CN217662979U

CN217662979U - Embedded magnetic stirring device and bioreactor

Info

Publication number: CN217662979U
Application number: CN202221709520.6U
Authority: CN
Inventors: 马学孟; 罗北雄
Original assignee: Zhuhai Singleuse Biological Technology Co ltd
Current assignee: Zhuhai Singleuse Biological Technology Co ltd
Priority date: 2022-07-04
Filing date: 2022-07-04
Publication date: 2022-10-28
Anticipated expiration: 2032-07-04

Abstract

The utility model provides an embedded magnetic stirring device and bioreactor, embedded magnetic stirring device includes the base, stirring rake subassembly and electromagnetic drive mechanism, be formed with open-top's cavity in the base, the stirring rake subassembly includes paddle and paddle base, the paddle sets up the top at the paddle base, the paddle base is rotationally installed in the cavity, be provided with the magnetic part in the paddle base, electromagnetic drive mechanism is located outside the base, electromagnetic drive mechanism interacts with the magnetic part and is used for driving the paddle base at the cavity internal rotation, be provided with the radial inside protruding spacing portion from the cavity inner wall along the cavity on the cavity inner wall, spacing portion and paddle base spacing cooperation in the axial of cavity, spacing portion adjoins with the upper end wall of paddle base. The utility model discloses, can reduce the risk that the stirring rake subassembly drops, improve stirring rake subassembly pivoted stability.

Description

Embedded magnetic stirring device and bioreactor

Technical Field

The utility model belongs to the technical field of bioreactor, concretely relates to embedded magnetic stirring device and bioreactor.

Background

In the field of biotechnology, existing pilot and pilot scale reactors employ various stirring systems, such as gas stirring, mechanical stirring systems, and the like. Wherein, the mechanical stirring system is provided with a motor directly connected with the stirring shaft, a shaft separated from the motor and magnetically driven and a shaftless magnetic driving mechanical stirring system. The direct connection of the motor to the stirring shaft involves the problem of dynamic sealing between the shaft and the reactor, and the leakage and contamination of the reactor are possible in particular in the field of microbial cultivation and the like due to the temperature resistance, pressure resistance and the like of the sealing material. In the magnetic driving mechanical stirring system, the sealing of the reactor adopts static sealing, thus reducing the possibility of leakage and contamination in the aspects of microorganism culture and the like.

The existing embedded magnetic stirring device comprises a base, an electromagnetic driving mechanism and a magnetic stirring paddle component, a cavity is arranged in the base, the stirring paddle component comprises a magnetic stirring piece and a plurality of stirring plates arranged on the upper end wall of the magnetic stirring piece, the magnetic stirring piece is arranged in the cavity, the electromagnetic driving mechanism and the magnetic stirring piece are matched to drive the magnetic stirring piece to rotate in the cavity, the stirring plates are obliquely arranged in the opposite direction of the rotation direction of the magnetic stirring piece, the scheme can prevent the stirring device from moving up and down in the working process, but specific requirements are required for the arrangement direction of the stirring plates, and the base is not limited to the magnetic stirring paddle component in the axial direction, so that the stirring paddle component has the risk of falling off from the base in the transportation or moving process, and the stirring paddle component is inconvenient to be installed back to the original position after being lost or falling off.

Disclosure of Invention

In order to solve the above problem, the utility model aims at providing a can reduce embedded magnetic stirring device who removes in-process stirring rake subassembly risk of droing.

The second purpose of the utility model is to provide a bioreactor including the embedded magnetic stirring device.

In order to achieve the first object, the utility model provides an embedded magnetic stirring device, including base, stirring rake subassembly and electromagnetic drive mechanism, be formed with open-top's cavity in the base, the stirring rake subassembly includes paddle and paddle base, the paddle sets up at the top of paddle base, the paddle base is rotationally installed in the cavity, be provided with the magnetic part in the paddle base, electromagnetic drive mechanism is located outside the base, electromagnetic drive mechanism and magnetic part interact are used for driving the paddle base to rotate in the cavity; the cavity inner wall is provided with a limiting part which protrudes inwards along the radial direction of the cavity from the cavity inner wall, and the limiting part is in limiting fit with the paddle base in the axial direction of the cavity.

