CN217025310U - Automatic cleaning device of medicament filling equipment - Google Patents
Automatic cleaning device of medicament filling equipment Download PDFInfo
- Publication number
- CN217025310U CN217025310U CN202220460552.0U CN202220460552U CN217025310U CN 217025310 U CN217025310 U CN 217025310U CN 202220460552 U CN202220460552 U CN 202220460552U CN 217025310 U CN217025310 U CN 217025310U
- Authority
- CN
- China
- Prior art keywords
- tank
- cip
- cleaning
- pipeline
- branch pipe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
- Cleaning By Liquid Or Steam (AREA)
- Cleaning In General (AREA)
Abstract
The utility model provides an automatic cleaning device of medicament filling equipment, which is used for cleaning one or more of a heating tank, a preparation tank, a liquid storage tank and a filling machine; the cleaning device comprises a CIP tank, a heat exchanger and a CIP cleaning pipeline, wherein the CIP tank and the heat exchanger are connected through a hot water pipeline, and the CIP tank is connected to equipment to be cleaned through the CIP cleaning pipeline; the CIP cleaning pipeline is connected with a compressed air pipeline. According to the automatic cleaning device for the medicament filling equipment, provided by the utility model, the cleaning solution or the disinfectant is introduced into each equipment, hose and the like for cleaning and disinfection, the disassembly and assembly operation is not needed, the manpower is saved, and the cleaning effect is good.
Description
Technical Field
The utility model belongs to the technical field of pharmacy, and particularly relates to a cleaning device of pharmaceutical equipment.
Background
Production equipment in the industries of food, medicine and the like needs to be cleaned regularly so as to meet the sanitary standard. The cleaning method includes a Cleaning In Place (CIP) method, a Cleaning Out of Place (COP) method in which the apparatus is removed and cleaned, and the like. COP generally adopts cleaning methods such as manual cleaning, foam cleaning, etc., all equipment is disassembled and manually cleaned: clean water washing, brush scrubbing, clean water washing of assembled equipment and the like are time-consuming and labor-consuming. In cleaning-in-place, the water used for flushing and the washing liquid are circulated in a closed circuit in the piping and production line of the apparatus without disassembling the apparatus. The on-site cleaning has high mechanization degree, and can be used for cleaning and purifying production equipment with strict requirement on sanitary level.
Patent application CN113731970A proposes a method for cleaning a pipeline with multiple tanks, which comprises the following steps: cleaning a pipe distribution: connecting adjacent pipelines with a liquid discharge pipe, connecting the container barrel with a connecting pipe, and communicating the tail end of the connecting pipe with the liquid discharge pipe; connecting air pipes between the adjacent air pipes so that the air pipes are communicated with each other; connecting a plurality of pipelines far away from the liquid discharge pipe and the air pipe with the same valve; pipeline disinfection: the container barrel is used for containing disinfectant, the valve is closed to discharge the disinfectant into the pipeline, and the disinfectant is used for soaking the inside of the pipeline and the air pipe; cleaning a pipeline: closing the valve to enable clean water in the pipeline to clean the interior of the air pipe, and finally opening the valve to clean the pipeline and the interior of the air pipe; and (5) resetting the pipeline. This prior art utilizes the antiseptic solution closed cycle in the pipeline of equipment, can soak, wash a plurality of pipelines and the inside of air hose simultaneously, has realized function synchronous, quick, that the cleaning nature is high. However, the technique needs to connect the pipeline during cleaning each time, and cannot completely realize automatic cleaning.
SUMMERY OF THE UTILITY MODEL
Aiming at the defects in the prior art, the utility model aims to provide an automatic cleaning device of medicament filling equipment, which is used for cleaning the equipment by using purified water and finishes the cleaning and disinfecting work by adopting less equipment with lower energy consumption; and the production automation degree is improved.
The technical scheme for realizing the aim of the utility model is as follows:
an automatic cleaning device of a medicament filling device is used for cleaning one or more of a heating tank, a preparation tank, a liquid storage tank and a filling machine; the cleaning device comprises a CIP tank, a heat exchanger and a CIP cleaning pipeline, wherein the CIP tank and the heat exchanger are connected through a hot water pipeline, and the CIP tank is connected to equipment to be cleaned through the CIP cleaning pipeline; the CIP cleaning pipeline is connected with a compressed air pipeline;
the CIP cleaning pipeline is connected to the top of the filling machine through a cleaning liquid inlet branch pipe, a cleaning liquid outlet branch pipe and a cleaning electromagnetic valve, and the cleaning liquid inlet branch pipe, the cleaning liquid outlet branch pipe and the CIP tank form a cleaning liquid circulation pipeline; a liquid inlet branch pipe, a liquid outlet branch pipe and a filling electromagnetic valve for filling liquid medicine are arranged at the top of the filling machine in parallel, and the liquid inlet branch pipe, the liquid outlet branch pipe and the liquid storage tank form a liquid medicine circulation path;
the CIP cleaning pipeline is connected to one or more of the heating tank, the preparation tank and the liquid storage tank through a branch pipe.
