CN217594595U

CN217594595U - Long chain polypeptide solid phase synthesis reactor

Info

Publication number: CN217594595U
Application number: CN202220010858.6U
Authority: CN
Inventors: 陈为光; 郑范娜; 严磊; 武兴伟
Original assignee: Anhui Guoping Pharmaceutical Co ltd
Current assignee: Anhui Guoping Pharmaceutical Co ltd
Priority date: 2022-01-05
Filing date: 2022-01-05
Publication date: 2022-10-18
Anticipated expiration: 2032-01-05

Abstract

The utility model relates to a long chain polypeptide solid phase synthesis reactor belongs to polypeptide synthesis technical field. The reactor for solid-phase synthesis of long-chain polypeptide comprises a box body, wherein a stirring mechanism is arranged in the box body, the stirring mechanism comprises a rotary table which is rotatably arranged on the side wall of the box body through a bearing, the rotary table is of a cylindrical structure with two open ends, a rotary shaft is arranged in the rotary table and is rotatably connected with the inner wall of the box body, and a first gear is fixedly arranged at one end of the rotary shaft; make rotor blade rotate through being provided with high-pressure nitrogen gas, and then drive first gear, second gear, carousel, commentaries on classics case in proper order and rotate for highly compressed nitrogen gas can get into in the box, lets the raw materials produce a large amount of bubbles, makes the stirring of raw materials more abundant, increases reaction rate, improves its production efficiency, reduce cost.

Description

Long chain polypeptide solid phase synthesis reactor

Technical Field

The utility model belongs to the technical field of the polypeptide synthesis, concretely relates to long chain polypeptide solid phase synthesis reactor.

Background

The synthesis reactor in patent CN201810640169.1 cannot fully and uniformly stir raw materials, so that the reaction efficiency is reduced, the reaction time is prolonged, and the production cost is increased.

SUMMERY OF THE UTILITY MODEL

In order to solve the problems in the prior art, the utility model provides a long-chain polypeptide solid phase synthesis reactor.

The purpose of the utility model can be realized by the following technical scheme:

the utility model provides a long chain polypeptide solid phase synthesis reactor, includes the box, the inside rabbling mechanism that is provided with of box, the rabbling mechanism includes rotates the carousel of installing on the box lateral wall through the bearing, the carousel is the open tubular structure in both ends, install the pivot in the carousel, the pivot is connected with the inner wall rotation of box, the one end fixed mounting of pivot has first gear, a plurality of inlet ports have been seted up on the first gear, pivot other end fixed mounting has rotor blade, the outside meshing of first gear is connected with the second gear, and the second gear rotates with the inner wall of box to be connected, the rack is installed to the inner wall of carousel, rack and the meshing of second gear, the outside of box is provided with the intake pipe, the intake pipe communicates with each other with outside high pressurized air source, be provided with the valve in the intake pipe, the intake pipe runs through the lateral wall of box and communicates with each other with the carousel is inside, the carousel is different from one side of intake pipe and installs the rotary box, the carousel communicates with each other with the rotary box, a plurality of having seted up gas leakage hole on the rotary box.

As the utility model discloses a preferred technical scheme of long chain polypeptide solid phase synthesis reactor, the outside of changeing the case is provided with the fixed block, a plurality of gas pocket has been seted up on the fixed block.

As the utility model discloses a preferred technical scheme of long chain polypeptide solid phase synthesis reactor, box outside symmetry is provided with heating mechanism, heating mechanism is including installing the heating cabinet on the box lateral wall, the heating groove has been seted up in the heating cabinet, be provided with heat conduction liquid in the heating groove, the lower extreme of heating groove extends to the middle part of box and is provided with the extension, the top of heating groove is provided with the heating rod, install the inlet tube on the heating cabinet lateral wall, install the temperature-sensing ware in the heating groove, the temperature-sensing ware is connected with the external power supply electricity, the lower surface mounting of extension has the delivery port.

As the utility model discloses a preferred technical scheme of long chain polypeptide solid phase synthesis reactor, the apron is installed to the top of box, the feed inlet has been seted up on the apron.

As the utility model discloses a preferred technical scheme of long chain polypeptide solid phase synthesis reactor, the discharge gate has been seted up to the lower surface of box, be provided with the valve in the discharge gate.

As the optimized technical scheme of the long-chain polypeptide solid-phase synthesis reactor of the utility model, the shape of the fixed block is an elliptical structure.

As the preferable technical scheme of the long-chain polypeptide solid phase synthesis reactor of the utility model, the lower surface of the extension part is provided with the support column.

