CN217410808U - Reagent dish and sample analysis appearance - Google Patents

Abstract

The application provides a reagent disk and a sample analyzer. This reagent dish includes: the sample quantitative tank is used for collecting quantitative samples, the diluent quantitative tank is used for collecting quantitative diluent, and the mixing tank is used for collecting quantitative samples and quantitative diluent. Wherein, be provided with the arch in the mixing tank, the arch is used for mixing the sample when reagent dish corotation/reversal. The reagent dish of this application is when rotating, and the motion of liquid in the mixing tank can aggravate to the arch in the mixing tank, makes the mixed effect of sample and diluent better to improve sample testing result's accuracy.

Description

Reagent disk and sample analyzer

Technical Field

The application relates to the technical field of biochemical analysis equipment, in particular to a reagent disk and a sample analyzer.

Background

The sample analyzer is mainly used for measuring biochemical and chemical components in clinical blood or other liquid samples, and is one of the commonly used inspection instruments for clinical analysis. Sample analyzers typically include a reagent tray through which a sample is tested.

In the prior art, when the reagent tray is used for detecting a sample, the liquid mixing effect in the mixing tank is poor, and the accuracy of sample detection is influenced.

SUMMERY OF THE UTILITY MODEL

The application provides a reagent dish and sample analysis appearance to solve prior art, the reagent dish is carrying out sample detection time measuring, and the liquid mixing effect in the mixing tank is not good, influences the technical problem of sample detection's accuracy.

In order to solve the technical problem, the application adopts a technical scheme that: providing a reagent disk comprising: the sample quantifying groove is used for collecting a quantified sample; the diluent quantifying tank is used for collecting quantitative diluent; the mixing tank is connected with the sample quantifying tank and the diluent quantifying tank respectively and is used for collecting quantitative samples and quantitative diluent, wherein a bulge is arranged in the mixing tank and is used for uniformly mixing the samples when the reagent disk rotates forwards or backwards.

Further, a first end of the protrusion is coupled to the side wall of the mixing tub, and a second end of the protrusion extends toward the inside of the mixing tub.

Further, the cross-sectional area of the first end of the protrusion is greater than the cross-sectional area of the second end of the protrusion.

Further, a protrusion is provided on a side wall of the mixing tank on a side close to the center of the reagent disk.

Further, the reagent dish still includes the microchannel, and the diluent ration groove is connected to the first end of microchannel, and the mixing tank is connected to the second end of microchannel, and the junction of microchannel and mixing tank is provided with the arch.

Further, the edge of the reagent disk is provided with a mark for marking the position of the reagent disk.

Further, the mark is a black rubber block.

Furthermore, the edge of the reagent disk is provided with a groove, and the black rubber block is embedded in the groove.

Further, the reagent disk further comprises: the sample quantifying tank is respectively connected with the sample tank and the sample overflow tank, the sample tank is used for placing a sample, and the sample overflow tank is used for collecting redundant samples; the dilution liquid tank is used for containing dilution liquid, and the dilution liquid overflow tank is used for collecting redundant dilution liquid; the vent hole, the diluent overflow groove and the sample overflow groove are respectively connected with the vent hole so as to share the vent hole.

In order to solve the technical problem, the other technical scheme adopted by the application is as follows: there is provided a sample analyzer comprising a reagent tray according to any of the above embodiments and a test seat cooperating with the reagent tray, the sample analyzer being for analysis of a blood sample.

The beneficial effect of this application is: be different from prior art's condition, this application provides a reagent dish, this reagent dish includes sample ration groove, diluent ration groove and mixing tank, and sample ration groove and diluent ration groove are connected respectively to the mixing tank, and wherein, sample ration groove is used for collecting quantitative sample, and diluent ration groove is used for collecting quantitative diluent, and mixing tank is used for collecting quantitative sample and quantitative diluent. Wherein, be provided with the arch in the mixing tank, the arch is used for mixing the sample when reagent dish corotation/reversal. The reagent dish of this application is when rotating, and the motion of liquid in the mixing tank can aggravate to the arch that sets up in the mixing tank, makes the mixed effect of sample and diluent better to improve sample test result's accuracy.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:

FIG. 1 is a schematic structural view of one embodiment of a reagent disk provided herein;

FIG. 2 is a schematic structural view of another embodiment of a reagent disk provided herein;

FIG. 3 is a schematic structural view of another embodiment of a sample well in the reagent disk shown in FIG. 1;

FIG. 4 is a schematic view of the structure of a stopper in the sample well shown in FIG. 3;

FIG. 5 is a schematic view of the reagent disk of FIG. 1 from another perspective;

FIG. 6 is an enlarged partial schematic view taken at circle A in FIG. 5;

FIG. 7 is an enlarged, fragmentary, schematic view of another embodiment taken at circle A of FIG. 5;

FIG. 8 is a schematic diagram of a circuit structure for marking the position of a marking block in the reagent tray provided by the present application;

FIG. 9 is a schematic illustration of the rotational speed of the reagent disk of FIG. 1 at different stages of operation.