It is from top to bottom visible, through the spacing portion that sets up for install the paddle base in the cavity spacing on the axial, can effectually reduce the risk that the paddle base drops, can not reciprocate when the paddle rotates simultaneously, guaranteed paddle pivoted stability.

Further, the limiting part is adjacent to the upper end wall of the blade base.

The further scheme is that a limiting groove is arranged on the outer peripheral wall of the paddle base in a penetrating mode along the axial direction of the paddle base, and the limiting portion can be in sliding fit with the limiting groove.

From top to bottom, compare in interference fit between paddle base and spacing portion, the mode that paddle base forced to impress in the cavity, not only there is wearing and tearing to lead to producing the piece between paddle base and the spacing portion, personnel's operational difficulty and installation time are long simultaneously, have great space between paddle base and the cavity inner wall, lead to the problem that paddle base moved about the existence in the course of the work, lead to energy loss, influence work efficiency. And this scheme through the spacing groove that sets up with spacing portion sliding fit, can be convenient with paddle base installation to the cavity in, reduced the clearance between paddle base and the cavity inner wall simultaneously.

The further scheme is that the limiting groove extends axially along the blade base.

The further proposal is that the number of the limiting parts is more than two, and the limiting parts are arranged at intervals along the circumference of the cavity;

the number of the limiting grooves is larger than or equal to that of the limiting parts.

It is from top to bottom visible, the area that spacing portion and paddle base contact can be increased to a plurality of stoppers, and every stopper of dispersion receives the effort that comes from the paddle base, reduces the risk that the stopper warp or damage.

The further scheme is that the limiting parts are uniformly arranged along the circumferential direction of the cavity.

From top to bottom, a plurality of spacing portions are evenly arranged along circumference, convenient assembly.

The further scheme is that the cavity and the blade base are coaxially arranged, and the inner wall of the cavity is abutted to the blade base.

From top to bottom, paddle base and cavity coaxial line set up, and cavity inner wall and paddle base adjoin to, can effectually prevent that paddle base from removing, improve magnetic stirring device's work efficiency.

The further scheme is that a protruding portion is arranged between the cavity and the paddle base, and the protruding portion is arranged on the inner wall of the cavity and is connected with the outer wall of the paddle base.

The further scheme is that a protruding part is arranged between the inner wall of the cavity and the paddle base, the protruding part is arranged on the inner wall of the cavity, the outer wall of the paddle base is abutted, or the protruding part is positioned on the outer wall of the paddle base and abutted to the base.

Therefore, the contact area between the paddle base and the inner wall of the cavity can be effectively reduced through the arranged protruding portion, friction loss between the paddle base and the inner wall of the cavity in the rotating process is reduced, and rotating efficiency is improved.

The electromagnetic driving mechanism is surrounded on the outer side of the peripheral wall of the base; or the electromagnetic driving mechanism is arranged below the base.

In order to realize the second objective, the utility model provides a pair of bioreactor includes the above-mentioned arbitrary embedded magnetic stirring device, and embedded magnetic stirring device sets up in bioreactor's bottom.

To sum up, the utility model discloses can effectually reduce the risk that the stirring rake subassembly drops.

Drawings

FIG. 1 is a sectional view of the bioreactor of the present invention.

Fig. 2 is an exploded view of the embedded magnetic stirring apparatus of the present invention.

Fig. 3 is a partial view of the embedded magnetic stirring device of the present invention.

Fig. 4 is a cross-sectional view of the embedded magnetic stirring device of the present invention.

Detailed Description

Referring to fig. 1 to 4, the bioreactor 1 provided in this embodiment includes a bag 2, a magnetic stirring device 3 and a mounting seat 4, wherein the magnetic stirring device 3 is disposed at the bottom of the bag 2. The magnetic stirring device 3 comprises a base 6, a stirring paddle component 7 and an electromagnetic driving mechanism 5. The base 6 is made of plastic, and the base 6 and the bag body 2 are integrally formed in a welding mode. The stirring paddle assembly 7 comprises a cylindrical paddle base 71 and four paddles 70 uniformly arranged along the circumference of the paddle base 71, the paddle base 71 comprises a housing 710 and a magnetic member 711 arranged in the housing 710, and the paddles 70 are vertically arranged on the upper end wall of the housing 710. In this embodiment, the magnetic member 711 has an annular structure.

