier tube.

In some implementations, the monitoring light may be used as both the detection light and the indication light, i.e., by controlling the reflection ratio of the light splitting film and the intensity of the monitoring light, the portion of the monitoring light that exits through the light splitting film may be used as the indication light; no indication light module or indication light laser is separately provided. The monitoring light can use visible light wavelength, and the light path can be determined to be normal by directly observing the monitoring light to be emitted from the treatment optical fiber.

In the present application, the light generator, including the therapeutic light generator and the monitoring light generator, may each comprise one or more light source modules and a corresponding controller, which may control emission parameters of the light source modules, such as output power, output period, output time domain, etc.

The therapeutic light generator may generate light for therapy, i.e. therapeutic light. Further, two or more therapeutic light generators may be provided, or the therapeutic light generator may include two or more light source modules, such that the laser therapy system of the present invention may output therapeutic light of two or more different wavelengths in a variety of time-domain manners, e.g., in some embodiments, two therapeutic lights may be output simultaneously; in still other embodiments, the first therapeutic light may be output alone and the second therapeutic light may be output alone; in other embodiments, the two therapeutic lights may be alternately output at fixed time intervals.

The monitoring light generator may generate light for monitoring whether or not a break occurs in the treatment optical fiber, i.e., monitoring light; two or more therapeutic light generators may be provided, or the monitoring light generator may include two or more light source modules, so that the laser ablation system of the present invention may output two or more different wavelengths of monitoring light.

Preferably, the wavelength of the monitoring light is different from the wavelength of the therapeutic light, more preferably the wavelength of the monitoring light is significantly different from or easily distinguishable from the wavelength of the therapeutic light.

Optionally, the laser treatment system of the present invention further comprises a cooling system for cooling the treatment fiber. The cooling system includes: the peristaltic pump pumps the cooling interstitial substance into the cooling sleeve, absorbs heat of the treatment optical fiber and then flows out of the cooling sleeve, so that the temperature of the treatment optical fiber and tissues nearby the treatment optical fiber is reduced.

Optionally, the laser treatment system of the present invention, the temperature measurement module includes a temperature measurement light source and a demodulation module. The thermometry light source and demodulation module may employ a suitable combination device, for example, in some embodiments, the thermometry light source is a C-band tunable laser and the demodulation module is a photodetector; in other embodiments, the thermometry light source is a C-band ASE light source and the demodulation module is a spectrum demodulation module. In still other embodiments, the thermometry light source is a tungsten halogen white light source and the demodulation module is a white light interferometric demodulation module. The temperature measuring light source emits temperature measuring light, the temperature measuring light is transmitted to the temperature measuring grating or the temperature measuring Fabry-Perot cavity sensor through the fiber core and then returns, and the demodulation module measures the returned temperature measuring light to obtain the temperature of the temperature measuring grating (such as the Bragg grating) or the temperature measuring Fabry-Perot cavity sensor.

The control center includes a host computer that can be loaded with a software program for performing the treatment, and an input-output device for displaying and receiving instructions.

The laser treatment system of the present invention includes various systems for treatment using laser, such as a laser interstitial hyperthermia system, a laser ablation system, a photodynamic therapy system, etc.;

in some embodiments, the laser therapy system of the invention is a laser thermal therapy system, a host computer of the system can load an ablation program, the temperature can be recorded in real time through a temperature measurement module, the temperature is monitored and displayed, the ablation condition is estimated according to the temperature and the duration time and is displayed on a three-dimensional model, and the output power of a laser generator is controlled through the temperature and the ablation condition feedback; when the abnormal monitoring light signal is received, the therapeutic light generator can be turned off in an emergency.

In some embodiments, the monitoring light generator is selected from: a red laser generating any one of the wavelength bands of 630 to 660nm, a near infrared laser generating any one of the wavelength bands of 1300 to 1320nm, and a near infrared laser generating any one of the wavelength bands of 1520 to 1565 nm.