Detailed Description

The technical solutions in the embodiments of the present application will be described clearly and completely with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only some embodiments of the present application, and not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

It should be noted that if directional indications (such as up, down, left, right, front, and back … …) are referred to in the embodiments of the present application, the directional indications are only used to explain the relative positional relationship between the components, the movement situation, and the like in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.

In addition, if there is a description relating to "first", "second", etc. in the embodiments of the present application, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present application.

Sample analyzers, also commonly referred to as biochemics, are instruments used to measure a particular chemical component in a sample to be tested. Because of its fast measuring speed, high accuracy and small reagent consumption, it is widely used in hospitals of all levels, epidemic prevention stations, pet hospitals, etc.

The sample analyzer is generally used for detecting and analyzing a sample through a reagent tray. The application provides a reagent dish, this reagent dish's simple structure, convenient to use, the cost is lower, and can improve sample testing result's accuracy. The reagent disk will be described in detail below.

Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a reagent disk provided in the present application. The reagent disk 10 of the present application comprises: and a sample groove 11, wherein the sample groove 11 is used for placing a sample, that is, when the sample is detected by the reagent tray 10, a certain amount of sample can be sucked by using a pipette (not shown) so as to slowly and uniformly sample the sample into the sample groove 11. Pipettes are used to transfer the sample and/or diluent to the reagent tray 10 for mixing. In other embodiments, the sample may be manually added to the sample well 11.

In this embodiment, the sample is a blood sample, and in other embodiments, the sample may be other body fluids such as saliva and urine. The following description will be given taking a sample as a blood sample.

As shown in fig. 1, the sample tank 11 includes: the sample adding tank 111 and the liquid storage tank 112 are arranged in a stepped mode, wherein the depth of the sample adding tank 111 is smaller than that of the liquid storage tank 112, when a sample is added, the sample is added into the sample adding tank 111, and the sample in the sample adding tank 111 flows into the liquid storage tank 112 under the action of gravity, so that the sample is filled.

Further, as shown in fig. 2, the reagent tray 10 includes a tray body (not shown) and a cover 101, the sample well 11 is disposed on the tray body, the cover 101 is disposed on the tray body to seal the tray body, a sample adding hole 102 is disposed on the cover 101, and the sample adding hole 102 is disposed corresponding to the sample adding well 111 to add a sample into the sample adding well 111 through the sample adding hole 102.

Further, as shown in fig. 1, a stopper 113 is provided on a side of the sample addition tank 111 adjacent to the reservoir 112. The stop 113 can identify the level of the sample injected into the sample well 11, preventing an excessive amount of sample from being injected into the sample well 11. Moreover, when the reagent disk 10 rotates, the blocking block 113 can also block the sample in the liquid storage tank 112 from flowing out of the sample adding groove 111, so as to prevent the reagent disk 10 from being polluted.

Therefore, the reagent disk 10 of the present application has a simple structure, and by providing the stopper 113 in the sample well 11, it is possible to prevent an excessive amount of sample from being injected into the sample well 11, and to prevent the sample from overflowing when the reagent disk 10 rotates, thereby improving the reliability of use of the reagent disk 10.

Further, the stopper 113 is located on the bottom wall of the sample adding groove 111, and one end of the stopper 113 is connected to the inner wall of the sample adding groove 111 on the side close to the center of the reagent disk 10. That is, the stopper 113 is located at a side close to the center of the reagent disk 10, so that the sample can be prevented from overflowing from the sample addition groove 111 when the reagent disk 10 is rotated.

Further, the other end of the stopper 113 extends into the sample adding groove 111 by a predetermined length, and the sample adding groove 111 has a first width in the extending direction of the stopper 113, and the predetermined length is smaller than the first width. That is, a gap is formed between the stopper 113 and the other inner wall of the sample addition tank 111, and by this arrangement, when a sample is added to the sample addition tank 111, the sample in the sample addition tank 111 can flow into the reservoir 112 through the gap, thereby preventing the suspension of the sample addition tank 111.

