CN217677460U

CN217677460U - Stirring impeller and biological reaction bag

Info

Publication number: CN217677460U
Application number: CN202220912658.XU
Authority: CN
Inventors: 马学孟; 朱学军; 邢孟珑; 刘帅
Original assignee: Zhuhai Singleuse Biological Technology Co ltd
Current assignee: Zhuhai Singleuse Biological Technology Co ltd
Priority date: 2022-04-19
Filing date: 2022-04-19
Publication date: 2022-10-28
Anticipated expiration: 2032-04-19

Abstract

The utility model provides a stirring impeller and a biological reaction bag, stirring impeller includes the roating seat, the encapsulation has the magnet subassembly in the roating seat, roating seat central authorities are provided with through-hole portion, install the bearing in the through-hole portion, be provided with a plurality of stirring rakes round the axis interval of roating seat on the roating seat, the stirring rake includes blade portion and first spacing portion, be provided with the spacing portion of second on the roating seat, first spacing portion includes the stopper, the one end and the blade portion fixed connection of stopper, it is formed with an arc piece all to the outside salient on the both sides wall that the stopper deviates from each other, the spacing portion of second is the spacing groove, the shape of spacing groove is the same with the shape of first spacing portion, first spacing portion is installed in the spacing portion of second. The utility model discloses the arc piece of outside outstanding formation on the both sides wall that first spacing portion deviates from each other can increase the area of first spacing portion and roating seat contact for the firm installation of stirring rake is in the roating seat swivel mount, and the structure is more firm, is difficult for droing.

Description

Stirring impeller and biological reaction bag

Technical Field

The utility model relates to a biological reaction's agitated vessel technical field especially relates to a stirring vane and a biological reaction bag.

Background

Currently, in the existing medicine production, disposable systems are concerned and applied by a plurality of pharmaceutical enterprises along with the rapid development of the counterfeit medicine market. Typical examples of single-use systems include bioreactors, including reactors used in fermentation, enzymatic reactions, cell culture.

The disposable bioreactor system is used for establishing a sterile environment and reducing the pollution risk and cross-contamination risk of products. Disposable mixing systems are a typical product of disposable bioreactor systems and have been recognized consistently by pharmaceutical companies. An example of a disposable mixing system is a magnetic blending system that magnetically couples a mixer inside a vessel (e.g., a bag of formula) to an external drive system (e.g., a motor) to eliminate contamination issues, create a completely sealed system, and prevent leaks. The magnetic stirring system may eliminate the need for sealing between the drive shaft and the vessel because the drive shaft does not need to penetrate the support structure wall of the vessel to mechanically rotate the stirrer.

The existing magnetic stirring impeller is positioned at the bottom in a stirring container and comprises a paddle, a base, a magnet and a bearing, wherein the paddle is fixed on a clamping seat at the periphery of the upper part of the base through a support at one corner of the paddle, the base is provided with a central through hole, the magnet is packaged and contained in the base, and the bearing is arranged at the lower part of the central through hole and is fixed with the base. The central through hole of the base is in a step shape, the diameters of the upper portion and the lower portion of the base are large, the diameter of the middle portion of the base is small, the multi-tooth buckle is arranged on the upper portion of the central through hole of the base, and the outer diameter of the multi-tooth buckle is the same as the diameter of the upper portion of the central through hole of the base. The number of the paddles is three, the shape of the paddles is rectangular, the shape of the support is cuboid, and the support is connected with the groove clamping seat through welding. But the cuboid support of this scheme is inconvenient to be installed and welded, and this support is less with recess cassette area of contact, and fixed firm inadequately.

Disclosure of Invention

In order to solve the above problems, a first object of the present invention is to provide a stirring impeller with a more firm structure.

The second purpose of the utility model is to provide a biological reaction bag comprising the first purpose.

In order to realize above-mentioned first purpose, the utility model provides a pair of impeller, including the roating seat, the encapsulation has the magnet subassembly in the roating seat, roating seat central authorities are provided with through-hole portion, install the bearing in the through-hole portion, be provided with a plurality of stirring rakes round the axis interval of roating seat on the roating seat, the stirring rake includes blade portion and first spacing portion, be provided with the spacing portion of second on the roating seat, first spacing portion includes the stopper, the one end and the blade portion fixed connection of stopper, all outside salient being formed with an arc piece on the both sides wall that the stopper deviates from each other, the spacing portion of second is the spacing groove, the shape of spacing groove is the same with the shape of first spacing portion, first spacing portion is installed in the spacing portion of second.