In a third aspect, the present application provides a magnetic resonance guided laser interstitial hyperthermia system characterized by comprising the treatment fiber or laser ablation system of the present invention; the magnetic resonance guided laser interstitial hyperthermia system can perform laser ablation of target tissue in a magnetic resonance environment, monitor ablation temperature by magnetic resonance and calculate ablation volume.

Further, in the case that the therapeutic optical fiber has a thermometry structure, the temperature calculated from the magnetic resonance image may also be compared and corrected using the temperature measured by the thermometry structure.

In order to make the above objects, features and advantages of the present invention more comprehensible, preferred embodiments accompanied with figures are described in detail below.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of a therapeutic optical fiber according to some embodiments of the present invention, showing various positions of a light splitting film therein;

FIG. 2 is a detailed view of a portion of the construction of two embodiments of FIG. 1;

FIG. 3 is a schematic view of a treatment tip portion of a treatment fiber according to another embodiment of the present invention;

FIG. 4 is a schematic view of a portion of a treatment fiber according to one embodiment of the invention, showing a thermometry structure;

FIG. 5 is a schematic diagram of the composition of a laser treatment system according to an embodiment of the present invention;

FIG. 6 is a schematic diagram of the composition of a laser treatment system according to an embodiment of the present invention;

FIG. 7 is a schematic diagram of the composition of a laser treatment system according to an embodiment of the present invention;

FIG. 8 is a schematic diagram of the composition of a laser treatment system according to an embodiment of the present invention;

FIG. 9 is a schematic diagram of the composition of a laser treatment system according to an embodiment of the present invention;

FIG. 10 is a schematic diagram of the composition of a laser treatment system according to an embodiment of the present invention;

FIG. 11 is a schematic diagram of the composition of a laser treatment system according to an embodiment of the present invention;

icon:

1-a therapeutic light generator; 2-monitoring a light generator; a 3-wavelength beam combining module; 4-a receiving and transmitting shunt device; 5-photodetector/photodetector assembly; 6-transmission optical fiber; 7-treatment optical fiber; 9-beam combiner; 10-a temperature measurement module; 70-light guide fiber; 71-a light-splitting film; 72-treatment end; 74-directional light extraction structure; 701-a core; 702-cladding; 703-a coating layer; 704-a fiber core; 705-first cladding; 706-a second cladding; 707-temperature measuring structure; 721-sleeve; 722-a treatment tip body; 723-welding or gluing.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

A therapeutic optical fiber, comprising: light guide fiber 70 and a treatment tip with a light splitting film, the composition of which further comprises: a light splitting membrane 71 and a treatment tip body 72. The treatment tip may emit treatment light in a desired direction, e.g., in some examples, the treatment tip may be a structure capable of scattering treatment light such that at least a portion of the treatment is emitted from a direction perpendicular to the long axis of the fiber, forming an annular emission; in other examples, the treatment tip may also be directionally refractive;

typically, the treatment fiber further comprises a connection connector for connection with the output end of the light generator and a coating layer, not shown, for protecting the treatment fiber body.

The position of the light-splitting film 71 relative to the treatment tip body 72 may be varied, three of which are illustrated in examples 1-3

Example 1

Referring to fig. 1A, there is shown a schematic view of a therapeutic optical fiber, in which a light guide fiber 70, a light splitting film 71, and a therapeutic tip body 72 are disposed in this order from a proximal end to a distal end.

FIG. 2A is a detailed view of a partial structure of an example therapeutic optical fiber shown in FIG. 1A, the light guide fiber 70 including a core 701, a cladding 702, and a coating 703; treatment tip 72 includes sleeve 721, treatment tip body 722; sleeve 721 is not necessary and is only required if therapeutic tip body 722 is to be processed by injection molding. In the case of having the sleeve 721, the sleeve 721 may be connected to the cladding 702 by welding or gluing, etc., as shown at 723; the light splitting film 71 is disposed between the fiber core 701 and the treatment tip body 722.

Example 2

Referring to fig. 1B, there is shown a schematic view of another therapeutic optical fiber, in which a light guide fiber 70, a therapeutic tip body 72, and a light splitting film 71 are disposed in order from a proximal end to a distal end.