Further, the ratio of the preset length to the first width is less than or equal to 0.7, that is, the ratio of the preset length to the first width may be 0.7, 0.5, 0.3, or the like.

Further, the height of the stopper 113 is smaller than the depth of the sample adding groove 111. In this way, the liquid level of the sample in the sample groove 11 can be identified by the stopper 113, for example, the upper surface of the stopper 113 is set to be the highest liquid level, so that the excessive sample is prevented from being added into the sample groove 11, and the sample overflows to contaminate the reagent disk 10.

Further, the side of the blocking block 113 close to the liquid storage tank 112 is flush with the inner wall of the liquid storage tank 112, that is, the blocking block 113 is located at the edge of the sample adding groove 111, so that the liquid in the sample storage groove 112 can be prevented from flowing back to the sample adding groove 111 when the reagent disk 10 rotates, and the reagent disk 10 can overflow from the sample adding groove 111, and the reliability of the reagent disk 10 is improved.

In another embodiment, as shown in fig. 3, fig. 3 is a schematic structural diagram of another embodiment of the sample groove 111 in the reagent disk 10 shown in fig. 1, in this embodiment, one end of the blocking block 113 is connected to the inner wall of the sample adding groove 111 on the side close to the center of the reagent disk 10, and the other end of the blocking block 113 is connected to the inner wall of the sample adding groove 111 on the side far from the center of the reagent disk 10. That is, the extension length of the block 113 is equal to the length of the sample addition groove 111 in the extension direction of the block 113. With this arrangement, when the reagent disk 10 is rotated, the liquid in the reservoir 112 can be prevented from entering the sample addition tank 111 and overflowing from the sample addition tank 111, thereby improving the reliability of the reagent disk 10.

Further, as shown in fig. 4, fig. 4 is a schematic structural view of another embodiment of the block 113 in the sample slot 11 shown in fig. 3, and a sinking platform 114 is disposed on a side of the block 113 away from the center of the reagent disk 10, so that the block 113 is disposed in a step shape. That is, make the stopper 113 can form high liquid level suggestion face 1131 and low liquid level suggestion face 1132, high liquid level suggestion face 1131 and low liquid level suggestion face 1132 are used for measuring maximum sample volume and minimum sample volume respectively, so, can remind operating personnel very conveniently. By the arrangement mode, the adding amount of the sample can be clearly identified, and excessive or insufficient adding of the sample is avoided, so that the accuracy of the sample measurement result is improved. It is understood that, in other embodiments, the sinking platform 114 may not be provided on the blocking block 113, so that the structure of the blocking block 113 can be simplified.

Further, as shown in fig. 5, the reagent tray 10 may further include a sample metering slot 12 and a sample overflow slot 13.

The sample quantitative well 12 is connected to the sample well 11, and the sample quantitative well 12 is used for collecting a quantitative sample from the sample well 11. The sample metering groove 12 is located at a side of the sample groove 11 near an edge of the reagent disk 10 so that the sample in the sample groove 11 can move to the sample metering groove 12 by a centrifugal force when the reagent disk 10 is rotated.

The sample overflow well 13 is connected to the sample quantitative well 12, and collects an excessive sample from the sample quantitative well 12.

For example, when the sample analyzer drives the reagent tray 10 to rotate at a high speed by a driving assembly (not shown), the sample enters the sample quantitative groove 12 from the sample groove 11 under the action of centrifugal force, and the excess sample enters the sample overflow groove 13. When the sample is a blood sample, particulate matter such as blood cells in the blood begins to be separated from the liquid, so that the portion of the sample quantitative groove 12 near the rotation center of the reagent disk 10 is substantially plasma, thereby achieving separation of blood cells and plasma.

Further, as shown by continuing to refer to fig. 6, fig. 6 is a partially enlarged schematic view of the circle a in fig. 5, the sample overflow groove 13 includes a first sub-groove 131 and a second sub-groove 132 which are arranged in a step, one end of the first sub-groove 131 is connected to the sample quantitative groove 12, the other end of the first sub-groove 131 is connected to the second sub-groove 132, and the depth of the second sub-groove 132 is greater than the depth of the first sub-groove 131.