It is from top to bottom visible, through setting up the arc piece of the outside outstanding formation on the both sides wall that the stopper of first spacing portion deviates from each other, increase area of contact between first spacing portion and the spacing groove and to radially spacing at the roating seat first spacing portion through the arc piece, the external force dispersion that the arc piece received has reduced the stress that the arc piece produced simultaneously for the more firm fixing of first spacing portion is in the spacing groove.

The further scheme is that the arc-shaped blocks on the stirring paddles are positioned on the same circumference, and the circle center of the circumference is positioned on the axis of the rotating seat.

The area of the cross section of the limiting block is gradually reduced along the direction from the part close to the through hole to the part far away from the through hole.

It is from top to bottom visible, the area of the cross section of stopper reduces along being close to the through-hole portion to keeping away from the direction of through-hole portion gradually, can increase with the area of contact of stopper and spacing groove for the stopper is spacing in the footpath of roating seat, makes more firm the fixing in the roating seat of stirring rake.

The further scheme is that the rotating seat comprises a fixedly connected seat body and a cover body, the through hole portion comprises a first through hole, the first through hole is located in the center of the seat body, the second limiting portion is arranged on the seat body, a plurality of cylindrical mounting grooves with openings at the bottom are formed in the seat body around the axis interval of the through hole portion, the magnet assembly comprises a plurality of cylindrical magnets, the number of the magnets is the same as that of the mounting grooves, one magnet is arranged in one mounting groove, the cover body is arranged at the bottom of the seat body, and the cover body seals the openings of the mounting grooves.

Therefore, the blades in the plastic bag are driven to move in a magnetic coupling transmission mode, a better magnetic stirring effect is achieved, and friction loss is reduced.

The further scheme is that, first through-hole is the echelonment, and first through-hole includes the first hole portion on upper portion, the second hole portion at middle part and the third hole portion of lower part, and the diameter of first hole portion is greater than the diameter of second hole portion, and the diameter of third hole portion is greater than the diameter of second hole portion, and bearing fixed mounting is provided with the latch subassembly in third hole portion on the roof of second hole portion, and the latch subassembly includes a plurality of latches of establishing round first through-hole axis interval ring.

The third hole part is in transition fit with the outer ring of the bearing.

The further scheme is that the through hole part comprises a second through hole, the second through hole is located in the center of the cover body, the diameter of the second through hole is larger than the inner diameter of the bearing inner ring and smaller than the outer diameter of the bearing inner ring, and the cover body and the inner ring of the bearing are in clearance fit.

The further scheme is that the through hole part comprises a second through hole, the second through hole is located in the center of the cover body, and the diameter of the second through hole is larger than the outer diameter of the bearing inner ring.

Further, the included angle between the blade part and the radial direction of the rotating seat comprises 45 degrees or 90 degrees.

From top to bottom, the slope of each blade portion certain angle is favorable to reducing the shearing force that the stirring rake brought.

In order to achieve the second objective, the present invention provides a bioreactor bag, which comprises any one of the aforementioned stirring impellers in the first objective, wherein the stirring impeller is located in the bioreactor bag and is disposed at the bottom of the bioreactor bag.

To sum up, the utility model discloses a set up the arc piece that sets up in first spacing portion, increase area of contact between first spacing portion and the spacing groove and to radially spacing at the roating seat first spacing portion through the arc piece, the external force dispersion that the arc piece received has reduced the stress that the arc piece produced to the stopper cross section reduces gradually along being close to through-hole portion to keeping away from the direction of through-hole portion, has increased the area of contact of stopper and spacing groove, makes the stopper radially spacing at the roating seat simultaneously. So that the first limiting part is more firmly fixed in the limiting groove.

Drawings

Fig. 1 is a structural view of an embodiment of the stirring impeller of the present invention.

Fig. 2 is an exploded view of an embodiment of the stirring impeller of the present invention.

Fig. 3 is a schematic bottom view of a rotary base according to an embodiment of the stirring impeller of the present invention.