FIG. 2B is a detailed view of a partial structure of an example therapeutic optical fiber shown in FIG. 1B, the light guide fiber 70 including a core 701, a cladding 702, and a coating 703; treatment tip 72 includes sleeve 721, treatment tip body 722; sleeve 721 is not required and may be omitted in some cases. In the case of having the sleeve 721, the sleeve 721 may be connected to the cladding 702 by welding or gluing, etc., as shown at 723; the light splitting membrane 71 is disposed distally of the treatment tip body 722.

Example 3

Referring to fig. 1C, there is shown a schematic view of yet another therapeutic optical fiber, in which a light guide fiber 70, a therapeutic tip body 72, a therapeutic tip directional light emitting structure 74, and a light splitting film 71 are disposed in order from a proximal end to a distal end; wherein the therapeutic light irradiates the tissue to be treated after passing through the directional light emitting structure 74, and the light splitting film 71 is positioned on the light path of the therapeutic light emitting therapeutic end body, preferably, the light splitting film 71 covers at least a part of the area, preferably all the area, of the therapeutic light emitting.

In the present invention, the sleeve may be a sleeve made of quartz, sapphire, PC, PTFE, or the like, which is transparent to therapeutic light.

In embodiments 1 to 3, the light guide fiber is preferably a multimode fiber having a core diameter of 50um to 1200 um.

Example 4

Fig. 3 shows a schematic view of another example of a therapeutic tip 72, in which a therapeutic tip body 722 and a light splitting film 71 are shown, in which a refractive cone 724 for changing the propagation direction of light is provided in the therapeutic tip body 722, and the hollow arrow indicates the transmission path of most of the light, that is, most of the therapeutic light and monitoring light are transmitted through a light guide fiber to reach the therapeutic tip 72, and then irradiate the cone 724, and exit along the radial direction of the therapeutic fiber; part of the monitoring light continues to propagate along the axial direction through the reserved channel port 725, and after reaching the light splitting film 71, the light path is shown by a double-headed arrow, and then returns along the original path, and the intensity of the returning monitoring light can be monitored by a photoelectric detector to judge whether abnormality occurs in the light path.

Examples 5 to 8: an embodiment of one-to-one correspondence modified on the basis of embodiments 1 to 4, i.e., embodiment 5 is an embodiment described on the basis of embodiment 1, and embodiment 8 is an embodiment described on the basis of embodiment 4, which are different from the corresponding basic solutions in that the light-guiding optical fiber portion is added with a temperature measuring structure; the light guide optical fiber is double-clad optical fiber, the specific structure of the light guide optical fiber comprises a fiber core, a first cladding layer and a second cladding layer, a Bragg grating for measuring temperature is arranged at the far end of the fiber core, the refractive index of the first cladding layer is smaller than that of the fiber core, the refractive index of the second cladding layer is smaller than that of the first cladding layer, the fiber core can transmit light for temperature monitoring, and the first cladding layer can transmit therapeutic light and monitoring light.

Referring to fig. 4, the structure of example 6 is described in detail, in which only the distal end of the therapeutic fiber is schematically shown, and the coating layer 703, the core 704, the first cladding layer 705, the second cladding layer 706, the therapeutic tip body 722, the sleeve 721 and the spectroscopic film 71 included in the light guiding fiber 70 are shown; the temperature measuring light 802 is transmitted in the fiber core 704, returns after reaching the Bragg grating 707, and carries temperature information; the therapeutic light 801 and the monitoring light 803 are transmitted through the first cladding layer, and after reaching the spectroscopic layer 71, the monitoring light 808 is turned back, and the optical path structure information is fed back.