The second sub-tank 132 and the first sub-tank 131 have a height difference, that is, the sample overflow tank 13 is provided with a size mutation in the axial direction, so that once entering the sample overflow tank 13, an unnecessary sample does not flow back to the sample quantification tank 12, and accurate quantification of the sample can be ensured.

Further, the ratio of the depth of the second subslot 132 to the depth of the first subslot 131 is greater than 1.2. For example, the ratio of the depth of the second subslot 132 to the depth of the first subslot 131 is 1.5, 2, or 2.5, and the like, wherein the greater the height difference between the second subslot 132 and the first subslot 131, the higher the reliability of preventing the excessive sample from flowing back to the sample quantifying trench 12.

Further, the first sub-groove 131 is provided with an arc-shaped chamfer near the bottom wall of the second sub-groove 132, that is, the junction of the first sub-groove 131 and the second sub-groove 132 is rounded to prevent the sample from flowing backwards.

Further, the depth of the sample quantitative groove 12 is smaller than the depth of the first subslot 131, facilitating the flow of the redundant sample from the sample quantitative groove 12 into the first subslot 131.

Further, as shown in fig. 6, a stopper 121 is provided on a side of the sample quantitative groove 12 close to the sample overflow groove 13. That is, the connection between the sample quantifying groove 12 and the sample overflow groove 13 may be provided with the stopper 121, and the stopper 121 is used to prevent the sample in the sample overflow groove 13 from flowing back into the sample quantifying groove 12, so as to ensure accurate quantification of the sample quantifying groove 12.

Further, the volume of the sample overflow bath 13 may be larger than the volume of the sample quantitative bath 12, so that the sample overflow bath 13 can collect more excessive samples.

Further, the second subslot 132 connects the first subslots 131 and extends in a direction away from the first subslots 131. The width of the second sub-groove 132 increases and then decreases along the extending direction of the second sub-groove 132, so as to drain the sample entering the sample overflow groove 13.

Further, the contour line of the sample overflow well 13 may include an arc line and/or a straight line. For example, as shown in FIG. 6, the contour lines of the sample overflow wells 13 may all be straight lines. In another embodiment, as shown in fig. 7, fig. 7 is a schematic structural diagram of another embodiment at circle a in fig. 5, and the profile of the sample overflow well 13 may further include an arc line, as shown in fig. 7, the profile line of one side of the sample overflow well 13 is a straight line, and the profile line of the other side of the sample overflow well 13 is an arc line, so as to better guide the sample entering into the sample overflow well 13.

Further, referring to fig. 5 and 6 again, a vent hole 31 may be further provided at one side of the sample overflow well 13, and the vent hole 31 is used to vent air bubbles flowing into the sample overflow well 13.

Specifically, as shown in fig. 6, the first sub-well 131 in the sample overflow well 13 is connected to the vent hole 31 through a channel 133, and the channel 133 extends toward the side near the center of the reagent disk 10. With this arrangement, the sample in the sample overflow well 13 can be prevented from overflowing through the vent hole 31 when the reagent disk 10 rotates.

Further, as shown in fig. 1, the reagent tray 10 further includes a dilution liquid tank 14, the dilution liquid tank 14 is used for holding a dilution liquid, and the dilution liquid may be water or other liquid, and may be added specifically according to needs. The dilution liquid tank 14 and the sample tank 11 are provided on the side of the reagent disk 10 near the center, and are arranged around the circumference of the reagent disk 10.

The reagent disk 10 further comprises a diluent quantitative groove 16, wherein the diluent quantitative groove 16 is used for collecting a certain amount of diluent from the diluent groove 14, and specifically, when the reagent disk 10 rotates, the diluent in the diluent groove 14 can enter the diluent quantitative groove 16 under the action of centrifugal force.

In the embodiment shown in fig. 1, the reagent disk 10 includes a sample quantifying groove 12, a diluent quantifying groove 16 and a mixing groove 17, the sample quantifying groove 12 and the diluent quantifying groove 16 are respectively connected to the mixing groove 17, and when the reagent disk 10 rotates, the diluent quantified in the diluent quantifying groove 16 and the sample quantified in the sample quantifying groove 12 move to the mixing groove 17 under the action of centrifugal force, so that the quantified sample and the quantified diluent can be uniformly mixed in the mixing groove 17.

