CN217156540U

CN217156540U - Magnetic particle motion control structure for chemiluminescence immunoassay analyzer

Info

Publication number: CN217156540U
Application number: CN202220920633.4U
Authority: CN
Inventors: 郎奎林; 邱胜; 胡亮; 张宁; 余农; 王永东
Original assignee: Kelaisi Shenzhen Technology Co ltd
Current assignee: Kelaisi Shenzhen Technology Co ltd
Priority date: 2022-04-19
Filing date: 2022-04-19
Publication date: 2022-08-09
Anticipated expiration: 2032-04-19

Abstract

The utility model discloses a magnetic particle motion control structure for a chemiluminescence immunoassay analyzer, which comprises a base; the supporting plate is rotatably arranged on the base, supporting holes distributed in a circumferential array are formed in the supporting plate, and the supporting holes are used for positioning and installing the reaction cups; the magnetic blocks are embedded in the base and distributed in an array mode along the circumferential direction of the supporting plate, and the height of each magnetic block is gradually reduced along the circumferential direction of the supporting plate; and the driving mechanism is used for driving the supporting disc to rotate. The utility model has the advantages that: can adsorb all magnetic particles in the reaction cup and guide to the bottom of a cup for all effective substance in the cup are all concentrated to the bottom of a cup, prevent that impurity from being mingled with in the magnetic particle, avoid effective substance to be siphoned away along with the waste liquid and cause the magnetism to lose, and obtain the higher effective substance of purity, and then promote the precision that immunoassay detected.

Description

Magnetic particle motion control structure for chemiluminescence immunoassay analyzer

Technical Field

The utility model relates to a medical science detects technical field, concretely relates to a magnetic particle motion control structure for chemiluminescence immunoassay appearance.

Background

Magnetic particle chemiluminescence immunoassay is a novel analysis method combining a magnetic separation technology, a chemiluminescence technology and an immunoassay technology. The suspended magnetic particles are used as a carrier, and the unique 3D surface and the higher specific surface area of the suspended magnetic particles provide sufficient contact area and higher sensitivity for capturing target molecules. Meanwhile, the superparamagnetism of the magnetic particles can realize multiple times of magnetic separation, thereby being beneficial to accelerating the detection speed and fully automating the instrument. Therefore, the magnetic particle chemical immunoassay method is widely applied to the field of biomedical detection at present due to the unique advantages.

In the course of the experiment of the chemiluminescence immunoassay analyzer, the steps of filling, mixing, incubation, washing, detection and the like are generally involved, wherein in the washing stage, the separation of the substance to be detected and other substances is mainly completed, and a substrate is added. The separation of the substance to be detected and other substances mainly depends on the absorption of effective substances by magnetic particles in the reaction cup, and then the waste liquid is absorbed by the liquid extraction needle. In the prior art, the magnetic particles in the washing stage can not sink into the bottom of the cup completely, part of the magnetic particles can suspend or remain on the wall of the cup, and when the liquid drawing needle extends into the reaction cup to draw waste liquid, the suspension or the effective substances remaining on the wall of the cup are easy to suck away, so that the accuracy of immunoassay detection is influenced.

SUMMERY OF THE UTILITY MODEL

In view of this, the utility model provides a magnetic particle motion control structure for chemiluminescence immunoassay appearance can adsorb all magnetic particles in the reaction cup and guide to the bottom of a cup to solve the corresponding technical problem that points out in the background art.

In order to achieve the above purpose, the utility model discloses technical scheme as follows:

a magnetic particle motion control structure for a chemiluminescence immunoassay analyzer is characterized by comprising:

a base;

the supporting plate is rotatably arranged on the base, supporting holes which are uniformly distributed in a circumferential array are formed in the supporting plate, and the supporting holes are used for positioning and installing the reaction cups;

the magnetic blocks are embedded in the base and uniformly distributed in an array along the circumferential direction where the supporting plate is located, and the height of each magnetic block is gradually reduced along the circumferential direction of the supporting plate; and the driving mechanism is used for driving the supporting disc to rotate.

Preferably, the method comprises the following steps: the upper end of the base is provided with a circular cavity, and the supporting disc is rotatably arranged in the circular cavity.

Preferably, the method comprises the following steps: the driving mechanism is a stepping motor arranged at the bottom of the base, and the stepping motor drives the supporting disc to rotate through a rotating shaft arranged at the bottom of the base.

Preferably, the method comprises the following steps: the base is provided with assembling grooves corresponding to the positions of the magnetic blocks, the depth of each assembling groove is equal, and the magnetic blocks are fixedly installed in the assembling grooves through cushion blocks.