Fig. 4 is a schematic cross-sectional view of an embodiment of the stirring impeller of the present invention.

Fig. 5 is an enlarged view of a point a in fig. 4.

Detailed Description

The embodiment is applied to a disposable bioreactor system which mainly comprises two parts, wherein one part is a bag body part of a disposable bioreactor bag and comprises a plastic bag body, a pipeline, a connecting piece, a filter and the like; the other one is reusable support and power equipment which comprises a support barrel, a caster base, a servo motor, a weighing module, a control panel and the like. The interior and exterior portions of the bag are separated by a spacer sleeve (not shown).

Referring to fig. 1 and 2 in combination with fig. 4, the stirring impeller provided by this embodiment includes a rotating base 1, a magnet assembly is fixedly mounted in the rotating base 1, a through hole portion 2 is provided in the center of the rotating base 1, a bearing 6 is fixedly mounted in the through hole portion 2, and four stirring paddles 3 are provided on the rotating base 1 at intervals around the axis of the rotating base 1. Alternatively, the number of paddles 3 is determined by design requirements.

The paddle 3 includes a paddle portion 31 and a first stopper portion 30, and an angle formed between the paddle portion 31 and the radial direction of the rotary base 1 is 0 °. Alternatively, the included angle may also be 45 °, 90 °, or other angles, which is the prior art and will not be described herein again. In this embodiment, the upper surface of the rotary base 1 is flush with the upper surface of the stirring paddle 3, that is, the upper surface of the rotary base 1 and the upper surface of the stirring paddle 3 are located on the same horizontal plane.

Blade portion 31 and first spacing portion 30 integrated into one piece are formed with the spacing groove 10 the same with first spacing portion 30 shape on the roating seat 1, and first spacing portion 30 includes stopper 300, and stopper 300's one end is connected with blade portion 31, and the equal outside salient is formed with an arc piece 301 on the both sides wall that stopper 300 deviates from each other, and arc piece 301 on four stirring rake 3 all is located same circumference, and the centre of a circle of this circumference is located the axis of roating seat 1. The first position-limiting part 30 is fixed in the position-limiting groove 10 by welding. Optionally, the circumferential wall of the rotating base 1 and the side wall of the arc block 301 are correspondingly provided with a limiting hole (not shown in the figure), and the arc block 301 and the rotating base 1 are fixed by a fastening member such as a bolt through the limiting hole.

Referring to fig. 3, the area of the cross section of the stopper 300 gradually decreases in a direction from being close to the through-hole portion 2 to being far from the through-hole portion 2. Alternatively, the area of the cross-section of the stopper 300 may be constant in a direction from near the through-hole portion 2 to far from the through-hole portion 2.

Referring to fig. 1 to 4, the rotating base 1 includes a base 5 and a cover 4 fixedly connected to each other, the through hole portion 2 includes a first through hole 52, the first through hole 11 is located at the center of the base 5, a limiting groove 10 is disposed on the base 5, six cylindrical mounting grooves 12 with bottom openings are disposed in the base 5 around an axis of the through hole portion 2 at intervals, the magnet assembly includes six cylindrical magnets 8, the number of the magnets 8 is the same as that of the mounting grooves 12, one magnet 8 is disposed in one mounting groove 12, the cover 4 is welded and fixed to the bottom of the base 5, and the cover 4 closes the openings of the mounting grooves 12. The rotating seat 1 and the stirring paddle 3 are both made of polypropylene materials.

The first through hole 11 is stepped, the first through hole 11 comprises an upper first hole part 110, a middle second hole part 111 and a lower third hole part 112, the diameter of the first hole part 110 is larger than that of the second hole part 111, the diameter of the third hole part 112 is larger than that of the second hole part 111, the bearing 6 is fixedly installed in the third hole part 112, and the bearing 6 is made of ceramic materials.

The top wall of the second hole portion 111 is provided with a latch assembly 7, and the latch assembly 7 includes a plurality of latches annularly arranged around the axis of the first through hole 11. The latch component 7 can make the stirring impeller and an isolation sleeve disc (not shown in the figure) arranged at the bottom of the biological reaction bag be fixedly connected in a rotatable way, and the latch component 7 is made of polyethylene. The latch component 7 is connected with the rotary seat 1 in an injection molding mode.