Example 9

Referring to fig. 4, there is shown a schematic diagram of a laser treatment system of the present invention, comprising: a therapeutic light generator 1, a monitoring light generator 2, a wavelength beam combining module 3, a transmitting-receiving branching device 4, a photodetector 5, a coupler 6, therapeutic optical fibers 7 described in embodiments 1 to 4, and a control center (not shown); the light generated by the therapeutic light generator 1 and the monitoring light generator 2 is combined by the wavelength beam combination module 3 and then delivered by the transmission optical fiber; the transmission fiber is connected to the treatment fiber 7 through the coupler 6. After reaching the receiving/transmitting branching device 4, the monitoring light generated by the monitoring light generator 2 reaches the treatment optical fiber 7 via the wavelength beam combining module, the transmission optical fiber and the coupler 6, and is reflected by the beam splitting film 71 in the treatment optical fiber 7, and returns to the receiving/transmitting detector 5 according to the reverse path of the original transmission path, and the receiving/transmitting detector 5 confirms whether the transmission light path is normal or not by continuously measuring the intensity of the received monitoring light, and communicates the result to the control center.

The therapeutic light generator 1 may comprise one or more sets of lasers, for example in case three sets of lasers are comprised, a first set of lasers being capable of generating a first therapeutic light (e.g. 980nm laser), a second set of lasers being capable of generating a second therapeutic light (e.g. 1064nm laser), a third set of lasers being capable of generating an indicator light; the first therapeutic light and the second therapeutic light may be combined at any time interval and light intensity. 980nm laser heats the tissue faster, requires short time, but has weak penetrating power, 1064nm has strong penetrating power, but heats the tissue slower, requires long time; the 980nm laser and the 1064nm laser may be used in combination with different temporal distributions by the controller: for example, using 980nm laser for ablation for a period of time and then using 1064nm laser for ablation for a period of time sequentially; for example, the laser of 980nm and 1064nm are used for ablation simultaneously, then 980nm laser is turned off, and 1064nm laser is used for continuous ablation for a period of time; for example, 980nm laser and 1064nm laser are alternately ablated at specific time intervals.

The monitoring light generator 2 can also comprise one or more groups of lasers, and during use, the monitoring light is obviously different from the therapeutic light, so that the interference is not generated as much as possible; each time, using a monitoring light with obvious difference from the wavelength of the therapeutic light; preferably, visible light can be used as the monitoring light, and at this time, the monitoring light can also be used as the indicating light, so that the simple system inspection before use is facilitated; that is, by controlling the reflection ratio of the light-splitting film and the intensity of the monitoring light, a part of the monitoring light transmitted through the light-splitting film is sufficiently observed directly, thereby determining that the optical path is normal.

The receiving and transmitting branching device 4 is provided with three ports, the first port is connected with the monitoring light generator 2, the second port is connected with the wavelength beam combining module 3, and the third port is connected with the light detector 5. It may be any of the following: an optical circulator, a fiber coupler/splitter, an isolator with an escape window, and a splitting plane.

The Photodetector (PD) 5 is capable of receiving and detecting the monitoring light reflected by the spectroscopic film 71, and may be selected from any one of the following: PIN photodiodes, avalanche Photodiodes (APDs), and photomultiplier tubes.

The control center can judge whether the transmission light path is normal or not according to the monitoring light condition detected by the photoelectric detection 5 and reflected by the light splitting film 71, namely, whether the optical fiber breaks at any position in the light path or not; the control center may also be loaded with a treatment plan, issuing control commands to the treatment light generator according to the treatment plan, generating treatment light according to a pre-designed power, time, etc.

The laser treatment system of this embodiment may further comprise a cooling circulation device comprising a peristaltic pump, a cooling fluid and a cooling sleeve, the cooling sleeve being used in combination with the treatment fiber, the cooling fluid may be any fluid suitable for cooling, preferably including double distilled water, medical saline, etc.; the cooling circulation device may also be provided with one or more monitoring sensors for measuring the pressure in the cooling jacket, the flow rate of the cooling fluid, etc., detecting whether a blockage has occurred, the cooling jacket being broken, etc.

The control center may be in communication with the therapeutic light generator 1, the monitoring light generator 2, the photodetector 5 and the cooling circulation device to send commands and receive feedback information to control the operation of the system by adjusting the power of the therapeutic light and the flow rate of the cooling fluid.