Preferably, the method comprises the following steps: the assembling groove is formed in the bottom of the base, the magnetic block and the cushion block are detachably installed in the assembling groove through the locking plate, and the cushion block is located at the upper end of the magnetic block.

Preferably, the method comprises the following steps: the number of the magnetic blocks is five.

Preferably, the method comprises the following steps: the number of the supporting holes is larger than that of the magnetic blocks.

Preferably, the method comprises the following steps: the liquid sucking device is characterized in that a cover plate is mounted at the upper end of the base, a grabbing opening and a liquid sucking hole are formed in the cover plate, and a liquid sucking needle is arranged above the cover plate in a position corresponding to the liquid sucking hole in a lifting mode.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the reaction cup is installed in the back of the support hole on the supporting disk, along with the rotation of supporting disk, each reaction cup all can follow each magnetic path lateral part and pass through, because each magnetic path is the height that reduces gradually at the supporting disk circumferencial direction, so the reaction cup passes through the back from the lateral part of all magnetic paths, the inside magnetic particle of reaction cup can be guided to the reaction cup bottom of cup gradually by the magnetism of each magnetic path, make all effective substance in the cup all concentrate to the bottom of cup, prevent that impurity from being mingled with in the magnetic particle, avoid effective substance to be siphoned away along with the waste liquid and cause the magnetism to lose, and obtain the higher effective substance of purity, and then promote the precision that immunoassay detected.

2. The magnetic block is arranged in a spiral step mode to guide magnetic particles to descend along the cup wall of the reaction cup, and the magnetic particle reduction device has the technical advantages of ingenious structural design, convenience in installation, low cost, wide market application prospect and the like.

Drawings

FIG. 1 is a cross-sectional view of a wash module in a chemiluminescent immunoassay analyzer;

FIG. 2 is an enlarged view taken along line A in FIG. 1;

FIG. 3 is a schematic perspective view of the washing module shown in FIG. 1 after the base 1 is hidden;

fig. 4 is a schematic view showing the installation of the support plate 2 inside the base 1;

FIG. 5 is a schematic view of the structure of the base 1 (bottom-up view);

fig. 6 is a schematic perspective view of the washing module shown in fig. 1.

Detailed Description

The present invention will be further described with reference to the following examples and accompanying drawings.

The present embodiment is described by taking an example of the application of the magnetic particle motion control structure to the washing module of the chemiluminescence immunoassay analyzer.

Referring to fig. 1 and 3, a washing module includes a base 1, as shown in fig. 4, the base 1 is a rectangular block structure, a circular chamber 1b is disposed at an upper end thereof, a supporting plate 2 is rotatably mounted in the circular chamber 1b, supporting holes 2a distributed in a circumferential array are disposed on the supporting plate 2, and the supporting holes 2a are used for positioning and mounting reaction cups a. A plurality of magnetic blocks 3 are embedded in the base 1, the magnetic blocks 3 are distributed in an array mode along the circumferential direction where the supporting plate 2 is located, and the height of each magnetic block 3 is gradually reduced along the circumferential direction of the supporting plate 2.

The bottom of base 1 installs actuating mechanism 4, and actuating mechanism 4 is used for driving supporting disk 2 and rotates in base 1. In the washing process of the washing module, after the reaction cups a are arranged in the supporting holes 2a on the supporting plate 2, each reaction cup a can pass through the side parts of the magnetic blocks 3 along with the rotation of the supporting plate 2, and because the heights of the magnetic blocks 3 in the circumferential direction of the supporting plate 2 are gradually reduced, after the reaction cups a pass through the side parts of all the magnetic blocks 3, magnetic particles in the reaction cups a can be gradually guided to the bottoms of the reaction cups a by the magnetism of the magnetic blocks 3, so that all effective substances in the cups are concentrated to the bottoms of the reaction cups along with the magnetic particles. Under this state, when imbibition needle 8 stretched into reaction cup a and inhales the waste liquid, only can inhale the invalid waste liquid in the cup, avoided the active material to be inhaled along with the waste liquid and led to the fact the magnetism to lose, and obtained the higher active material of purity, and then promoted the precision that immunoassay detected.