The preparation tank is filled with the production liquid medicine, and the liquid medicine is injected into the liquid storage tank which is connected with the filling machine; preparing the liquid tank and then carrying out the next batch of production; the heating tank is filled with hot water, and the hot water is sometimes used for preparing the liquid medicine.
The filling machine is an automatic device for filling medicine bottles with liquid medicine, and is connected with a vacuum tank for pumping the liquid medicine into the medicine bottles by vacuum. The filling machine is provided with 30-50 hoses, and one hose is introduced into one medicine bottle. According to the technology, the cleaning pipeline connected with the liquid inlet pipeline in parallel is additionally arranged at the top of the filling machine, and cleaning liquid or disinfectant can be introduced into each hose to clean and disinfect. Because microorganisms can be bred quickly when liquid does not flow, liquid inlet pipelines and cleaning liquid inlet pipelines of the cleaning device are circulating pipelines with liquid inlet and liquid outlet, and liquid constantly flows no matter whether filling or cleaning (controlled by an electromagnetic valve) is performed.
Wherein, the heat exchanger takes steam as a heat exchange medium.
The cleaning is performed by using purified water at 50 ℃, the disinfection is performed by using purified water at 80 ℃, and the purified water tank is connected with the heat exchanger, so that the water temperature in the cleaning pipeline can be controlled according to the process requirement; the same purifying water tank is used for cleaning and disinfection, so that water is saved.
The preparation tank is connected with the liquid storage tank through a liquid medicine pipeline, and a filter is arranged on the liquid medicine pipeline.
In the production process, the liquid medicine needs to be filtered, a filter element is arranged in the filter and needs to be cleaned, and the filter needs to be cleaned during CIP cleaning.
Preferably, the CIP tank is connected with a purified water pipeline and an alkali tank.
And a valve is arranged on a pipeline connected with the alkali tank. Alkali is needed for special cleaning and acid cleaning passivation; alkali is not used in the conventional cleaning.
Further preferably, respirators are arranged at the tops of the CIP tank, the preparation tank, the liquid storage tank and the heating tank.
The CIP cleaning pipeline is connected to the tops of the preparation tank, the liquid storage tank and the heating tank through branch pipes, and the bottoms of the preparation tank, the liquid storage tank and the heating tank are connected to the CIP tank through CIP loops.
Wherein the CIP loop is further connected to the heat exchanger by a branch pipe. The heat exchanger takes steam as a heat exchange medium.
Wherein the CIP loop is further connected with a discharge pipeline.
The CIP cleaning pipeline and the CIP loop are respectively provided with a valve, a flowmeter and a temperature sensor, and the valve, the flowmeter and the temperature sensor are connected to a control system.
Valves are also arranged on the pipelines such as the discharge pipeline, the compressed air pipeline and the like and are connected to the control system.
The automatic cleaning device can perform cleaning or disinfecting operation,
the cleaning operation is as follows: heating the purified water in the CIP tank to 50 ℃, cleaning the heating tank, the preparation tank, the liquid storage tank and the filling machine through cleaning pipelines, enabling the cleaning liquid to flow out of the bottom of each cleaned device, return to the CIP tank, clean the preparation tank again and the like, and circularly performing until the conductivity of the discharged water is less than 0.2 mu S, and discharging;
the cleaning operation is as follows: the purified water in the CIP tank is heated to 80 ℃, enters a heating tank, a preparation tank, a liquid storage tank and a filling machine through cleaning pipelines, and the disinfectant flows out from the bottom of each sterilized device, returns to the CIP tank, enters the preparation tank again and the like, and is circulated until the conductivity of the discharged water is less than 0.2 mu S and is discharged.