Referring to fig. 5, the second bore portion 111 is in clearance fit with the inner ring of the bearing and the third bore portion 112 is in transition fit with the outer ring of the bearing. The through hole portion 2 includes a second through hole 40, the second through hole 40 is located at the center of the cover 4, the diameter of the second through hole 40 is larger than the outer diameter of the inner ring of the bearing 6, and in this embodiment, the diameter of the second through hole 40 is equal to the diameter of the third hole portion 112. Optionally, the through hole portion 2 includes a second through hole 40, the second through hole 40 is located at the center of the cover 4, the diameter of the second through hole 40 is larger than the inner diameter of the inner ring of the bearing 6 and smaller than the outer diameter of the inner ring of the bearing 6, and the cover 4 and the inner ring of the bearing 6 are in clearance fit.

Finally, it should be emphasized that the above-described embodiments are merely preferred examples of the present invention, and are not intended to limit the invention, as various changes and modifications may be made by those skilled in the art, and any changes, equivalents, modifications, etc. made within the spirit and scope of the present invention are intended to be included within the scope of the present invention.

Claims

1. A stirring impeller comprises a rotary seat, wherein a magnet assembly is packaged in the rotary seat, a through hole part is formed in the center of the rotary seat, a bearing is installed in the through hole part, a plurality of stirring paddles are arranged on the rotary seat at intervals around the axis of the rotary seat and comprise a blade part and a first limiting part, and a second limiting part is arranged on the rotary seat;

the method is characterized in that:

first spacing portion includes the stopper, the one end and the blade portion fixed connection of stopper, all outwards the salient is formed with an arc piece on the both sides wall that the stopper deviates from each other, the spacing portion of second is the spacing groove, the shape of spacing groove with the shape of first spacing portion is the same, first spacing portion is installed in the second spacing portion.

2. A mixing impeller according to claim 1, wherein:

the arc-shaped blocks on the stirring paddles are positioned on the same circumference, and the circle center of the circumference is positioned on the axis of the rotating seat.

3. A mixing impeller according to claim 1 or 2, wherein:

4. A mixing impeller according to claim 1 or 2, wherein:

the roating seat includes fixed connection's pedestal and lid, through-hole portion includes first through-hole, first through-hole is located pedestal central authorities, the spacing portion of second sets up on the pedestal, round in the pedestal the axis spaced ring of through-hole portion is equipped with a plurality of bottom open-ended cylindrical mounting grooves, the magnet subassembly includes a plurality of cylindrical magnets, the quantity of magnet with the quantity of mounting groove is the same, one be provided with a magnet in the mounting groove, the lid sets up the bottom of pedestal, the lid seals the opening of mounting groove.

5. A mixing impeller according to claim 4, wherein:

first through-hole is the echelonment, first through-hole is including the first hole portion that is located the upper portion, the second hole portion that is located the middle part and the third hole portion that is located the lower part, the diameter of first hole portion is greater than the diameter of second hole portion, the diameter of third hole portion is greater than the diameter of second hole portion, bearing fixed mounting is in third hole portion, be provided with the latch subassembly on the roof of second hole portion, the latch subassembly includes a plurality ofly round the latch that first through-hole axis interval ring was established.

6. A mixing impeller according to claim 5, wherein:

the second hole part is in clearance fit with the inner ring of the bearing, and the third hole part is in transition fit with the outer ring of the bearing.

7. A mixing impeller according to claim 5, wherein:

the through hole part comprises a second through hole, the second through hole is positioned in the center of the cover body, the diameter of the second through hole is larger than the inner diameter of the bearing inner ring and smaller than the outer diameter of the bearing inner ring, and the cover body is in clearance fit with the inner ring of the bearing.

8. A mixing impeller according to claim 5, wherein:

the through hole part comprises a second through hole, the second through hole is located in the center of the cover body, and the diameter of the second through hole is larger than the outer diameter of the bearing inner ring.

9. A mixing impeller according to claim 1 or 2, wherein:

the included angle between the blade part and the radial direction of the rotating seat comprises 45 degrees or 90 degrees.

10. A bioreactor bag comprising a magnetic drive disposed outside the bioreactor bag, wherein:

comprising a stirring impeller according to any one of claims 1 to 9, said stirring impeller being located within said bioreactor bag and disposed at the bottom of said bioreactor bag.