In this embodiment, the number of the supporting holes 2a is greater than the number of the magnetic blocks 3, specifically: the number of the supporting holes 2a is 10, and the number of the magnetic blocks 3 is five. So design, can set up other washing stations on washing module, like: waste liquid absorption, reaction cup grabbing and the like. Further, as shown in fig. 6, a cover plate 7 is mounted on the upper end of the base 1, a grabbing opening 7a and a liquid suction hole 7b are formed in the cover plate 7, and a liquid suction needle 8 is arranged above the cover plate 7 at a position corresponding to the liquid suction hole 7b in a lifting manner. Supporting disk 2 rotates in base 1 inside can take reaction cup a to snatch mouthful 7a and inhale below the liquid hole 7b, snatch reaction cup a from making things convenient for outside manipulator to and make things convenient for liquid suction needle 8 directly to stretch into the reaction cup a in and absorb the waste liquid.

As shown in fig. 2, the base 1 is provided with assembling grooves 1a at positions corresponding to the magnetic blocks 3, the grooves of the assembling grooves 1a have the same depth, and the magnetic blocks 3 are fixedly mounted in the assembling grooves 1a through the spacers 5. By the design, the assembling groove 1a of the base 1 can be conveniently machined, and on the basis, the height of the magnetic block 3 can be controlled by adjusting the thickness of the cushion block 5. Further, as shown in fig. 5, an assembly groove 1a is formed in the bottom of the base 1, the magnetic block 3 and the cushion block 5 are detachably mounted in the assembly groove 1a through a locking plate 6, and the cushion block 5 is located at the upper end of the magnetic block 3. So design, can be according to the inside magnetic particle volume of reaction cup, the concrete height of each magnetic path 3 of in good time adjustment uses more in a flexible way, is applicable to multiple detection mode, and practicality, economic nature are better.

The driving mechanism 4 at the bottom of the base 1 can adopt the existing mature technology, such as: with step motor as the power supply, at the vertical pivot of establishing in 1 bottom of base, the pivot upper end is connected in 2 bottom centers of supporting disk department, and the lower extreme is connected with step motor power, and step motor work can drive supporting disk 2 and rotate.

Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and the scope of the present invention.

Claims

1. A magnetic particle motion control structure for a chemiluminescent immunoassay analyzer, comprising:

a base (1);

a support plate (2) rotatably mounted on the base (1), wherein support holes (2a) distributed in a circumferential array are formed in the support plate (2), and the support holes (2a) are used for positioning and mounting reaction cups (a);

the magnetic blocks (3) are embedded in the base (1), the magnetic blocks (3) are uniformly distributed in an array along the circumferential direction where the supporting plate (2) is located, and the height of each magnetic block (3) is gradually reduced along the circumferential direction of the supporting plate (2); and

and the driving mechanism (4) is used for driving the supporting disc (2) to rotate.

2. The magnetic particle motion control structure for a chemiluminescent immunoassay analyzer of claim 1 wherein: the upper end of the base (1) is provided with a circular cavity (1b), and the supporting disc (2) is rotatably arranged in the circular cavity (1 b).

3. The magnetic particle motion control structure for a chemiluminescent immunoassay analyzer of claim 1 wherein: the driving mechanism (4) is a stepping motor arranged at the bottom of the base (1), and the stepping motor drives the supporting disc (2) to rotate through a rotating shaft arranged at the bottom of the base (1).

4. The magnetic particle motion control structure for a chemiluminescent immunoassay analyzer of claim 1 wherein: the magnetic block assembling device is characterized in that assembling grooves (1a) are formed in the positions, corresponding to the magnetic blocks (3), of the base (1), the groove depths of the assembling grooves (1a) are equal, and the magnetic blocks (3) are fixedly installed in the assembling grooves (1a) through cushion blocks (5).

5. The magnetic particle motion control structure for a chemiluminescent immunoassay analyzer of claim 4 wherein: the assembling groove (1a) is formed in the bottom of the base (1), the magnetic block (3) and the cushion block (5) are detachably installed in the assembling groove (1a) through a locking plate (6), and the cushion block (5) is located at the upper end of the magnetic block (3).

6. The magnetic particle motion control structure for a chemiluminescent immunoassay analyzer of claim 1 wherein: the number of the magnetic blocks (3) is five.

7. The magnetic particle motion control structure for a chemiluminescent immunoassay analyzer of claim 1 wherein: the number of the supporting holes (2a) is larger than that of the magnetic blocks (3).

8. The magnetic particle motion control structure for a chemiluminescent immunoassay analyzer of claim 7 wherein: the liquid sucking machine is characterized in that a cover plate (7) is installed at the upper end of the base (1), a grabbing opening (7a) and a liquid sucking hole (7b) are formed in the cover plate (7), and a liquid sucking needle (8) is arranged above the cover plate (7) in a position corresponding to the liquid sucking hole (7b) in a liftable mode.