CN217212756U

CN217212756U - Detection device for immunochromatography

Info

Publication number: CN217212756U
Application number: CN202220880722.0U
Authority: CN
Inventors: 王国新; 廖滔
Original assignee: Wwhs Biotech Inc
Current assignee: Wwhs Biotech Inc
Priority date: 2022-04-14
Filing date: 2022-04-14
Publication date: 2022-08-16
Anticipated expiration: 2032-04-14

Abstract

The utility model discloses a detection apparatus for be used for immunity chromatography relates to biological detection technical field. The test strip device comprises a reaction tube, a reaction tube cap arranged at the top of the reaction tube and a test strip with one end extending to the inside of the reaction tube, wherein the test strip can be inserted into a test strip jack of the reaction tube cap, and a detection bin and a sample bin which are communicated with each other are arranged inside the reaction tube. By arranging the reaction tube, the reaction tube cap and the test strip, the test strip is inserted into the test strip slot on the reaction tube cap before detection, and after a sample is added into the sample bin, the reaction tube cap with the test strip is inserted along the direction of the test strip corresponding to the detection bin and covers the reaction tube cap tightly, so that detection can be performed. Compared with a conventional detection mode, the device can ensure that the whole detection process is finished in a closed system, so that the potential biological pollution problem is avoided, the test result is more accurate, the economic benefit is met, and the device has a wide application prospect.

Description

Detection device for immunochromatography

Technical Field

The utility model relates to a biological detection technical field specifically is a detection device for immunochromatography.

Background

The colloidal gold immunochromatography is a rapid diagnosis technology, the principle is that a specific antibody is firstly fixed in a certain zone of a nitrocellulose membrane (NC membrane), after one end of a dry sample pad is immersed in a sample (nasal swab/oropharyngeal swab/saliva swab extract, serum, plasma, whole blood, urine, feces, sputum and the like), the sample moves forwards along the membrane due to capillary action, when the dry sample pad moves to an NC membrane area fixed with the antibody, corresponding antigen in the sample is specifically combined with the antibody, so that the area can display a certain color, qualitative or semi-quantitative detection data of the sample are provided, and thus specific immunodiagnosis is realized. The immunochromatographic test strip generally consists of a sample application area, a reaction area and a water absorption area. The sample loading region contains immune marker particles, and the immune colloidal gold particles are adsorbed to the region usually by glass fibers; and the reaction zone is sprayed with two reaction lines, one is a detection line and the other is a quality control line. The detection line is used for detecting the reactivity of the (antigen) substance and the coating antigen (antibody or antigen carried by the antibody) of the immune marker particles; the quality control line is used for detecting the activity and the degree of the coated protein on the immune marker particles, and after the immune marker is released from the sample adding region, part of the immune marker passes through the reaction region and continues to the adsorption region to finish chromatography, thereby achieving the purpose of speed-dependent detection.

In the traditional colloidal gold immunochromatography, a chromatography test strip needs to be placed in a test card shell, and then a sample is added into a sample adding hole of the test card shell to complete the immunochromatography.

SUMMERY OF THE UTILITY MODEL

The utility model provides a detection device for immunochromatography to solve the problem in the background art.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a detection apparatus for be used for immunochromatography, includes the reaction tube, set up in the reaction tube block at reaction tube top and set up in the inside and one end of reaction tube block and extend to the inside test strip of reaction tube, the inside of reaction tube is provided with detection storehouse and the sample storehouse that is linked together, the test strip is kept away from the one end of reaction tube block and is extended to the inside that detects the storehouse.

Furthermore, a partition plate is arranged inside the reaction tube, and a through hole is formed in the bottom of the partition plate.

Further, the detection chamber and the sample chamber are formed by dividing the space inside the reaction tube by a partition plate.

Further, the volume of the detection chamber is smaller than or equal to the volume of the sample chamber.

Further, the test strip includes absorption pad, NC membrane, combination pad and sample pad, absorption pad, NC membrane, combination pad and sample pad set up from last to down in proper order.

Furthermore, the highest liquid level line is carved on the sample pad.

Furthermore, the bottom of the reaction tube cap is provided with a slot, and the top end of the absorption pad is movably inserted into the slot.