Example 10

With reference to fig. 6, description will be made on the basis of embodiment 9, in which the laser treatment system includes: 3

therapeutic light generators

1,3

monitoring light generators

2,3 wavelength

beam combining modules

3, 3 receiving and transmitting branching devices 4,3

photodetectors

5,3

couplers

6,3 therapeutic optical fibers 7 described in embodiments 1-4, and a control center 0; the therapeutic light generator 1, the monitoring light generator 2, the wavelength beam combining module 3, the receiving and transmitting branching device 4, the photoelectric detector 5, the coupler 6 and the therapeutic optical fiber 7 form a subsystem, namely, 3 subsystems are simultaneously connected with the control center 0, and in each subsystem, the light generated by the therapeutic light generator 1 and the monitoring light generator 2 is combined through the wavelength beam combining module 3 and then delivered through the transmission optical fiber; the transmission fiber is connected to the treatment fiber 7 through the coupler 6. After reaching the receiving/transmitting branching device 4, the monitoring light generated by the monitoring light generator 2 reaches the treatment optical fiber 7 via the wavelength beam combining module, the transmission optical fiber and the coupler 6, and is reflected by the beam splitting film 71 in the treatment optical fiber 7, and returns to the receiving/transmitting detector 5 according to the reverse path of the original transmission path, and the receiving/transmitting detector 5 confirms whether the transmission light path is normal or not by continuously measuring the intensity of the received monitoring light, and communicates the result to the control center. The control center can control each subsystem separately, namely, the use of different subsystems is not interfered with each other.

The therapeutic light generator 1 may comprise one or more sets of lasers, for example in case three sets of lasers are comprised, a first set of lasers being capable of generating a first therapeutic light (e.g. 980nm laser), a second set of lasers being capable of generating a second therapeutic light (e.g. 1064nm laser), a third set of lasers being capable of generating an indicator light; the first therapeutic light and the second therapeutic light may be combined at any time interval and light intensity.

The monitoring light generator 2 may also comprise one or more sets of lasers.

The subsystem of this embodiment may further be provided with an indication light module, which may be integrated in the therapeutic light source module, or may be separately provided, and when separately provided, enter the therapeutic optical fiber through the wavelength beam combining module.

It is understood that the first therapeutic light and the second therapeutic light may also use other wavelengths of laser light suitable for laser hyperthermia, and that such wavelength schemes are included within the scope of the present invention; the indication light is typically selected to be visible light.

It is understood that the number of subsystems may be arbitrary, such as 2, 4, 5, etc., and that such ranges are included within the scope of the present invention.

The present embodiment may further include 3 corresponding cooling circulation devices, i.e. each subsystem includes one cooling circulation device, the cooling circulation device includes a peristaltic pump, a cooling fluid and a cooling jacket, the cooling jacket is used in combination with the treatment optical fibers, each treatment optical fiber may be used together with the corresponding cooling jacket, and the cooling fluid may be any fluid suitable for cooling, preferably including double distilled water, medical physiological saline, etc.; the cooling circulation device may also be provided with one or more monitoring sensors for measuring the pressure in the cooling jacket, the flow rate of the cooling fluid, etc., detecting whether a blockage has occurred, the cooling jacket being broken, etc.

The control center simultaneously and respectively controls the 3 laser thermal therapy subsystems. The control center may control each subsystem to use the same or different treatment protocols, e.g., 980nm wavelength may be used in the first subsystem, 1064nm wavelength may be used in the second subsystem, 980nm and 1064nm wavelengths may be used in the third subsystem; for example, three subsystems each use therapeutic light wavelengths of 980nm in combination with 1064nm, but with different ablation times and intervals; the treatment scheme not only comprises wavelength, but also comprises parameters such as laser output power, light emitting time, light emitting mode, laser emitting angle, cooling fluid flow and the like.