The utility model has the beneficial effects that:
according to the automatic cleaning device for the medicament filling equipment, cleaning liquid or disinfectant is introduced into each equipment, hose and the like for cleaning and disinfection, disassembly and assembly operations are not needed, manpower is saved, and the cleaning effect is good;
according to the utility model, the purification water tank is connected with the heat exchanger, and the water temperature in the cleaning pipeline can be controlled according to the process requirement; the same purifying water tank is used for cleaning and disinfection, so that water is saved.
Drawings
Fig. 1 is a schematic view of the automatic cleaning device of the medicine filling apparatus of the present invention.
Fig. 2 is a schematic view of a filling machine.
In the figure, 1 is a CIP tank, 2 is an alkali tank, 3 is a heating tank, 4 is a preparation tank, 5 is a liquid storage tank, 6 is a heat exchanger, 7 is a filling machine, 7’In the cleaning process, the cleaning liquid inlet branch pipe 701 is a cleaning liquid inlet branch pipe, the liquid inlet branch pipe 702 is a liquid inlet branch pipe for filling liquid medicine, the filling solenoid valve 703 is a filling solenoid valve, the hose 704 is a cleaning solenoid valve 705 is a cleaning solenoid valve, the liquid outlet branch pipe 706 is a liquid outlet branch pipe, the filter 8 is a filter, and the CIP loop 9 is a CIP loop.
Detailed Description
The following examples are intended to illustrate the utility model but are not intended to limit the scope of the utility model.
To make the implementation, technical solution and advantages of the present invention clearer, the technical solution in the embodiment of the present invention will be described in more detail below with reference to the accompanying drawings in the embodiment of the present invention. In the drawings, the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The described embodiments are only some, but not all embodiments of the utility model.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings, and are merely intended to facilitate the description of the present invention and to simplify the description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the scope of the present invention.
Unless otherwise specified, the means employed in the examples are all technical means known in the art.
Example 1
Referring to fig. 1, the present embodiment provides an automatic cleaning device for a medicament filling apparatus, which is used for cleaning a heating tank 3, a preparation tank 4, a liquid storage tank 5, and a filling machine 7; the device comprises a CIP tank 1, a heat exchanger 6 and a CIP cleaning pipeline, wherein the CIP tank 1 and the heat exchanger 6 are connected through a hot water pipeline, and the CIP tank 1 is connected to equipment to be cleaned through the CIP cleaning pipeline; the CIP cleaning pipeline is connected with a compressed air pipeline;
referring to fig. 2, the CIP cleaning pipeline is connected to the top of the filling machine 7 through a cleaning liquid inlet branch pipe 701, a cleaning liquid outlet branch pipe, and a cleaning solenoid valve 705, and the cleaning liquid inlet branch pipe, the cleaning liquid outlet branch pipe, and the CIP tank 1 form a cleaning liquid circulation pipeline; a liquid inlet branch pipe 702, a liquid outlet branch pipe 706 and a filling electromagnetic valve 703 for filling liquid medicine are further arranged in parallel at the top of the filling machine, and the liquid inlet branch pipe, the liquid outlet branch pipe and the liquid storage tank form a liquid medicine circulation path (only one filling machine is provided in the device of the embodiment, and fig. 1 shows a filling machine 7' during cleaning, which shows that a liquid medicine pipeline and a cleaning pipeline are connected in parallel); during filling, the liquid medicine enters the medicine bottle through the hose 704. Cleaning solution cleans hose 704 and enters CIP loop 9. The filling machine 7 is provided with 48 hoses, only one of which is shown in fig. 2.
The CIP cleaning pipeline is respectively connected to the heating tank 3, the preparation tank 4 and the liquid storage tank 5 through branch pipes. The bottoms of the preparation tank 4, the reservoir tank 5, the heating tank 3 are connected to the CIP tank by a CIP circuit 9. The preparation tank 4 is connected with the liquid storage tank 5 through a liquid medicine pipeline, and a filter 8 is arranged on the liquid medicine pipeline.
Wherein, the CIP tank 1 is connected with a purified water pipeline and an alkali tank 2.
Further preferably, respirators are arranged at the tops of the CIP tank 1, the preparation tank 4, the liquid storage tank 5 and the heating tank 3.
Wherein the CIP loop 9 is further connected to the heat exchanger by a branch pipe. The CIP loop 9 is also connected with a discharge pipe.
The CIP cleaning pipeline and the CIP loop are respectively provided with a valve, a flowmeter and a temperature sensor, and the valve, the flowmeter and the temperature sensor are connected to a control system. Valves are also arranged on the pipelines such as the discharge pipeline, the compressed air pipeline and the like and are connected to the control system.