The utility model has the advantages that:

1. during the use, let in high-pressure nitrogen gas toward the intake pipe, high-pressure nitrogen gas makes rotor blade rotate, and then drives first gear, second gear, carousel, commentaries on classics case in proper order and rotates for highly compressed nitrogen gas can get into in the box, lets the raw materials produce a large amount of bubbles, makes the stirring of raw materials more abundant, increases reaction rate, improves its production efficiency, reduce cost.

2. Through being provided with the heating rod and heating the heat conduction liquid of heating inslot, the person of being convenient for heats the box, has increased the reaction rate of raw materials in the box, has improved the work efficiency of device, can monitor the temperature of heating inslot through being provided with temperature-sensing ware in addition, avoids the temperature too high, leads to the polypeptide degeneration.

Drawings

In order to facilitate understanding for those skilled in the art, the present invention will be further described with reference to the accompanying drawings.

Fig. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic view of the stirring mechanism;

FIG. 3 is a schematic structural view of a turntable;

description of the main elements

In the figure: 1. a box body; 2. a heating mechanism; 21. a heating rod; 22. a water inlet pipe; 23. a heating tank; 24. a temperature sensor; 25. a heating box; 26. a water outlet; 3. a stirring mechanism; 31. a turntable; 32. a first gear; 33. a rotating shaft; 34. a rotor blade; 35. a second gear; 36. an air inlet pipe; 37. air holes; 38. air leakage holes; 39. box turning; 310. a fixed block; 4. and (7) a cover plate.

Detailed Description

To further illustrate the technical means and effects of the present invention adopted to achieve the objects of the present invention, the following detailed description of the embodiments, structures, features and effects according to the present invention will be made with reference to the accompanying drawings and preferred embodiments.

Referring to fig. 1-3, a long-chain polypeptide solid-phase synthesis reactor includes a case 1, a stirring mechanism 3 is disposed inside the case 1, the stirring mechanism 3 includes a rotating disc 31 rotatably mounted on a side wall of the case 1 through a bearing, the rotating disc 31 is of a cylindrical structure with two open ends, a rotating shaft 33 is mounted in the rotating disc 31, the rotating shaft 33 is rotatably connected to an inner wall of the case 1, a first gear 32 is fixedly mounted at one end of the rotating shaft 33, a plurality of air inlets are formed in the first gear 32, a rotating blade 34 is fixedly mounted at the other end of the rotating shaft 33, a second gear 35 is engaged with an outer side of the first gear 32, the second gear 35 is rotatably connected to the inner wall of the case 1, a rack is mounted on an inner wall of the rotating disc 31, the rack is engaged with the second gear 35, an air inlet pipe 36 is disposed on an outer side of the case 1, the air inlet pipe 36 is communicated with an external high-pressure air source, a valve is disposed on the air inlet pipe 36, the air inlet pipe 36 penetrates through the side wall of the case 1 and is communicated with the inside of the rotating disc 31, a rotating disc 31 is mounted with a rotating case 39, a plurality of air outlets are formed in the rotating case 39, a plurality of air outlets are disposed on the rotating case 310, and a plurality of fixing blocks 310 are disposed on the rotating case 39, and a plurality of fixing blocks 310 are disposed on the rotating case 310.

In this embodiment, let in high-pressure nitrogen gas toward intake pipe 36, high-pressure nitrogen gas makes rotor blade 34 rotate, and then drives first gear 32, second gear 35, carousel 31, commentaries on classics case 39 rotation in proper order for highly compressed nitrogen gas can get into in box 1, lets the raw materials produce a large amount of bubbles, makes the stirring of raw materials more abundant, increases reaction rate, improves its production efficiency, reduce cost.

Further, 1 outside symmetry of box is provided with heating mechanism 2, heating mechanism 2 is including installing the heating cabinet 25 on 1 lateral wall of box, heating tank 23 has been seted up in the heating cabinet 25, be provided with heat-conducting liquid in the heating tank 23, the lower extreme of heating tank 23 extends to the middle part of box 1 and is provided with the extension, the lower surface mounting of extension has the support column, the top of heating tank 23 is provided with heating rod 21, install inlet tube 22 on the heating cabinet 25 lateral wall, install temperature-sensing ware 24 in the heating tank 23, temperature-sensing ware 24 is connected with the external power supply electricity, the lower surface mounting of extension has delivery port 26.

Further, an apron 4 is installed above the box 1, a feed inlet is formed in the apron 4, a discharge outlet is formed in the lower surface of the box 1, and a valve is arranged in the discharge outlet.

In this embodiment, heat the heat conduction liquid in the heating tank 23 through being provided with the heating rod 21, convenient to use person heats box 1, has increased the reaction rate of raw materials in the box 1, has improved the work efficiency of device, can monitor the temperature in the heating tank 23 through being provided with temperature-sensing ware 24 in addition, avoids the temperature too high, leads to the polypeptide degeneration.

The utility model discloses a theory of operation and use flow: raw materials enter the box body 1 from a feeding hole, a valve on the air inlet pipe 36 is opened, nitrogen enters the rotary table 31 from the air inlet pipe 36, high-pressure nitrogen drives the rotary blade 34 to rotate, the first gear 32 is driven to rotate, the first gear 32 drives the second gear 35 to rotate, the second gear 35 drives the rotary table 31 to rotate, the rotary table 31 drives the rotary table 39 to rotate, nitrogen in the rotary table 39 is thrown out from the air leakage hole 38 and then enters the box body 1 from the air hole 37, the raw materials are stirred, the high-pressure nitrogen drives the rotary blade 34 to rotate, the first gear 32 and the second gear 35 are sequentially driven, the rotary table 31 and the rotary table 39 rotate, high-pressure nitrogen can enter the box body 1, the raw materials can generate a large amount of bubbles, the stirring of the raw materials is more sufficient, the reaction rate is increased, the production efficiency is improved, the cost is reduced, the heating rod 21 is started to heat the heat conducting liquid in the heating groove 23, a user can heat the box body 1 conveniently, the reaction speed of the raw materials in the box body 1 is increased, the working efficiency of the device is improved, the temperature in the heating groove 23 can be monitored by the temperature sensor 24, and polypeptide denaturation is avoided.

The above description is only a preferred embodiment of the present invention, and the present invention is not limited to the above description, and although the present invention has been disclosed by the preferred embodiment, it is not limited to the present invention, and any person skilled in the art can make modifications or changes equivalent to the equivalent embodiments by utilizing the above disclosed technical contents without departing from the technical scope of the present invention, but all the modifications, changes and changes of the technical spirit of the present invention made to the above embodiments are also within the scope of the technical solution of the present invention.

Claims

1. The utility model provides a long chain polypeptide solid phase synthesis reactor, includes box (1), its characterized in that: the utility model discloses a novel box, including box (1), stirring mechanism (3), carousel (31) are installed on box (1) lateral wall through the bearing rotation, carousel (31) are the open tubular structure in both ends, install pivot (33) in carousel (31), pivot (33) rotate with the inner wall of box (1) and are connected, the one end fixed mounting of pivot (33) has first gear (32), a plurality of inlet ports have been seted up on first gear (32), pivot (33) other end fixed mounting has rotor blade (34), the outside meshing of first gear (32) is connected with second gear (35), and second gear (35) rotate with the inner wall of box (1) and are connected, the rack is installed to the inner wall of carousel (31), rack and second gear (35) meshing, the outside of box (1) is provided with intake pipe (36), intake pipe (36) run through the lateral wall of box (1) and communicate with each other than inside with box (31), carousel (31) are different in one side of intake pipe (36) install commentaries on classics case (39), carousel (31) communicate with each other the commentaries on the case (39), carousel (39) are seted up a plurality of hourglass case (39).

2. The reactor for solid phase synthesis of long chain polypeptides according to claim 1, wherein: the outer side of the rotating box (39) is provided with a fixing block (310), and the fixing block (310) is provided with a plurality of air holes (37).

3. The reactor for solid phase synthesis of long chain polypeptides according to claim 1, wherein: the utility model discloses a heating box, including box (1), heating mechanism (2) is including installing heating cabinet (25) on box (1) lateral wall, heating tank (23) have been seted up in heating cabinet (25), the lower extreme of heating tank (23) extends to the middle part of box (1) and is provided with the extension, the top of heating tank (23) is provided with heating rod (21), install inlet tube (22) on heating cabinet (25) lateral wall, install temperature-sensing ware (24) in heating tank (23), the lower surface mounting of extension has delivery port (26).

4. The reactor for solid phase synthesis of long chain polypeptides according to claim 1, wherein: the box is characterized in that a cover plate (4) is installed above the box body (1), and a feeding hole is formed in the cover plate (4).

5. The reactor for solid phase synthesis of long chain polypeptides according to claim 1, wherein: the lower surface of the box body (1) is provided with a discharge hole, and a valve is arranged in the discharge hole.

6. The reactor for solid phase synthesis of long chain polypeptides according to claim 2, wherein: the fixing block (310) is in an elliptical structure.

7. The reactor for solid phase synthesis of long chain polypeptides according to claim 3, wherein: and a support column is arranged on the lower surface of the extension part.