Example 11

Referring to fig. 7, the laser treatment system of this embodiment includes: a therapeutic light generator 1, a monitoring light generator 2, a wavelength beam combining module 3, a receiving and transmitting branching device 4, a photoelectric detector assembly 5, a coupler 6,3 therapeutic optical fibers 7 described in embodiments 1-4, and a control center 0; the therapeutic light generator 1 comprises four groups of lasers and a controller, wherein the four groups of lasers are respectively a first group, a second group, a third group and a fourth group, the lasers of the first group to the third group can generate therapeutic light with different wavelengths and can be used singly or in combination, and the fourth group of lasers generate indicating light for rapidly detecting whether a light path is normal or not, namely, the indicating light is independently started before the use, and whether the therapeutic optical fiber can emit the indicating light is observed; the monitoring light generator 2 comprises 3 lasers (LD 1-3), the photoelectric detector 5 comprises 3 photoelectric detectors (PD 1-3), the 3 lasers (LD 1-3) generate monitoring light with different wavelengths, the monitoring light can be respectively reflected by the light splitting films of the three treatment optical fibers, the wavelengths of the detection light fall into the high reflection wavelength range of the light splitting films, and then the detection light returns from the light splitting films and can reach the 3 detectors of the photoelectric detector assembly 5 through the receiving and transmitting branching device 4 for detection respectively; i.e. the light splitting film of each treatment fiber can reflect monitoring light of different wavelengths.

The embodiment may further include 3 corresponding cooling circulation devices, that is, one cooling circulation device for each therapeutic optical fiber, where the cooling circulation device includes a peristaltic pump, a cooling fluid and a cooling sleeve, the cooling sleeve is used in combination with the therapeutic optical fiber, each therapeutic optical fiber is used together with the corresponding cooling sleeve, and the cooling fluid may be any fluid suitable for cooling, preferably including double distilled water, medical physiological saline, and the like; the cooling circulation device may also be provided with one or more monitoring sensors for measuring the pressure in the cooling jacket, the flow rate of the cooling fluid, etc., detecting whether a blockage has occurred, the cooling jacket being broken, etc. The control center can be in communication with and individually controlled by 3 cooling circulation devices.

It will be appreciated that, based on the present embodiment, other numbers of treatment fibers may be included in the laser hyperthermia system of the present invention, including, for example, 2, 4, 5, 6, etc.; it is within the scope of the present invention that the therapeutic light generated by the therapeutic light source module and the monitoring light generated by the monitoring module may be split into corresponding portions, such as 2 portions, 4 portions, 5 portions, 6 portions, etc., by the beam splitter.

Example 12

Referring to fig. 8, description is made on the basis of the scheme of embodiment 9, which is different from embodiment 9 in that it further includes a temperature measuring module 9 including a temperature measuring light source and a demodulation module; the treatment fiber is the treatment fiber described in examples 5-8. The temperature measuring light generated by the temperature measuring module 10 enters the treatment optical fiber 7 together with other light (treatment light and monitoring light) through the beam combiner 9, the temperature measuring light is transmitted through the fiber core of the treatment optical fiber, and the other light is transmitted through the first cladding.

Example 13

Referring to fig. 9, description is made on the basis of the scheme of embodiment 10, which is different from embodiment 10 in that each subsystem further includes a temperature measuring module 9 including a temperature measuring light source and a demodulation module; the treatment fiber is the treatment fiber described in examples 5-8. The temperature measuring light generated by the temperature measuring module 9 enters the treatment optical fiber 7 together with other light (treatment light and monitoring light) through the beam combiner 10, the temperature measuring light is transmitted through the fiber core of the treatment optical fiber, and the other light is transmitted through the first cladding.