Base 6 central authorities undercut is formed with first concave station 60, be formed with open-top's cylindrical cavity 61 in the first concave station 60, the rotatable setting of paddle base 71 is in cavity 61, paddle base 71 and cavity 61 coaxial line set up, electromagnetic drive mechanism 5 is located mount pad 4, the central authorities undercut of mount pad 4 is formed with second concave station 40, be formed with the installation cavity in the second concave station 40, electromagnetic drive mechanism 5 encircles the outside of establishing at second concave station 40 periphery wall, first concave station 60 is installed in the installation cavity, make bag body 2 location install on mount pad 4, electromagnetic drive mechanism 5 and magnetic part 711 interact, it is rotatory to make electromagnetic drive mechanism 5 can drive magnetic part 711, thereby it is rotatory in cavity 61 to drive stirring rake subassembly 7, stir the liquid in the bag body 2.

In practical use, the magnetic member 711 is generally a high-performance rare earth magnet capable of generating a strong magnetic field, such as a magnet made of neodymium, iron, or boron.

Alternatively, the magnetic members 711 may be a plurality of first magnets uniformly arranged along the circumferential direction of the blade base 71, the electromagnetic driving mechanism 5 may also be located below the second concave platform 40, and the electromagnetic driving mechanism 5 includes a plurality of second magnets matched with the first magnets, and the rotation of the plurality of second magnets drives the first magnets to rotate, so as to drive the stirring paddle assembly 7 to rotate.

The inner wall of the cavity 61 is provided with 4 limiting parts 63 protruding inwards along the radial direction of the cavity 61, the four limiting parts 63 are uniformly arranged along the circumferential direction of the cavity 61, the outer circumferential wall of the shell 710 is provided with four limiting grooves 713 in a penetrating manner along the axial direction of the blade base 71, each limiting part 63 corresponds to one limiting groove 713, and the limiting parts 63 are in sliding fit with the limiting grooves 713. When the paddle assembly 7 is installed, the limiting portion 63 is aligned to the limiting groove 713 in the axial direction, the paddle assembly 7 is inserted into the limiting groove 713, and after the paddle assembly 7 is installed in place, the paddle assembly 7 is rotated, so that the limiting portion 63 is located above the upper end wall of the housing 710, and the limiting portion 63 limits the paddle assembly 7 in the axial direction. In this embodiment, the stopper groove 713 extends in the axial direction of the paddle base 71. Alternatively, the stopper groove 713 extends in a curved or zigzag shape. Of course, the number of the stopper portions 63 may be one or more, and the number of the stopper grooves 713 may be greater than or equal to the number of the stopper portions 63.

Optionally, a mounting groove (not shown in the figure) extending along the radial direction is formed in the inner wall of the cavity 61, the limiting portion 63 is disposed in the mounting groove, the limiting portion 63 can only move in the radial direction of the cavity 61 in the mounting groove, the limiting portion 63 includes a spring (not shown in the figure) and a limiting block (not shown in the figure) connected along the radial direction, the spring is disposed on a side of the limiting block away from the cavity 61, the spring and the limiting block are both mounted in the mounting groove, a portion of the limiting block extends into the cavity 61, a guide surface is disposed on a side wall of the limiting block away from the bottom wall of the cavity 61, the guide surface is inclined toward the central axis of the cavity 61, when the paddle assembly 7 is mounted, the guide surface of the limiting block is forced to drive the limiting block to move toward the inner wall of the cavity 61 along the radial direction of the cavity 61, and when the paddle base 71 is mounted in place, the spring can restore the limiting block to enable the limiting block to abut against the upper end wall of the housing 710.