Further, as shown in fig. 1, a protrusion 171 is provided in the mixing groove 17, and the protrusion 171 is used to mix the sample uniformly when the reagent disk 10 is rotated in the forward/reverse direction. That is, when the reagent disk 10 rotates in the forward direction and rotates in the reverse direction alternately, the protrusions 171 in the mixing tank 17 can intensify the movement of the liquid in the mixing tank 17, so that the mixing effect of the sample and the diluent is better, and the accuracy of the detection result of the sample is improved.

Further, as shown in fig. 1, a first end of the protrusion 171 is connected to a sidewall of the mixing tub 17, and a second end of the protrusion 171 extends toward the inside of the mixing tub 17. In the embodiment shown in FIG. 1, the cross-sectional area of a first end of protrusion 171 is greater than the cross-sectional area of a second end of protrusion 171. Preferably, the cross-sectional area of protrusion 171 decreases gradually in a direction from the first end to the second end of protrusion 171. Through this kind of mode of setting, can carry out the drainage to the liquid in the mixing tank 17, do benefit to the flow of the liquid in the mixing tank 17 to the sample mixture in making the mixing tank 17 is more even. In other embodiments, the cross-sectional area of the first end of the protrusion 171 may be equal to the cross-sectional area of the second end, so that the mold opening structure of the protrusion 171 can be simplified, and the production of the reagent disk 10 is facilitated.

Alternatively, the protrusion 171 is provided on the inner wall of the mixing groove 17 on the side close to the center of the reagent disk 10. In another embodiment, the protrusion 171 may also be provided on the inner wall of the mixing groove 17 on the side away from the center of the reagent disk 10.

As shown in fig. 1, two protrusions 171 are provided in the mixing tank 17 in the present application, and the two protrusions 171 are provided on the inner wall of the mixing tank 17 at intervals. And one of the protrusions 171 is connected to the diluent holding tank 16 to guide the liquid in the diluent holding tank 16 into the mixing tank 17.

Specifically, as shown in fig. 1, the reagent disk 10 further includes a micro flow channel 21, a first end of the micro flow channel 21 is connected to the diluent quantifying groove 16, a second end of the micro flow channel 21 is connected to the mixing groove 17, a protrusion 171 is disposed at a connection position of the micro flow channel 21 and the mixing groove 17, the diluent is introduced into the mixing groove 17 through the protrusion 171, and the diluent can be introduced into a deep position of the mixing groove 17, so as to prevent the diluent from overflowing from the mixing groove 17.

In other embodiments, 1, 3, 4, or 5 protrusions 171 may be disposed in the mixing groove 17, and may be specifically disposed according to the length of the mixing groove 17, which is not specifically limited herein.

Further, as shown in fig. 1 and 5, the reagent tray 10 further includes a diluent overflow groove 18, and the diluent overflow groove 18 is connected to the diluent quantitative groove 16. The diluent overflow trough 18 is used to collect excess diluent from the dilution dosing trough 16.

The diluent overflow launder 18 is also connected to the exhaust holes 31 to exhaust the gas flowing into the diluent overflow launder 18 through the exhaust holes 31. That is, in the present application, the diluent overflow groove 18 and the sample overflow groove 13 share the vent hole 31, and by such an arrangement, the structure of the reagent disk 10 can be simplified, the mold opening manufacturing process can be reduced, and the production cost of the reagent disk 10 can be saved.

Further, as shown in fig. 1 and 5, the reagent disk 10 further includes a diluent transition groove 15, the diluent transition groove 15 is located between the diluent groove 14 and the diluent quantitative groove 16 and is respectively connected to the diluent quantitative groove 16 and the diluent groove 14, and the diluent overflow groove 18 is connected to the diluent quantitative groove 16. When the reagent disk 10 rotates, the diluent enters the diluent transition groove 15 from the diluent groove 14, enters the diluent quantifying groove 16 from the diluent transition groove 15, and the redundant diluent enters the diluent overflow groove 18.

As shown in fig. 1 and 5, the diluent overflow groove 18 further includes a first sub diluent overflow groove 181 and a second sub diluent overflow groove 182 which are connected to each other, a diluent self-check groove 19 may be further disposed between the first sub diluent overflow groove 181 and the second sub diluent overflow groove 182, when the reagent disk 10 rotates, the diluent in the diluent groove 14 enters the diluent quantitative groove 16 from the diluent transition groove 15, the excess diluent enters the first sub diluent overflow groove 181 and further enters the diluent self-check groove 19 and the second sub diluent overflow groove 182, and the second sub diluent overflow groove 182 is connected to the vent hole 31, so that the gas entering the diluent overflow groove 18 can also be discharged from the vent hole 31.