Further, the shape of the reaction tube is one of a circle and a polygon.

Furthermore, the reaction tube is made of transparent materials.

Compared with the prior art, the utility model provides a detection device for immunochromatography possesses following beneficial effect:

this a detection device for immunochromatography, through setting up the reaction tube, reaction tube block and test strip, insert the test strip slot on the reaction tube block earlier before the detection, the reaction tube block that will have the test strip after treating the sample and adding the sample storehouse is followed the test strip and is corresponded the detection storehouse direction and insert and cover the reaction tube block tightly, can detect, compare in conventional detection mode, the device can ensure that whole testing process all accomplishes in airtight system, avoid potential biological pollution problem, the test result is more accurate, accord with economic benefits, wide application prospect has.

Drawings

FIG. 1 is a schematic view of the present invention;

FIG. 2 is a schematic diagram of the reaction tube cap and the test strip of the present invention;

FIG. 3 is a top view of the reaction tube structure of the present invention;

FIG. 4 is a schematic view of the reaction tube cap structure of the present invention;

FIG. 5 is a sectional view of the reaction tube structure of the present invention;

fig. 6 is a schematic view of the detection process of the present invention.

In the figure: 1. a reaction tube; 11. a partition plate; 12. a detection bin; 13. a sample bin; 14. a through hole; 2. a reaction tube cap; 21. a slot; 3. a test strip; 31. an absorbent pad; 32. NC film; 33. a bonding pad; 34. a sample pad; 35. highest liquid level line.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts all belong to the protection scope of the present invention.

Referring to fig. 1-6, the utility model discloses a detection device for immunochromatography, which comprises a reaction tube 1, a reaction tube cap 2 arranged on the top of the reaction tube 1, and a test strip 3 arranged inside the reaction tube cap 2 and having one end extending to the inside of the reaction tube 1, wherein the inside of the reaction tube 1 is provided with a detection bin 12 and a sample bin 13 which are communicated, one end of the test strip 3 far away from the reaction tube cap 2 extends to the inside of the detection bin 12, and the device can also be matched with a sample collector, such as various swabs (nasal swab, oropharyngeal swab, saliva swab); sample types such as serum, plasma, whole blood, urine and the like can be not provided with a sample collector; for sample types such as feces and sputum, a corresponding sample collector can be selected and matched, and the opening of the brand-new reaction tube 1 is sealed by adopting an aluminum foil sealing film.

Specifically, the detection bin 12 and the sample bin 13 are formed by dividing the space inside the reaction tube 1 by a partition plate 11, the partition plate 11 is arranged inside the reaction tube 1, a through hole 14 is formed in the bottom of the partition plate 11, the through hole 14 is formed and used for communicating the detection bin 12 with the sample bin 13, and the reaction tube 1 can be used for containing diluent and can also be used for detection.

Specifically, the volume of the detection chamber 12 is smaller than or equal to the volume of the sample chamber 13.

Specifically, the test strip 3 includes an absorption pad 31, an NC membrane 32, a combination pad 33 and a sample pad 34, the absorption pad 31, the NC membrane 32, the combination pad 33 and the sample pad 34 are sequentially arranged from top to bottom, a highest liquid level line 35 is carved on the sample pad 34, the height of the test strip 3 matches the inner depth of the reaction tube 1, it is ensured that the liquid level of a diluent in the reaction tube 1 cannot exceed the highest liquid level line 35 on the sample pad, the structure of the test strip 3 is consistent with that of a conventional immunochromatographic test strip, a white handle glue is wrapped in the area of the sample pad 34, a blue handle glue (or other colors) is wrapped in the area of the absorption pad, the test strip 3 is usually sealed in an aluminum foil bag with a drying agent and can be taken out during use, and the test strip 3 can be a colloidal gold test strip 3 and also can be a test strip 3 for other qualitative or semi-quantitative detection.

Specifically, slot 21 has been seted up to reaction tube block 2 bottom, the top activity of absorbing pad 31 is pegged graft in slot 21's inside, and slot 21's setting has made things convenient for and has installed test strip 3, and the operation mode is more convenient, and reaction tube block 2 can cover reaction tube 1 well to there is good gas tightness, slot 21's size and test strip 3's width and thickness phase-match.