Example 13

Referring to fig. 10, description is made on the basis of the scheme of embodiment 11, which is different from embodiment 11 in that it further includes a temperature measuring module including a temperature measuring light source and a demodulation module; the treatment fiber is the treatment fiber described in examples 5-8. The temperature measuring light source emits temperature measuring light, the temperature measuring light is transmitted to the temperature measuring structure through the fiber core and then returns, the temperature measuring light enters the corresponding first to third treatment optical fibers through the corresponding first to third beam combiners, the treatment light and the monitoring light are transmitted through the fiber core of the treatment optical fiber, the treatment light and the monitoring light are transmitted through the first cladding, after the temperature measuring optical fiber reaches the temperature measuring module, the temperature information is carried back, the demodulation module measures the returned temperature measuring light, and the temperature of the temperature measuring structure (such as Bragg grating or an extrinsic primary cavity) of the corresponding treatment optical fiber is obtained.

The temperature measuring light source and the demodulation module can adopt proper combination equipment:

when the temperature measuring structure is Bragg grating or extrinsic primary cavity:

optionally, the temperature measuring light source is a C-band tunable laser, and the demodulation module is a photoelectric detector;

optionally, the temperature measuring light source is a C-band ASE light source, and the demodulation module is a spectrum demodulation module.

When the temperature measuring structure is an extrinsic primary cavity:

combinations of devices that can also be used are: the temperature measuring light source is a halogen tungsten lamp white light source, and the demodulation module is a white light interference demodulation module.

It will be appreciated that, based on the present embodiment, other numbers of treatment fibers may be included in the laser hyperthermia system of the present invention, including, for example, 2, 4, 5, 6, etc.; the therapeutic light generated by the therapeutic light source module and the monitoring light generated by the monitoring module can be divided into corresponding parts by the beam splitter, the temperature measuring light is divided into corresponding parts by the beam splitter, such as 2 parts, 4 parts, 5 parts, 6 parts and the like, and then the therapeutic light and the monitoring light respectively enter the therapeutic optical fibers in one-to-one correspondence by the beam combiners in corresponding quantity, and the schemes are also within the scope of the invention.

Example 14

Referring to fig. 11, description is made on the basis of the scheme of embodiment 13, which is different from embodiment 13 in that the system of this embodiment includes 3 thermometry modules, no beam splitter is required any more, the thermometry light generated by each thermometry module enters the corresponding first to third treatment optical fibers together with the treatment light and the monitoring light through the corresponding first to third beam combiners, the thermometry light is transmitted through the fiber cores of the treatment optical fibers, the treatment light and the monitoring light are transmitted through the first cladding, after the thermometry optical fibers reach the thermometry module, the temperature information is carried back, and the demodulation module measures the returned thermometry light to obtain the temperature of the thermometry structure (such as bragg grating or the extrinsic primary cavity) of the corresponding treatment optical fiber.

It will be appreciated that the embodiments of the laser hyperthermia system described above can be combined with each other and that such solutions are also within the scope of the present invention.

Example 15

A magnetic resonance guided laser hyperthermia system comprising the treatment optical fiber of one or more of embodiments 1 to 8, or comprising the laser hyperthermia system of one of embodiments 9 to 14; the magnetic resonance guided laser hyperthermia system can perform laser ablation of target tissue in a magnetic resonance environment, monitor ablation temperature by magnetic resonance and calculate ablation volume. The basic structural composition of the magnetic resonance guided laser hyperthermia system can be found in the company's prior application 201810459539.1.

The system of the invention comprises:

magnetic resonance equipment, a workstation and the laser thermal therapy system of the invention;

the magnetic resonance device can perform image acquisition before and during operation;

the workstation comprises a host and a man-machine interaction module (such as a touch screen), wherein the host is in communication connection with the magnetic resonance device, can receive preoperative and intraoperative medical image information of the magnetic resonance device and other imaging devices (such as CT), receive the documenting of a patient, and generate an operation scheme according to 3D modeling of the preoperative medical image information; generating a real-time temperature image according to the magnetic resonance information, planning a treatment area, displaying intraoperative information, sending control information to a laser hyperthermia instrument, calculating temperature and predicting ablation, performing fusion display on the temperature image and a 3D model in a man-machine interaction module, and the like;

the host is loaded with a temperature measuring program capable of executing temperature correction, and the temperature measuring program can execute the following method:

continuously obtaining the temperature of the temperature measuring module by using the temperature sensing module as a reference temperature;

after the end of a round of operation of magnetic resonance scanning, the temperature of the temperature measuring module is obtained through magnetic resonance image calculation to be used as the calculated temperature,

after obtaining the actual temperature once, comparing the absolute value of the difference between the reference temperature and the calculated temperature at the same moment with a preset threshold value;

when the reference temperature exceeds the warning temperature, the treatment laser is immediately turned off;

and when the reference temperature and the calculated temperature exceed the threshold value, correcting the calculated temperature and then continuing the next round of magnetic resonance temperature measurement.