Further, as shown in fig. 1, the reagent disk further includes an annular groove 51 and a reaction detection groove 52 connected to the annular groove 51, when the reagent disk 10 rotates, the sample in the mixing groove 17 moves into the annular groove 51 under the action of centrifugal force and flows into the reaction detection groove 52 through a micro flow channel 53 between the annular groove 51 and the reaction detection groove 52, and the reaction detection groove 52 is filled with a reagent in advance, so that the diluted sample reacts with the reagent.

As shown in fig. 1, the reagent tray 10 may further include a mixed solution overflow trough 172, and the mixed solution overflow trough 172 is used for collecting excess mixed solution. Specifically, the mixed solution overflow groove 172 is connected to the annular groove 51, and when the reagent tray 10 rotates, the liquid in the mixing tank 17 enters the reaction detection tank 52 through the annular groove 51, and the excess mixed solution enters the mixed solution overflow groove 172.

Further, as shown in fig. 1, the edge of the reagent disk 10 is provided with a mark 41 for marking the position of the reagent disk 10. In this embodiment, the mark 41 may be a black rubber block, which is used for positioning the reagent disk 10. The positioning mode is economical and reliable, the scheme is simpler than that of directly designing the prism around the reagent disk 10, the mold opening cost is reduced, the contrast between the black rubber and the disk body of the reagent disk 10 is obvious, and the positioning reliability is good.

Fig. 8 is a schematic diagram of a circuit structure for positioning by the marker 41. By providing a photoelectric sensor, when the reagent disk 10 is rotated, the mark 41 on the reagent disk 10 is sensed to position the reagent disk 10.

Further, as shown in fig. 1, the edge of the reagent disk 10 is provided with a groove 411, and the black rubber block is embedded in the groove 411 so that the surface of the black rubber block is flush with the surface of the reagent disk 10. The fixing mode is simple, the fixing cost is low, and the black rubber block can be conveniently mounted and dismounted.

In other embodiments, the mark 41 may have other structures, for example, the mark 41 may be a two-dimensional code, an ink block coated on the surface of the reagent disk 10, or the like.

By way of example, in one particular embodiment, the reagent disk 10 operates as follows: when the reagent disk 10 is used, a proper amount of blood is taken from a fingertip, a vein, or the like of a human, and then a sample is injected into the sample groove 11 from the sample addition hole 102; simultaneously, opening the seal of the diluent sealing bag to enable the diluent to enter the diluent tank 14; the reagent disk 10 is then fixed to a motor and begins to rotate.

As shown in fig. 9, in the first rotation stage, the motor drives the reagent disk 10 to rotate at a high speed, and keeps the rotation speed constant for a period of time; the blood sample enters the sample quantifying groove 12 from the sample groove 11 under the action of centrifugal force, redundant sample enters the sample overflow groove 13, and granular substances such as blood cells in the blood start to be separated from liquid, so that the part of the sample quantifying groove 12 close to the rotation center of the reagent disk 10 is basically plasma, the sample in the sample groove 11 is not easy to overflow when the reagent disk 10 rotates due to the action of the blocking block 113, and the sample is not easy to flow back due to the height difference between the first sub-groove 131 and the second sub-groove 132 in the sample overflow groove 13; in the first stage, the diluent enters the diluent transition groove 15 from the diluent groove 14 under the action of centrifugal force, then enters the diluent quantifying groove 16, and the redundant diluent enters the diluent self-checking groove 19, the first sub-diluent overflow groove 181 and the second sub-diluent overflow groove 182; then the motor is decelerated to stop in a short time, the reagent disk 10 is kept still for a period of time, and in the process, under the capillary action of the micro-channel 22, the blood plasma passes through the micro-channel 22 and reaches the edge of the mixing tank 17; meanwhile, under the capillary action of the micro-channel 21, the diluent passes through the micro-channel 21 and reaches the edge of the mixing tank 17; wait for the next centrifugation to start.

As shown in fig. 9, in the second phase, the reagent disk 10 is driven by the motor to rotate continuously, and the plasma enters the mixing tank 17 from the micro flow channel 22; quantitative diluent enters the mixing tank 17 from the micro-channel 21; the motor drives the reagent disk 10 to rotate in a mode of decelerating from high speed to low speed and then accelerating to high speed, and the circulation is repeated for many times, so that the blood plasma and the diluent are fully mixed in the mixing tank 17. Then, it is allowed to stand for a further period of time during which the mixed liquid reaches the edge of the annular groove 51 by capillary action of the micro flow channel 23.