A protruding portion is arranged between the inner wall of the cavity 61 and the shell 710, the protruding portion comprises a plurality of ribs 712 which are arranged on the outer circumferential wall of the shell 710 at intervals and are uniformly arranged along the circumferential direction of the shell 710, the ribs 712 extend along the axial direction of the shell 710, the radial cross section of each rib 712 is in an arc shape, and the inner circumferential wall of the cavity 61 is abutted to the ribs 712. The protrusion further includes a plurality of protrusions 62 uniformly arranged on the bottom wall of the cavity 61, and the protrusions 62 are hemispherical, and the bottom wall of the housing 710 is adjacent to the protrusions 62. Alternatively, the protrusion also includes a plurality of protrusions provided on the outer circumferential wall of the housing 710.

Alternatively, the projection 62 may be provided on the lower end wall of the housing 710; or ribs 712 may be provided on the inner circumferential wall of the cavity 61.

Of the four paddles 70, the distance and angle between adjacent two paddles 70 are respectively the same. The blade 70 comprises a first blade portion 700 and a second blade portion 701 arranged radially of the cavity 61 and connected, the second blade portion 701 being connected to an upper end wall of the shell 710, the first blade portion 700 being located outside the cavity 61, the first blade portion 700 extending radially of the blade base 71. Alternatively, the number of the paddles 70 may be one or more than one.

Alternatively, the paddle 70 is disposed obliquely on the upper end wall of the housing 710, and the paddle 70 is inclined toward the direction opposite to the direction of rotation of the paddle base 71.

Finally, it should be emphasized that the above-described is merely a preferred embodiment of the present invention, and is not intended to limit the invention, as various changes and modifications may be made by those skilled in the art, and any changes, equivalents, modifications, etc. made within the spirit and scope of the present invention are intended to be included within the scope of the present invention.

Claims

1. The embedded magnetic stirring device comprises a base, a stirring paddle component and an electromagnetic driving mechanism;

a cavity with an opening at the top is formed in the base, the stirring paddle assembly comprises a paddle and a paddle base, the paddle is arranged at the top of the paddle base, the paddle base is rotatably arranged in the cavity, a magnetic part is arranged in the paddle base, the electromagnetic driving mechanism is positioned outside the base, and the electromagnetic driving mechanism and the magnetic part interact with each other to drive the paddle base to rotate in the cavity;

the method is characterized in that:

the blade base is characterized in that a limiting part which protrudes inwards from the inner wall of the cavity along the radial direction of the cavity is arranged on the inner wall of the cavity, and the limiting part is in limiting fit with the blade base in the axial direction of the cavity.

2. The in-line magnetic stirring device of claim 1, wherein:

the limiting portion is adjacent to the upper end wall of the paddle base.

3. The in-line magnetic stirring device of claim 2, wherein:

follow on the periphery wall of paddle base the axial of paddle base is provided with the spacing groove with running through, spacing portion can with spacing groove sliding fit.

4. The in-line magnetic stirring device of claim 3, wherein:

the limiting groove extends axially along the blade base.

5. The in-line magnetic stirring device of claim 3, wherein:

the number of the limiting parts is more than two, and the limiting parts are arranged at intervals along the circumferential direction of the cavity;

6. The in-line magnetic stirring device of claim 5, wherein:

the plurality of limiting parts are uniformly arranged along the circumferential direction of the cavity.

7. The in-line magnetic stirring device of any one of claims 1 to 6, wherein:

the cavity and the paddle base are coaxially arranged, and the inner wall of the cavity is adjacent to the paddle base.

8. The in-line magnetic stirring device of claim 7, wherein:

the paddle comprises a base, a cavity and a blade base, wherein a protruding portion is arranged between the inner wall of the cavity and the blade base, the protruding portion is arranged on the inner wall of the cavity and the outer wall of the blade base is adjacent to the protruding portion, or the protruding portion is located on the outer wall of the blade base and is adjacent to the base.

9. The in-line magnetic stirring device of any one of claims 1 to 6, wherein:

the electromagnetic driving mechanism surrounds the outer side of the peripheral wall of the base; or the electromagnetic driving mechanism is arranged below the base.

10. A bioreactor, characterized by:

comprising the in-line magnetic stirring device of any one of claims 1 to 9, the in-line magnetic stirring device being disposed at the bottom of the bioreactor.