CN217660301U - Porous artificial vertebral body - Google Patents
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- CN217660301U CN217660301U CN202122891725.2U CN202122891725U CN217660301U CN 217660301 U CN217660301 U CN 217660301U CN 202122891725 U CN202122891725 U CN 202122891725U CN 217660301 U CN217660301 U CN 217660301U
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Abstract
The utility model provides a porous artificial vertebral body, which belongs to the technical field of biomedical materials. The utility model provides a porous artificial vertebral body which comprises a porous main body structure (1), wherein the porosity is 50-80%; the porous body structure (1) has an upper and a lower surface and four side surfaces; a hollow bone grafting channel (2) is arranged in the porous main body structure (1), and the bone grafting channel penetrates through the upper surface and the lower surface of the porous main body structure (1); and the solid reinforcing ribs (3) vertically penetrate through the upper surface and the lower surface of the porous main body structure (1). The porous artificial vertebral body provided by the utility model has high porosity, which is beneficial to the fusion and growth of new bone tissues; the utility model discloses regard as the main part of artifical centrum with porous major structure (1), set up solid strengthening rib (3) in porous major structure (1), can make the mechanical properties and the natural bone matching of porous artifical centrum when guaranteeing porous artifical centrum intensity.
Description
Technical Field
The utility model relates to the technical field of biomedical materials, in particular to a porous artificial vertebral body.
Background
Trauma, disease, or congenital factors can cause a variety of spinal injuries and deformities that ultimately can result in impairment of vertebral body function. Spinal injuries can be traumatic, such as vertebral body fractures, or non-traumatic deformities caused by tumors or bony degeneration of vertebral bodies. In the treatment of most spinal injuries, an anterior reconstruction of the spine is required, most commonly with total removal of the damaged vertebral body. In a typical anterior procedure, a partial or total surgical resection is made of the vertebral body and two adjacent intervertebral discs, followed by artificial vertebral body replacement in the void created after removal of the vertebral body and intervertebral discs.
The existing artificial vertebral body is an integrated artificial vertebral body of a personalized plate body based on 3D printing, such as patent CN106923941A, but only one side surface of the artificial vertebral body is of a void structure, the porosity is low, and only limited bone ingrowth is allowed; and the structure has the elasticity modulus far higher than that of human bones, and the mechanical property is not matched with that of natural bones, so that the stress shielding phenomenon can be generated, and the bone absorption and the bone dissolution are caused.
SUMMERY OF THE UTILITY MODEL
In view of this, the present invention provides a porous artificial vertebral body. The utility model provides a porous artificial centrum mechanical properties matches, is favorable to the integration of bone tissue to grow into with natural bone.
In order to realize the purpose of the utility model, the utility model provides a following technical scheme:
the utility model provides a porous artificial vertebral body, which comprises a porous main body structure 1, wherein the porosity of the porous main body structure 1 is 50-80%; the porous main body structure 1 is provided with an upper surface, a lower surface and four side surfaces, and the upper surface and the lower surface of the porous main body structure 1 are bone connection surfaces; a hollow bone grafting channel 2 is arranged in the porous main body structure 1 and penetrates through the upper surface and the lower surface of the porous main body structure 1;
and the solid reinforcing ribs 3 vertically penetrate through the upper surface and the lower surface of the porous main body structure 1.
Preferably, the porous artificial vertebral body is made of pure tantalum or tantalum alloy.
Preferably, the upper surface and the lower surface of the porous main body structure 1 form an included angle of 0-7 degrees.
Preferably, one side surface of the porous main body structure 1 is an outer convex arc surface, and the other three side surfaces are planes; the upper and lower surfaces of the porous main body structure 1 are wave-shaped surfaces.
Preferably, the wave crest distance of the wavy surface is 1-1.5 mm, and the wave depth is 0.5-1 mm.
Preferably, the outer convex arc-shaped surface of the porous main body structure 1 is provided with an instrument hole 4, and the instrument hole 4 is communicated with the hollow bone grafting channel 2.
Preferably, the number of the solid reinforcing ribs 3 is 4, and the cross sections of the 4 solid reinforcing ribs 3 coincide with the diagonal lines of the upper surface and the lower surface of the porous main body structure 1.
Preferably, the thickness of the solid reinforcing rib 3 is 0.5-1.5 mm.
Preferably, the pore diameter of the porous main body structure 1 is 300 to 1500 μm, and the filament diameter is 200 to 350 μm.
Preferably, the distance between the edge of the hollow bone grafting channel 2 and the side wall of the porous main body structure 1 is 2-3 mm.
The utility model provides a porous artificial vertebral body, which comprises a porous main body structure 1, wherein the porosity of the porous main body structure 1 is 50-80%; the porous main body structure 1 is provided with an upper surface, a lower surface and four side surfaces, and the upper surface and the lower surface of the porous main body structure 1 are bone connection surfaces; a hollow bone grafting channel 2 is arranged in the porous main body structure 1 and penetrates through the upper surface and the lower surface of the porous main body structure 1; and the solid reinforcing ribs 3 vertically penetrate through the upper surface and the lower surface of the porous main body structure 1. The porous artificial vertebral body provided by the utility model has high porosity, which is beneficial to the fusion and growth of new bone tissues; the utility model discloses regard as the main part of artifical centrum with porous major structure 1, set up solid strengthening rib 3 in porous major structure 1, can make the mechanical properties and the natural bone matching of porous artifical centrum when guaranteeing porous artifical centrum intensity. The utility model provides a porous artificial centrum compressive strength is 20 ~ 80MPa, and bending strength is 25 ~ 120MPa, and maximum torque is 20 ~ 100N cm, and elastic modulus is 1 ~ 4GPa, and mechanical properties matches with natural bone, can effectively reduce stress shielding, reduces the bone dissolution phenomenon.
Further, the utility model provides a material of porous artificial centrum is pure tantalum or tantalum alloy, and is very stable in human tissue environment, and biocompatibility is excellent.
The utility model provides a preparation method of above-mentioned porous artificial centrum, porous artificial centrum is prepared to the mode that this method adopted vibration material disk to make, and the precision is high, easily realize industrialization batch production.
Drawings
FIG. 1 is a schematic structural view of the porous artificial vertebral body of the present invention;
FIG. 2 is a front view of the porous artificial vertebral body of the present invention;
FIG. 3 is a left side view of the porous artificial vertebral body of the present invention;
FIG. 4 is a top view of the porous artificial vertebral body of the present invention;
FIG. 5 is a partial optical micrograph of a porous host structure 1;
FIG. 6 is an SEM image of the porous host structure 1;
FIG. 7 is a compression curve of the porous tantalum 60% porosity equivalent test piece of the present invention;
FIG. 8 is a bending curve of the porous tantalum 60% porosity equivalent test piece of the present invention;
fig. 9 is a torsion curve of the porous tantalum 60% porosity equivalent test piece of the present invention;
FIG. 10 is a compression fatigue curve of the porous tantalum 60% porosity equivalent test piece of the present invention;
FIG. 11 is a graph showing the staining experiment results of co-cultured viable and dead cells of porous tantalum and HUVEC according to the present invention;
in FIGS. 1-4, 1-porous body structure, 2-hollow bone grafting channel, 3-solid reinforcing rib, 4-instrument hole, 5-annular reinforcing rib.
Detailed Description
The utility model provides a porous artificial vertebral body, which comprises a porous main body structure 1, wherein the porosity of the porous main body structure 1 is 50-80%; the porous main body structure 1 is provided with an upper surface, a lower surface and four side surfaces, and the upper surface and the lower surface of the porous main body structure 1 are bone connection surfaces; a hollow bone grafting channel 2 is arranged in the porous main body structure 1 and penetrates through the upper surface and the lower surface of the porous main body structure 1;
and the porous body structure also comprises a plurality of solid reinforcing ribs 3 vertically penetrating through the upper surface and the lower surface of the porous body structure 1.
The utility model provides a porous artificial vertebral body, which comprises a porous main body structure 1. In the present invention, the porosity of the porous body structure 1 is 50 to 80%, preferably 70 to 75%. In the present invention, the pore diameter of the porous main body structure 1 is preferably 300 to 1500 μm, more preferably 300 to 800 μm, and still more preferably 400 to 600 μm; the porous body structure 1 preferably has a filament diameter of 200 to 350. Mu.m, more preferably 250 to 300. Mu.m.
In the present invention, the porous body structure 1 has upper and lower surfaces and four sides, and the shape is similar to a rectangular parallelepiped. In the present invention, the height of the porous main body structure 1 is 17-62 mm, preferably 25-50 mm; each 1.5mm is a specification, the length of the upper surface cross section and the lower surface cross section is preferably 11 to 14mm, and the width is preferably 11 to 14mm.
In the utility model, the upper and lower surfaces of the porous main body structure 1 are bone connection surfaces; in the present invention, the upper and lower surfaces of the porous main body structure 1 preferably have an included angle of 0 to 7 degrees, and more preferably 3 to 5 degrees. In the present invention, when the angle between the upper and lower surfaces of the porous main body structure 1 is 0 °, the upper and lower surfaces are parallel.
In the present invention, the upper and lower surfaces of the porous body structure 1 are preferably wavy surfaces. In the present invention, the crest pitch (or trough pitch) of the wavy surface is preferably 1 to 1.5mm, and the wave depth is preferably 0.5 to 1mm.
In the present invention, one side of the porous main body structure 1 is preferably an outer convex arc surface, and the other three sides are preferably planes. In the utility model discloses, the cambered surface radius of evagination arc surface is preferred 12 ~ 16mm.
The utility model discloses in, porous main structure 1 is inside to be equipped with cavity bone grafting passageway 2, the bone grafting passageway runs through porous main structure 1's upper and lower surface. The utility model discloses in, the preferred fillet rectangle of cross section of cavity bone grafting passageway 2, the preferred 6 ~ 8mm of length of fillet rectangle, the preferred 4 ~ 6mm of width, the preferred 1 ~ 1.5mm of fillet radius. In the present invention, the diagonal center of the cross section of the hollow bone grafting passage 2 is preferably coincident with the diagonal centers of the upper and lower surfaces of the porous main body structure 1. In the present invention, the distance from the edge of the hollow bone grafting passage 2 to the side wall of the porous main body structure 1 is preferably 2 to 3mm, and more preferably 2.5mm.
The utility model discloses in, porous major structure 1's evagination arc surface has seted up apparatus hole 4, apparatus hole 4 and cavity bone grafting passageway 2 intercommunication. In the utility model, the height and width difference of the instrument hole 4 are preferably more than or equal to 2mm, which is convenient for clamping in the operation process. As a specific embodiment of the present invention, the instrument hole 4 has a height of 6mm and a width of 3mm.
The utility model discloses in, the concrete position of seting up of apparatus hole 4 carry out corresponding design according to actual conditions can.
The utility model provides a porous artificial vertebral body is still including running through perpendicularly many solid strengthening ribs 3 of porous main structure 1 upper and lower surface. In the present invention, the number of the solid reinforcing ribs 3 is preferably 4, and the cross section of the 4 solid reinforcing ribs 3 coincides with the diagonal of the upper and lower surfaces of the porous main body structure 1. In the present invention, the thickness of the solid reinforcing rib 3 is preferably 0.5 to 1.5mm, and more preferably 1mm.
In the present invention, when the outer convex arc surface of the porous main body structure 1 is provided with the instrument hole 4, the annular reinforcing rib 5 is preferably provided around the instrument hole 4, and the annular reinforcing rib 5 is preferably solid. In the present invention, the thickness of the annular reinforcing rib 5 is preferably 0.5 to 1.5mm, and more preferably 1mm.
The utility model discloses in, the material of porous artificial centrum is pure tantalum or tantalum alloy. In the utility model discloses, pure tantalum is preferred medical pure tantalum, and the purity is preferred 99.99%. The tantalum alloy is preferably tantalum-zirconium alloy, and the mass percentage of tantalum in the tantalum alloy is preferably 80-95%. More preferably 85 to 90%.
The utility model discloses in, porous artificial centrum compressive strength is 20 ~ 80MPa, and bending strength is 25 ~ 120MPa, and the maximum torque is 20 ~ 100N cm, and elastic modulus is 1 ~ 4GPa, and mechanical properties matches with natural bone, can effectively reduce stress shielding, reduces the bone dissolution phenomenon.
As a specific embodiment of the present invention, the structural schematic view of the porous artificial vertebral body is shown in fig. 1, the front view is shown in fig. 2, the side view is shown in fig. 3, and the top view is shown in fig. 4. In FIGS. 1-4, 1-porous body structure, 2-hollow bone grafting channel, 3-solid reinforcing rib, 4-instrument hole, 5-annular reinforcing rib.
In the utility model, the preparation method of the porous artificial vertebral body comprises the following steps:
and preparing the porous artificial vertebral body by adopting an additive manufacturing mode.
In the present invention, the additive manufacturing method is preferably a powder bed laser melting method or a powder bed electron beam melting method.
In the present invention, the parameters of the powder laser melting method preferably include:
the laser power is 150-350W, and more preferably 200-300W;
the scanning speed is 100-500 mm/s, more preferably 200-400 mm/s;
the scanning line pitch is 0.05 to 0.15mm, more preferably 0.08 to 0.12mm:
the temperature of the substrate is 100-200 ℃, and more preferably 120-160 ℃;
the thickness of the sliced layer is 0.02 to 0.05mm, more preferably 0.03 to 0.04mm.
In the present invention, the parameters of the powder bed electron beam melting method preferably include:
the preheating temperature is 750-1500 ℃, and more preferably 1000-1200 ℃:
the scanning current is 2-20 mA, and more preferably 5-15 mA;
the scanning speed is 1.0 × 10 4 ～1.0×10 6 mm/s, more preferably 1.0X 10 5 mm/s；
The thickness of the sliced layer is 20 to 100. Mu.m, more preferably 40 to 80 μm.
In the present invention, the method for preparing a porous artificial vertebral body by additive manufacturing preferably comprises the following steps:
and importing the three-dimensional model file of the porous artificial vertebral body into additive manufacturing equipment, wherein alloy powder is paved in the additive manufacturing equipment in advance, additive manufacturing parameters are set, and the powder material is sintered into the shape of the imported model in a layer-by-layer fusion stacking mode to obtain the porous artificial vertebral body.
In the present invention, the additive manufacturing parameters are preferably the same as the parameters of the above powder laser melting method or the parameters of the powder bed electron beam melting method, and are not described herein again.
Obtain behind the porous artificial vertebral body, the utility model discloses it is preferred right porous artificial vertebral body carries out the aftertreatment, the aftertreatment is preferred including following step:
the obtained porous artificial vertebral body is preferably subjected to powder cleaning, linear cutting, support removal, sand blasting, ultrasonic treatment, cleaning, drying and sterilization in sequence. The utility model discloses do not have special requirement to above-mentioned operation, use this field conventional method to carry out above-mentioned operation can.
In the present invention, when the additive manufacturing method is a powder laser melting method, it is preferable that the method further includes a heat treatment between the ultrasonic treatment and the cleaning, wherein the heat treatment temperature is preferably 900 to 1100 ℃, and the heat preservation time is preferably 1 to 2 hours.
The porous artificial vertebral body provided by the present invention will be described in detail with reference to the following embodiments, but they should not be construed as limiting the scope of the present invention.
Example 1
The porous artificial vertebral body with the structure shown in the figures 1-4 is prepared by adopting a powder laser melting method, and the specific operation steps are as follows:
the three-dimensional model file of the porous artificial vertebral body is led into powder bed laser melting additive manufacturing equipment, sufficient medical pure tantalum metal powder is paved in the additive manufacturing equipment in advance, appropriate process parameters (specifically: the layer thickness is 0.03mm, the substrate temperature is 100 ℃, the laser power is 250W, the scanning speed is 200mm/S, and the scanning line interval is 0.09 mm) are selected, and the powder material is sintered into the shape of the lead-in model in a layer-by-layer melting and stacking mode.
And taking out the sintered workpiece, and sequentially performing powder cleaning, linear cutting, support removal, sand blasting, ultrasonic cleaning, heat treatment, final cleaning, drying and sterilization.
The obtained porous artificial vertebral body consists of a porous main body structure 1 and a solid reinforcing rib 3, wherein the porous main body structure 1 is provided with six outer surfaces, namely an upper outer surface, a lower outer surface, a left outer surface, a right outer surface, a front outer surface and a rear outer surface, and a bone grafting channel penetrating through the whole vertebral body is arranged between the upper outer surface and the lower outer surface; the front surface of the artificial vertebral body is an arc surface, the back, left and right surfaces are planes, the upper and lower surfaces are wave-shaped, round corners or oblique angle transition is formed between the front, back, left and right surfaces, the upper and lower surfaces are bone fusion surfaces, and the included angle of the surfaces is 7 degrees; the wave surface wave crest (wave trough) distance is 1.5mm, and the depth is 1mm.
The section of the bone grafting channel is a rounded rectangle, starts from the center of the upper surface and the center of the lower surface, and penetrates through the whole porous main body structure 1. The distance from the edge of the bone grafting passage to the outer surface of the vertebral body is 3mm.
The center of the front surface is provided with an instrument hole 4 which is communicated with the bone grafting channel. The instrument hole 4 is 6mm in height and 3mm in width.
The solid reinforcing ribs 3 start from the angular points of the outer edge of the vertebral body, end at the angular points corresponding to the bone grafting channel and extend from the upper surface to the lower surface; the thickness of the reinforcing rib is 1.5mm.
The porosity of the porous body structure 1 was 70%, the average pore diameter was 800 μm, and the average filament diameter was 300. Mu.m.
A partial optical micrograph of the porous body structure 1 is shown in fig. 5, and it can be seen from fig. 5 that the porous body structure 1 has a porous structure characteristic, specifically, a non-regular bionic trabecular porous structure.
Fig. 6 shows a partial SEM image of the porous body structure 1, and fig. 6 shows partial SEM images of different positions (a) and (b). As can be seen from fig. 6, the porous body structure 1 has a rich pore structure.
And testing the compressive strength, the bending strength and the maximum torque of the obtained porous artificial vertebral body according to YS/T1132, YS/T1133 and GB/T101285 standards, wherein the compressive strength, the bending strength and the maximum torque of the obtained porous artificial vertebral body are 33.6MPa, 53MPa and 69N cm.
Performance testing
(1) An equivalent test piece with the porosity of 60% is prepared in the manner of example 1, and the compression strength, the bending strength, the maximum torque and the elastic modulus of the equivalent test piece are tested, and the compression curve, the bending curve, the torsion curve and the compression fatigue curve of the equivalent test piece are shown in fig. 7, 8, 9 and 10 respectively. The multiple curves in each of fig. 7-10 represent the test results of repeated experiments.
As can be seen from figures 7 to 10, the porous artificial vertebral body of the utility model has the mechanical property matched with the human skeleton.
(2) The porous tantalum biomaterial is used for carrying out corresponding cell experiments on NIH-3T3 and HUVEC two strains of cells, the growth condition of the cells is observed through a fluorescence microscope, and the proliferation and attachment capacity of the cells on the porous tantalum material is researched.
FIG. 11 is a staining result of co-culture of cells and porous tantalum for 7d, in FIG. 11, green fluorescence is an index of live cells, and red fluorescence is an index of dead cells, and it can be seen from FIG. 11 that the cells are obviously proliferated, the material is basically wrapped, the amount of red fluorescence is very small, and the cell viability is strong.
As can be seen from the above embodiments, the utility model provides a porous artificial vertebral body mechanical properties matches with natural bone, is favorable to the fusion of bone tissue to grow into.
Example 2
The porous artificial vertebral body with the structure shown in figures 1-4 is prepared by a powder electron beam melting method, and the specific operation steps are as follows:
and introducing the three-dimensional model file of the porous artificial vertebral body into powder bed electron beam melting additive manufacturing equipment, paving sufficient tantalum-zirconium alloy powder in the additive manufacturing equipment in advance, selecting proper process parameters, and sintering the powder material into a shape of an introduced model in a layer-by-layer melting and stacking mode.
The process parameters are as follows:
preheating temperature is 1000 deg.C, current is 10mA, and scanning speed is 1.0 × 10 5 mm/s, slice layer thickness of 40um.
And taking out the sintered workpiece, and sequentially carrying out sand blasting, ultrasonic cleaning, drying and sterilization.
The obtained porous artificial vertebral body consists of a porous main body structure 1 and a solid reinforcing rib 3, wherein the porous main body structure 1 is provided with six outer surfaces, namely an upper outer surface, a lower outer surface, a left outer surface, a right outer surface, a front outer surface and a rear outer surface, and a bone grafting channel penetrating through the whole vertebral body is arranged between the upper outer surface and the lower outer surface; the front surface of the artificial vertebral body is an arc surface, the back, left and right surfaces are planes, the upper and lower surfaces are wave-shaped, round corners or oblique angle transition is formed between the front, back, left and right surfaces, the upper and lower surfaces are bone fusion surfaces, and the included angle of the surfaces is 7 degrees; the distance between wave crests (wave troughs) on the wavy surface is 1mm, and the depth is 0.8mm.
The section of the bone grafting channel is a rounded rectangle, starts from the center of the upper surface and the center of the lower surface, and penetrates through the whole porous main body structure 1. The distance from the edge of the bone grafting passage to the outer surface of the vertebral body is 3mm.
The center of the front surface is provided with an instrument hole 4 which is communicated with the bone grafting channel. The instrument hole 4 is 6mm in height and 3mm in width.
The solid reinforcing ribs 3 start from the corner points of the outer edge of the vertebral body, end at the corresponding corner points of the bone grafting channel and extend from the upper surface to the lower surface; the thickness of the reinforcing rib is 1.5mm.
The porosity of the porous body structure 1 was 70%, the average pore diameter was 1000 μm, and the average filament diameter was 350 μm.
The compressive strength, the bending strength and the maximum torque of the obtained porous artificial vertebral body are tested according to YS/T1132, YS/T1133 and GB/T101285, and the compression strength, the bending strength and the maximum torque of the obtained porous artificial vertebral body are 51.4MPa, 85.2MPa and 94N cm through testing.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. The porous artificial vertebral body is characterized by comprising a porous main body structure (1), wherein the porosity of the porous main body structure (1) is 50-80%; the porous main body structure (1) is provided with an upper surface, a lower surface and four side surfaces, and the upper surface and the lower surface of the porous main body structure (1) are bone connection surfaces; a hollow bone grafting channel (2) is arranged in the porous main body structure (1), and the bone grafting channel penetrates through the upper surface and the lower surface of the porous main body structure (1);
and the solid reinforcing ribs (3) vertically penetrate through the upper surface and the lower surface of the porous main body structure (1).
2. The porous artificial vertebral body of claim 1 wherein the porous artificial vertebral body is made of pure tantalum or tantalum alloy.
3. The porous artificial vertebral body according to claim 1 or 2, characterized in that the upper and lower surfaces of the porous body structure (1) have an angle of 0-7 °.
4. The porous artificial vertebral body according to claim 1, characterized in that one side of the porous body structure (1) is an outwardly convex curved surface and the remaining three sides are planar; the upper surface and the lower surface of the porous main body structure (1) are wavy surfaces.
5. The porous artificial vertebral body of claim 4 wherein the undulating surface has a crest spacing of 1 to 1.5mm and an undulation depth of 0.5 to 1mm.
6. The porous artificial vertebral body according to claim 4, characterized in that the outer convex arc-shaped surface of the porous main body structure (1) is provided with instrument holes (4), and the instrument holes (4) are communicated with the hollow bone grafting passage (2).
7. The porous artificial vertebral body according to claim 1, characterized in that the number of the solid reinforcing ribs (3) is 4, and the cross section of the 4 solid reinforcing ribs (3) is coincident with the diagonal of the upper and lower surfaces of the porous main body structure (1).
8. The porous artificial vertebral body according to claim 1, characterized in that the thickness of the solid reinforcing ribs (3) is 0.5-1.5 mm.
9. The porous artificial vertebral body according to claim 1, characterized in that the pore size of the porous body structure (1) is 300-1500 μm and the filament diameter is 200-350 μm.
10. Porous artificial vertebral body according to claim 1, characterized in that the edge of the hollow bone grafting passage (2) is at a distance of 2-3 mm from the side wall of the porous body structure (1).
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