The host receives feedback information of the monitoring module, and when receiving the breaking signal, all lasers generating therapeutic light are immediately turned off, so that accidental damage is prevented.

It will be clear to those skilled in the art that, for convenience and brevity of description, specific working procedures of the above-described system and apparatus may refer to corresponding procedures in the foregoing method embodiments, which are not described herein again.

In addition, in the description of embodiments of the present invention, unless explicitly stated and limited otherwise, the term "coupled" is to be interpreted broadly, as for example, whether fixedly coupled, detachably coupled, or integrally coupled; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.

Finally, it should be noted that: the above examples are only specific embodiments of the present invention, and are not intended to limit the scope of the present invention, but it should be understood by those skilled in the art that the present invention is not limited thereto, and that the present invention is described in detail with reference to the foregoing examples: any person skilled in the art may modify or easily conceive of the technical solution described in the foregoing embodiments, or perform equivalent substitution of some of the technical features, while remaining within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention, and are intended to be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A therapeutic optical fiber, comprising: a light guide fiber and a treatment tip comprising a light splitting film; the treatment fiber may transmit at least two different wavelengths of light, at least one of which is treatment light for treatment and at least one of which is monitoring light for monitoring breakage; the light-splitting film is arranged on a light path of the therapeutic light after exiting from the light-guiding optical fiber, the light-splitting film has high permeability for the therapeutic light, and the light-splitting film has high reflectivity for the monitoring light.

2. The therapeutic optical fiber according to claim 1, wherein the structure of the therapeutic optical fiber is judged whether to be broken by receiving and detecting the monitoring light reflected by the light-splitting film using a photodetector.

3. The therapeutic optical fiber according to claim 1, wherein the spectroscopic film is configured to be any of the following:

a: the light splitting film is arranged at the proximal end of the treatment end head;

b: the light splitting film is arranged at the distal end of the treatment end;

c: the beam splitting film is arranged at the position where the therapeutic light leaves the therapeutic end.

4. The laser treatment fiber according to claim 1, wherein the light guide fiber is a double-clad fiber comprising a core, a first cladding and a second cladding, the distal end of the core being provided with a temperature measurement structure.

5. The laser treatment fiber according to claim 4, wherein the thermometry structure is a bragg grating.

6. A laser treatment system, comprising: a control center, at least one therapeutic light generator, at least one monitoring light generator, a wavelength combining module, a transceiver branching device, at least one photodetector, at least one therapeutic optical fiber of any one of claims 1-5; the therapeutic light generated by the therapeutic light generator and the monitoring light generated by the monitoring light generator are coupled into the therapeutic optical fiber after being combined by the wavelength beam combining module.

7. The laser therapy system of claim 6, wherein the therapeutic light generator and the monitoring light generator each comprise one or more laser generators and corresponding controllers.

8. The laser therapy system of claim 7, wherein the control center is communicatively coupled to the controller to control the output of the laser generator.

9. The laser therapy system of claim 6, further comprising a thermometry module comprising a thermometry light source and a demodulation module.

10. A laser treatment system comprising a control operation center and the treatment fiber according to any one of claims 1 to 4 or the laser treatment system according to any one of claims 5 to 9, wherein the control operation center controls the output power of the laser generator through the ablation process fed back by the ablation prediction module.

11. A magnetic resonance guided laser hyperthermia system comprising the treatment optical fiber of any of claims 1-4, or the laser treatment system of any of claims 5-9.