Wherein, the heat exchanger 6 takes steam as a heat exchange medium and provides 50 ℃ purified water for cleaning and 80 ℃ purified water for disinfection.
The automatic cleaning device can perform cleaning or disinfecting operation,
the cleaning operation is as follows: heating the purified water in the CIP tank to 50 ℃, cleaning the preparation tank, the liquid storage tank and the filling machine through a cleaning pipeline, enabling the cleaning liquid to flow out of the bottom of each cleaned device, return to the CIP tank, clean the preparation tank again and the like, and circulating until the conductivity of the discharged water is less than 0.2 mu S, and discharging.
The cleaning operation is as follows: the purified water in the CIP tank is heated to 80 ℃, enters the preparation tank, the liquid storage tank and the filling machine through cleaning pipelines, and the disinfectant flows out from the bottom of each sterilized device, returns to the CIP tank, enters the preparation tank again and the like, and is circulated until the conductivity of the discharged water is less than 0.2 mu S and is discharged.
Example 2
The embodiment provides an automatic cleaning device of a medicament filling device, which is used for cleaning a heating tank, a preparation tank, a liquid storage tank and a filling machine; the cleaning device comprises a CIP tank 1, a heat exchanger 6 and a CIP cleaning pipeline, wherein the CIP tank 1 and the heat exchanger 6 are connected through a hot water pipeline, and the CIP tank 1 is connected to equipment to be cleaned through the CIP cleaning pipeline; the CIP cleaning pipeline is connected with a compressed air pipeline;
in this embodiment, the CIP cleaning pipeline is connected to the top of the filling machine 7 through the cleaning liquid inlet branch pipe 701, the cleaning liquid outlet branch pipe, and the cleaning solenoid valve 705, and the cleaning liquid inlet branch pipe, the cleaning liquid outlet branch pipe, and the CIP tank 1 form a cleaning liquid circulation pipeline; a liquid inlet branch pipe 702, a liquid outlet branch pipe 706 and a filling electromagnetic valve 703 for filling liquid medicine are also arranged in parallel at the top of the filling machine, and the liquid inlet branch pipe, the liquid outlet branch pipe and the liquid storage tank form a liquid medicine circulation path;
the CIP cleaning pipeline is connected to the heating tank 3, the preparation tank 4 and the liquid storage tank 5 through branch pipes. The preparation tank 4 is connected with the liquid storage tank 5 through a liquid medicine pipeline, and a filter 8 is arranged on the liquid medicine pipeline.
Wherein, the CIP tank 1 is connected with a purified water pipeline.
Further preferably, respirators are arranged at the tops of the CIP tank 1, the heating tank 3, the preparation tank 4 and the liquid storage tank 5.
Wherein the bottoms of the preparation tank 4, the liquid storage tank 5 and the heating tank 3 are connected to the CIP tank through CIP loops. The CIP loop is also connected to the heat exchanger by a branch pipe. The CIP loop is also connected with a discharge pipeline.
The CIP cleaning pipeline and the CIP loop are respectively provided with a valve, a flowmeter and a temperature sensor, and the valve, the flowmeter and the temperature sensor are connected to a control system. Valves are also arranged on the discharge pipeline, the compressed air pipeline and the like and are connected to the control system.
Wherein, the heat exchanger 6 takes steam as a heat exchange medium and provides 50 ℃ purified water for cleaning and 80 ℃ purified water for disinfection.
The apparatus was cleaned in the same manner as in example 1.
Although the present invention has been described in terms of the above embodiments, those skilled in the art will recognize that changes and modifications can be made without departing from the spirit and scope of the utility model.
Claims (8)
1. An automatic cleaning device of a medicament filling device is used for cleaning one or more of a heating tank, a preparation tank, a liquid storage tank and a filling machine; the cleaning device is characterized by comprising a CIP tank, a heat exchanger and a CIP cleaning pipeline, wherein the CIP tank and the heat exchanger are connected through a hot water pipeline, and the CIP tank is connected to equipment to be cleaned through the CIP cleaning pipeline; the CIP cleaning pipeline is connected with a compressed air pipeline;
the CIP cleaning pipeline is connected to the top of the filling machine through a cleaning liquid inlet branch pipe, a cleaning liquid outlet branch pipe and a cleaning electromagnetic valve, and the cleaning liquid inlet branch pipe, the cleaning liquid outlet branch pipe and the CIP tank form a cleaning liquid circulation pipeline; a liquid inlet branch pipe, a liquid outlet branch pipe and a filling electromagnetic valve for filling liquid medicine are also arranged in parallel at the top of the filling machine, and the liquid inlet branch pipe, the liquid outlet branch pipe and the liquid storage tank form a liquid medicine circulation path;
the CIP cleaning pipeline is connected to one or more of the heating tank, the preparation tank and the liquid storage tank through a branch pipe.