In the third stage, the reagent tray 10 is driven by the motor to rotate continuously, the mixed liquid enters the annular groove 51 through the micro-flow channel 23 under the action of centrifugal force, the reaction detection grooves 52 are filled one by one through the radial micro-flow channels 53 connected with the reaction detection grooves 52, and the mixed liquid dissolves the reagents pre-loaded in the reaction detection grooves 52; the motor drives the reagent disk 10 to rotate, and the rotation mode is as follows: the speed is changed from high-speed forward rotation to high-speed reverse rotation, then the speed is changed to high-speed forward rotation, and the cycle is repeated for many times, so that the mixed solution and the reagent are fully reacted; the redundant mixed liquid enters a mixed liquid overflow trough 172; the reaction was carried out for a period of time for optical detection. Wherein, a black rubber block is arranged in the groove 411 for positioning the black rubber, which is used for accurate positioning before the optical detection of the reagent disk 10.

In summary, the reagent tray 10 can prevent the sample from overflowing from the sample groove 11 when rotating, and the sample in the sample overflow groove 13 does not flow back, so that the quantification of the sample is more accurate, and in addition, the protrusion 171 arranged in the mixing groove 17 can make the liquid in the mixing groove 17 mix more uniformly, thereby improving the reliability of sample detection. In addition, the edge of the reagent disk 10 is provided with a mark, which can be a black rubber block, so as to mark the position of the reagent disk 10, the positioning cost of the reagent disk 10 is low, and the positioning is more accurate. The reagent disk 10 is simple in structure and capable of improving reliability of sample detection.

The present application further provides a sample analyzer, which includes the reagent disk 10 of any of the above embodiments and a test seat matched with the reagent disk 10, and the sample analyzer is used for analyzing blood samples. For the specific structure of the reagent disk 10, please refer to the drawings of the foregoing embodiments and the related text descriptions, which are not repeated herein.

The above description is only an embodiment of the present application, and is not intended to limit the scope of the present application, and all equivalent structures or equivalent processes performed by the present application and the contents of the attached drawings, which are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.

Claims (10)

1. A reagent disk, comprising:

the sample quantifying groove is used for collecting a quantified sample;

the diluent quantifying tank is used for collecting a quantitative diluent;

and the mixing tank is respectively connected with the sample quantifying tank and the diluent quantifying tank and used for collecting the quantitative sample and the quantitative diluent, wherein a bulge is arranged in the mixing tank and used for uniformly mixing the sample when the reagent disk rotates forwards or backwards.

2. The reagent disk of claim 1, wherein a first end of the protrusion is coupled to a sidewall of the mixing well and a second end of the protrusion extends into the mixing well.

3. The reagent disk of claim 2, wherein a cross-sectional area of a first end of the protrusion is greater than a cross-sectional area of a second end of the protrusion.

4. A reagent disk according to claim 2 wherein the projections are provided on the side wall of the mixing channel on the side thereof adjacent the centre of the reagent disk.

5. The reagent disk of claim 1, further comprising a micro flow channel, a first end of the micro flow channel being connected to the diluent quantifying tank, a second end of the micro flow channel being connected to the mixing tank,

the connection part of the micro flow channel and the mixing tank is provided with the bulge.

6. A reagent tray according to claim 1 wherein the edge of the reagent tray is provided with indicia for marking the position of the reagent tray.

7. The reagent disk of claim 6, wherein the indicia are black rubber blocks.

8. The reagent disk of claim 7, wherein a groove is arranged at the edge of the reagent disk, and the black rubber block is embedded in the groove.

9. The reagent disk of claim 1, further comprising:

the sample quantifying tank is respectively connected with the sample tank and the sample overflow tank, the sample tank is used for placing the sample, and the sample overflow tank is used for collecting redundant samples;

the dilution liquid tank is used for containing the dilution liquid, and the dilution liquid overflow tank is used for collecting redundant dilution liquid;

and the diluent overflow groove and the sample overflow groove are respectively connected with the exhaust hole so as to share the exhaust hole.

10. A sample analyzer, comprising a reagent disk of any one of claims 1-9 and a test platform engaged with the reagent disk, wherein the sample analyzer is used for analyzing a blood sample.

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