Specifically, the shape of the reaction tube 1 is one of a circle and a polygon, the reaction tube 1 may be a circle, a polygon or other shapes, and a circle is preferred as the shape of the reaction tube 1 in this embodiment.

Specifically, reaction tube 1 makes for transparent material, and transparent material can select for use transparent plastic or clear glass, and the preferred plastics material of reaction tube cap 2 makes, and the device can detect all kinds of samples (including all kinds of swabs (nose swab, oropharynx swab, saliva swab), serum, plasma, whole blood, urine, excrement and urine, sputum) for the testing process goes on in inclosed system, has ensured biological safety.

When in use, firstly, the test strip 3 is taken out of the aluminum foil bag, the absorption pad 31 of the test strip 3 is inserted into the slot 21 of the reaction tube cap 2 for standby, the aluminum foil sealing film on the reaction tube 1 is torn, the sample is added into the sample bin 13 in the reaction tube 1, for various swabs, the broken part of the swab is broken, the swab head is soaked in the diluent of the reaction tube 1, for a blood sample (or excrement or urine) can be directly added into the sample bin 13, the sample needs to be shaken up for 10-20 seconds after being added, the reaction tube cap 2 with the test strip 3 is inserted into the reaction tube 1, the test strip 3 is determined to be placed in the detection bin 12 of the reaction tube 1, the test result is observed and recorded, the reaction tube 1 is ensured to be placed in a vertical state, can not be inverted, is placed transversely and obliquely, after the test is finished, the whole reaction tube 1 is placed in a special biological safety bag for professional treatment, the operation of the device is completed as described above.

In summary, the detection device for immunochromatography is provided with the reaction tube 1, the reaction tube cap 2 and the test strip 3, the test strip 3 is inserted into the slot 21 before detection, the reaction tube cap 2 with the test strip 3 is inserted into the detection bin 12 along the test strip 3 after a sample is added into the sample bin 13, and the reaction tube cap 2 is tightly covered, so that detection can be performed, and qualitative detection can be performed by judging a detection knot according to color; for semi-quantitative detection, the semi-quantitative detection result can be judged through a colorimetric card. Compared with a conventional detection mode, the device can ensure that the whole detection process is finished in a closed system, so that the potential biological pollution problem is avoided, the test result is more accurate, the economic benefit is met, and the device has a wide application prospect.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a detection device for immunochromatography, includes reaction tube (1), sets up in reaction tube block (2) at reaction tube (1) top and sets up in inside and one end of reaction tube block (2) and extend to inside test strip (3) of reaction tube (1), its characterized in that: the inside of reaction tube (1) is provided with detection storehouse (12) and sample storehouse (13) that are linked together, the one end that reaction tube block (2) was kept away from in test strip (3) extends to the inside in detection storehouse (12).

2. The detection device for immunochromatography according to claim 1, wherein: a partition plate (11) is arranged inside the reaction tube (1), and a through hole (14) is formed in the bottom of the partition plate (11).

3. A test device for immunochromatography according to claim 2, wherein: the detection bin (12) and the sample bin (13) are formed by dividing the space inside the reaction tube (1) by a partition plate (11).

4. A test device for immunochromatography according to claim 3, wherein: the volume of the detection chamber (12) is less than or equal to the volume of the sample chamber (13).

5. The detection device for immunochromatography according to claim 1, wherein: the test strip (3) comprises an absorption pad (31), an NC membrane (32), a combination pad (33) and a sample pad (34), wherein the absorption pad (31), the NC membrane (32), the combination pad (33) and the sample pad (34) are sequentially arranged from top to bottom.

6. A test device for immunochromatography according to claim 5, wherein: the sample pad (34) is provided with a highest liquid level line (35).

7. A test device for immunochromatography according to claim 5, wherein: the bottom of the reaction tube cap (2) is provided with a test strip slot (21), and the top end of the absorption pad (31) is movably inserted into the slot (21).

8. The detection device for immunochromatography according to claim 1, wherein: the shape of the reaction tube (1) is one of circular and polygonal.

9. The detection device for immunochromatography according to claim 1, wherein: the reaction tube (1) is made of transparent materials.