2. The automatic cleaning device for a drug filling apparatus according to claim 1, wherein the preparation tank is connected to the liquid storage tank through a liquid medicine pipe, and a filter is provided on the liquid medicine pipe.
3. The automatic cleaning device for a chemical filling apparatus according to claim 1, wherein the CIP tank is connected to a purified water pipe and an alkaline tank.
4. The automatic cleaning device for the medicament filling equipment according to any one of claims 1 to 3, wherein respirators are arranged at the tops of the CIP tank, the preparation tank, the liquid storage tank and the heating tank.
5. The automatic cleaning device for a drug filling apparatus according to claim 1, wherein the CIP cleaning pipe is connected to the top of the preparation tank, the reservoir tank, and the heating tank through a branch pipe, and the bottom of the preparation tank, the reservoir tank, and the heating tank is connected to the CIP tank through a CIP circuit.
6. The automatic cleaning device of a medication filling apparatus according to claim 5, wherein the CIP circuit is further connected to the heat exchanger by a branch pipe.
7. The automatic cleaning device for a drug filling apparatus according to claim 5, wherein a drain line is further connected to the CIP circuit.
8. The automatic cleaning device for the medicine filling equipment according to claim 6 or 7, wherein the CIP cleaning pipeline and the CIP loop are provided with a valve, a flow meter and a temperature sensor, and the valve, the flow meter and the temperature sensor are connected to a control system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220460552.0U CN217025310U (en) | 2022-03-04 | 2022-03-04 | Automatic cleaning device of medicament filling equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220460552.0U CN217025310U (en) | 2022-03-04 | 2022-03-04 | Automatic cleaning device of medicament filling equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217025310U true CN217025310U (en) | 2022-07-22 |
Family
ID=82453173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220460552.0U Active CN217025310U (en) | 2022-03-04 | 2022-03-04 | Automatic cleaning device of medicament filling equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217025310U (en) |
-
2022
- 2022-03-04 CN CN202220460552.0U patent/CN217025310U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5405452A (en) | Milk pipeline washing system | |
| CN107801888A (en) | Sterilization processing line and its purification method | |
| CN109757991B (en) | Water dispenser | |
| US20120227767A1 (en) | Washing Machine and Corresponding Washing Method | |
| CN218079467U (en) | CIP online cleaning equipment | |
| JP2022093496A (en) | Cleaning and sterilizing method of aseptic filling machine and aseptic filling machine | |
| CN114618361A (en) | Full-automatic aseptic liquid preparation system | |
| US20230217885A1 (en) | Cip system | |
| CN217025310U (en) | Automatic cleaning device of medicament filling equipment | |
| CN111214857A (en) | Alcohol precipitation jar on-line cleaning device | |
| CN110976410A (en) | Cleaning pipeline system for cleaning lumen instrument and use method thereof | |
| CN219378325U (en) | Cleaning system suitable for liquid jar is joined in marriage to L-carnitine for injection | |
| CN210146565U (en) | Three-tank online cleaning workstation | |
| CN113145585B (en) | Cleaning device of pot matching machine | |
| CN110170482A (en) | Three tank on-line cleaning work stations | |
| JP2023083439A (en) | Cleaning and sterilization method for carbon dioxide gas line of aseptic filling machine, and aseptic filling machine | |
| CN214735140U (en) | Water treatment equipment for cleaning and disinfecting endoscope | |
| CN213214837U (en) | Liquid milk disinfection and feeding system | |
| CN209410840U (en) | A kind of sterile liquid storage pot system | |
| CN211705361U (en) | Hydrologic cycle formula ampoule sterilizer | |
| CN208500554U (en) | A kind of noresidue pure water equipment of automatically washing and sterilizing | |
| CN220877311U (en) | Empty system of eliminating of fermentation tube way | |
| CN109757989B (en) | Water dispenser | |
| CN206298582U (en) | A kind of liquid mixing system of continuous liquid supply | |
| CN217525031U (en) | Feeding bottle cleaning and disinfecting all-in-one |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |