CN101766843B - Artificial bone with porous laminated structure and passages and preparation method thereof - Google Patents
Artificial bone with porous laminated structure and passages and preparation method thereof Download PDFInfo
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- CN101766843B CN101766843B CN 201019114034 CN201019114034A CN101766843B CN 101766843 B CN101766843 B CN 101766843B CN 201019114034 CN201019114034 CN 201019114034 CN 201019114034 A CN201019114034 A CN 201019114034A CN 101766843 B CN101766843 B CN 101766843B
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Abstract
The invention relates to an artificial bone with a porous laminated structure and passages, which belongs to the technical field of biomedical materials. The artificial bone is alternately laminated and formed by compact layers and porous layers which are made of calcium phosphate base biological ceramic materials, and in addition, passages for conveying cells and body fluid are arranged in the direction which forms a set angle with the laminated layers. The preparation method comprises the following step: mixing powder such as hydroxylapatite, beta-tricalcium phosphate and the like through using deionized water as medium to be prepared into pulp. A three-dimensional gel laminated forming system is adopted for preparing ceramic blanks formed by the compact layers, the porous layers and the passages, and then the ceramic blanks are sintered at a high temperature for preparing the artificial bone. The invention has the characteristics that the artificial bone has high mechanical strength, has the porous structure with the effects of osteoplast adhesion, propagation, growth and vascularization, can be used as the artificial bone, can also be used as a bone tissue engineering support frame, and has wide application prospects in clinics in the orthopedics department.
Description
Technical field
The invention belongs to the bio-medical material technical field, particularly a kind of artificial bone, particularly relate to a kind of artificial bone with porous laminated structure and passage,
Background technology
The bone defect repair that causes due to wound, infection, tumor resection and osteomyelitis etc. is one of the difficult problem in orthopaedics field always.The main method of at present bone reparation is to carry out the bone transplant operation---being about to has the damaged a kind of operation that maybe needs the position strengthening, fix from body bone, allograph bone or artificial bone graft to the patient body Endoskeleton.
Autologous bone transplanting has higher osteoinductive, without immunological rejection, but can increase operation wound, and the source of bone is also very limited.Not only there is source problem in allogenic bone transplantation, but also can produce immunological rejection and postoperative complication etc., in migration process, probably the disease of source body is passed to receptor.The calcium orthophosphate base bioceramic artificial bone has good biocompatibility and biological activity and biodegradability, is one of important directions of bone renovating material development.The block calcium orthophosphate base bio-ceramic artificial bone who uses at present mainly contains two types of whole compact-type and porous types, the compact-type artificial bone, intensity is high, can be used for the damaged reparation of weight bearing area bone, but lack hole and body fluid passage that osteocyte is grown into, be unfavorable for the formation of adhesion, propagation, differentiation, growth and the new bone tissue of osteocyte.The porous type artificial bone has the pore structure that osteocyte is grown into and vascularization forms, and be conducive to the reconstruction of osseous tissue, but intensity is low, can not be used for the damaged reparation of weight bearing area bone, and range of application is restricted.Preparation had both had higher intensity, and the novel artificial bone by the pore structure with bone cell growth has the important clinical practical value.
Summary of the invention
The object of the invention is to provides a kind of artificial bone with porous laminated structure and passage for overcoming the weak point of prior art, has both had higher intensity, has again the body fluid circulation, the passage of Growth of Cells and vascularization, excellent performance, the characteristics that the suitability is wide.
Above-mentioned purpose adopts following technical proposals to realize:
A kind of artificial bone with porous laminated structure and passage of the present invention, it is characterized in that, described artificial bone is by dense layer and the molding of porous layer alternative stacked of calcium orthophosphate base bioceramic material, and is provided with the passage of carrying cell, body fluid on the direction that becomes set angle with lamination.
The present invention proposes to prepare the method for above-mentioned artificial bone, specifically comprises the following steps:
(1) be the hydroxyapatite (HA) of 0～100wt% with content, (β-TCP) powder mixes the bata-tricalcium phosphate of 100wt%～0, obtains the calcium orthophosphate base bioceramic mixed-powder;
(2) will press the mixed-powder of solid concentration percent by volume 30～60vol% with deionized water, with respect to the gellant sodium alginate of the percentage by weight 0.5～1.5wt% of deionized water, mixing and ball milling 2～6 hours is mixed with the ceramic size of dense layer molding;
(3) will press the mixed-powder of solid concentration percent by volume 20～60vol% with deionized water, with respect to the gellant sodium alginate of the percentage by weight 0.5～1.5wt% of deionized water, with respect to the foaming agent sodium lauryl sulphate of the percentage by weight 0.2～0.8wt% of deionized water, with respect to the foam stabilizer lauryl alcohol of the percentage by weight 0.02～0.1wt% of deionized water, carry out mixing and ball milling 2～6 hours, and be mixed with the ceramic size of porous molding layer;
(4) analytical pure calcium chloride is dissolved in deionized water, is mixed with the calcium chloride solution that concentration is 1～5M, as the gel initiator;
(5) the dense layer molding slurry and the porous molding layer slurry that step (2), (3) are mixed with, the calcium chloride solution that is mixed with take step (4) is as the gel initiator, laminated forming alternately in three dimensional gel laminated forming system, and becoming the direction of set angle with lamination, drill through the passage of carrying cell, body fluid, be prepared into ceramic body;
(6) with the base substrate of step (5) preparation, at room temperature natural drying more than 24 hours, is placed in electrically heated drying cabinet, is incubated 6～12 hours under 80～120 ℃, makes the base substrate oven dry;
(7) with the base substrate of step (6) oven dry, in high-temperature electric resistance furnace, be warming up to gradually 1050 ℃～1350 ℃, sintering 2～6 hours makes sintered body, after then cooling to 300 ℃, and furnace cooling;
(8) sintered body that step (7) is made is processed into the artificial bone of various shapes according to the damaged reparation requirement of bone, is used for bone reparation or bone tissue engineering stent material.
The artificial bone of the present invention has the following advantages:
1. the artificial bone of the present invention is selected the calcium orthophosphate base bioceramic preparation, has good biocompatibility and biological activity, by adjusting the component of calcium orthophosphate base bioceramic, also can regulate and control artificial bone degradation speed in vivo.
2. the artificial bone of the present invention has adopted the dense layer structure, has improved the intensity of artificial bone, also can regulate and control the intensity of artificial bone by adjusting thickness, the density of dense layer, to be fit to the requirement of different parts bone defect repair.
3. the artificial bone of the present invention has adopted honeycomb sandwich, and is provided with passage, is conducive to growing into and vascularization of osteocyte, can accelerate the reconstruction of new bone tissue.
4. the artificial bone structure of the present invention is simple, and preparation cost is low, is suitable for mass production, and can repair needs according to bone, and be processed into various shapes, satisfy the requirement that the different parts bone is repaired, also can be used as bone tissue engineering stent material, have broad application prospects on Orthopedic Clinical.
Description of drawings
Fig. 1 is the structural representation of the artificial bone of the present invention.
The specific embodiment
Artificial bone with porous laminated structure and passage that the present invention proposes and preparation method thereof reaches by reference to the accompanying drawings embodiment and is described further:
Artificial bone with porous laminated structure and passage of the present invention, its structure as shown in Figure 1, described artificial bone is by the dense layer 1 of calcium orthophosphate base bioceramic material and porous layer 2 is overlapped forms, and in the direction angled with lamination, is provided with the passage 3 of carrying cell, body fluid.Wherein, the thickness of dense layer can be 0.1～2mm.The thickness of porous layer can be 0.3～2mm; The pore diameter of porous layer can be 0.1～0.8mm; The porosity of porous layer can be 20%～80%.The angle of carrying cell, the channel diameter of body fluid to can be between this passage of 0.5～2mm and lamination can be 10 °～90 °; Spacing between the central point of described adjacent two conveying cells, body fluid channel cross-section is 1-3mm.
Each parameter of artificial bone of the present invention can be by the process conditions of adjustment preparation method and the proportioning realization of each composition, and the gross thickness of artificial bone can be determined according to practical application.
The present invention proposes to prepare the method for above-mentioned artificial bone, specifically comprises the following steps:
(1) be the hydroxyapatite (HA) of 0～100wt% with content, (β-TCP) powder mixes the bata-tricalcium phosphate of 100wt%～0, obtains the calcium orthophosphate base bioceramic mixed-powder;
(2) mixed-powder in (1) and deionized water are pressed solid concentration percent by volume 30～60vol%, gellant sodium alginate content is with respect to the percentage by weight 0.5～1.5wt% of deionized water, ball milling mixed 2～6 hours, and preparation is used for the ceramic size of dense layer molding;
(3) mixed-powder in (1) and deionized water are pressed solid concentration percent by volume 20～60vol%, gellant sodium alginate content is with respect to the percentage by weight 0.5～1.5wt% of deionized water, the foaming agent Sodium Dodecyl Sulfate is with respect to the percentage by weight 0.2～0.8wt% of deionized water, the foam stabilizer dodecanol content is with respect to the percentage by weight 0.02～0.1wt% of deionized water, ball milling mixed 2～6 hours, and preparation is used for the ceramic size of porous molding layer;
(4) analytical pure calcium chloride is dissolved in deionized water, compound concentration is the calcium chloride solution of 1～5M, as the gel initiator;
(5) dense layer molding slurry and the porous molding layer slurry (2), (3) prepared, take (4) preparation calcium chloride solution as the gel initiator, laminated forming alternately in three dimensional gel laminated forming system, after lamination is completed, in the direction angled with lamination, drill through decide the passage of diameter, preparation ceramic body;
(6) with the base substrate of (5) preparation, natural drying at room temperature was placed in electrically heated drying cabinet more than 24 hours, at 80～120 ℃, was incubated oven dry in 6～12 hours;
The base substrate of (7) (6) being dried, at high-temperature electric resistance furnace, in air atmosphere, heat up gradually (heating up as the speed with 100～150 ℃/min), under 1050～1350 ℃, 2～6 hours sintering of temperature retention time, then the speed with 150～200 ℃/min cools to (as the speed cooling with 150～200 ℃/min) after 300 ℃, furnace cooling;
(8) sintered body according to the damaged reparation requirement of bone, is processed into various shapes, is used for the bone reparation.
Embodiment one:
The present embodiment artificial bone is by dense layer and the molding of porous layer alternative stacked of calcium orthophosphate base bioceramic material, and in the direction angled with lamination, is provided with the passage of carrying cell, body fluid.Wherein, the dense layer thickness of artificial bone is 0.1mm, and porous layer thickness is 0.3mm, and pore diameter is that 0.1～0.3mm, porosity are 20%～60%, and channel diameter is 0.5～0.6mm, and the angle between passage and lamination is 10 °, and the duct spacing is 1-2mm.
The preparation method of the present embodiment comprises the following steps:
(1) take the hydroxyapatite (HA) of 100wt% as material powder;
(2) powder in (1) and deionized water are pressed solid concentration percent by volume 30vol%, gellant sodium alginate content is with respect to the percentage by weight 0.5wt% of deionized water, and ball milling mixed 2 hours, and preparation is used for the ceramic size of dense layer molding;
(3) powder in (1) and deionized water are pressed solid concentration percent by volume 20%, gellant sodium alginate content is with respect to the percentage by weight 0.5% of deionized water, the foaming agent Sodium Dodecyl Sulfate is with respect to the percentage by weight 0.2wt% of deionized water, the foam stabilizer dodecanol content is with respect to the percentage by weight 0.02wt% of deionized water, ball milling mixed 2 hours, and preparation is used for the ceramic size of porous molding layer;
(4) analytical pure calcium chloride is dissolved in deionized water, compound concentration is the calcium chloride solution of 1M, as the gel initiator;
(5) dense layer molding slurry and the porous molding layer slurry (2), (3) prepared, take (4) preparation calcium chloride solution as the gel initiator, laminated forming alternately in three dimensional gel laminated forming system, every layer of dense layer slurry bed thickness is 0.12mm, porous layer slurry bed thickness is 0.4mm, after lamination is completed, is becoming the direction of 10 ° with lamination, drill through the passage of a plurality of diameter 0.62mm, the preparation ceramic body;
((6) with the base substrate of (5) preparation, natural drying at room temperature was placed in electrically heated drying cabinet after 24 hours, at 80 ℃, was incubated oven dry in 6 hours;
The base substrate of (7) (6) being dried, at high-temperature electric resistance furnace, in air atmosphere, after being warmed up to gradually 1050 ℃, heat preservation sintering 6 hours, after then cooling to 300 ℃, furnace cooling;
(8) sintered body according to the damaged reparation requirement of bone, is processed into various shapes, is used for bone reparation or bone tissue engineering scaffold.
Embodiment two:
The present embodiment artificial bone is by dense layer and the molding of porous layer alternative stacked of calcium orthophosphate base bioceramic material, and in the direction angled with lamination, is provided with the passage of carrying cell, body fluid.Wherein, the dense layer thickness of artificial bone is 0.5mm, and porous layer thickness is 0.6mm, and pore diameter is that 0.2～0.4mm, porosity are 30%～70%, and channel diameter is 1mm, and the angle between passage and lamination is that 30 ° of spacings between passage are 2-3mm.
The preparation method of the present embodiment comprises the following steps:
(1) be that the bata-tricalcium phosphate of 100wt% is as material powder with content;
(2) powder in (1) and deionized water are pressed solid concentration percent by volume 40vol%, gellant sodium alginate content is with respect to the percentage by weight 0.8wt% of deionized water, and ball milling mixed 3 hours, and preparation is used for the ceramic size of dense layer molding;
(3) mixed-powder in (1) and deionized water are pressed solid concentration percent by volume 30vol%, gellant sodium alginate content is with respect to the percentage by weight 0.8wt% of deionized water, the foaming agent Sodium Dodecyl Sulfate is with respect to the percentage by weight 0.4wt% of deionized water, the foam stabilizer dodecanol content is with respect to the percentage by weight 0.05wt% of deionized water, ball milling mixed 3 hours, and preparation is used for the ceramic size of porous molding layer;
(4) analytical pure calcium chloride is dissolved in deionized water, compound concentration is the calcium chloride solution of 2M, as the gel initiator;
(5) dense layer molding slurry and the porous molding layer slurry (2), (3) prepared, take (4) preparation calcium chloride solution as the gel initiator, laminated forming alternately in three dimensional gel laminated forming system, dense layer slurry bed thickness is 0.62mm, porous layer slurry bed thickness is 0.75mm, after lamination is completed, is becoming the direction of 30 ° with lamination, drill through the passage of diameter 1mm, the preparation ceramic body;
(6) with the base substrate of (5) preparation, natural drying at room temperature was placed in electrically heated drying cabinet after 30 hours, at 90 ℃, was incubated oven dry in 8 hours;
(7) with the base substrate of (6) oven dry, at high-temperature electric resistance furnace, in air atmosphere, be warmed up to gradually 1150 ℃, heat preservation sintering 5 hours, after then cooling to 300 ℃, furnace cooling;
(8) sintered body according to the damaged reparation requirement of bone, is processed into various shapes, is used for bone reparation or bone tissue engineering scaffold.
Embodiment three:
The present embodiment artificial bone is by dense layer and the molding of porous layer alternative stacked of calcium orthophosphate base bioceramic material, and in the direction angled with lamination, is provided with the passage of carrying cell, body fluid.Wherein, the dense layer thickness of artificial bone is 1.6mm, and porous layer thickness is 1.6mm, and pore diameter is that 0.3～0.5mm, porosity are 30%～60%, and channel diameter is 1.2mm, and the angle between passage and lamination is that 60 ° of spacings between passage are 1-3mm.
The preparation method of the present embodiment comprises the following steps:
(1) be the hydroxyapatite (HA) of 60wt% with content, (β-TCP) powder mixes the bata-tricalcium phosphate of 40wt%;
(2) mixed-powder in (1) and deionized water are pressed solid concentration percent by volume 50vol%, gellant sodium alginate content is with respect to the percentage by weight 1.2wt% of deionized water, ball milling mixed 5 hours, and preparation is used for the ceramic size of dense layer molding;
(3) mixed-powder in (1) and deionized water are pressed solid concentration percent by volume 50vol%, gellant sodium alginate content is with respect to the percentage by weight 1.2wt% of deionized water, the foaming agent Sodium Dodecyl Sulfate is with respect to the percentage by weight 0.6wt% of deionized water, the foam stabilizer dodecanol content is with respect to the percentage by weight 0.081wt% of deionized water, ball milling mixed 4 hours, and preparation is used for the ceramic size of porous molding layer;
(4) analytical pure calcium chloride is dissolved in deionized water, compound concentration is the calcium chloride solution of 4M, as the gel initiator;
(5) dense layer molding slurry and the porous molding layer slurry (2), (3) prepared, take (4) preparation calcium chloride solution as the gel initiator, laminated forming alternately in three dimensional gel laminated forming system, dense layer slurry bed thickness is 2mm, porous layer slurry bed thickness is 2mm, after lamination is completed, is becoming the direction of 60 ° with lamination, drill through the passage of diameter 1.5mm, the preparation ceramic body;
(6) with the base substrate of (5) preparation, natural drying at room temperature was placed in electrically heated drying cabinet after 36 hours, at 100 ℃, was incubated oven dry in 10 hours;
(7) with the base substrate of (6) oven dry, at high-temperature electric resistance furnace, in air, heat up gradually, at 1250 ℃, heat preservation sintering 3 hours, after then cooling to 300 ℃, furnace cooling;
(8) sintered body according to the damaged reparation requirement of bone, is processed into various shapes, is used for bone reparation or bone tissue engineering scaffold.
Embodiment four:
The present embodiment artificial bone is by dense layer and the molding of porous layer alternative stacked of calcium orthophosphate base bioceramic material, and in the direction angled with lamination, is provided with the passage of carrying cell, body fluid.Wherein, the dense layer thickness of artificial bone is 2mm, and porous layer thickness is 2mm, and pore diameter is that 0.5～0.8mm, porosity are 40%～80%, and channel diameter is 2mm, and the angle between passage and lamination is that 90 ° of spacings between passage are 1-3mm.
The preparation method of the present embodiment comprises the following steps:
(1) be the hydroxyapatite (HA) of 50wt% with content, (β-TCP) powder mixes the bata-tricalcium phosphate of 50wt%～0;
(2) mixed-powder in (1) and deionized water are pressed solid concentration percent by volume 60vol%, gellant sodium alginate content is with respect to the percentage by weight 1.5wt% of deionized water, ball milling mixed 6 hours, and preparation is used for the ceramic size of dense layer molding;
(3) mixed-powder in (1) and deionized water are pressed solid concentration percent by volume 60vol%, gellant sodium alginate content is with respect to the percentage by weight 1.5wt% of deionized water, the foaming agent Sodium Dodecyl Sulfate is with respect to the percentage by weight 0.8wt% of deionized water, the foam stabilizer dodecanol content is with respect to the percentage by weight 0.1wt% of deionized water, ball milling mixed 6 hours, and preparation is used for the ceramic size of porous molding layer;
(4) analytical pure calcium chloride is dissolved in deionized water, compound concentration is the calcium chloride solution of 5M, as the gel initiator;
(5) dense layer molding slurry and the porous molding layer slurry (2), (3) prepared, take (4) preparation calcium chloride solution as the gel initiator, laminated forming alternately in three dimensional gel laminated forming system, dense layer slurry bed thickness is 2.5mm, porous layer slurry bed thickness is 2.5mm, after lamination is completed, is becoming the direction of 90 ° with lamination, drill through the passage of diameter 2.5mm, the preparation ceramic body;
(6) with the base substrate of (5) preparation, natural drying at room temperature was placed in electrically heated drying cabinet after 48 hours, at 120 ℃, was incubated oven dry in 12 hours;
(7) with the base substrate of (6) oven dry, at high-temperature electric resistance furnace, in air atmosphere, be warmed up to gradually 1350 ℃, heat preservation sintering 2 hours, after then cooling to 300 ℃, furnace cooling;
(8) sintered body according to the damaged reparation requirement of bone, is processed into various shapes, is used for the bone reparation.
Claims (7)
1. artificial bone with porous laminated structure and passage, it is characterized in that, described artificial bone is by dense layer and the molding of porous layer alternative stacked of calcium orthophosphate base bioceramic material, and is provided with the passage of carrying cell, body fluid on the direction that becomes set angle with lamination; Prepare described artificial bone, comprise the following steps:
(1) be hydroxyapatite (HA) powder of 0～100wt% with content, (β-TCP) powder mixes the bata-tricalcium phosphate of 100wt%～0, obtains the calcium orthophosphate base bioceramic mixed-powder;
(2) will press the mixed-powder of solid concentration percent by volume 30～60vol% with deionized water, with respect to the gellant sodium alginate of the percentage by weight 0.5～1.5wt% of deionized water, mixing and ball milling 2～6 hours is mixed with the ceramic size of dense layer molding;
(3) will press the mixed-powder of solid concentration percent by volume 20～60vol% with deionized water, with respect to the gellant sodium alginate of the percentage by weight 0.5～1.5wt% of deionized water, with respect to the foaming agent sodium lauryl sulphate of the percentage by weight 0.2～0.8wt% of deionized water, with respect to the foam stabilizer lauryl alcohol of the percentage by weight 0.02～0.1wt% of deionized water, carry out mixing and ball milling 2～6 hours, and be mixed with the ceramic size of porous molding layer;
(4) analytical pure calcium chloride is dissolved in deionized water, is mixed with the calcium chloride solution that concentration is 1～5M, as the gel initiator;
(5) the dense layer molding slurry and the porous molding layer slurry that step (2), (3) are mixed with, the calcium chloride solution that is mixed with take step (4) is as the gel initiator, laminated forming alternately in three dimensional gel laminated forming system, and becoming the direction of set angle with lamination, drill through the passage of carrying cell, body fluid, be prepared into ceramic body;
(6) with the base substrate of step (5) preparation, at room temperature natural drying more than 24 hours, is placed in electrically heated drying cabinet, is incubated 6～12 hours under 80～120 ℃, makes the base substrate oven dry;
(7) with the base substrate of step (6) oven dry, in high-temperature electric resistance furnace, be warming up to gradually 1050 ℃～1350 ℃, sintering 2～6 hours makes sintered body, after then cooling to 300 ℃, and furnace cooling;
(8) sintered body that step (7) is made is processed into the artificial bone of various shapes according to the damaged reparation requirement of bone, is used for bone reparation or bone tissue engineering stent material.
2. artificial bone according to claim 1, it is characterized in that: the thickness of described dense layer is 0.1～2mm.
3. artificial bone according to claim 1, it is characterized in that: the thickness of described porous layer is 0.3～2mm.
4. according to claim 1 or 3 described artificial bones, it is characterized in that: the pore diameter of described porous layer is 0.1～0.8mm.
5. according to claim 1 or 3 described artificial bones, it is characterized in that: the porosity of described porous layer is 20%～80%.
6. artificial bone according to claim 1, it is characterized in that: the channel diameter of described conveying cell, body fluid is 0.5～2mm.
7. artificial bone according to claim 1, it is characterized in that: the passage of described conveying cell, body fluid and the angle between lamination are 10 °～90 °; Spacing between the central point of adjacent two conveying cells, body fluid channel cross-section is 1-3mm.
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| US9295757B2 (en) * | 2008-06-10 | 2016-03-29 | Cook Biotech Incorporated | Quilted implantable graft |
| CA2728240C (en) | 2008-06-10 | 2016-11-15 | Cook Biotech Incorporated | Quilted implantable graft |
| CN102935246B (en) * | 2011-08-15 | 2015-02-04 | 国家纳米科学中心 | Three-dimensional cell culture scaffold, its preparation method and application |
| CN103182099B (en) * | 2011-12-31 | 2015-02-18 | 深圳兰度生物材料有限公司 | Porous active artificial bone and preparation method thereof |
| CN103230621A (en) * | 2013-03-18 | 2013-08-07 | 北京航空航天大学 | Preparation method of high-connectivity porous support |
| CN103565558B (en) * | 2013-10-21 | 2015-07-01 | 西安交通大学 | High-strength double-network hydrogel/bioceramic composite stent and preparation method thereof |
| CN105380732B (en) * | 2015-12-14 | 2017-05-31 | 宋占涛 | Bone renovating material with more-dimensional channels structure |
| CN105816917B (en) * | 2016-04-27 | 2019-08-20 | 南宁越洋科技有限公司 | A kind of high tenacity super abrasive artificial bone and preparation method thereof for repairing bone defect |
| CN107307926B (en) * | 2017-08-11 | 2024-03-19 | 上海交通大学医学院附属第九人民医院 | Porous beta-tricalcium phosphate medicine slow-release system and preparation method thereof |
| CN108530052A (en) * | 2018-03-27 | 2018-09-14 | 深圳德智达科技有限公司 | A method of utilizing gel effect 3D printing people's ceramic artificial bone |
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| CN1486752A (en) * | 2003-08-06 | 2004-04-07 | 浙江大学 | Composite metal-based porous metal oxide/hydroxyapatite artificial bone and its prepn process |
| CN1644221A (en) * | 2005-01-26 | 2005-07-27 | 徐小良 | Composite material for porous material and gel use thereof |
| CN101265121A (en) * | 2008-04-02 | 2008-09-17 | 西安理工大学 | Method for preparing porous ceramic by electrostatic field and magnetic field co-inducing crystallization technique |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1486752A (en) * | 2003-08-06 | 2004-04-07 | 浙江大学 | Composite metal-based porous metal oxide/hydroxyapatite artificial bone and its prepn process |
| CN1644221A (en) * | 2005-01-26 | 2005-07-27 | 徐小良 | Composite material for porous material and gel use thereof |
| CN101265121A (en) * | 2008-04-02 | 2008-09-17 | 西安理工大学 | Method for preparing porous ceramic by electrostatic field and magnetic field co-inducing crystallization technique |
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